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Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C–mutant non-small cell lung cancer

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nature.com/articles/s41388-026-03877-8
Jul 2026
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Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior

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sciencedirect.com/science/article/pii/S2589004226019917
Jun 2026
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Insulin-like growth factor 1 receptor regulates breast cancer cell adhesion through beta-1 integrin

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pmc.ncbi.nlm.nih.gov/articles/PMC13229645/
May 2026
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FEBS Press

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  DOI: 10.1002/1878-0261.70266
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70266
Apr 2026
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BPS Publications

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  DOI: 10.1111/bph.70455
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
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Ets1-dependent Mek-Erk signaling drives adipose tissue macrophage anti-inflammatory polarization to ameliorates insulin resistance

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sciencedirect.com/science/article/pii/S2211124726003220
Mar 2026
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Insulin receptor trafficking and interactions in muscle cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12963976/
Feb 2026
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2026.02.11.705361v1.full-html.html

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54.241.53.176/5c618bd82011554652ee37be2d6b5f0590a656fa/2026.02.11.705361v1.full-html.html
Nov 2025
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Insulin-Like Growth Factor 1 Receptor Regulates Breast Cancer Cell Adhesion through Beta-1 Integrin

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pmc.ncbi.nlm.nih.gov/articles/PMC12458451/
Oct 2025
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Reversal of diet-induced obesity by central insulin sensitizer FSTL1

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sciencedirect.com/science/article/pii/S0896627325007494
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Tuning insulin receptor signaling using de novo-designed agonists

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  DOI: 10.1016/j.molcel.2025.09.020
  
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1-s2.0-S2589004225019431-main-html.html

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54.241.53.176/eeb39d9bee7752f597857d9a83090e282b37f221/1-s2.0-S2589004225019431-main-html.html
Mar 2025
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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

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1. scibot 13 Mar 2025
  
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sciencedirect.com/science/article/pii/S2211124725001524
Jan 2025
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Lactate homeostasis is maintained through regulation of glycolysis and lipolysis

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Nov 2024
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Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females

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pmc.ncbi.nlm.nih.gov/articles/PMC11491842/
Sep 2024
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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway

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Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity

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1. scibot 25 Sep 2024
  
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1

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Apr 2024
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Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption

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ncbi.nlm.nih.gov/pmc/articles/PMC11039404/
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Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1

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ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
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Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

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Feb 2024
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Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans

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Nov 2023
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Insulin receptor loss impairs mammary tumorigenesis in mice

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Sep 2023
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British J Pharmacology - 2023 - Dai-html.html

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52.53.155.43/8d076c70ed36377d24eb7bc3686db861bc15751d/British J Pharmacology - 2023 - Dai-html.html
Jul 2023
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Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus

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  DOI: 10.1210/clinem/dgad413
  
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Mar 2023
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SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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Jan 2023
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SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2

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Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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Nov 2022
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Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier

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A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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  DOI: 10.1158/2767-9764.crc-22-0256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
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Androgens improve ovarian follicle function impaired by glucocorticoids through an androgen-IGF1-FSH synergistic effect

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ncbi.nlm.nih.gov/pmc/articles/PMC9627217/
Oct 2022
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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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1. scibot 26 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105233
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
Mar 2022
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Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells

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  DOI: 10.1016/j.celrep.2022.110548
  
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sciencedirect.com/science/article/pii/S2211124722002893
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Symmetric and asymmetric receptor conformation continuum induced by a new insulin

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  DOI: 10.1038/s41589-022-00981-0
  
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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Translational and post-translational control of human naïve versus primed pluripotency

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

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An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3

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Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels

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Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model

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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

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IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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Contrasting Effects of IGF Binding Protein-3 Expression in Mammary Tumor Cells and the Tumor Microenvironment

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Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Systematic Functional Annotation of Somatic Mutations in Cancer

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A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions

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Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model

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Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation

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