189 Matching Annotations
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724004777
  3. Apr 2024
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  7. Feb 2024
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    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    1. scibot 03 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830876/
  9. Jan 2024
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    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
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    sciencedirect.com/science/article/pii/S0021925824000176
  11. Dec 2023
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    sciencedirect.com/science/article/pii/S1534580723006214
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    Sequestration of translation initiation factors in p62 condensates
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    1. scibot 17 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015954
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
  15. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    1. scibot 29 Nov 2023
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    sciencedirect.com/science/article/pii/S2589004223023556
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    1. scibot 17 Nov 2023
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    sciencedirect.com/science/article/pii/S2666379123004792
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    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    1. scibot 03 Nov 2023
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  19. 52.53.155.43 52.53.155.43
    s11684-022-0959-5 (1)-html.html
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    1. scibot 03 Nov 2023
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      DOI: 10.3389/fncel.2020.552213

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  20. Oct 2023
  21. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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  22. Sep 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    sciencedirect.com/science/article/pii/S0022316623352799
  24. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  25. Aug 2023
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    sciencedirect.com/science/article/pii/S221112472300997X
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
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    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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      DOI: 10.1158/1535-7163.MCT-23-0110

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  30. Jul 2023
  31. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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  34. Jun 2023
  35. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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      DOI: 10.1523/JNEUROSCI.0146-23.2023

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  36. May 2023
  37. 52.53.155.43 52.53.155.43
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    1. scibot 27 May 2023
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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    sciencedirect.com/science/article/pii/S2211124722008944
  39. Apr 2023
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    sciencedirect.com/science/article/pii/S2589004223006557
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    sciencedirect.com/science/article/pii/S1535610823000946
  42. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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      DOI: 10.1002/iub.2722

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  44. Mar 2023
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    Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells
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    sciencedirect.com/science/article/pii/S2211124723001675
  46. Feb 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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      DOI: 10.1016/j.isci.2023.106169

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    sciencedirect.com/science/article/pii/S2589004223002468
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
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    Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle
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    sciencedirect.com/science/article/pii/S0016648023000369
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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      DOI: 10.1111/jnc.15771

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    onlinelibrary.wiley.com/doi/epdf/10.1111/jnc.15771
  51. Jan 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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      DOI: 10.7150/thno.75973

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    ncbi.nlm.nih.gov/pmc/articles/PMC9830446/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma
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      DOI: 10.1158/0008-5472.CAN-21-3868

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  54. Nov 2022
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  108. academic.oup.com academic.oup.com
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  110. Jul 2021
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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      phospho‐p70S6 kinase (Thr389) rabbit mAb

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    Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time
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  115. Jun 2021
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    Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties
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  117. May 2021
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    AMPK‐regulated miRNA‐210‐3p is activated during ischaemic neuronal injury and modulates PI3K‐p70S6K signalling
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition
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  125. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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    Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
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  130. Mar 2021
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    An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
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  132. Feb 2021
  133. www.cell.com www.cell.com
    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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  134. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  135. Jan 2021
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    Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma
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    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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    Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity
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  140. Dec 2020
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    Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth
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  142. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  143. Nov 2020
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  146. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system
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  147. Oct 2020
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    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  151. Sep 2020
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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  153. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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  154. dev.biologists.org dev.biologists.org
    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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    Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1
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    A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
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    mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux
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    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling
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    Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
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    Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster
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    m6A Facilitates eIF4F-Independent mRNA Translation
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    Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity
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    Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis
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    Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance
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    An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice
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    eIF4A inactivates TORC1 in response to amino acid starvation
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    Regulation of mTORC1 by lysosomal calcium and calmodulin
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    Dynamics of mTORC1 activation in response to amino acids
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    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
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    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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