59 Matching Annotations
  1. Dec 2023
  2. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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    sciencedirect.com/science/article/pii/S1097276523009681
  3. Nov 2023
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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      DOI: 10.1016/j.cmet.2023.10.016

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    sciencedirect.com/science/article/abs/pii/S1550413123003856
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    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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    1. scibot 17 Nov 2023
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      DOI: 10.15252/embr.202357339

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    embopress.org/doi/full/10.15252/embr.202357339
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    CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions
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    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113306

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    sciencedirect.com/science/article/pii/S2211124723013189
  7. Oct 2023
  8. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  9. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112868

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    sciencedirect.com/science/article/pii/S2211124723008793
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
  12. Jun 2023
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    Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.xcrm.2023.101073

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    sciencedirect.com/science/article/pii/S2666379123001921
  14. May 2023
  15. 52.53.155.43 52.53.155.43
    Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model
    1
    1. scibot 04 May 2023
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      DOI: 10.36922/an.v1i3.153

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    52.53.155.43/438598aeab07baaec772d6c22da43b4baf80f7c8/202211301546121b45a6671-html.html
  16. Apr 2023
  17. www.sciencedirect.com www.sciencedirect.com
    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112316

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    sciencedirect.com/science/article/pii/S2211124723003273
  18. link.springer.com link.springer.com
    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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    1. scibot 01 Apr 2023
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      DOI: 10.1186/s12985-023-02021-2

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    link.springer.com/article/10.1186/s12985-023-02021-2
  19. Feb 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    1. scibot 23 Feb 2023
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      DOI: 10.1016/j.isci.2023.106169

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    sciencedirect.com/science/article/pii/S2589004223002468
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    Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix
    1
    1. scibot 11 Feb 2023
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      DOI: 10.1016/j.isci.2023.105965

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    sciencedirect.com/science/article/pii/S2589004223000421
  22. Dec 2022
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111837

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    sciencedirect.com/science/article/pii/S2211124722017296
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    1. scibot 18 Dec 2022
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      DOI: 10.1016/j.molcel.2022.11.021

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    sciencedirect.com/science/article/pii/S1097276522011340
  25. Oct 2022
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.chembiol.2022.10.002

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    sciencedirect.com/science/article/pii/S2451945622003567
  27. Aug 2022
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.crmeth.2022.100271

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    sciencedirect.com/science/article/pii/S2667237522001485
  29. Jul 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
    1
    1. scibot 27 Jul 2022
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      DOI: 10.1016/j.cmet.2022.07.003

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    sciencedirect.com/science/article/pii/S1550413122003023
  31. May 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry
    1
    1. scibot 21 May 2022
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      DOI: 10.7554/eLife.77696

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    ncbi.nlm.nih.gov/pmc/articles/PMC9113749/
  33. www.sciencedirect.com www.sciencedirect.com
    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    1. scibot 19 May 2022
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      DOI: 10.1016/j.devcel.2022.04.018

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    sciencedirect.com/science/article/pii/S1534580722002866
  34. Mar 2022
  35. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 31 Mar 2022
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      DOI: 10.1111/bph.14558

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14558
  36. www.sciencedirect.com www.sciencedirect.com
    Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
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    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.molcel.2022.02.031

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    sciencedirect.com/science/article/pii/S1097276522002052
  37. 52.53.155.43 52.53.155.43
    japplphysiol.00536.2021-html.html
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    1. scibot 03 Mar 2022
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      DOI: 10.1152/japplphysiol.00536.2021

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    52.53.155.43/29de5e7222342c85eeeb25aa2522e8bbef77b2f2/japplphysiol.00536.2021-html.html
  38. Feb 2022
  39. www.sciencedirect.com www.sciencedirect.com
    Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation
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    1. scibot 23 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110407

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    sciencedirect.com/science/article/pii/S2211124722001310
  40. Dec 2021
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    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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      DOI: 10.1016/j.devcel.2021.11.009

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    sciencedirect.com/science/article/pii/S1534580721008947
  42. Oct 2021
  43. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
    1
    1. scibot 06 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109785

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    sciencedirect.com/science/article/pii/S2211124721012444
  44. Aug 2021
  45. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    1. scibot 10 Aug 2021
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      DOI: 10.1111/bph.14558

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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14558
  46. Jul 2021
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
    1
    1. scibot 31 Jul 2021
      rabbit anti‐P‐4E‐BP1

      DOI: 10.1002/ijc.32709

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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32709
  48. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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    1. scibot 28 Jul 2021
      Phospho-4E-BP1 (Ser65) Antibody

      DOI: 10.1016/j.immuni.2019.03.005

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    sciencedirect.com/science/article/pii/S1074761319300950
  49. Jun 2021
  50. www.sciencedirect.com www.sciencedirect.com
    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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      DOI: 10.1016/j.celrep.2021.109264

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    sciencedirect.com/science/article/pii/S2211124721006318
  51. May 2021
  52. www.sciencedirect.com www.sciencedirect.com
    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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      Rabbit polyclonal anti-phospho-4E-BP1 (Ser65)

      DOI: 10.1016/j.devcel.2020.11.016

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    sciencedirect.com/science/article/pii/S1534580720309254
  53. Apr 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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      DOI: 10.1016/j.chembiol.2020.06.011

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    sciencedirect.com/science/article/pii/S2451945620302348
  55. Feb 2021
  56. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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      DOI: 10.1016/j.molcel.2020.11.027

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    cell.com/molecular-cell/abstract/S1097-2765(20)30827-3
  57. Nov 2020
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    1. scibot 21 Nov 2020
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      DOI: 10.7554/eLife.55994

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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  59. Sep 2020
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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      DOI: 10.1523/JNEUROSCI.0642-19.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6867816/
  61. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo
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    1. scibot 26 Sep 2020
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      DOI: 10.1002/glia.23911

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    onlinelibrary.wiley.com/doi/10.1002/glia.23911
  62. www.sciencedirect.com www.sciencedirect.com
    Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells
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      DOI: 10.1016/j.molcel.2020.06.005

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    sciencedirect.com/science/article/pii/S1097276520303907
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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      DOI: 10.1016/j.stem.2019.12.006

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    sciencedirect.com/science/article/pii/S1934590919305247
  64. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    1. scibot 15 Sep 2020
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      DOI: 10.7554/eLife.37993

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  67. Jan 2020
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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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  76. Nov 2018
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    Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster
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  83. Nov 2017
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model
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