1,290 Matching Annotations
  1. Jul 2021
  2. www.sciencedirect.com www.sciencedirect.com
    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
    1
    1. scibot 27 Jul 2021
      RRID:AB_33092

      DOI: 10.1016/j.devcel.2018.01.010

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    sciencedirect.com/science/article/pii/S1534580718300108
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    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
    1
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      DOI: 10.1016/j.ccell.2017.10.007

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    sciencedirect.com/science/article/pii/S1535610817304609
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    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
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      DOI: 10.1016/j.ebiom.2016.06.007

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    sciencedirect.com/science/article/pii/S2352396416302511
  5. rupress.org rupress.org
    Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination
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    1. scibot 23 Jul 2021
      7076

      DOI: 10.1083/jcb.202006043

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    rupress.org/jcb/article/220/6/e202006043/211984/Parkin-independent-mitophagy-via-Drp1-mediated
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    An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells
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    sciencedirect.com/science/article/pii/S2666166721003841
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    sciencedirect.com/science/article/pii/S2211124721008238
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    Peroxisomes in the mouse parotid glands: An in-depth morphological and molecular analysis
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    sciencedirect.com/science/article/pii/S0940960221001047
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    β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression
    1
    1. scibot 21 Jul 2021
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    sciencedirect.com/science/article/pii/S1074761321002648
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    KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
    1
    1. scibot 14 Jul 2021
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      DOI: 10.1111/bph.15438

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    ncbi.nlm.nih.gov/pmc/articles/PMC8251890/
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    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
    1
    1. scibot 14 Jul 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8271203/
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    Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis
    1
    1. scibot 14 Jul 2021
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    sciencedirect.com/science/article/pii/S2211124721007592
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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    1. scibot 13 Jul 2021
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    sciencedirect.com/science/article/pii/S1534580721005177
  14. www.cell.com www.cell.com
    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    1. scibot 03 Jul 2021
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
  15. Jun 2021
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    Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy
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    1. scibot 30 Jun 2021
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    sciencedirect.com/science/article/pii/S1534580721004810
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
    1
    1. scibot 30 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109291

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    sciencedirect.com/science/article/pii/S2211124721006628
  18. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    1. scibot 29 Jun 2021
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      DOI: 10.1158/1078-0432.CCR-20-3365

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    clincancerres.aacrjournals.org/content/27/12/3432
  19. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    1. scibot 29 Jun 2021
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      DOI: 10.1155/2021/6687089

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    hindawi.com/journals/mi/2021/6687089/tab2/
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    LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes
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    1. scibot 19 Jun 2021
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      DOI: 10.1016/j.cub.2021.05.052

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    sciencedirect.com/science/article/pii/S0960982221007508
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1
    1
    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.isci.2021.102645

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    ncbi.nlm.nih.gov/pmc/articles/PMC8185223/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver
    1
    1. scibot 17 Jun 2021
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      DOI: 10.1126/sciadv.abf9141

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    ncbi.nlm.nih.gov/pmc/articles/PMC8177709/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
    1
    1. scibot 17 Jun 2021
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      DOI: 10.7554/eLife.67315

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    ncbi.nlm.nih.gov/pmc/articles/PMC8192125/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
    1
    1. scibot 16 Jun 2021
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      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
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    Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
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    1. scibot 11 Jun 2021
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    sciencedirect.com/science/article/pii/S1074761321002107
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    ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S1097276521003658
  27. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
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      DOI: 10.1016/j.celrep.2021.109190

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  28. May 2021
  29. www.sciencedirect.com www.sciencedirect.com
    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    sciencedirect.com/science/article/pii/S2405471221001575
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8106883/
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    A systematic analysis of signaling reactivation and drug resistance
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    sciencedirect.com/science/article/pii/S221112472100499X
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    Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
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    sciencedirect.com/science/article/pii/S1934590921001818
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    Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy
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    link.springer.com/article/10.1007/s00109-021-02091-1
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    Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
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    sciencedirect.com/science/article/pii/S2211124721004964
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    β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria
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      DOI: 10.7554/eLife.67552

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    ncbi.nlm.nih.gov/pmc/articles/PMC8102061/
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    Invariant natural killer T cells coordinate removal of senescent cells
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    sciencedirect.com/science/article/pii/S266663402100163X
  40. academic.oup.com academic.oup.com
    Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity
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      DOI: 10.1210/endocr/bqaa142

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    academic.oup.com/endo/article/161/11/bqaa142/5893756
  41. journals.physiology.org journals.physiology.org
    The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model
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    1. scibot 10 May 2021
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      DOI: 10.1152/ajpcell.00299.2020

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    journals.physiology.org/doi/abs/10.1152/ajpcell.00299.2020
  42. rupress.org rupress.org
    Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
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    1. scibot 09 May 2021
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      DOI: 10.1084/jem.20200662

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    rupress.org/jem/article/218/3/e20200662/211733/Loss-of-tRNA-modifying-enzyme-Elp3-activates-a-p53
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    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.vph.2020.106775

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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification
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    Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
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    The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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    Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form
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    A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
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    LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2
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    Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
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    iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia
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    Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
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    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
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    Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A
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    Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics
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    LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection
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    Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP
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    The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
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    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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    Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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    PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis
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    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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    Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA
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  135. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation
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    Deficiency of microglial autophagy increases the density of oligodendrocytes and susceptibility to severe forms of seizures
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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    Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M
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    Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors
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    Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
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    NUPR1 is a critical repressor of ferroptosis
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    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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  148. Jan 2021
  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
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    Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution
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    The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
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    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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  157. Dec 2020
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    FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells
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    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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    Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction
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    Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats
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  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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    Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
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    A novel HDAC6 inhibitor improves myelination of Schwann cells in a model of Charcot‐Marie‐Tooth disease type 1A
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  165. Nov 2020
  166. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti
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    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis
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    PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
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      DOI: 10.1016/j.immuni.2017.11.003

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      Curator: @evieth

      SciCrunch record: RRID:AB_330924

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      RRID:AB_330924 RRIDCUR:Validated
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    cell.com/immunity/abstract/S1074-7613(17)30480-6
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    Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
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    1. scibot 23 Sep 2020
      RRID:AB_330924

      DOI: 10.1016/j.cmet.2020.06.002

      Resource: (Cell Signaling Technology Cat# 7076, RRID:AB_330924)

      Curator: @Naa003

      SciCrunch record: RRID:AB_330924

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      RRID:AB_330924 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S155041312030303X