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    Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway
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    Semaphorin3C identified as mediator of neuroinflammation and microglia polarization after spinal cord injury
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    The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
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    SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation
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    Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress
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    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells
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    Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses
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    Alternative mRNA splicing events and regulators in epidermal differentiation
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    The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
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    In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux
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    Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
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    Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation
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    Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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  31. Jan 2024
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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    The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression
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    Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes
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  40. Dec 2023
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    Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro
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    Nanocurcumin attenuates pyroptosis and inflammation through inhibiting NF-κB/GSDMD signal in high altitude-associated acute liver injury
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  43. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke
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    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    Serotonin 2C receptors are also important in head-twitch responses in male mice
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    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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  131. Jan 2023
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    CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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  158. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 29 Jul 2022
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      DOI: 10.1111/bph.15912

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    2. scibot 29 Jul 2022
      RRID:AB_331284

      DOI: 10.1111/bph.15912

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15912
  177. www.sciencedirect.com www.sciencedirect.com
    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
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    1. scibot 08 Jul 2022
      RRID:AB_331284

      DOI: 10.1016/j.isci.2022.104607

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    sciencedirect.com/science/article/pii/S2589004222008793
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification
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    1. scibot 06 Jul 2022
      RRID:AB_331284

      DOI: 10.3389/fcvm.2022.885293

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    ncbi.nlm.nih.gov/pmc/articles/PMC9251177/
  179. Jun 2022
  180. www.sciencedirect.com www.sciencedirect.com
    The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
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    1. scibot 22 Jun 2022
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      DOI: 10.1016/j.isci.2022.104561

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    sciencedirect.com/science/article/pii/S2589004222008331
  181. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    1. scibot 17 Jun 2022
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      DOI: 10.1016/j.isci.2022.104519

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    sciencedirect.com/science/article/pii/S2589004222007908
  182. academic.oup.com academic.oup.com
    Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1/2 and inflammasome activation in PCOS
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    1. scibot 03 Jun 2022
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      DOI: 10.1210/clinem/dgac281

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac281/6581607
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury
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    1. scibot 01 Jun 2022
      RRID:AB_331284

      DOI: 10.3390/toxins14050337

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    ncbi.nlm.nih.gov/pmc/articles/PMC9147548/
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    1. scibot 01 Jun 2022
      RRID:AB_331284

      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  185. May 2022
  186. www.nature.com www.nature.com
    Effects of interleukin 1β on long noncoding RNA and mRNA expression profiles of human synovial fluid derived mesenchymal stem cells
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    1. scibot 21 May 2022
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      DOI: 10.1038/s41598-022-12190-9

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    nature.com/articles/s41598-022-12190-9
  187. www.sciencedirect.com www.sciencedirect.com
    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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    1. scibot 11 May 2022
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      DOI: 10.1016/j.celrep.2022.110796

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    sciencedirect.com/science/article/pii/S2211124722005630
  188. www.nature.com www.nature.com
    Activation of cannabinoid receptors in breast cancer cells improves osteoblast viability in cancer-bone interaction model while reducing breast cancer cell survival and migration
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    1. scibot 10 May 2022
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      DOI: 10.1038/s41598-022-11116-9

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    nature.com/articles/s41598-022-11116-9
  189. www.sciencedirect.com www.sciencedirect.com
    Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
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    1. scibot 06 May 2022
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      DOI: 10.1016/j.ccell.2022.04.011

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    sciencedirect.com/science/article/pii/S1535610822001738
  190. Apr 2022
  191. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism
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    1. scibot 28 Apr 2022
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      DOI: 10.1111/bph.15827

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15827
  192. www.sciencedirect.com www.sciencedirect.com
    Long-term and potent IOP-lowering effect of IκBα-siRNA in a nonhuman primate model of chronic ocular hypertension
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    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104149

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    sciencedirect.com/science/article/pii/S2589004222004199
  193. www.sciencedirect.com www.sciencedirect.com
    Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses
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    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110727

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    sciencedirect.com/science/article/pii/S2211124722004880
  194. www.sciencedirect.com www.sciencedirect.com
    Secreted NF-κB suppressive microbial metabolites modulate gut inflammation
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    1. scibot 14 Apr 2022
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      DOI: 10.1016/j.celrep.2022.110646

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    sciencedirect.com/science/article/pii/S2211124722003989
  195. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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    1. scibot 12 Apr 2022
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      DOI: 10.1111/cns.13839

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    onlinelibrary.wiley.com/doi/10.1111/cns.13839
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
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    1. scibot 01 Apr 2022
      RRID:AB_331284

      DOI: 10.3389/fphar.2022.824138

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    ncbi.nlm.nih.gov/pmc/articles/PMC8957965/
  197. Mar 2022
  198. www.sciencedirect.com www.sciencedirect.com
    PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation
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    1. scibot 31 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110603

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    sciencedirect.com/science/article/pii/S2211124722003515
  199. www.sciencedirect.com www.sciencedirect.com
    Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
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    1. scibot 27 Mar 2022
      RRID:AB_331284

      DOI: 10.1016/j.ebiom.2022.103950

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    sciencedirect.com/science/article/pii/S2352396422001347
  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors
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    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.chom.2017.04.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC8938989/
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    1. scibot 23 Mar 2022
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      DOI: 10.1016/j.isci.2022.104009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8927994/
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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    1. scibot 17 Mar 2022
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      DOI: 10.1016/j.isci.2022.103979

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    ncbi.nlm.nih.gov/pmc/articles/PMC8914552/
  203. www.sciencedirect.com www.sciencedirect.com
    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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    1. scibot 16 Mar 2022
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      DOI: 10.1016/j.celrep.2022.110513

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    sciencedirect.com/science/article/pii/S2211124722002492
  204. journals.lww.com journals.lww.com
    Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.335163

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    journals.lww.com/nrronline/Fulltext/2022/17090/Urolithin_A_alleviates_blood_brain_barrier.32.aspx
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
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    1. scibot 09 Mar 2022
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      DOI: 10.3389/fimmu.2022.837497

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    ncbi.nlm.nih.gov/pmc/articles/PMC8899187/
  206. academic.oup.com academic.oup.com
    Corticotropin-releasing factor aggravates ischemic stroke injury by the inflammatory activation of microglia
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      DOI: 10.1210/endocr/bqac013

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    academic.oup.com/endo/article/163/3/bqac013/6523128
  207. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    1. scibot 04 Mar 2022
      Cell Signaling Tehnology cat# 3033

      DOI: 10.1016/j.celrep.2022.110354

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    sciencedirect.com/science/article/pii/S2211124722000705
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.69982

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    ncbi.nlm.nih.gov/pmc/articles/PMC8860447/
  209. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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      DOI: 10.7554/eLife.72849

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    elifesciences.org/articles/72849
  210. www.sciencedirect.com www.sciencedirect.com
    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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      DOI: 10.1016/j.celrep.2022.110444

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    sciencedirect.com/science/article/pii/S2211124722001711
  211. Feb 2022
  212. www.sciencedirect.com www.sciencedirect.com
    CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson’s disease
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      DOI: 10.1016/j.phrs.2022.106133

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    sciencedirect.com/science/article/pii/S1043661822000780
  213. www.sciencedirect.com www.sciencedirect.com
    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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      DOI: 10.1016/j.isci.2022.103859

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    sciencedirect.com/science/article/pii/S2589004222001298
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis
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      DOI: 10.7554/eLife.72579

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    ncbi.nlm.nih.gov/pmc/articles/PMC8806187/
  215. Jan 2022
  216. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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      DOI: 10.1016/j.celrep.2022.110302

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    sciencedirect.com/science/article/pii/S2211124722000146
  217. www.sciencedirect.com www.sciencedirect.com
    Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome
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      DOI: 10.1016/j.jcmgh.2021.12.002

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    sciencedirect.com/science/article/pii/S2352345X21002526
  218. www.sciencedirect.com www.sciencedirect.com
    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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      DOI: 10.1016/j.biopha.2022.112615

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    sciencedirect.com/science/article/pii/S0753332222000038