110 Matching Annotations
  1. Last 7 days
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    Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes
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      DOI: 10.1038/s44319-024-00140-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094177/
  3. May 2024
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    ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
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  5. Feb 2024
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    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
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    sciencedirect.com/science/article/pii/S1097276524000510
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells
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  9. Jan 2024
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    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
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    sciencedirect.com/science/article/pii/S2211124723016698
  11. Dec 2023
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    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
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      DOI: 10.3389/fnmol.2023.1323431

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    ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
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    Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
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    sciencedirect.com/science/article/pii/S2212877823001850
  14. Oct 2023
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    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
  16. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
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  18. Aug 2023
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    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
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  20. Jul 2023
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    Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
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    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
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    sciencedirect.com/science/article/pii/S1931312823002238
  23. Jun 2023
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    Nutrient-dependent regulation of β-cell proinsulin content
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    sciencedirect.com/science/article/pii/S0021925823018641
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    sciencedirect.com/science/article/pii/S2211124723006435
  26. May 2023
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    Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes
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      DOI: 10.1210/endocr/bqad035

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    academic.oup.com/endo/article/164/4/bqad035/7056674
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    A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment.
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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      DOI: 10.1038/s41467-022-31905-0

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  31. Apr 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    sciencedirect.com/science/article/pii/S0960982223004608
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    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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      DOI: 10.1186/s12985-023-02021-2

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    link.springer.com/article/10.1186/s12985-023-02021-2
  34. Mar 2023
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    sciencedirect.com/science/article/pii/S2211124723003078
  37. Feb 2023
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endoplasmic reticulum associated degradation is essential for maintaining the viability or function of mature myelinating cells in adults
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      DOI: 10.1002/glia.24346

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  39. Jan 2023
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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  41. journals.lww.com journals.lww.com
    Valproate reduces retinal ganglion cell apoptosis in rats... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.357913

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    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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  43. Nov 2022
  44. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
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    cell.com/cell-reports/abstract/S2211-1247(22)01347-X
  45. Sep 2022
  46. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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  47. Aug 2022
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    Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development
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  49. Jul 2022
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    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  51. www.embopress.org www.embopress.org
    Neuron-specific translational control shift ensures proteostatic resilience during ER stress
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  52. Jun 2022
  53. 52.53.155.43 52.53.155.43
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    Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress
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      DOI: 10.7554/eLife.73466

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    ncbi.nlm.nih.gov/pmc/articles/PMC9191892/
  56. Mar 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium
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    Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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      DOI: 10.1152/ajpendo.00236.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
  60. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15806
  61. Feb 2022
  62. www.sciencedirect.com www.sciencedirect.com
    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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  63. Jan 2022
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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  66. Dec 2021
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    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
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  68. Oct 2021
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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  70. Sep 2021
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    Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis
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  73. Aug 2021
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    Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis
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    Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  78. Jul 2021
  79. elifesciences.org elifesciences.org
    Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
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    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  84. Jun 2021
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    HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response
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  86. May 2021
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
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    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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  91. Apr 2021
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  94. Feb 2021
  95. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
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  97. Jan 2021
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    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
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    The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation
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    Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling
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  101. Dec 2020
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    CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance
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    Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
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  104. Nov 2020
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    GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
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  106. Oct 2020
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    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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  108. Sep 2020
  109. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response
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    MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system
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    Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults
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    The integrated stress response induces R-loops and hinders replication fork progression
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    Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking
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    Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia
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    Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
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  116. Jan 2020
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    CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
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  118. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
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    Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice
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    Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
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    Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
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    Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)
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  146. Nov 2017
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    Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation
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    Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
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    Translational control of auditory imprinting and structural plasticity by eIF2α
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