154 Matching Annotations
  1. Jul 2025
  2. www.science.org www.science.org
    Distinct adipose progenitor cells emerging with age drive active adipogenesis
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    science.org/doi/10.1126/science.adj0430
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227656/
  5. Jun 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12181884/
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    Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket
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    sciencedirect.com/science/article/pii/S258900422400124X
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  9. May 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077877/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
  12. Apr 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
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    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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    sciencedirect.com/science/article/pii/S1074761325001244
  15. Mar 2025
  16. www.sciencedirect.com www.sciencedirect.com
    Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection
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    sciencedirect.com/science/article/pii/S2211124725002098
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11927619/
  18. www.science.org www.science.org
    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    science.org/doi/10.1126/sciadv.adi9885
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    Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway
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    sciencedirect.com/science/article/pii/S1567576925003844
  20. Feb 2025
  21. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities
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    onlinelibrary.wiley.com/doi/10.1002/pro.70072
  22. dx.doi.org dx.doi.org
    The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence
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    dx.doi.org/10.1210/endocr/bqae136
  23. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17463
  24. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225002901-main-html.html
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    52.53.155.43/ad050befce46ee469606c03d2c9e736a6b526b04/1-s2.0-S2589004225002901-main-html.html
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    STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma
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    sciencedirect.com/science/article/pii/S1534580725000346
  26. 52.53.155.43 52.53.155.43
    Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
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    52.53.155.43/ccdd8f2b9b0076ccdaf42c273b248e5adbb5da1d/2024.09.09.611621v1.full-html.html
  27. Jan 2025
  28. www.sciencedirect.com www.sciencedirect.com
    Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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    sciencedirect.com/science/article/pii/S1550413124004844
  29. www.sciencedirect.com www.sciencedirect.com
    Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10
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    sciencedirect.com/science/article/pii/S1535610824004793
  30. Dec 2024
  31. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-024-02097-4
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct Effects of the Janus Kinase Inhibitor Baricitinib on Sensory Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11593535/
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    Pancreatic β cell interleukin-22 receptor subunit alpha 1 deficiency impairs β cell function in type 2 diabetes via cytochrome b5 reductase 3
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    sciencedirect.com/science/article/pii/S2211124724014086
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    A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury
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    sciencedirect.com/science/article/pii/S2666379124006207
  35. www.sciencedirect.com www.sciencedirect.com
    Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior
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    sciencedirect.com/science/article/pii/S1074761324005235
  36. www.sciencedirect.com www.sciencedirect.com
    Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis
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    sciencedirect.com/science/article/pii/S1931312824004372
  37. Sep 2024
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11389550/
  39. Aug 2024
  40. www.sciencedirect.com www.sciencedirect.com
    Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
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    sciencedirect.com/science/article/pii/S2211124724009665
  41. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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    sciencedirect.com/science/article/pii/S1534580724004428
  42. Jul 2024
  43. www.mdpi.com www.mdpi.com
    Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord
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    mdpi.com/1422-0067/25/13/7168
  44. www.sciencedirect.com www.sciencedirect.com
    Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling
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    sciencedirect.com/science/article/pii/S2666379124003720
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
  47. May 2024
  48. link.springer.com link.springer.com
    IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway
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    link.springer.com/article/10.1038/s41420-024-01995-4
  49. www.sciencedirect.com www.sciencedirect.com
    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    sciencedirect.com/science/article/pii/S1934590924001425
  50. Apr 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anorexia-Induced Hypoleptinemia Drives Adaptations in the JAK2/STAT3 Pathway in the Ventral and Dorsal Hippocampus of Female Rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC11054075/
  52. www.sciencedirect.com www.sciencedirect.com
    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
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    sciencedirect.com/science/article/pii/S0006295224001886
  53. www.sciencedirect.com www.sciencedirect.com
    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    sciencedirect.com/science/article/pii/S1550413124000536
  54. www.sciencedirect.com www.sciencedirect.com
    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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    sciencedirect.com/science/article/pii/S0092867424003039
  55. Mar 2024
  56. 52.53.155.43 52.53.155.43
    Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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    52.53.155.43/ef706d7fedeb9d14a9f80c03d77786b7f4c289d6/bqae035-html.html
  57. www.nature.com www.nature.com
    Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
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    nature.com/articles/s41401-024-01249-0
  58. Feb 2024
  59. www.sciencedirect.com www.sciencedirect.com
    IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724001633
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844828/
  61. Jan 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10772350/
  63. Dec 2023
  64. www.sciencedirect.com www.sciencedirect.com
    BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
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    sciencedirect.com/science/article/pii/S1534580723006160
  65. Nov 2023
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  67. Oct 2023
  68. onlinelibrary.wiley.com onlinelibrary.wiley.com
    STAT3 modulates CD4+ T mitochondrial dynamics and function in aging
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    onlinelibrary.wiley.com/doi/10.1111/acel.13996
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC10591052/
  70. Sep 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment
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    ncbi.nlm.nih.gov/pmc/articles/PMC10472096/
  72. Aug 2023
  73. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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    ncbi.nlm.nih.gov/pmc/articles/PMC10392084/
  75. Jul 2023
  76. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Chen - Anthelmintics nitazoxanide protects against experimental pulmonary fibrosis-html.html
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    52.53.155.43/01e7f498781407a431fc8d9b3b9cdd8be1437af6/British J Pharmacology - 2023 - Chen - Anthelmintics nitazoxanide protects against experimental pulmonary fibrosis-html.html
  77. www.sciencedirect.com www.sciencedirect.com
    STAT3 regulates antiviral immunity by suppressing excessive interferon signaling
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    sciencedirect.com/science/article/pii/S2211124723008173
  78. www.sciencedirect.com www.sciencedirect.com
    LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer
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    sciencedirect.com/science/article/pii/S1534580723003040
  79. May 2023
  80. www.sciencedirect.com www.sciencedirect.com
    Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through a ROS-dependent mechanism
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    sciencedirect.com/science/article/pii/S2589004223008659
  81. Apr 2023
  82. www.sciencedirect.com www.sciencedirect.com
    CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue
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    sciencedirect.com/science/article/pii/S2211124723004357
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104468/
  85. www.science.org www.science.org
    IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
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    science.org/doi/10.1126/sciadv.adf4490
  86. Mar 2023
  87. www.sciencedirect.com www.sciencedirect.com
    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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    sciencedirect.com/science/article/pii/S2211124723002164
  88. Feb 2023
  89. www.sciencedirect.com www.sciencedirect.com
    Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux
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    sciencedirect.com/science/article/pii/S2211124723001481
  90. Dec 2022
  91. www.sciencedirect.com www.sciencedirect.com
    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    sciencedirect.com/science/article/pii/S2211124722017132
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC9708799/
  93. Nov 2022
  94. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15949
  95. www.sciencedirect.com www.sciencedirect.com
    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    sciencedirect.com/science/article/pii/S2352345X22001989
  96. www.sciencedirect.com www.sciencedirect.com
    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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    sciencedirect.com/science/article/pii/S2352396422004947
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
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    onlinelibrary.wiley.com/doi/10.1002/glia.24292
  98. Sep 2022
  99. www.sciencedirect.com www.sciencedirect.com
    Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin
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    sciencedirect.com/science/article/pii/S221112472201227X
  100. journals.plos.org journals.plos.org
    CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells
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    journals.plos.org/plosone/article
  101. Aug 2022
  102. www.sciencedirect.com www.sciencedirect.com
    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    sciencedirect.com/science/article/pii/S2211124722010865
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9438971/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Obesity and Fatty Acids Promote Mitochondrial Translocation of STAT3 Through ROS-Dependent Mechanisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC9344057/
  105. Jul 2022
  106. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
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    52.53.155.43/eeb521b7ce9ed18aede2526ed77220c5d9e406f5/British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
  107. Jun 2022
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  109. Mar 2022
  110. academic.oup.com academic.oup.com
    Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioac020/6517230
  111. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
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    onlinelibrary.wiley.com/doi/10.1002/jnr.25036
  112. Feb 2022
  113. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
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    pubmed.ncbi.nlm.nih.gov/35196494/
  114. www.sciencedirect.com www.sciencedirect.com
    Ligand-mediated PAI-1 inhibition in a mouse model of peritoneal carcinomatosis
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    sciencedirect.com/science/article/pii/S266637912200026X
  115. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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    nature.com/articles/s41375-020-01077-1
  116. Jan 2022
  117. www.sciencedirect.com www.sciencedirect.com
    Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis
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