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  2. pathsocjournals.onlinelibrary.wiley.com pathsocjournals.onlinelibrary.wiley.com
    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    1. scibot 18 Apr 2024
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      DOI: 10.1002/path.6282

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  3. Apr 2024
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    Microglia aging in the hippocampus advances through intermediate states that drive inflammatory activation and cognitive decline
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    biorxiv.org/content/10.1101/2024.04.09.588665v1
  5. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
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  6. Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    1. scibot 09 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
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    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
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    sciencedirect.com/science/article/pii/S1550413124000500
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    SARS-CoV-2 targets ribosomal RNA biogenesis
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    sciencedirect.com/science/article/pii/S2211124724002195
  11. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    1. scibot 27 Feb 2024
      Cell Signaling Technology#2217

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    sciencedirect.com/science/article/pii/S2589004224003420
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    1. scibot 11 Feb 2024
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    1. scibot 01 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  15. Jan 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    1. scibot 25 Jan 2024
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      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  17. Dec 2023
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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    1. scibot 02 Dec 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
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    LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting
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      DOI: 10.1152/japplphysiol.00246.2022

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  20. Nov 2023
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    FMRP phosphorylation modulates neuronal translation through YTHDF1
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    sciencedirect.com/science/article/pii/S1097276523008651
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    Tsc2 coordinates neuroprogenitor differentiation
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    sciencedirect.com/science/article/pii/S2589004223025191
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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    sciencedirect.com/science/article/pii/S2211124723012639
  25. Oct 2023
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    A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
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    sciencedirect.com/science/article/pii/S221112472301272X
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    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    sciencedirect.com/science/article/pii/S1550413123003674
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    sciencedirect.com/science/article/pii/S1934590923003594
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    sciencedirect.com/science/article/pii/S002839082300357X
  30. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    sciencedirect.com/science/article/pii/S1535610823003185
  32. Sep 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    sciencedirect.com/science/article/pii/S0022316623352799
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    Screening in serum-derived medium reveals differential response to compounds targeting metabolism
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    sciencedirect.com/science/article/abs/pii/S2451945623002799
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
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      DOI: 10.7554/eLife.85036

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    ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
  37. Aug 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A unique poly(A) tail profile uncovers the stability and translational activation of TOP transcripts during neuronal differentiation.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10448114/
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    sciencedirect.com/science/article/pii/S2589004223016176
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    LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
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    sciencedirect.com/science/article/pii/S2211124723009865
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10401073/
  42. Jul 2023
  43. www.sciencedirect.com www.sciencedirect.com
    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    sciencedirect.com/science/article/pii/S2589004223014189
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    sciencedirect.com/science/article/pii/S2211124723008124
  45. 52.53.155.43 52.53.155.43
    cd-23-0475-html.html
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    Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling
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    sciencedirect.com/science/article/pii/S0278584623001082
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    Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration
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      DOI: 10.1016/j.neuron.2023.06.005

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    sciencedirect.com/science/article/pii/S0896627323004658
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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      DOI: 10.1158/1535-7163.MCT-22-0224

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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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  99. Sep 2022
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    Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction
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    Multi-omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma
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  102. Aug 2022
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    Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
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    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine metabolism modulates chondrocyte inflammatory response
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    Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity
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  107. Jul 2022
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    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  113. Jun 2022
  114. 52.53.155.43 52.53.155.43
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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  116. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  126. Apr 2022
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  130. Mar 2022
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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  135. Feb 2022
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  139. Jan 2022
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  142. Dec 2021
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  144. www.nature.com www.nature.com
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  145. Nov 2021
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    Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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  194. www.sciencedirect.com www.sciencedirect.com
    Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function
    1
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  195. Jun 2021
  196. www.cell.com www.cell.com
    TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis
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    cell.com/cell-reports/fulltext/S2211-1247(21)00644-6
  197. www.sciencedirect.com www.sciencedirect.com
    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    sciencedirect.com/science/article/pii/S1097276521004445
  198. May 2021
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
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  200. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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  201. academic.oup.com academic.oup.com
    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
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    Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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  208. Apr 2021
  209. www.sciencedirect.com www.sciencedirect.com
    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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    SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  219. Mar 2021
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  222. Feb 2021
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    ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation - Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok, 2021
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  224. www.cell.com www.cell.com
    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    cell.com/molecular-cell/abstract/S1097-2765(20)30836-4
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  226. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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  227. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive pharmacogenomic characterization of gastric cancer
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  228. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  230. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response
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  231. Jan 2021
  232. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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  233. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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  234. Dec 2020
  235. www.cell.com www.cell.com
    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
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