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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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  DOI: 10.1016/j.xcrm.2025.102317
  
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1-s2.0-S2589004225017158-main-html.html

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1. scibot 29 Aug 2025
  
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Aug 2025
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AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102299
  
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HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

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  DOI: 10.1158/0008-5472.CAN-24-0456
  
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5-HT6 Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5-HT6 Receptor Constitutive Activity

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  DOI: 10.1111/jnc.70179
  
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

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  DOI: 10.1016/j.devcel.2025.07.014
  
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Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

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  DOI: 10.1016/j.neuron.2025.07.010
  
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Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

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  DOI: 10.1016/j.celrep.2025.116097
  
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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aryal-et-al-2025-ketone-body--hydroxybutyrate-mediated-histone--hydroxybutyrylation-upregulates-lipolysis-and-html.html

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Jul 2025
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.23.666448
  
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/science.adm9805
  
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.ads2923
  
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1-s2.0-S2589004225014555-main-html.html

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113194
  
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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1. scibot 16 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
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FMRP drives mRNP targets into translationally silenced complexes

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.012
  
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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.cell.2024.05.025
  
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Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102218
  
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A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model

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  DOI: 10.1038/s41598-025-08345-z
  
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The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

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  DOI: 10.1210/endocr/bqae041
  
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Jun 2025
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Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake

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  DOI: 10.1016/j.xcrm.2025.102163
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00236-8
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Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

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  DOI: 10.1158/2767-9764.CRC-23-0506
  
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RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis

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  DOI: 10.1186/s12964-025-02278-w
  
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Oncogenic H-RAS induces metformin resistance in head and neck cancer by promoting glycolytic metabolism

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  DOI: 10.1158/1940-6207.CAPR-24-0124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11969736/
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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  DOI: 10.1016/j.molcel.2025.05.003
  
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Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

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  DOI: 10.7554/eLife.97671
  
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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  DOI: 10.1016/j.celrep.2025.115444
  
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Impact of ATF6 deletion on the embryonic brain development

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  DOI: 10.1016/j.isci.2025.112569
  
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Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

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  DOI: 10.1038/s42003-025-08002-1
  
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

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De novo serine biosynthesis is protective in mitochondrial disease

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  DOI: 10.1016/j.celrep.2025.115710
  
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m6A alters ribosome dynamics to initiate mRNA degradation

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  DOI: 10.1016/j.cell.2025.04.020
  
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cell.com/cell/abstract/S0092-8674(25)00455-6
Apr 2025
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Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis

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  DOI: 10.1016/j.celrep.2025.115468
  
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Mar 2025
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Vagal pathway activation links chronic stress to decline in intestinal stem cell function

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1. scibot 24 Mar 2025
  
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  DOI: 10.1016/j.stem.2025.02.016
  
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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

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1. scibot 23 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.023
  
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cell.com/immunity/fulltext/S1074-7613(25)00090-1
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 21 Mar 2025
  
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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

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Dietary nitrate supplementation mitigates age-related changes at the neuromuscular junction in mice

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1-s2.0-S2589004225002901-main-html.html

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TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion

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RIOK3 mediates the degradation of 40S ribosomes

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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

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Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

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can-24-0456-html.html

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Maternal gut microbiota influence stem cell function in offspring

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells

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Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

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Midkine as a driver of age-related changes and increase in mammary tumorigenesis

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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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Anabolic deficits and divergent unfolded protein response underlie skeletal and cardiac muscle growth impairments in the Yoshida hepatoma tumor model of cancer cachexia

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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe Disease

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Aug 2024
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Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

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Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression

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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

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Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy

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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)

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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease

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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

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Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury

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Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy

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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation

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Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model

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Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline

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12958_2024_1204_MOESM1_ESM-html.html

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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SARS-CoV-2 targets ribosomal RNA biogenesis

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Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity

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Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer

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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling

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Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner

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LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting

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FMRP phosphorylation modulates neuronal translation through YTHDF1

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Tsc2 coordinates neuroprogenitor differentiation

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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Insulin receptor loss impairs mammary tumorigenesis in mice

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A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit

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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis

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Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine

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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults

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Screening in serum-derived medium reveals differential response to compounds targeting metabolism

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RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

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A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

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A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.

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mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway

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LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis

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Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma

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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

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Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis

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Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling

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Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration

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Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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mct-22-0224 (1)-html.html

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response

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ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

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Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice

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Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

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FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation

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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

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The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity

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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways

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The p-rpS6-zone delineates wounding responses and the healing process

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size

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Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation

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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling

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Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

1
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A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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GOT1 regulates CD8+ effector and memory T cell generation

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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Axonal plasticity in response to active forces generated through magnetic nano-pulling

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Long-lasting BDNF signaling alterations in the amygdala of adolescent female rats exposed to the activity-based anorexia model

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells

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Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

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Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma

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Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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Glutamine metabolism modulates chondrocyte inflammatory response

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Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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Context-dependent regulation of ferroptosis sensitivity

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Jun 2022
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mcr-21-0657-html.html

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Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110884
  
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.018
  
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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

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  DOI: 10.1016/j.celrep.2022.110824
  
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Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model

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  DOI: 10.1016/j.isci.2022.104334
  
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EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma

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  DOI: 10.1158/2159-8290.CD-21-1168
  
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The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

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  DOI: 10.7554/eLife.69255
  
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PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease

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1. scibot 11 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.020
  
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Translational Strategies for Repotrectinib in Neuroblastoma

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  DOI: 10.1158/1535-7163.MCT-21-0126
  
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Patient-derived models of brain metastases recapitulate human disseminated disease

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Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling

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  DOI: 10.1158/1541-7786.MCR-20-0753
  
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Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice

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The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets

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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

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Mar 2022
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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

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Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

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Feb 2022
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Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress

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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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1. scibot 12 Feb 2022
  
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  DOI: 10.15252/embj.2021108119
  
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