110 Matching Annotations
  1. Apr 2026
  2. aacrjournals.org aacrjournals.org
    Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer
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    aacrjournals.org/mct/article/25/4/662/776472/Targeting-Tumor-Microenvironment-Derived-NRG1-HER2
  3. Feb 2026
  4. www.nature.com www.nature.com
    Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1
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    nature.com/articles/s41401-026-01754-4
  5. Jan 2026
  6. www.sciencedirect.com www.sciencedirect.com
    Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes
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    sciencedirect.com/science/article/pii/S1550413125005479
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811739/
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    Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer
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    sciencedirect.com/science/article/pii/S1535610825005483
  9. Dec 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12990061/
  11. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225025404-main-html.html
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    54.241.53.176/91848baea2783d76c3a2268cf866a68ea99b11d4/1-s2.0-S2589004225025404-main-html.html
  12. Oct 2025
  13. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
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    Isoformic PD-1 impedes B cell activation and function in HIV-1 infection
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    sciencedirect.com/science/article/pii/S221112472501112X
  15. Sep 2025
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    Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease
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    sciencedirect.com/science/article/pii/S2352396425003688
  17. Aug 2025
  18. www.sciencedirect.com www.sciencedirect.com
    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
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    sciencedirect.com/science/article/pii/S1074761325003267
  19. Jun 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141803/
  21. journals.sagepub.com journals.sagepub.com
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    journals.sagepub.com/doi/full/10.1177/15347354251344592
  22. May 2025
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
  24. www.sciencedirect.com www.sciencedirect.com
    KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy
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    sciencedirect.com/science/article/pii/S1535610825001394
  25. www.sciencedirect.com www.sciencedirect.com
    Stromal lipid species dictate melanoma metastasis and tropism
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    sciencedirect.com/science/article/pii/S1535610825001382
  26. Apr 2025
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    Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling
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    sciencedirect.com/science/article/pii/S1550413125002074
  28. Mar 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
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    pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC11870434/
  31. 52.53.155.43 52.53.155.43
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  32. Feb 2025
  33. www.sciencedirect.com www.sciencedirect.com
    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    sciencedirect.com/science/article/pii/S221112472500052X
  34. Jan 2025
  35. www.nature.com www.nature.com
    Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
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    nature.com/articles/s41598-024-83912-4
  36. Dec 2024
  37. 52.53.155.43 52.53.155.43
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    Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124724013779
  39. Sep 2024
  40. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
  41. Aug 2024
  42. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  43. Jun 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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    ncbi.nlm.nih.gov/pmc/articles/PMC11133927/
  45. May 2024
  46. www.sciencedirect.com www.sciencedirect.com
    Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder
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    sciencedirect.com/science/article/pii/S2352396424001968
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
  48. Apr 2024
  49. www.sciencedirect.com www.sciencedirect.com
    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    sciencedirect.com/science/article/pii/S2211124724004601
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
  51. Mar 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  53. Feb 2024
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
  56. Jan 2024
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  58. Dec 2023
  59. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    sciencedirect.com/science/article/pii/S2211124723015474
  60. Sep 2023
  61. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    sciencedirect.com/science/article/pii/S2211124723010811
  62. Aug 2023
  63. www.sciencedirect.com www.sciencedirect.com
    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    sciencedirect.com/science/article/pii/S2589004223016176
  64. Jun 2023
  65. www.sciencedirect.com www.sciencedirect.com
    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
  66. www.sciencedirect.com www.sciencedirect.com
    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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    sciencedirect.com/science/article/pii/S1934590923002114
  67. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    sciencedirect.com/science/article/pii/S2451945623001502
  68. May 2023
  69. www.sciencedirect.com www.sciencedirect.com
    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    sciencedirect.com/science/article/pii/S2211124723004928
  70. Apr 2023
  71. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    sciencedirect.com/science/article/pii/S1550413123001262
  72. Jan 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9830446/
  74. Nov 2022
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9646953/
  76. Oct 2022
  77. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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    sciencedirect.com/science/article/pii/S2451945622003609
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
  79. Sep 2022
  80. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    sciencedirect.com/science/article/pii/S2211124722011287
  81. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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    journals.plos.org/plosone/article
  82. Aug 2022
  83. www.jneurosci.org www.jneurosci.org
    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    jneurosci.org/content/42/31/6090
  84. Jul 2022
  85. www.sciencedirect.com www.sciencedirect.com
    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    sciencedirect.com/science/article/pii/S221112472200897X
  86. 52.53.155.43 52.53.155.43
    JNEUROSCI.1989-21.2022.full-html.html
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  87. www.sciencedirect.com www.sciencedirect.com
    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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    sciencedirect.com/science/article/pii/S1550413122002273
  88. May 2022
  89. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  90. www.nature.com www.nature.com
    Convergent somatic mutations in metabolism genes in chronic liver disease
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    nature.com/articles/s41586-021-03974-6
  91. Mar 2022
  92. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    sciencedirect.com/science/article/pii/S2211124722002583
  93. 52.53.155.43 52.53.155.43
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  94. Feb 2022
  95. journals.plos.org journals.plos.org
    A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
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    journals.plos.org/plosbiology/article
  96. Jan 2022
  97. www.sciencedirect.com www.sciencedirect.com
    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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    sciencedirect.com/science/article/pii/S1074761321005343
  98. Nov 2021
  99. 52.53.155.43 52.53.155.43
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    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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  101. Oct 2021
  102. www.jneurosci.org www.jneurosci.org
    Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1
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    jneurosci.org/content/41/39/8163
  103. www.sciencedirect.com www.sciencedirect.com
    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    sciencedirect.com/science/article/pii/S1534580721007267
  104. academic.oup.com academic.oup.com
    Insulin increases adipose adiponectin in pregnancy by inhibiting ubiquitination and degradation: Impact of obesity
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab680/6370132
  105. Sep 2021
  106. www.sciencedirect.com www.sciencedirect.com
    KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
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    sciencedirect.com/science/article/pii/S1097276521007358
  107. Aug 2021
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC8333185/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  112. Jul 2021
  113. www.heliyon.com www.heliyon.com
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  114. May 2021
  115. academic.oup.com academic.oup.com
    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    academic.oup.com/jes/article/5/5/bvab024/6145120
  116. www.sciencedirect.com www.sciencedirect.com
    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    sciencedirect.com/science/article/pii/S0896627321001562
  117. www.sciencedirect.com www.sciencedirect.com
    Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
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    sciencedirect.com/science/article/pii/S1534580720305888
  118. Apr 2021
  119. www.sciencedirect.com www.sciencedirect.com
    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    sciencedirect.com/science/article/pii/S1550413120304204
  120. Feb 2021
  121. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  122. www.sciencedirect.com www.sciencedirect.com
    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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    sciencedirect.com/science/article/pii/S2211124721000784
  123. Jan 2021
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
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    ncbi.nlm.nih.gov/pmc/articles/PMC7778269/
  125. Oct 2020
  126. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    elifesciences.org/articles/57395
  127. www.sciencedirect.com www.sciencedirect.com
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    sciencedirect.com/science/article/pii/S2211124720312122
  128. Sep 2020
  129. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    pubmed.ncbi.nlm.nih.gov/32679108/
  130. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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  131. www.sciencedirect.com www.sciencedirect.com
    Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration
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  132. www.sciencedirect.com www.sciencedirect.com
    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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