106 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    1. scibot 15 Nov 2024
      RRID:AB_331168

      DOI: 10.1016/j.str.2024.10.020

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    sciencedirect.com/science/article/pii/S0969212624004556
  3. Aug 2024
  4. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    1. scibot 02 Aug 2024
      anti‐phospho‐AKT

      DOI: 10.15252/embr.202050835

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    embopress.org/doi/full/10.15252/embr.202050835
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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    1. scibot 02 Aug 2024
      RRID:AB_331168

      DOI: 10.1002/jnr.23999

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23999/full
  6. Jul 2024
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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    1. scibot 23 Jul 2024
      RRID:AB_331168

      DOI: 10.1111/acel.14258

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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
  8. www.sciencedirect.com www.sciencedirect.com
    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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    1. scibot 04 Jul 2024
      RRID:AB_331168

      DOI: 10.1016/j.atherosclerosis.2024.118531

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    sciencedirect.com/science/article/pii/S0021915024010992
  9. Jun 2024
  10. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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    1. scibot 06 Jun 2024
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      DOI: 10.1101/2024.02.09.579580

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      RRID:AB_331168

      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  11. May 2024
  12. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 30 May 2024
      RRID:AB_331168

      DOI: 10.1111/bph.16420

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16420
  13. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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    1. scibot 10 May 2024
      RRID:AB_331168

      DOI: 10.1038/nature05972

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      RRID:AB_331168

      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
  14. www.cell.com www.cell.com
    Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders
    1
    1. scibot 10 May 2024
      RRID:AB_331168

      DOI: 10.1016/j.isci.2024.109802

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    cell.com/iscience/abstract/S2589-0042(24)01024-1
  15. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
      RRID:AB_331168

      DOI: 10.1016/j.celrep.2024.114173

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      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  16. dx.doi.org dx.doi.org
    The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway
    1
    1. scibot 09 May 2024
      RRID:AB_331168

      DOI: 10.1210/endocr/bqae039

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    dx.doi.org/10.1210/endocr/bqae039
  17. 52.53.155.43 52.53.155.43
    bqae039-html.html
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    1. scibot 09 May 2024
      RRID:AB_331168

      DOI: 10.6084/m9.figshare.24398467.v2

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      RRID:AB_331168

      DOI: 10.1210/endocr/bqae039

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    52.53.155.43/ab567994747ba987c62f3a62774a1442bfaf3557/bqae039 (1)-html.html
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
    1
    1. scibot 03 May 2024
      RRID:AB_331168

      DOI: 10.7554/eLife.89100

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  19. Apr 2024
  20. www.sciencedirect.com www.sciencedirect.com
    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
    1
    1. scibot 12 Apr 2024
      CST, #4058

      DOI: 10.1016/j.biopha.2024.116575

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    sciencedirect.com/science/article/pii/S0753332224004591
  21. Feb 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    1. scibot 11 Feb 2024
      RRID:AB_331168

      DOI: 10.1158/2767-9764.CRC-23-0321

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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  23. www.sciencedirect.com www.sciencedirect.com
    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
    1
    1. scibot 06 Feb 2024
      RRID:AB_3075350

      DOI: 10.1016/j.cmet.2024.01.005

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    sciencedirect.com/science/article/pii/S1550413124000068
  24. Nov 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Insulin receptor loss impairs mammary tumorigenesis in mice
    1
    1. scibot 02 Nov 2023
      RRID:AB_331168

      DOI: 10.1016/j.celrep.2023.113251

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    sciencedirect.com/science/article/pii/S2211124723012639
  26. Sep 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
    1
    1. scibot 08 Sep 2023
      RRID:AB_331168

      DOI: 10.1158/2159-8290.CD-23-0475

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    ncbi.nlm.nih.gov/pmc/articles/PMC10481131/
  28. Jul 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
    1
    1. scibot 29 Jul 2023
      RRID:AB_331168

      DOI: 10.1016/j.isci.2023.107265

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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
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    1. scibot 29 Jul 2023
      RRID:AB_331168

      DOI: 10.7717/peerj.15630

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    ncbi.nlm.nih.gov/pmc/articles/PMC10373645/
  31. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    1. scibot 27 Jul 2023
      RRID:AB_331168

      DOI: 10.1016/j.celrep.2023.112869

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    sciencedirect.com/science/article/pii/S221112472300880X
  32. www.sciencedirect.com www.sciencedirect.com
    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    1. scibot 21 Jul 2023
      RRID:AB_331168

      DOI: 10.1016/j.cels.2023.06.005

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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  33. 52.53.155.43 52.53.155.43
    cd-23-0475-html.html
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    1. scibot 13 Jul 2023
      RRID:AB_331168

      DOI: 10.1158/2159-8290.cd-23-0475

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    52.53.155.43/ab02200bf4457c1e8196af2525f73574a3d0dd99/cd-23-0475-html.html
  34. Jun 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling
    1
    1. scibot 30 Jun 2023
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      DOI: 10.33549/physiolres.935019

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    ncbi.nlm.nih.gov/pmc/articles/PMC10292815/
  36. www.sciencedirect.com www.sciencedirect.com
    Overcoming MET-mediated resistance in oncogene-driven NSCLC
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    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.isci.2023.107006

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    sciencedirect.com/science/article/pii/S2589004223010830
  37. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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      RRID:AB_331168

      DOI: 10.1523/JNEUROSCI.0146-23.2023

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    jneurosci.org/content/43/15/2631
  38. Apr 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
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    1. scibot 08 Apr 2023
      RRID:AB_331168

      DOI: 10.1016/j.isci.2023.106495

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    sciencedirect.com/science/article/pii/S2589004223005722
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphate Depletion in Insulin-Insensitive Skeletal Muscle Drives AMPD Activation and Sarcopenia in Chronic Kidney DIsease
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      DOI: 10.1016/j.isci.2023.106355

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    ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
  41. Mar 2023
  42. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
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      DOI: 10.1016/j.cmet.2023.03.004

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    sciencedirect.com/science/article/pii/S1550413123000827
  43. Dec 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes
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      DOI: 10.3389/fcell.2022.1033501

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    ncbi.nlm.nih.gov/pmc/articles/PMC9716095/
  45. Nov 2022
  46. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 20 Nov 2022
      RRID:AB_331168

      DOI: 10.1111/bph.15971

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15971
  47. Sep 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis
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      DOI: 10.1016/j.devcel.2022.08.008

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    sciencedirect.com/science/article/pii/S1534580722005949
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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      DOI: 10.1158/2159-8290.CD-21-0551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  50. Aug 2022
  51. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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      DOI: 10.1016/j.celrep.2022.111267

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    sciencedirect.com/science/article/pii/S2211124722010853
  52. Jul 2022
  53. www.sciencedirect.com www.sciencedirect.com
    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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      DOI: 10.1016/j.cmet.2022.06.007

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    sciencedirect.com/science/article/pii/S1550413122002273
  54. Jun 2022
  55. link.springer.com link.springer.com
    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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      DOI: 10.1186/s12964-022-00843-1

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    link.springer.com/article/10.1186/s12964-022-00843-1
  56. www.sciencedirect.com www.sciencedirect.com
    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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      DOI: 10.1016/j.celrep.2022.110910

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  57. Apr 2022
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    The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
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  59. Jan 2022
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    Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  62. Dec 2021
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    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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  64. www.sciencedirect.com www.sciencedirect.com
    Leptin coordinates efferent sympathetic outflow to the white adipose tissue through the midbrain centrally-projecting Edinger-Westphal nucleus in male rats
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  65. Nov 2021
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    p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts
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  67. Oct 2021
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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  69. Sep 2021
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  72. Aug 2021
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    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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  74. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  78. Jul 2021
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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  82. academic.oup.com academic.oup.com
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    Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet–Induced Obesity
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  85. May 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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  91. Apr 2021
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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  93. Jan 2021
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  95. Nov 2020
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  97. Oct 2020
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    Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance
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  100. Sep 2020
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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      anti-phospho-Akt (Ser473)

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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  106. Apr 2020
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  108. Jan 2020
  109. www.sciencedirect.com www.sciencedirect.com
    A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation
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    Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells - Canadian Journal of Physiology and Pharmacology
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    Chronic light cycle-disruption alters central insulin and leptin signalling as well as metabolic markers in male mice
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    Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation
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      DOI: 10.1016/j.celrep.2019.05.019

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  121. Nov 2018
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    Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen
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    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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    Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells
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    Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
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    Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
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    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
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      Cell Signaling#4058

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  132. Nov 2017
  133. www.sciencedirect.com www.sciencedirect.com
    Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling
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  134. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protease activated receptor 2 controls myelin development, resiliency and repair
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    Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
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    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
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