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Sep 2025
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease

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  DOI: 10.1016/j.ebiom.2025.105924
  
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sciencedirect.com/science/article/pii/S2352396425003688
Aug 2025
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
Jun 2025
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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12141803/
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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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journals.sagepub.com/doi/full/10.1177/15347354251344592
May 2025
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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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sciencedirect.com/science/article/pii/S1535610825001394
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Stromal lipid species dictate melanoma metastasis and tropism

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Apr 2025
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Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling

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Mar 2025
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Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine

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pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease

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  DOI: 10.1101/2025.02.12.637918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870434/
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1-s2.0-S2589004225004043-main-html.html

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52.53.155.43/a54d23b2534862197be3e5d5ad98a8cc187610fd/1-s2.0-S2589004225004043-main-html.html
Feb 2025
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Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

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sciencedirect.com/science/article/pii/S221112472500052X
Jan 2025
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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

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  DOI: 10.1038/s41598-024-83912-4
  
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nature.com/articles/s41598-024-83912-4
Dec 2024
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1-s2.0-S2589004224027895-main-html.html

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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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  DOI: 10.1016/j.celrep.2024.115026
  
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Sep 2024
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Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer

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  DOI: 10.1038/s41467-024-51831-7
  
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nature.com/articles/s41467-024-51831-7
Aug 2024
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mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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  DOI: 10.1152/ajpcell.00385.2020
  
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journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
Jun 2024
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Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta

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  DOI: 10.1016/j.isci.2024.109921
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
May 2024
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Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder

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The Janus kinase 1 is critical for pancreatic cancer initiation and progression

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pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
Apr 2024
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Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect

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Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

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ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
Mar 2024
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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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  DOI: 10.1080/15384047.2024.2332000
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
Feb 2024
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Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer

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Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells

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  DOI: 10.1158/0008-5472.CAN-23-1632
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
Jan 2024
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Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice

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  DOI: 10.1152/ajpregu.00274.2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
Dec 2023
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Epinephrine inhibits PI3Kα via the Hippo kinases

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Sep 2023
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TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

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Aug 2023
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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

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Jun 2023
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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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  DOI: 10.1016/j.stem.2023.05.015
  
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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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  DOI: 10.1016/j.chembiol.2023.05.007
  
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May 2023
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MTHFD2 reprograms macrophage polarization by inhibiting PTEN

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  DOI: 10.1016/j.celrep.2023.112481
  
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Apr 2023
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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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  DOI: 10.1016/j.cmet.2023.03.021
  
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Jan 2023
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Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression

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  DOI: 10.7150/thno.75973
  
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B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells

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Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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Convergent somatic mutations in metabolism genes in chronic liver disease

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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors

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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

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Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

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m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity

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Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1

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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice

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Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity

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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice

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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

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Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

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Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

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PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons

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Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease

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Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate

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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

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EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

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Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase)

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Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

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PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression

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