159 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β2-integrins control HIF1α activation in human neutrophils
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    1. scibot 07 Nov 2024
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      DOI: 10.3389/fimmu.2024.1406967

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    pmc.ncbi.nlm.nih.gov/articles/PMC11513320/
  4. Oct 2024
  5. aacrjournals.org aacrjournals.org
    Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/1541-7786.MCR-20-0115

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    aacrjournals.org/mcr/article/19/1/61/271645/Metformin-Mitigates-DPP-4-Inhibitor-Induced-Breast
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    1. scibot 02 Oct 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
  7. Sep 2024
  8. www.sciencedirect.com www.sciencedirect.com
    gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224020728
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    Metformin decelerates aging clock in male monkeys
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    sciencedirect.com/science/article/pii/S0092867424009140
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies
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    1. scibot 12 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11381840/
  11. Aug 2024
  12. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    link.springer.com/article/10.1007/s12035-024-04425-9
  13. www.mdpi.com www.mdpi.com
    Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice
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    mdpi.com/2073-4409/10/12/3314/htm
  14. Jul 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
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    1. scibot 19 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
  16. www.sciencedirect.com www.sciencedirect.com
    Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms
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    1. scibot 19 Jul 2024
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    1. scibot 06 Jul 2024
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  18. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
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    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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    elifesciences.org/articles/98649
  19. May 2024
  20. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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      DOI: 10.1113/JP285339

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  21. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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      DOI: 10.1152/ajpcell.00669.2023

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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  22. www.sciencedirect.com www.sciencedirect.com
    Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
    1
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    sciencedirect.com/science/article/pii/S2666379124002568
  23. Apr 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
    1
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      Cell Signaling, 2971

      DOI: 10.1016/j.antiviral.2024.105891

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    sciencedirect.com/science/article/pii/S0166354224001001
  26. www.cell.com www.cell.com
    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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    1. scibot 23 Apr 2024
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
  27. www.sciencedirect.com www.sciencedirect.com
    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
  28. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    1. scibot 10 Apr 2024
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      DOI: 10.1210/endocr/bqae044

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  29. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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  30. Mar 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    1. scibot 09 Mar 2024
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      DOI: 10.1016/j.isci.2024.109249

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  32. Feb 2024
  33. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  34. Jan 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
  36. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  37. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Simulated altitude is medicine: intermittent exposure to hypobaric hypoxia and cold accelerates injured skeletal muscle recovery
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    1. scibot 07 Jan 2024
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      DOI: 10.1113/JP285398

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  38. Dec 2023
  39. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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      DOI: 10.1152/japplphysiol.00247.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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      DOI: 10.1152/japplphysiol.00246.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC9678411/
  42. Nov 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  44. Oct 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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      DOI: 10.1016/j.neuropharm.2023.109767

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    sciencedirect.com/science/article/pii/S002839082300357X
  46. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  47. www.sciencedirect.com www.sciencedirect.com
    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  48. Sep 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    sciencedirect.com/science/article/pii/S1097276523006950
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    WNK1 is required during male pachynema to sustain fertility.
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      DOI: 10.1016/j.isci.2023.107616

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    sciencedirect.com/science/article/pii/S2589004223016930
  51. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  52. Aug 2023
  53. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
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      anti-Phospho-mTOR (Ser2448) rabbit pAb

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  164. Sep 2020
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    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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  178. Jan 2020
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  180. dev.biologists.org dev.biologists.org
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    Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation
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    Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
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  189. Nov 2018
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    TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
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  191. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    1. scibot 08 Nov 2017
      AB_330970

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    sciencedirect.com/science/article/pii/S2405471216304082
  207. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
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    1. scibot 08 Nov 2017
      AB 330970 

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2971, RRID:AB_330970)

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    academic.oup.com/endo/article/157/12/4641/2758409/Developmental-Programming-Insulin-Sensitizer
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of mTORC1 by lysosomal calcium and calmodulin
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    1. scibot 08 Nov 2017
      AB_330970

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2971, RRID:AB_330970)

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      RRID:AB_330970 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5106211/