145 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  3. Aug 2024
  4. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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      DOI: 10.1007/s12035-024-04425-9

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    link.springer.com/article/10.1007/s12035-024-04425-9
  5. www.mdpi.com www.mdpi.com
    Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice
    1
    1. scibot 02 Aug 2024
      2972

      DOI: 10.3390/cells10123314

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    mdpi.com/2073-4409/10/12/3314/htm
  6. Jul 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.isci.2024.110415

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    ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
  8. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
    1
    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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    elifesciences.org/articles/98649
  9. May 2024
  10. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    1. scibot 25 May 2024
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      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  11. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
    2
    1. scibot 24 May 2024
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      DOI: 10.1152/ajpcell.00669.2023

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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  12. Apr 2024
  13. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
    1
    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004777
  14. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1210/endocr/bqae044

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  15. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
    1
    1. scibot 05 Apr 2024
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  16. Mar 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1016/j.isci.2024.109249

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  18. Feb 2024
  19. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  20. Jan 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.molcel.2024.01.002

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    sciencedirect.com/science/article/pii/S1097276524000030
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108733

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
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      DOI: 10.1016/j.ebiom.2023.104887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709029/
  24. www.sciencedirect.com www.sciencedirect.com
    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
    1
    1. scibot 12 Jan 2024
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      DOI: 10.1016/j.ccell.2023.12.019

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    sciencedirect.com/science/article/pii/S1535610823004476
  25. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1152/ajpregu.00274.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  27. Dec 2023
  28. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  29. www.sciencedirect.com www.sciencedirect.com
    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
    1
    1. scibot 15 Dec 2023
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      DOI: 10.1016/j.nbd.2023.106370

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    sciencedirect.com/science/article/pii/S0969996123003868
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amniotic MSC affect CD8 naive polarization toward SLEC/MPEC subsets by down-modulating IL-12Rβ1 and IL-2Rα signaling pathways
    1
    1. scibot 14 Dec 2023
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      DOI: 10.1016/j.isci.2023.108483

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709131/
  31. www.sciencedirect.com www.sciencedirect.com
    Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
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    1. scibot 07 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113529

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    sciencedirect.com/science/article/pii/S2211124723015413
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.isci.2023.108446

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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
  33. Nov 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  35. Oct 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    1. scibot 21 Oct 2023
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      DOI: 10.1016/j.neuropharm.2023.109767

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    sciencedirect.com/science/article/pii/S002839082300357X
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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    1. scibot 17 Oct 2023
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      DOI: 10.1186/s12967-023-04542-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
  38. www.sciencedirect.com www.sciencedirect.com
    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
    1
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  39. Sep 2023
  40. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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    1. scibot 14 Sep 2023
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      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  41. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
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      DOI: 10.1210/clinem/dgad464

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  42. Aug 2023
  43. 52.53.155.43 52.53.155.43
    PIIS2589004223017029-html.html
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
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      DOI: 10.1016/j.cmet.2023.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
  45. Jul 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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      DOI: 10.1016/j.pnpbp.2023.110822

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    sciencedirect.com/science/article/pii/S0278584623001082
  47. Jun 2023
  48. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
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      DOI: 10.1038/s41417-023-00637-8

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    nature.com/articles/s41417-023-00637-8
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  51. May 2023
  52. academic.oup.com academic.oup.com
    Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment
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      DOI: 10.1210/clinem/dgad190

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad190/7111800
  53. www.sciencedirect.com www.sciencedirect.com
    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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      DOI: 10.1016/j.celrep.2022.111085

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    sciencedirect.com/science/article/pii/S2211124722008877
  54. www.mdpi.com www.mdpi.com
    GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
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      DOI: 10.3390/biomedicines11051305

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    mdpi.com/2227-9059/11/5/1305
  55. Apr 2023
  56. link.springer.com link.springer.com
    Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
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    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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  58. Mar 2023
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    Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity
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  60. Feb 2023
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    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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  62. Jan 2023
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    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
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    Glutamine and leucine administration attenuates muscle atrophy in sepsis
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    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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  68. Dec 2022
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  71. Nov 2022
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  73. Oct 2022
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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  75. Jul 2022
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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  77. Jun 2022
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  80. May 2022
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    Gold(III)-P-chirogenic complex induce mitochondrial dysfunction in triple-negative breast cancer
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  85. Mar 2022
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    Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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  90. Feb 2022
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    Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways
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  93. Jan 2022
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    Approaches and Protocols to Analyze Autophagy and Its Role in Death of Apoptosis-Resistant Senescent Tumor Cells
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  96. Dec 2021
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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  100. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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  103. Oct 2021
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  105. Sep 2021
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    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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  108. Aug 2021
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    Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice
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    Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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  160. Jan 2020
  161. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons
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  164. www.sciencedirect.com www.sciencedirect.com
    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
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  165. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
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    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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  169. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells
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  170. academic.oup.com academic.oup.com
    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
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      DOI: 10.1016/j.molcel.2018.12.001

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  174. Nov 2018
  175. www.sciencedirect.com www.sciencedirect.com
    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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    Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
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    Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
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    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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    Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.
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  182. Nov 2017
  183. www.sciencedirect.com www.sciencedirect.com
    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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  186. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  187. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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      AB_330978

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  188. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
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      AB 330978 

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