109 Matching Annotations
  1. Feb 2026
  2. www.nature.com www.nature.com
    Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1
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    nature.com/articles/s41401-026-01754-4
  3. Jan 2026
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    Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes
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    sciencedirect.com/science/article/pii/S1550413125005479
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811739/
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    Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer
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    sciencedirect.com/science/article/pii/S1535610825005483
  7. Dec 2025
  8. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts
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    sciencedirect.com:5037/science/article/pii/S2211124725014755
  9. 54.241.53.176 54.241.53.176
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  10. Oct 2025
  11. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
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    Isoformic PD-1 impedes B cell activation and function in HIV-1 infection
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  13. Sep 2025
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    Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S2352396425003688
  15. Aug 2025
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    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
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  17. Jun 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141803/
  19. journals.sagepub.com journals.sagepub.com
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    journals.sagepub.com/doi/full/10.1177/15347354251344592
  20. May 2025
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy
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    Stromal lipid species dictate melanoma metastasis and tropism
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  24. Apr 2025
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    Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling
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  26. Mar 2025
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease
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  29. 52.53.155.43 52.53.155.43
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  30. Feb 2025
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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  32. Jan 2025
  33. www.nature.com www.nature.com
    Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
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  34. Dec 2024
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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  37. Sep 2024
  38. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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  39. Aug 2024
  40. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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  41. Jun 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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  43. May 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder
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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  46. Apr 2024
  47. www.sciencedirect.com www.sciencedirect.com
    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
  49. Mar 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  51. Feb 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  54. Jan 2024
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  56. Dec 2023
  57. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    sciencedirect.com/science/article/pii/S2211124723015474
  58. Sep 2023
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  60. Aug 2023
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    sciencedirect.com/science/article/pii/S2589004223016176
  62. Jun 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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  66. May 2023
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    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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  68. Apr 2023
  69. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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  70. Jan 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9830446/
  72. Nov 2022
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9646953/
  74. Oct 2022
  75. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    sciencedirect.com/science/article/pii/S2451945622003609
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
  77. Sep 2022
  78. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2211124722011287
  79. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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  80. Aug 2022
  81. www.jneurosci.org www.jneurosci.org
    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    jneurosci.org/content/42/31/6090
  82. Jul 2022
  83. www.sciencedirect.com www.sciencedirect.com
    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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  84. 52.53.155.43 52.53.155.43
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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  86. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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  88. www.nature.com www.nature.com
    Convergent somatic mutations in metabolism genes in chronic liver disease
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    nature.com/articles/s41586-021-03974-6
  89. Mar 2022
  90. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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  92. Feb 2022
  93. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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  94. Jan 2022
  95. www.sciencedirect.com www.sciencedirect.com
    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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  96. Nov 2021
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    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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  99. Oct 2021
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    Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1
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    jneurosci.org/content/41/39/8163
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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  102. academic.oup.com academic.oup.com
    Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab680/6370132
  103. Sep 2021
  104. www.sciencedirect.com www.sciencedirect.com
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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  105. Aug 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC8333185/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  110. Jul 2021
  111. www.heliyon.com www.heliyon.com
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  112. May 2021
  113. academic.oup.com academic.oup.com
    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    academic.oup.com/jes/article/5/5/bvab024/6145120
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
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  116. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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  118. Feb 2021
  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  120. www.sciencedirect.com www.sciencedirect.com
    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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  121. Jan 2021
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
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    ncbi.nlm.nih.gov/pmc/articles/PMC7778269/
  123. Oct 2020
  124. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    elifesciences.org/articles/57395
  125. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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  126. Sep 2020
  127. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    pubmed.ncbi.nlm.nih.gov/32679108/
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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  129. www.sciencedirect.com www.sciencedirect.com
    Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration
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  130. www.sciencedirect.com www.sciencedirect.com
    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
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