85 Matching Annotations
  1. Aug 2024
  2. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    1. scibot 02 Aug 2024
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      DOI: 10.1152/ajpcell.00385.2020

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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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    1. scibot 03 Jun 2024
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      DOI: 10.1016/j.isci.2024.109921

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    ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
  5. May 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.ebiom.2024.105161

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    sciencedirect.com/science/article/pii/S2352396424001968
  7. www.cell.com www.cell.com
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    1. scibot 14 May 2024
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    cell.com/cell-reports/fulltext/S2211-1247(24)00530-8
  8. Apr 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    1. scibot 24 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114132

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    sciencedirect.com/science/article/pii/S2211124724004601
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101510

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
  11. Mar 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  13. Feb 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    1. scibot 11 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0321

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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
    1
    1. scibot 03 Feb 2024
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      DOI: 10.1158/0008-5472.CAN-23-1632

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  16. Jan 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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    1. scibot 05 Jan 2024
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      DOI: 10.1152/ajpregu.00274.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  18. Dec 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015474
  20. Sep 2023
  21. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113070

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    sciencedirect.com/science/article/pii/S2211124723010811
  22. Aug 2023
  23. www.sciencedirect.com www.sciencedirect.com
    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    1. scibot 23 Aug 2023
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      DOI: 10.1016/j.isci.2023.107540

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    sciencedirect.com/science/article/pii/S2589004223016176
  24. Jun 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.ccell.2023.05.016

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    sciencedirect.com/science/article/pii/S1535610823001836
  26. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  27. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.05.007

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    sciencedirect.com/science/article/pii/S2451945623001502
  28. May 2023
  29. www.sciencedirect.com www.sciencedirect.com
    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    1. scibot 11 May 2023
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      DOI: 10.1016/j.celrep.2023.112481

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    sciencedirect.com/science/article/pii/S2211124723004928
  30. Apr 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
    1
    1. scibot 21 Apr 2023
      RRID:AB_331163

      DOI: 10.1016/j.cmet.2023.03.021

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    sciencedirect.com/science/article/pii/S1550413123001262
  32. Jan 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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    1. scibot 15 Jan 2023
      RRID:AB_331163

      DOI: 10.7150/thno.75973

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    ncbi.nlm.nih.gov/pmc/articles/PMC9830446/
  34. Nov 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    1. scibot 18 Nov 2022
      RRID:AB_331163

      DOI: 10.1016/j.isci.2022.105419

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    ncbi.nlm.nih.gov/pmc/articles/PMC9646953/
  36. Oct 2022
  37. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    1. scibot 28 Oct 2022
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      DOI: 10.1016/j.chembiol.2022.10.006

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    sciencedirect.com/science/article/pii/S2451945622003609
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
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    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.isci.2022.105233

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
  39. Sep 2022
  40. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111304

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    sciencedirect.com/science/article/pii/S2211124722011287
  41. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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    1. scibot 14 Sep 2022
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      DOI: 10.1371/journal.pone.0273711

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    journals.plos.org/plosone/article
  42. Aug 2022
  43. www.jneurosci.org www.jneurosci.org
    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    1. scibot 04 Aug 2022
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      DOI: 10.1523/JNEUROSCI.1989-21.2022

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    jneurosci.org/content/42/31/6090
  44. Jul 2022
  45. www.sciencedirect.com www.sciencedirect.com
    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    1. scibot 30 Jul 2022
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      DOI: 10.1016/j.celrep.2022.111095

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    sciencedirect.com/science/article/pii/S221112472200897X
  46. 52.53.155.43 52.53.155.43
    JNEUROSCI.1989-21.2022.full-html.html
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    1. scibot 29 Jul 2022
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      DOI: 10.1523/jneurosci.1989-21.2022

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    52.53.155.43/ff46bc3d23e518f0db8966b4d429d2ce1bef32f5/JNEUROSCI.1989-21.2022.full-html.html
  47. www.sciencedirect.com www.sciencedirect.com
    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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    1. scibot 06 Jul 2022
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      DOI: 10.1016/j.cmet.2022.06.007

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    sciencedirect.com/science/article/pii/S1550413122002273
  48. May 2022
  49. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    1. scibot 26 May 2022
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      DOI: 10.1016/j.molcel.2022.04.034

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    sciencedirect.com/science/article/pii/S1097276522004348
  50. www.nature.com www.nature.com
    Convergent somatic mutations in metabolism genes in chronic liver disease
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    1. scibot 05 May 2022
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      DOI: 10.1038/s41586-021-03974-6

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    nature.com/articles/s41586-021-03974-6
  51. Mar 2022
  52. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    sciencedirect.com/science/article/pii/S2211124722002583
  53. 52.53.155.43 52.53.155.43
    japplphysiol.00536.2021-html.html
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  54. Feb 2022
  55. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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      DOI: 10.1371/journal.pbio.3001502

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    journals.plos.org/plosbiology/article
  56. Jan 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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      DOI: 10.1016/j.immuni.2021.12.001

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    sciencedirect.com/science/article/pii/S1074761321005343
  58. Nov 2021
  59. 52.53.155.43 52.53.155.43
    ajpcell.00385.2020-html.html
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    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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      DOI: 10.1016/j.celrep.2021.109968

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    sciencedirect.com/science/article/pii/S2211124721014479
  61. Oct 2021
  62. www.jneurosci.org www.jneurosci.org
    Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1
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      DOI: 10.1523/JNEUROSCI.2432-20.2021

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    jneurosci.org/content/41/39/8163
  63. www.sciencedirect.com www.sciencedirect.com
    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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      DOI: 10.1016/j.devcel.2021.09.008

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    sciencedirect.com/science/article/pii/S1534580721007267
  64. academic.oup.com academic.oup.com
    Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity
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      DOI: 10.1210/clinem/dgab680

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  65. Sep 2021
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    sciencedirect.com/science/article/pii/S1097276518302211
  116. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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      AB 331163

      Curator: @bandrow

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
  117. www.sciencedirect.com www.sciencedirect.com
    Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis
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      RRID:AB_331163

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    sciencedirect.com/science/article/pii/S1550413117306204
  118. Nov 2017
  119. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    1. scibot 08 Nov 2017
      RRID:AB_331163

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 4056, RRID:AB_331163)

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      RRID:AB_331163 RRIDCUR:Validated
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    elifesciences.org/articles/29241
  120. www.jneurosci.org www.jneurosci.org
    ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase)
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    1. scibot 08 Nov 2017
      AB_331163

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    jneurosci.org/content/37/10/2709
  121. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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    1. scibot 08 Nov 2017
      AB_331163

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 4056, RRID:AB_331163)

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    sciencedirect.com/science/article/pii/S009286741631460X
  122. jcs.biologists.org jcs.biologists.org
    PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression
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    1. scibot 08 Nov 2017
      AB_331163

      Curator: @gabimpine

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    jcs.biologists.org/content/127/24/5253