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PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

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1. scibot 09 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-1126
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13056290/
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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sciencedirect.com:5037/science/article/pii/S1550413125005273
Nov 2025
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1-s2.0-S2589004225024058-main-html.html

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1. scibot 22 Nov 2025
  
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  AB_331228
  
  DOI: 10.1016/j.isci.2025.114144
  
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54.241.53.176/363ac440fe4fd09e6c215b8cac88403cba003940/1-s2.0-S2589004225024058-main-html.html
Oct 2025
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Lipid-regulated phosphorylation hierarchy of the T cell receptor tyrosine motifs

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.molcel.2025.09.005
  
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sciencedirect.com/science/article/pii/S1097276525007464
Jul 2025
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PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116071
  
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sciencedirect.com/science/article/pii/S2211124725008423
Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115595
  
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sciencedirect.com/science/article/pii/S2211124725003663
Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
Feb 2025
aacrjournals.org aacrjournals.org

MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming

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1. scibot 20 Feb 2025
  
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  DOI: 10.1158/2326-6066.CIR-23-0666
  
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aacrjournals.org/cancerimmunolres/article/12/9/1268/747083/MerTK-Induces-Dysfunctional-Dendritic-Cells-by
Jan 2025
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ERBB4 selectively amplifies TGF-β pro-metastatic responses

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1. scibot 24 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115210
  
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sciencedirect.com/science/article/pii/S2211124724015614
Dec 2024
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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.026
  
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sciencedirect.com/science/article/pii/S1097276524009511
Jul 2024
52.53.155.43 52.53.155.43

cir-23-0666-html.html

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1. scibot 11 Jul 2024
  
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  DOI: 10.1158/2326-6066.cir-23-0666
  
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52.53.155.43/224a4a827b6902bac940b427dd8ec5d00c9bcdbc/cir-23-0666-html.html
May 2024
www.mdpi.com www.mdpi.com

Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase

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1. scibot 31 May 2024
  
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  DOI: 10.3390/biom14060631
  
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mdpi.com/2218-273X/14/6/631
Feb 2024
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Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis

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1. scibot 09 Feb 2024
  
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  RRID:AB_331228
  
  DOI: 10.1016/j.phrs.2024.107096
  
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sciencedirect.com/science/article/pii/S1043661824000409
Jun 2023
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The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity

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1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.immuni.2023.06.002
  
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sciencedirect.com/science/article/pii/S1074761323002376
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipids regulate peripheral serotonin release via gut CD1d

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1. scibot 24 Jun 2023
  
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  RRID:AB_331228
  
  DOI: 10.1016/j.immuni.2023.06.001
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10527042/
May 2023
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DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β

1
1. scibot 05 May 2023
  
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  RRID:AB_331228
  
  DOI: 10.1016/j.celrep.2023.112445
  
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sciencedirect.com/science/article/pii/S2211124723004564
Apr 2023
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Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions

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1. scibot 20 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.02.015
  
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sciencedirect.com/science/article/pii/S1534580723000746
Feb 2023
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Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy

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1. scibot 11 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.106064
  
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sciencedirect.com/science/article/pii/S2589004223001414
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Hexane fraction of Prunus japonica thunb. Seed extract enhances boar sperm motility via CatSper ion channel

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1. scibot 10 Feb 2023
  
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  DOI: 10.1016/j.heliyon.2023.e13616
  
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sciencedirect.com/science/article/pii/S240584402300823X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver

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1. scibot 02 Feb 2023
  
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  DOI: 10.7554/eLife.82311
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9889086/
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

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1. scibot 26 Aug 2022
  
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  DOI: 10.7554/eLife.76436
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9388098/
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A dRASSF-STRIPAK-Imd-JAK/STAT axis controls antiviral immune response in Drosophila

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1. scibot 02 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111143
  
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sciencedirect.com/science/article/pii/S2211124722009524
May 2022
elifesciences.org elifesciences.org

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

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1. scibot 11 May 2022
  
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  DOI: 10.7554/eLife.75233
  
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elifesciences.org/articles/75233
Apr 2022
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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.chembiol.2022.03.010
  
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sciencedirect.com/science/article/pii/S2451945622001271
Aug 2021
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The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors

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1. scibot 14 Aug 2021
  
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  DOI: 10.1016/j.chembiol.2021.07.008
  
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sciencedirect.com/science/article/pii/S2451945621003482
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Untitled document

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1. scibot 07 Aug 2021
  
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  DOI: 10.1016/j.devcel.2018.10.029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6302072/
www.nature.com www.nature.com

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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1. scibot 06 Aug 2021
  
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  DOI: 10.1038/s41467-021-24687-4
  
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nature.com/articles/s41467-021-24687-4
Jul 2021
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Untitled document

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.devcel.2018.10.029
  
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sciencedirect.com/science/article/pii/S1534580718309183
academic.oup.com academic.oup.com

Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis

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1. scibot 30 Jul 2021
  
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  RRID:AB_331228
  
  DOI: 10.1210/js.2018-00140
  
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academic.oup.com/jes/article/3/1/69/5150428
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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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1. scibot 21 Jul 2021
  
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  DOI: 10.1016/j.molcel.2021.06.027
  
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sciencedirect.com/science/article/pii/S1097276521005074
May 2021
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Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation

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1. scibot 25 May 2021
  
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  DOI: 10.1016/j.neuron.2021.04.021
  
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sciencedirect.com/science/article/pii/S0896627321002877
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Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.06.021
  
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sciencedirect.com/science/article/pii/S1097276520304238
Mar 2021
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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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1. scibot 01 Mar 2021
  
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  DOI: 10.1016/j.devcel.2020.12.016
  
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sciencedirect.com/science/article/pii/S1534580720310224
Sep 2020
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c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.03.005
  
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sciencedirect.com/science/article/pii/S221112472030303X
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Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.devcel.2020.01.007
  
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PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation

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1. scibot 10 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.02.035
  
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Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

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  DOI: 10.7554/eLife.45303
  
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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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  DOI: 10.1016/j.molcel.2019.09.007
  
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N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

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  DOI: 10.7554/eLife.47673
  
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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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  DOI: 10.1016/j.chembiol.2019.06.003
  
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

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  DOI: 10.1016/j.cell.2019.09.008
  
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A mechanism in Agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

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  DOI: 10.7554/eLife.49180
  
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Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss

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  DOI: 10.1523/JNEUROSCI.2983-18.2018
  
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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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  DOI: 10.1016/j.devcel.2018.12.021
  
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Prolonged Exposure to Insulin Inactivates Akt and Erk1/2 and Increases Pancreatic Islet and INS1E β-Cell Apoptosis

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  DOI: 10.1210/js.2018-00140
  
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Nov 2018
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Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

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1. scibot 05 Nov 2018
  
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Untitled document

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Nov 2017
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A Split-Abl Kinase for Direct Activation in Cells

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

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Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

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