157 Matching Annotations
  1. Jun 2024
  2. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    1. scibot 30 Jun 2024
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      DOI: 10.1016/j.isci.2024.110132

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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  3. www.cell.com www.cell.com
    CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
    1
    1. scibot 29 Jun 2024
      RRID:AB_331212

      DOI: 10.1016/j.isci.2024.109978

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    cell.com/iscience/abstract/S2589-0042(24)01200-8
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
    1
    1. scibot 22 Jun 2024
      RRID:AB_331212

      DOI: 10.1083/jcb.202402144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11169917/
  5. www.sciencedirect.com www.sciencedirect.com
    The ribotoxic stress response drives UV-mediated cell death
    1
    1. scibot 06 Jun 2024
      RRID:AB_331212

      DOI: 10.1016/j.cell.2024.05.018

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    sciencedirect.com/science/article/pii/S0092867424005270
  6. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.010

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    sciencedirect.com/science/article/pii/S1534580724003277
  7. May 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
    1
    1. scibot 02 May 2024
      RRID:AB_331212

      DOI: 10.1016/j.xgen.2024.100550

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
  9. Apr 2024
  10. rupress.org rupress.org
    DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response
    2
    1. scibot 25 Apr 2024
      RRID:AB_331212

      DOI: 10.1083/jcb.202303141

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    2. scibot 25 Apr 2024
      RRID:AB_331212

      DOI: 10.1083/jcb.202303141

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    rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
  11. www.sciencedirect.com www.sciencedirect.com
    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    1. scibot 09 Apr 2024
      RRID:AB_331212

      DOI: 10.1016/j.celrep.2024.114024

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    sciencedirect.com/science/article/pii/S2211124724003528
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma
    1
    1. scibot 03 Apr 2024
      RRID:AB_331212

      DOI: 10.1158/1078-0432.CCR-23-1003

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
  13. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
    1. scibot 02 Apr 2024
      AB_331212

      DOI: 10.1016/j.cell.2024.03.002

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    2. scibot 02 Apr 2024
      AB_331212

      DOI: 10.1016/j.cell.2024.03.002

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    sciencedirect.com/science/article/pii/S0092867424002502
  14. Mar 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
    1
    1. scibot 29 Mar 2024
      AB_331212

      DOI: 10.1016/j.molcel.2024.02.032

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    sciencedirect.com/science/article/pii/S1097276524001758
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
    1
    1. scibot 16 Mar 2024
      RRID:AB_331212

      DOI: 10.1038/s44319-024-00089-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  17. Feb 2024
  18. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
    1
    1. scibot 24 Feb 2024
      RRID:AB_331212

      DOI: 10.1158/1078-0432.CCR-23-2005

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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  19. www.sciencedirect.com www.sciencedirect.com
    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
    1
    1. scibot 22 Feb 2024
      RRID:AB_331212

      DOI: 10.1016/j.xcrm.2024.101434

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    sciencedirect.com/science/article/pii/S2666379124000570
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
    1
    1. scibot 21 Feb 2024
      RRID:AB_331212

      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
    1
    1. scibot 16 Feb 2024
      RRID:AB_331212

      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
  22. www.sciencedirect.com www.sciencedirect.com
    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    1. scibot 13 Feb 2024
      RRID:AB_331212

      DOI: 10.1016/j.celrep.2024.113778

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    sciencedirect.com/science/article/pii/S2211124724001062
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
    1. scibot 08 Feb 2024
      RRID:AB_331212

      DOI: 10.1016/j.isci.2024.108925

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
      RRID:AB_331212

      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  25. Jan 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
    1
    1. scibot 19 Jan 2024
      RRID:AB_331212

      DOI: 10.1016/j.xcrm.2023.101376

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    sciencedirect.com/science/article/pii/S2666379123006055
  27. www.sciencedirect.com www.sciencedirect.com
    Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair
    1
    1. scibot 09 Jan 2024
      RRID:AB_331312

      DOI: 10.1016/j.celrep.2023.113656

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    sciencedirect.com/science/article/pii/S2211124723016674
  28. Dec 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
      RRID:AB_331212

      DOI: 10.1016/j.isci.2023.108659

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    sciencedirect.com/science/article/pii/S2589004223027360
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe
    1
    1. scibot 23 Dec 2023
      AB_331212

      DOI: 10.1158/2767-9764.CRC-23-0306

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    ncbi.nlm.nih.gov/pmc/articles/PMC10734389/
  31. www.sciencedirect.com www.sciencedirect.com
    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
    1
    1. scibot 20 Dec 2023
      RRID:AB_331212

      DOI: 10.1016/j.xcrm.2023.101326

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    sciencedirect.com/science/article/pii/S2666379123005438
  32. www.sciencedirect.com www.sciencedirect.com
    IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
    1
    1. scibot 16 Dec 2023
      AB_331212

      DOI: 10.1016/j.molcel.2023.11.022

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    sciencedirect.com/science/article/pii/S109727652300967X
  33. 52.53.155.43 52.53.155.43
    ccr-23-2005-html.html
    1
    1. scibot 01 Dec 2023
      RRID:AB_331212

      DOI: 10.1158/1078-0432.ccr-23-2005

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    52.53.155.43/8373d350712629607ae5ff64c6434e7646ebbbe9/ccr-23-2005-html.html
  34. Nov 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
    1
    1. scibot 03 Nov 2023
      RRID:AB_331212

      DOI: 10.1158/1078-0432.CCR-23-0103

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
  36. www.sciencedirect.com www.sciencedirect.com
    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
    1
    1. scibot 02 Nov 2023
      RRID:AB_331212

      DOI: 10.1016/j.celrep.2023.113307

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    sciencedirect.com/science/article/pii/S2211124723013190
  37. Oct 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113180

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    sciencedirect.com/science/article/pii/S2211124723011920
  39. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
    1
    1. scibot 07 Oct 2023
      AB_331212

      DOI: 10.1158/1078-0432.ccr-23-0103

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    52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
  40. www.sciencedirect.com www.sciencedirect.com
    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
    1
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      DOI: 10.1016/j.celrep.2023.113144

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    sciencedirect.com/science/article/pii/S2211124723011567
  41. Sep 2023
  42. 52.53.155.43 52.53.155.43
    can-22-3646-html.html
    1
    1. scibot 22 Sep 2023
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      DOI: 10.1158/0008-5472.can-22-3646

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  43. Aug 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
    1
    1. scibot 31 Aug 2023
      RRID:AB_331212

      DOI: 10.21203/rs.3.rs-3182731/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
    1
    1. scibot 26 Aug 2023
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      DOI: 10.1158/2767-9764.CRC-23-0268

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    ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
  46. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
    1
    1. scibot 11 Aug 2023
      AB_331212

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  47. 52.53.155.43 52.53.155.43
    crc-23-0268-html.html
    1
    1. scibot 11 Aug 2023
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      DOI: 10.1158/2767-9764.crc-23-0268

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  48. 52.53.155.43 52.53.155.43
    SSRN-id4513724-html.html
    1
    1. scibot 10 Aug 2023
      AB_331212

      DOI: 10.2139/ssrn.4513724

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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
    1
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      DOI: 10.1016/j.isci.2023.107449

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    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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  51. Jul 2023
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    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway
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  57. Jun 2023
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    Detection of endogenous translesion DNA synthesis in single mammalian cells
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    DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    Integrator facilitates RNAPII removal to prevent transcription-replication collisions and genome instability
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  62. May 2023
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    ATR protects centromere identity by promoting DAXX association with PML nuclear bodies
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  66. Apr 2023
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    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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  68. www.science.org www.science.org
    Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
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    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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  71. Mar 2023
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations
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  75. Jan 2023
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication
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  78. Nov 2022
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    Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
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  80. Aug 2022
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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  82. Jul 2022
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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  86. May 2022
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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  88. Apr 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
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  91. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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  94. Jan 2022
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
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  98. Dec 2021
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    Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  102. Nov 2021
  103. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts
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  105. Oct 2021
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    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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    NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer
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  110. Sep 2021
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    CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models
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  112. Aug 2021
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    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
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    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
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  118. Jul 2021
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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      Phospho-Chk1 S345

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    Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression
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    An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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  125. Jun 2021
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    MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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  128. May 2021
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    TopBP1 assembles nuclear condensates to switch on ATR signaling
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    CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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    HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis
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  136. Apr 2021
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    Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
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  138. Mar 2021
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    Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication
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    Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies
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  141. Feb 2021
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure
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  146. Jan 2021
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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  148. Dec 2020
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
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    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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  152. Oct 2020
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    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
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  154. Sep 2020
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth
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    Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
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  159. Aug 2020
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    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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  161. Jan 2020
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    IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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    C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
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    The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics
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    Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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    ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response
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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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    MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
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    Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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    DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
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    Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
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      DOI: 10.1016/j.molcel.2018.12.021

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  181. Nov 2018
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    β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
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    ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    Mapping the Genetic Landscape of Human Cells
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    Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    SLFN11 Blocks Stressed Replication Forks Independently of ATR
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
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    Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
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  195. Nov 2017
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    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
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    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
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    NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres
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