301 Matching Annotations
  1. Jan 2021
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
    1
    1. scibot 26 Jan 2021
      RRID:AB_331355

      DOI: 10.1111/acel.13302

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    onlinelibrary.wiley.com/doi/full/10.1111/acel.13302
  3. Dec 2020
  4. www.cell.com www.cell.com
    Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε
    1
    1. scibot 10 Dec 2020
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      DOI: 10.1016/j.molcel.2020.10.016

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30723-1
  5. elifesciences.org elifesciences.org
    Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival
    1
    1. scibot 09 Dec 2020
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      DOI: 10.7554/eLife.62377

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    elifesciences.org/articles/62377
  6. Nov 2020
  7. www.sciencedirect.com www.sciencedirect.com
    RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly
    1
    1. scibot 24 Nov 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.108405

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    sciencedirect.com/science/article/pii/S2211124720313942
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
    1
    1. scibot 05 Nov 2020
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      DOI: 10.1096/fj.201900991R

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    ncbi.nlm.nih.gov/pmc/articles/PMC6894087/
  9. Oct 2020
  10. www.cell.com www.cell.com
    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
    1
    1. scibot 16 Oct 2020
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      DOI: 10.1016/j.stem.2020.05.008

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    cell.com/cell-stem-cell/abstract/S1934-5909(20)30206-X
  11. Sep 2020
  12. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
    1
    1. scibot 30 Sep 2020
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      DOI: 10.1016/j.celrep.2020.108196

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    pubmed.ncbi.nlm.nih.gov/32997991/
  13. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation
    1
    1. scibot 26 Sep 2020
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      DOI: 10.1016/j.celrep.2020.108154

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    pubmed.ncbi.nlm.nih.gov/32937139/
  14. www.pnas.org www.pnas.org
    Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway
    1
    1. scibot 25 Sep 2020
      RRID:AB_331355

      DOI: 10.1073/pnas.2002427117

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    pnas.org/content/117/30/17842
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model
    1
    1. scibot 23 Sep 2020
      AB_331355

      DOI: 10.1152/ajpendo.00553.2018

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    ncbi.nlm.nih.gov/pmc/articles/PMC6689739/
  16. elifesciences.org elifesciences.org
    The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
    1
    1. scibot 23 Sep 2020
      RRID:AB_331355

      DOI: 10.7554/eLife.57381

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    elifesciences.org/articles/57381
  17. elifesciences.org elifesciences.org
    Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
    1
    1. scibot 23 Sep 2020
      RRID:AB_331355

      DOI: 10.7554/eLife.60048

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    elifesciences.org/articles/60048
  18. www.sciencedirect.com www.sciencedirect.com
    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
    1
    1. scibot 16 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.01.024

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    sciencedirect.com/science/article/pii/S2211124720300334
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GC content shapes mRNA storage and decay in human cells
    1
    1. scibot 16 Sep 2020
      RRID:AB_331355

      DOI: 10.7554/eLife.49708

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    ncbi.nlm.nih.gov/pmc/articles/PMC6944446/
  20. www.sciencedirect.com www.sciencedirect.com
    Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2
    1
    1. scibot 16 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.02.007

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    sciencedirect.com/science/article/pii/S2211124720301613
  21. www.jneurosci.org www.jneurosci.org
    Regulation of Hippocampal Memory by mTORC1 in Somatostatin Interneurons
    1
    1. scibot 15 Sep 2020
      RRID:AB_331355

      DOI: 10.1523/JNEUROSCI.0728-19.2019

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    jneurosci.org/content/39/43/8439
  22. www.sciencedirect.com www.sciencedirect.com
    FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
    1
    1. scibot 14 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.02.076

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    sciencedirect.com/science/article/pii/S2211124720302503
  23. www.sciencedirect.com www.sciencedirect.com
    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
    1
    1. scibot 14 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.107806

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    sciencedirect.com/science/article/pii/S2211124720307877
  24. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
    1
    1. scibot 10 Sep 2020
      RRID:AB_331355

      DOI: 10.7554/eLife.37993

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    elifesciences.org/articles/37993
  25. www.sciencedirect.com www.sciencedirect.com
    Metabolic Control over mTOR-Dependent Diapause-like State
    1
    1. scibot 09 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.devcel.2019.12.018

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    sciencedirect.com/science/article/pii/S1534580719310676
  26. www.sciencedirect.com www.sciencedirect.com
    Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors
    1
    1. scibot 08 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.107954

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    sciencedirect.com/science/article/pii/S2211124720309359
  27. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
    1
    1. scibot 07 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.ccell.2019.12.006

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    sciencedirect.com/science/article/pii/S1535610819305768
  28. www.sciencedirect.com www.sciencedirect.com
    Structure of the Inhibited State of the Sec Translocon
    1
    1. scibot 06 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.molcel.2020.06.013

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    sciencedirect.com/science/article/pii/S1097276520303981
  29. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
    1
    1. scibot 06 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.01.080

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    sciencedirect.com/science/article/pii/S2211124720301054
  30. www.sciencedirect.com www.sciencedirect.com
    FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
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    1. scibot 06 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.02.082

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    sciencedirect.com/science/article/pii/S2211124720302564
  31. www.sciencedirect.com www.sciencedirect.com
    Kinetic Heterogeneity of Cancer Cell Fractional Killing
    1
    1. scibot 04 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.107845

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    sciencedirect.com/science/article/pii/S2211124720308263
  32. www.sciencedirect.com www.sciencedirect.com
    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
    1
    1. scibot 04 Sep 2020
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      DOI: 10.1016/j.devcel.2020.01.025

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    sciencedirect.com/science/article/pii/S1534580720300575
  33. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
    1
    1. scibot 03 Sep 2020
      RRID:AB_331355

      DOI: 10.1016/j.celrep.2020.107568

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    sciencedirect.com/science/article/pii/S2211124720305179
  34. Aug 2020
  35. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
    1
    1. scibot 29 Aug 2020
      RRID:AB_331335

      DOI: 10.1096/fj.201902305R

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      Curator comments: Rabbit Anti-S6 Ribosomal Protein Monoclonal Antibody, Unconjugated, Clone 5G10 Cell Signaling Technology Cat# 2217

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
  36. Jan 2020
  37. www.eneuro.org www.eneuro.org
    Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1523/ENEURO.0168-19.2019

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    eneuro.org/content/6/3/ENEURO.0168-19.2019
  38. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
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    mTORC1/rpS6 and spermatogenic function in the testis – insights from the adjudin model
    1
    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.reprotox.2019.07.002

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    sciencedirect.com/science/article/pii/S0890623819301388
  40. academic.oup.com academic.oup.com
    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
    1
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      DOI: 10.1210/en.2019-00410

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    academic.oup.com/endo/article/160/11/2600/5535649
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    Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons
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      DOI: 10.1016/j.celrep.2019.06.080

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    sciencedirect.com/science/article/pii/S2211124719308605
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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      DOI: 10.1016/j.celrep.2019.08.084

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    sciencedirect.com/science/article/pii/S2211124719311465
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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      DOI: 10.1016/j.celrep.2019.07.027

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    sciencedirect.com/science/article/pii/S2211124719309246
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    Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled
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      DOI: 10.1016/j.cub.2019.06.018

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    sciencedirect.com/science/article/pii/S0960982219307110
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    1. scibot 13 Jan 2020
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      DOI: 10.1111/jnc.14874

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14874
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    GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
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      DOI: 10.1016/j.stem.2019.06.004

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    The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21
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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    sciencedirect.com/science/article/pii/S1535610817305159
  89. www.sciencedirect.com www.sciencedirect.com
    Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

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    sciencedirect.com/science/article/pii/S153561081730555X
  90. www.sciencedirect.com www.sciencedirect.com
    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S1550413117306290
  91. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S1550413117306745
  92. www.sciencedirect.com www.sciencedirect.com
    KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

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    sciencedirect.com/science/article/pii/S0092867417315003
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
    2
    1. scibot 05 Nov 2018
      RRID:AB_331355

      Curator: @evieth

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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      RRID:AB_331355 RRIDCUR:Validated
    2. scibot 05 Nov 2018
      RRID:AB_331355

      Curator: @evieth

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
  94. academic.oup.com academic.oup.com
    Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice
    1
    1. scibot 05 Nov 2018
      AB_331355

      Curator: @evieth

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    academic.oup.com/endo/article/159/1/519/4562294
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5714502/
  96. www.sciencedirect.com www.sciencedirect.com
    Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut
    1
    1. scibot 05 Nov 2018
      AB_331355

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    sciencedirect.com/science/article/pii/S2405471217304490
  97. www.sciencedirect.com www.sciencedirect.com
    Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
    1
    1. scibot 05 Nov 2018
      RRID:AB_331355

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    sciencedirect.com/science/article/pii/S1074761317304727
  98. Nov 2017
  99. www.sciencedirect.com www.sciencedirect.com
    mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517306081
  100. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_331355

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1534580717305968
  101. www.sciencedirect.com www.sciencedirect.com
    Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles
    1
    1. scibot 08 Nov 2017
      Rabbit anti-S6 ribosomal Protein (5G10)Cell Signaling TechnologyCat#2217

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867417304282
  102. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
    1. scibot 08 Nov 2017
      CSTCat#2217

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S1074761317302339
  103. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    elifesciences.org/articles/25237
  104. www.sciencedirect.com www.sciencedirect.com
    Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S1097276517303611
  105. www.sciencedirect.com www.sciencedirect.com
    Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S2352396417302098
  106. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @Zeljana_Babic

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S1535610817301022
  107. www.sciencedirect.com www.sciencedirect.com
    An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
    1
    1. scibot 08 Nov 2017
      Rabbit monoclonal anti-S6 Ribosomal Protein (5G10)

      Curator: @chewbeccax

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    sciencedirect.com/science/article/pii/S0092867416316671
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational control of auditory imprinting and structural plasticity by eIF2α
    1
    1. scibot 08 Nov 2017
      AB_331355

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5245967/
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice
    1
    1. scibot 08 Nov 2017
      Cell Signaling 2217S

      Curator: @bandrow

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      (Cell Signaling Technology Cat# 2217, RRID:AB_331355)

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      RRID:AB_331355 RRIDCUR:Missing
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    ncbi.nlm.nih.gov/pmc/articles/PMC5061884/