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76 Matching Annotations

Jul 2025
www.science.org www.science.org

Transfer RNA acetylation regulates in vivo mammalian stress signaling

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  DOI: 10.1126/sciadv.ads2923
  
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PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

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1. scibot 17 Jul 2025
  
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  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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  DOI: 10.1158/0008-5472.CAN-24-2471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
Jun 2025
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PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

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1. scibot 25 Jun 2025
  
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  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

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  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
Apr 2025
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Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma

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1. scibot 11 Apr 2025
  
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  DOI: 10.1186/s13062-025-00645-8
  
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link.springer.com/article/10.1186/s13062-025-00645-8
Mar 2025
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 24 Mar 2025
  
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  DOI: 10.1101/2025.03.18.644053
  
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  DOI: 10.1101/2025.03.18.644053
  
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biorxiv.org/content/10.1101/2025.03.18.644053v1
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 21 Mar 2025
  
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  DOI: 10.1126/sciadv.ads2923
  
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Feb 2025
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PDF-html.html

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1. scibot 28 Feb 2025
  
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  DOI: 10.1101/2025.02.17.638725
  
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52.53.155.43/14aa111ce8a1e5484e892552f2e3d7e5be8c5aa9/PDF-html.html
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GDF-15 predicts epithelioid hemangioendothelioma aggressiveness and is down-regulated by sirolimus through ATF4/ATF5 suppression

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1078-0432.CCR-23-3991
  
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aacrjournals.org/clincancerres/article/30/22/5122/749578/GDF-15-Predicts-Epithelioid-Hemangioendothelioma
Nov 2024
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β2-integrins control HIF1α activation in human neutrophils

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1. scibot 07 Nov 2024
  
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  RRID:AB_330947
  
  DOI: 10.3389/fimmu.2024.1406967
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513320/
Sep 2024
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A TBK1-independent primordial function of STING in lysosomal biogenesis

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
Jul 2024
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Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles

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1. scibot 17 Jul 2024
  
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  DOI: 10.14814/phy2.16145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
Jun 2024
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cmet.2024.05.014
  
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sciencedirect.com/science/article/pii/S1550413124001906
Dec 2023
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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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1. scibot 16 Dec 2023
  
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  RRID:AB_330947
  
  DOI: 10.1016/j.molcel.2023.11.023
  
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sciencedirect.com/science/article/pii/S1097276523009681
Nov 2023
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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.cmet.2023.10.016
  
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sciencedirect.com/science/article/abs/pii/S1550413123003856
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Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism

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1. scibot 17 Nov 2023
  
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  RRID:AB_330947
  
  DOI: 10.15252/embr.202357339
  
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embopress.org/doi/full/10.15252/embr.202357339
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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113306
  
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sciencedirect.com/science/article/pii/S2211124723013189
Oct 2023
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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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1. scibot 20 Oct 2023
  
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  DOI: 10.15252/embr.202356815
  
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embopress.org/doi/10.15252/embr.202356815
Jul 2023
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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  DOI: 10.1016/j.celrep.2023.112868
  
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112794
  
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Jun 2023
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Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model

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  DOI: 10.1016/j.xcrm.2023.101073
  
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sciencedirect.com/science/article/pii/S2666379123001921
May 2023
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Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model

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1. scibot 04 May 2023
  
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  DOI: 10.36922/an.v1i3.153
  
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52.53.155.43/438598aeab07baaec772d6c22da43b4baf80f7c8/202211301546121b45a6671-html.html
Apr 2023
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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  DOI: 10.1016/j.celrep.2023.112316
  
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SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

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  DOI: 10.1186/s12985-023-02021-2
  
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link.springer.com/article/10.1186/s12985-023-02021-2
Feb 2023
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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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  DOI: 10.1016/j.isci.2023.106169
  
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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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  DOI: 10.1016/j.isci.2023.105965
  
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Dec 2022
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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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  DOI: 10.1016/j.celrep.2022.111837
  
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sciencedirect.com/science/article/pii/S2211124722017296
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Ring domains are essential for GATOR2-dependent mTORC1 activation

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  DOI: 10.1016/j.molcel.2022.11.021
  
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sciencedirect.com/science/article/pii/S1097276522011340
Oct 2022
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Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation

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  DOI: 10.1016/j.chembiol.2022.10.002
  
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sciencedirect.com/science/article/pii/S2451945622003567
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
Jul 2022
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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function

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  DOI: 10.1016/j.cmet.2022.07.003
  
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sciencedirect.com/science/article/pii/S1550413122003023
May 2022
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Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

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1. scibot 21 May 2022
  
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  DOI: 10.7554/eLife.77696
  
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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BPS Publications

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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

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Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation

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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

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Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster

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academic.oup.com/biolreprod/article/98/1/102/4638519
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Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice

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1. scibot 05 Nov 2018
  
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  AB_330947
  
  Curator: @evieth
  
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academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/iox150/4638519
academic.oup.com academic.oup.com

Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

1
1. scibot 05 Nov 2018
  
  in Public
  
  AB_330947
  
  Curator: @evieth
  
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  (Cell Signaling Technology Cat# 9451, RRID:AB_330947)
  
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academic.oup.com/endo/article/159/1/519/4562294
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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1. scibot 08 Nov 2017
  
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  RRID:AB_330947
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1097276517304914
elifesciences.org elifesciences.org

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

1
1. scibot 08 Nov 2017
  
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  AB_330947
  
  Curator: @kaitlinsung
  
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  (Cell Signaling Technology Cat# 9451, RRID:AB_330947)
  
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elifesciences.org/articles/23063
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Regulation of mTORC1 by lysosomal calcium and calmodulin

1
1. scibot 08 Nov 2017
  
  in Public
  
  AB_330947
  
  Curator: @chewbeccax
  
  Resource used:
  
  (Cell Signaling Technology Cat# 9451, RRID:AB_330947)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in a Mouse Model

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_330947
  
  Curator: @gabimpine
  
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  (Cell Signaling Technology Cat# 9451, RRID:AB_330947)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4107404/

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