115 Matching Annotations
  1. Sep 2024
  2. www.frontiersin.org www.frontiersin.org
    Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis
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    1. scibot 26 Sep 2024
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    frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1437854/full
  3. www.sciencedirect.com www.sciencedirect.com
    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224021187
  4. Aug 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control
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    1. scibot 18 Aug 2024
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    sciencedirect.com/science/article/pii/S1931312824002658
  6. Jul 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
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    1. scibot 11 Jul 2024
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      DOI: 10.1016/j.neuron.2019.09.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC6895427/
  8. Jun 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes
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    1. scibot 08 Jun 2024
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    sciencedirect.com/science/article/pii/S2589004224011519
  10. May 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes
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    1. scibot 17 May 2024
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      DOI: 10.1038/s44319-024-00140-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094177/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-stress in mouse serotonin neurons triggers a depressive phenotype alleviated by ketamine targeting eIF2α signaling
    1
    1. scibot 09 May 2024
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      DOI: 10.1016/j.isci.2024.109787

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    ncbi.nlm.nih.gov/pmc/articles/PMC11070602/
  13. Feb 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
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    1. scibot 13 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.015

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    sciencedirect.com/science/article/pii/S1097276524000510
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
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    sciencedirect.com/science/article/pii/S1097276524000091
  16. link.springer.com link.springer.com
    Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells
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    1. scibot 01 Feb 2024
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      DOI: 10.1186/s12915-024-01829-w

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    link.springer.com/article/10.1186/s12915-024-01829-w
  17. Jan 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113658

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    sciencedirect.com/science/article/pii/S2211124723016698
  19. Dec 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
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    1. scibot 28 Dec 2023
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      DOI: 10.3389/fnmol.2023.1323431

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    ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
  21. www.sciencedirect.com www.sciencedirect.com
    Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
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    1. scibot 14 Dec 2023
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      DOI: 10.1016/j.molmet.2023.101851

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    sciencedirect.com/science/article/pii/S2212877823001850
  22. Oct 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EDEM1 regulates the insulin mRNA level by inhibiting the endoplasmic reticulum stress-induced IRE1/JNK/c-Jun pathway
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    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.isci.2023.107956

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    ncbi.nlm.nih.gov/pmc/articles/PMC10562789/
  24. Sep 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.xcrm.2023.101206

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    sciencedirect.com/science/article/pii/S2666379123003737
  26. Aug 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
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    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.cmet.2023.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
  28. Jul 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.cels.2023.06.001

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    sciencedirect.com/science/article/abs/pii/S2405471223001540
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    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
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      DOI: 10.1016/j.chom.2023.05.030

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    sciencedirect.com/science/article/pii/S1931312823002238
  31. Jun 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Nutrient-dependent regulation of β-cell proinsulin content
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    1. scibot 29 Jun 2023
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      DOI: 10.1016/j.jbc.2023.104836

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    sciencedirect.com/science/article/pii/S0021925823018641
  33. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    1. scibot 22 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
  34. May 2023
  35. academic.oup.com academic.oup.com
    Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes
    1
    1. scibot 12 May 2023
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      DOI: 10.1210/endocr/bqad035

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    academic.oup.com/endo/article/164/4/bqad035/7056674
  36. www.sciencedirect.com www.sciencedirect.com
    A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment.
    1
    1. scibot 06 May 2023
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      DOI: 10.1016/j.isci.2023.106687

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    sciencedirect.com/science/article/pii/S2589004223007642
  37. www.sciencedirect.com www.sciencedirect.com
    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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      DOI: 10.1016/j.celrep.2022.111077

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    sciencedirect.com/science/article/pii/S2211124722008750
  38. www.nature.com www.nature.com
    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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    1. scibot 05 May 2023
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      DOI: 10.1038/s41467-022-31905-0

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    nature.com/articles/s41467-022-31905-0
  39. Apr 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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      DOI: 10.1016/j.cub.2023.04.012

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    sciencedirect.com/science/article/pii/S0960982223004608
  41. link.springer.com link.springer.com
    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
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    1. scibot 01 Apr 2023
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      DOI: 10.1186/s12985-023-02021-2

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    link.springer.com/article/10.1186/s12985-023-02021-2
  42. Mar 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    1. scibot 30 Mar 2023
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      DOI: 10.1016/j.cell.2023.02.037

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    sciencedirect.com/science/article/pii/S0092867423002155
  44. www.sciencedirect.com www.sciencedirect.com
    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  45. Feb 2023
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Endoplasmic reticulum associated degradation is essential for maintaining the viability or function of mature myelinating cells in adults
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      DOI: 10.1002/glia.24346

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    onlinelibrary.wiley.com/doi/10.1002/glia.24346
  47. Jan 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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      DOI: 10.1016/j.celrep.2022.111965

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    sciencedirect.com/science/article/pii/S2211124722018691
  49. journals.lww.com journals.lww.com
    Valproate reduces retinal ganglion cell apoptosis in rats... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.357913

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    journals.lww.com/nrronline/Fulltext/2023/07000/Valproate_reduces_retinal_ganglion_cell_apoptosis.37.aspx
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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      DOI: 10.1158/2159-8290.CD-21-0680

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    ncbi.nlm.nih.gov/pmc/articles/PMC9262860/
  51. Nov 2022
  52. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
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    cell.com/cell-reports/abstract/S2211-1247(22)01347-X
  53. Sep 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    sciencedirect.com/science/article/pii/S1535610822003804
  55. Aug 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development
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    sciencedirect.com/science/article/pii/S2211124722009913
  57. Jul 2022
  58. www.sciencedirect.com www.sciencedirect.com
    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
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  59. www.embopress.org www.embopress.org
    Neuron-specific translational control shift ensures proteostatic resilience during ER stress
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      DOI: 10.15252/embj.2021110501

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    embopress.org/doi/10.15252/embj.2021110501
  60. Jun 2022
  61. 52.53.155.43 52.53.155.43
    cd-21-0680-html.html
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    Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila
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    sciencedirect.com/science/article/pii/S2211124722007409
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress
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      DOI: 10.7554/eLife.73466

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  64. Mar 2022
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    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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  68. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway
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  69. Feb 2022
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    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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  71. Jan 2022
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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  74. Dec 2021
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    Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
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  76. Oct 2021
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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  78. Sep 2021
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    Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis
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  81. Aug 2021
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    Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis
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    Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila
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    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  86. Jul 2021
  87. elifesciences.org elifesciences.org
    Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS
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  88. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
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    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  92. Jun 2021
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    HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response
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  94. May 2021
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development
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  99. Apr 2021
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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  102. Feb 2021
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    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
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  105. Jan 2021
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    The Integrated UPR and ERAD in Oligodendrocytes Maintain Myelin Thickness in Adults by Regulating Myelin Protein Translation
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    Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling
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  109. Dec 2020
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    Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
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  112. Nov 2020
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  114. Oct 2020
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    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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  116. Sep 2020
  117. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response
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    MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system
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    Endoplasmic reticulum associated degradation is required for maintaining endoplasmic reticulum homeostasis and viability of mature Schwann cells in adults
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    The integrated stress response induces R-loops and hinders replication fork progression
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    Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice
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    Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)
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  154. Nov 2017
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    Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation
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    Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
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