115 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
    1
    1. scibot 25 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001903
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    sciencedirect.com/science/article/pii/S2666379124001794
  4. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1038/s41419-024-06534-8

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    nature.com/articles/s41419-024-06534-8
  5. Mar 2024
  6. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
    1
    1. scibot 21 Mar 2024
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      DOI: 10.1101/2024.02.29.582877

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    biorxiv.org/content/10.1101/2024.02.29.582877v1
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
    1
    1. scibot 19 Mar 2024
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      DOI: 10.7554/eLife.87386

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942603/
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    1. scibot 19 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001722
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
    2
    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113935

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      DOI: 10.1016/j.celrep.2024.113935

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    sciencedirect.com/science/article/pii/S2211124724002638
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
    1
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    sciencedirect.com/science/article/pii/S2211124724002365
  11. Feb 2024
  12. link.springer.com link.springer.com
    CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1038/s41388-024-02968-8

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    link.springer.com/article/10.1038/s41388-024-02968-8
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
    1. scibot 06 Feb 2024
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    sciencedirect.com/science/article/pii/S1097276524000091
  14. Jan 2024
  15. www.sciencedirect.com www.sciencedirect.com
    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.11.035

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    sciencedirect.com/science/article/pii/S1097276523009802
  16. Dec 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  18. Nov 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113437

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    sciencedirect.com/science/article/pii/S2211124723014493
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
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    Mass isolation of staged Drosophila pupal intestines for analysis of protein ubiquitylation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xpro.2023.102713

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    sciencedirect.com/science/article/pii/S2666166723006809
  22. Oct 2023
  23. link.springer.com link.springer.com
    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
    1
    1. scibot 31 Oct 2023
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      DOI: 10.1186/s13041-023-01064-4

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    link.springer.com/article/10.1186/s13041-023-01064-4
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    Methotrexate-based PROTACs as DHFR-specific chemical probes
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.chembiol.2023.09.014

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    sciencedirect.com/science/article/pii/S2451945623003331
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    Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.devcel.2023.09.007

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    sciencedirect.com/science/article/pii/S153458072300494X
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    Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113211

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    sciencedirect.com/science/article/pii/S2211124723012238
  27. www.cell.com www.cell.com
    AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113110

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    cell.com/cell-reports/abstract/S2211-1247(23)01121-X
  28. Sep 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration
    1
    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.chembiol.2023.08.004

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    sciencedirect.com/science/article/abs/pii/S2451945623002763
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
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    1. scibot 12 Sep 2023
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      DOI: 10.1016/j.isci.2023.107762

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    ncbi.nlm.nih.gov/pmc/articles/PMC10492219/
  31. Aug 2023
  32. www.sciencedirect.com www.sciencedirect.com
    E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
    1
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.021

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    sciencedirect.com/science/article/pii/S1097276523005634
  33. Jul 2023
  34. www.sciencedirect.com www.sciencedirect.com
    The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
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    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112851

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    sciencedirect.com/science/article/pii/S2211124723008628
  35. Jun 2023
  36. www.sciencedirect.com www.sciencedirect.com
    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.cmet.2023.05.011

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    sciencedirect.com/science/article/pii/S1550413123002097
  37. www.sciencedirect.com www.sciencedirect.com
    LEAFY homeostasis is regulated via ubiquitin-dependent degradation and sequestration in cytoplasmic condensates
    1
    1. scibot 01 Jun 2023
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      DOI: 10.1016/j.isci.2023.106880

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    sciencedirect.com/science/article/pii/S2589004223009574
  38. May 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers
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      DOI: 10.1016/j.ebiom.2023.104634

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    sciencedirect.com/science/article/pii/S2352396423001998
  40. Apr 2023
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    Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD
    1
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      DOI: 10.1016/j.celrep.2023.112319

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    sciencedirect.com/science/article/pii/S2211124723003303
  42. Mar 2023
  43. www.sciencedirect.com www.sciencedirect.com
    The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis
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      DOI: 10.1016/j.celrep.2023.112288

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    sciencedirect.com/science/article/pii/S2211124723002991
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    A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites
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    sciencedirect.com/science/article/pii/S2352396423000452
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
  46. Jan 2023
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    Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
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      DOI: 10.1016/j.devcel.2022.12.012

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    sciencedirect.com/science/article/pii/S1534580722008942
  48. 52.53.155.43 52.53.155.43
    Global cancer statistics, 2012
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      DOI: 10.2139/ssrn.4278954

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    52.53.155.43/a02c96445d7922530f409187fd9f1b81c5a72867/SSRN-id4278954-html.html
  49. Nov 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
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      DOI: 10.1016/j.chembiol.2022.10.007

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    sciencedirect.com/science/article/pii/S2451945622003610
  51. Oct 2022
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemical screen uncovers novel structural classes of inhibitors of the papain-like protease of coronaviruses
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      DOI: 10.1016/j.isci.2022.105254

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    ncbi.nlm.nih.gov/pmc/articles/PMC9526870/
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    OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis
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      DOI: 10.1016/j.celrep.2022.111561

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    sciencedirect.com/science/article/pii/S221112472201422X
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The protease DDI2 regulates NRF1 activation in response to cadmium toxicity
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      DOI: 10.1016/j.isci.2022.105227

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    ncbi.nlm.nih.gov/pmc/articles/PMC9557025/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
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      DOI: 10.1016/j.ebiom.2022.104278

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    ncbi.nlm.nih.gov/pmc/articles/PMC9535427/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis
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      DOI: 10.1016/j.isci.2022.105161

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  57. Sep 2022
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
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  60. Jul 2022
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    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
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    Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
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    Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.
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  68. May 2022
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    Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
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  70. Apr 2022
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    Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
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  74. Mar 2022
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization
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    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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  79. Feb 2022
  80. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
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  82. Oct 2021
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector
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  86. Sep 2021
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    Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
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    SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
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  89. Aug 2021
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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  92. Jul 2021
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    The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis
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  94. Jun 2021
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    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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  96. May 2021
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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  100. Apr 2021
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    Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing
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    Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors
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  103. Feb 2021
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis
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    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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  107. Nov 2020
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    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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    (−)-Epicatechin reduces muscle waste after complete spinal cord transection in a murine model: role of ubiquitin–proteasome system
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  110. Sep 2020
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    Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase
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  114. www.cell.com www.cell.com
    Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis
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    Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline
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    Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity
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  118. Jan 2020
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
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    A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
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    C2‐lacking isoform of Nedd4‐2 regulates excitatory synaptic strength through GluA1 ubiquitination‐independent mechanisms
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    Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
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    Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
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    VCP Machinery Mediates Autophagic Degradation of Empty Argonaute
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    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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    Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
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    Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions
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    Chloroplast Biogenesis Controlled by DELLA-TOC159 Interaction in Early Plant Development
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    BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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    Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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    Defining a Cancer Dependency Map
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    Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18
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    RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity
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