132 Matching Annotations
  1. May 2026
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell-Permeable Itaconate
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    onlinelibrary.wiley.com/doi/10.1002/jcp.70185
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    Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR
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    sciencedirect.com/science/article/pii/S2451945626001376
  4. Apr 2026
  5. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70440
  6. Mar 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrative Multi-omic Classification Reveals Distinct Origins and Evolutionary Trajectories of Thymic Epithelial Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012242/
  8. Feb 2026
  9. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226005195-main-html.html
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  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905276/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SHP2 regulates VEGFR2 Y1175/ PLCγ signaling to impair tumor endothelial barrier stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12915272/
  12. Jan 2026
  13. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004226001598-main-html.html
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  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811739/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12793832/
  17. Oct 2025
  18. www.sciencedirect.com www.sciencedirect.com
    Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2589004225019844
  19. www.biorxiv.org www.biorxiv.org
    Metabolic Alterations driven by PFKFB3 upregulation confer Resistance to Trastuzumab in HER2-Positive Breast Cancer
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    biorxiv.org/content/10.1101/2025.10.09.681343v1
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
  21. Sep 2025
  22. www.sciencedirect.com www.sciencedirect.com
    Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma
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    sciencedirect.com/science/article/pii/S2211124725011131
  23. Aug 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
  26. Jul 2025
  27. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214875/
  29. Jun 2025
  30. 52.53.155.43 52.53.155.43
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  31. Mar 2025
  32. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  33. Feb 2025
  34. 52.53.155.43 52.53.155.43
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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  36. www.biorxiv.org www.biorxiv.org
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    biorxiv.org/content/10.1101/2025.01.28.635193v1
  37. Dec 2024
  38. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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  39. Nov 2024
  40. www.sciencedirect.com www.sciencedirect.com
    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    sciencedirect.com/science/article/pii/S0969212624004556
  41. Aug 2024
  42. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23999/full
  44. Jul 2024
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
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    Local vascular Klotho mediates diabetes-induced atherosclerosis via ERK1/2 and PI3-kinase-dependent signaling pathways.
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    sciencedirect.com/science/article/pii/S0021915024010992
  47. Jun 2024
  48. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  49. May 2024
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16420
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  52. www.cell.com www.cell.com
    Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders
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  53. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
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    The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway
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    dx.doi.org/10.1210/endocr/bqae039
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
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    ncbi.nlm.nih.gov/pmc/articles/PMC11060712/
  57. Apr 2024
  58. www.sciencedirect.com www.sciencedirect.com
    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    sciencedirect.com/science/article/pii/S0753332224004591
  59. Feb 2024
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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    sciencedirect.com/science/article/pii/S1550413124000068
  62. Nov 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Insulin receptor loss impairs mammary tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124723012639
  64. Sep 2023
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10481131/
  66. Jul 2023
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10373645/
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  71. 52.53.155.43 52.53.155.43
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  72. Jun 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Age-Dependent Effects of Remote Preconditioning in Hypertensive Rat Hearts are Associated With Activation of RISK Signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10292815/
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    Overcoming MET-mediated resistance in oncogene-driven NSCLC
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    sciencedirect.com/science/article/pii/S2589004223010830
  75. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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    jneurosci.org/content/43/15/2631
  76. Apr 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Adipocyte-derived chemerin rescues lipid overload-induced cardiac dysfunction
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphate Depletion in Insulin-Insensitive Skeletal Muscle Drives AMPD Activation and Sarcopenia in Chronic Kidney DIsease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10040733/
  79. Mar 2023
  80. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
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  81. Dec 2022
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC9716095/
  83. Nov 2022
  84. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  85. Sep 2022
  86. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  88. Aug 2022
  89. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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  90. Jul 2022
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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  92. Jun 2022
  93. link.springer.com link.springer.com
    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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    link.springer.com/article/10.1186/s12964-022-00843-1
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    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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  95. Apr 2022
  96. www.sciencedirect.com www.sciencedirect.com
    The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
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  97. Jan 2022
  98. www.eneuro.org www.eneuro.org
    Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice
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    eneuro.org/content/6/2/ENEURO.0418-18.2019
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  100. Dec 2021
  101. www.nature.com www.nature.com
    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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    Leptin coordinates efferent sympathetic outflow to the white adipose tissue through the midbrain centrally-projecting Edinger-Westphal nucleus in male rats
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  103. Nov 2021
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts
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  105. Oct 2021
  106. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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  107. Sep 2021
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    Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
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    Metabolic endotoxemia is dictated by the type of lipopolysaccharide
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  110. Aug 2021
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    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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  113. academic.oup.com academic.oup.com
    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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    academic.oup.com/endo/article/158/10/3399/4037402/Renal-Metabolic-Programming-Is-Linked-to-the
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  116. Jul 2021
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    Selective androgen receptor modulator S42 suppresses prostate cancer cell proliferation
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  121. academic.oup.com academic.oup.com
    Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet–Induced Obesity
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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