332 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
    1
    1. scibot 10 Nov 2024
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      DOI: 10.7554/eLife.97854

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    pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
  3. Oct 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
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    1. scibot 04 Oct 2024
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      DOI: 10.1016/j.ccell.2024.09.002

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    sciencedirect.com/science/article/pii/S1535610824003507
  5. Sep 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    1. scibot 25 Sep 2024
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      DOI: 10.1038/s44319-024-00217-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia
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    1. scibot 25 Sep 2024
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      DOI: 10.14814/phy2.70044

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    ncbi.nlm.nih.gov/pmc/articles/PMC11410559/
  8. www.sciencedirect.com www.sciencedirect.com
    RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
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    1. scibot 14 Sep 2024
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    sciencedirect.com/science/article/pii/S1097276524007007
  9. 52.53.155.43 52.53.155.43
    Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease
    1
    1. scibot 05 Sep 2024
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      DOI: 10.1101/2024.07.19.604372

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    52.53.155.43/094bf1894e7037610818c8319cb16bd0730a5b11/2024.07.19.604372v1.full-html.html
  10. Aug 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114663

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    sciencedirect.com/science/article/pii/S2211124724010143
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1038/s41598-024-69749-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11319469/
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
    1
    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006191
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    A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S193459092400256X
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    Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009690
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    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
    1
    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S1931312824002713
  17. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1210/endocr/bqac170

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    academic.oup.com/endo/article-abstract/163/12/bqac170/6763139
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  19. Jul 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
    1
    1. scibot 31 Jul 2024
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      DOI: 10.1158/2767-9764.CRC-24-0247

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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
  21. www.sciencedirect.com www.sciencedirect.com
    Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
    2
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114542

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    sciencedirect.com/science/article/pii/S2211124724008714
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.isci.2024.109912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
  23. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
    1
    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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    elifesciences.org/articles/98649
  24. Jun 2024
  25. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cmet.2024.05.015

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    sciencedirect.com/science/article/pii/S1550413124001918
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
    1. scibot 03 Jun 2024
      RRID:AB_331355

      DOI: 10.1016/j.isci.2024.109983

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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  27. May 2024
  28. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
    1
    1. scibot 25 May 2024
      AB_331355

      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  29. www.jbc.org www.jbc.org
    Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury
    1
    1. scibot 25 May 2024
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      DOI: 10.1016/j.jbc.2024.107405

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    jbc.org/article/S0021-9258(24)01906-9/abstract
  30. 52.53.155.43 52.53.155.43
    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
    3
    1. scibot 24 May 2024
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      DOI: 10.1152/ajpgi.00126.2023

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      DOI: 10.1152/ajpgi.00126.2023

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      DOI: 10.1152/ajpgi.00126.2023

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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
  31. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.molcel.2024.04.026

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    sciencedirect.com/science/article/pii/S1097276524003939
  32. www.sciencedirect.com www.sciencedirect.com
    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.bbadis.2024.167249

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    sciencedirect.com/science/article/pii/S0925443924002382
  33. www.sciencedirect.com www.sciencedirect.com
    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
    1
    1. scibot 17 May 2024
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      DOI: 10.1016/j.ajpath.2024.04.006

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    sciencedirect.com/science/article/pii/S0002944024001743
  34. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
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      DOI: 10.1016/j.celrep.2024.114173

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      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  35. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
    1
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      DOI: 10.1016/j.cmet.2024.04.015

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    sciencedirect.com/science/article/pii/S1550413124001359
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
    1
    1. scibot 01 May 2024
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      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  37. Apr 2024
  38. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
    1
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      DOI: 10.1002/path.6282

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    pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.6282
  39. www.biorxiv.org www.biorxiv.org
    Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline
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      DOI: 10.1101/2024.04.09.588665

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    biorxiv.org/content/10.1101/2024.04.09.588665v1
  40. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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      DOI: 10.1186/s12958-024-01204-y

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    52.53.155.43/d3bb518aa444c98d6cfb77a0666830bf57a4ed47/12958_2024_1204_MOESM1_ESM-html.html
  41. Mar 2024
  42. www.sciencedirect.com www.sciencedirect.com
    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
    1
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      DOI: 10.1016/j.isci.2024.109249

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
  44. www.sciencedirect.com www.sciencedirect.com
    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    sciencedirect.com/science/article/pii/S1550413124000500
  45. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 targets ribosomal RNA biogenesis
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      DOI: 10.1016/j.celrep.2024.113891

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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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    FMRP phosphorylation modulates neuronal translation through YTHDF1
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
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    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
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    Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma
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  77. Jul 2023
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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  151. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  161. Apr 2022
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    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  165. Mar 2022
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    Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  177. Dec 2021
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  180. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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    Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c
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    SLC1A5 provides glutamine and asparagine necessary for bone development in mice
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  189. Oct 2021
  190. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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    MMP Inhibition Attenuates Hypertensive Eccentric Cardiac Hypertrophy and Dysfunction by Preserving Troponin I and Dystrophin
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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    Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study
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    Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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