136 Matching Annotations
  1. Apr 2024
  2. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
    1
    1. scibot 10 Apr 2024
      AB_330978

      DOI: 10.1210/endocr/bqae044

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    dx.doi.org/10.1210/endocr/bqae044
  3. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1186/s12958-024-01204-y

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    52.53.155.43/d3bb518aa444c98d6cfb77a0666830bf57a4ed47/12958_2024_1204_MOESM1_ESM-html.html
  4. Mar 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1016/j.isci.2024.109249

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  6. Feb 2024
  7. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  8. Jan 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.molcel.2024.01.002

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    sciencedirect.com/science/article/pii/S1097276524000030
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108733

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P. mirabilis-derived pore-forming haemolysin, HpmA drives intestinal alpha-synuclein aggregation in a mouse model of neurodegeneration
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1016/j.ebiom.2023.104887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709029/
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
    1
    1. scibot 12 Jan 2024
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      DOI: 10.1016/j.ccell.2023.12.019

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    sciencedirect.com/science/article/pii/S1535610823004476
  13. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1152/ajpregu.00274.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  15. Dec 2023
  16. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
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    PI3K signaling promotes formation of lipid-laden foamy macrophages at the spinal cord injury site
    1
    1. scibot 15 Dec 2023
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      DOI: 10.1016/j.nbd.2023.106370

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    sciencedirect.com/science/article/pii/S0969996123003868
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amniotic MSC affect CD8 naive polarization toward SLEC/MPEC subsets by down-modulating IL-12Rβ1 and IL-2Rα signaling pathways
    1
    1. scibot 14 Dec 2023
      RRID:AB_330978

      DOI: 10.1016/j.isci.2023.108483

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709131/
  19. www.sciencedirect.com www.sciencedirect.com
    Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy
    1
    1. scibot 07 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113529

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    sciencedirect.com/science/article/pii/S2211124723015413
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
    1
    1. scibot 02 Dec 2023
      RRID:AB_330978

      DOI: 10.1016/j.isci.2023.108446

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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
  21. Nov 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  23. Oct 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
    1
    1. scibot 21 Oct 2023
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      DOI: 10.1016/j.neuropharm.2023.109767

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    sciencedirect.com/science/article/pii/S002839082300357X
  25. link.springer.com link.springer.com
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
    1
    1. scibot 17 Oct 2023
      RRID:AB_330978

      DOI: 10.1186/s12967-023-04542-4

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    link.springer.com/article/10.1186/s12967-023-04542-4
  26. www.sciencedirect.com www.sciencedirect.com
    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  27. Sep 2023
  28. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
    1
    1. scibot 14 Sep 2023
      RRID:AB_330978

      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  29. dx.doi.org dx.doi.org
    Insulin Signaling Is Preserved in Skeletal Muscle During Early Diabetic Ketoacidosis
    1
    1. scibot 14 Sep 2023
      RRID:AB_330978

      DOI: 10.1210/clinem/dgad464

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    dx.doi.org/10.1210/clinem/dgad464
  30. Aug 2023
  31. 52.53.155.43 52.53.155.43
    PIIS2589004223017029-html.html
    1
    1. scibot 18 Aug 2023
      RRID:AB_330978

      DOI: 10.1016/j.isci.2023.107625

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    52.53.155.43/258d74bd1c79cf4d725c254c0f9188b69c056c90/PIIS2589004223017029-html.html
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
    1
    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.cmet.2023.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
  33. Jul 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
    1
    1. scibot 13 Jul 2023
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      DOI: 10.1016/j.pnpbp.2023.110822

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    sciencedirect.com/science/article/pii/S0278584623001082
  35. Jun 2023
  36. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1038/s41417-023-00637-8

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    nature.com/articles/s41417-023-00637-8
  37. www.sciencedirect.com www.sciencedirect.com
    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.canlet.2023.216264

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    sciencedirect.com/science/article/pii/S030438352300215X
  38. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  39. May 2023
  40. academic.oup.com academic.oup.com
    Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment
    1
    1. scibot 06 May 2023
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      DOI: 10.1210/clinem/dgad190

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgad190/7111800
  41. www.sciencedirect.com www.sciencedirect.com
    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
    1
    1. scibot 05 May 2023
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      DOI: 10.1016/j.celrep.2022.111085

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    sciencedirect.com/science/article/pii/S2211124722008877
  42. www.mdpi.com www.mdpi.com
    GM1 Oligosaccharide Efficacy in Parkinson’s Disease: Protection against MPTP
    1
    1. scibot 04 May 2023
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      DOI: 10.3390/biomedicines11051305

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    mdpi.com/2227-9059/11/5/1305
  43. Apr 2023
  44. link.springer.com link.springer.com
    Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1186/s12916-023-02848-0

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    link.springer.com/article/10.1186/s12916-023-02848-0
  45. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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      DOI: 10.1002/iub.2722

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
  46. Mar 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity
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      DOI: 10.1016/j.cmet.2023.02.006

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    sciencedirect.com/science/article/pii/S1550413123000426
  48. Feb 2023
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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      DOI: 10.1111/jnc.15771

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    onlinelibrary.wiley.com/doi/epdf/10.1111/jnc.15771
  50. Jan 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
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      DOI: 10.1016/j.xgen.2022.100250

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    sciencedirect.com/science/article/pii/S2666979X22002130
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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      DOI: 10.7150/thno.75973

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    ncbi.nlm.nih.gov/pmc/articles/PMC9830446/
  53. www.sciencedirect.com www.sciencedirect.com
    Glutamine and leucine administration attenuates muscle atrophy in sepsis
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      DOI: 10.1016/j.lfs.2022.121327

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    sciencedirect.com/science/article/pii/S002432052201027X
  54. www.sciencedirect.com www.sciencedirect.com
    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
    1
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      DOI: 10.1016/j.celrep.2022.111984

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    sciencedirect.com/science/article/pii/S2211124722018885
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
    1
    1. scibot 07 Jan 2023
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      DOI: 10.1158/2159-8290.CD-21-0680

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  56. Dec 2022
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  59. Nov 2022
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  61. Oct 2022
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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  63. Jul 2022
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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  65. Jun 2022
  66. 52.53.155.43 52.53.155.43
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  68. May 2022
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  73. Mar 2022
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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  78. Feb 2022
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  81. Jan 2022
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  84. Dec 2021
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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  88. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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  91. Oct 2021
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  93. Sep 2021
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    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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  96. Aug 2021
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    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  105. Jul 2021
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    Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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  158. academic.oup.com academic.oup.com
    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
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      DOI: 10.1016/j.molcel.2018.12.001

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      DOI: 10.1016/j.chembiol.2019.03.012

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      DOI: 10.1016/j.immuni.2019.01.021

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  162. Nov 2018
  163. www.sciencedirect.com www.sciencedirect.com
    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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    Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
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    Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
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    Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase–mTORC1 Translational Pathway
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  168. europepmc.org europepmc.org
    Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.
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  170. Nov 2017
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    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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  174. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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      AB_330978

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  176. academic.oup.com academic.oup.com
    Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS
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