84 Matching Annotations
  1. Sep 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12422933/
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    1-s2.0-S2589004225018139-main-html.html
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  4. Jul 2025
  5. www.nature.com www.nature.com
    Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
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    nature.com/articles/s42003-025-08440-x
  6. Jun 2025
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162862/
  8. Apr 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fatty acid uptake activates an AXL–CAV1–β-catenin axis to drive melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11960706/
  10. Mar 2025
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    PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy
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    sciencedirect.com/science/article/pii/S1535610825000765
  12. www.biorxiv.org www.biorxiv.org
    Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes
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    biorxiv.org/content/10.1101/2025.02.24.639480v1
  13. Jan 2025
  14. www.sciencedirect.com www.sciencedirect.com
    CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
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    sciencedirect.com/science/article/pii/S0896627324009152
  15. Nov 2024
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    sciencedirect.com/science/article/pii/S2589004224023587
  17. Oct 2024
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    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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    sciencedirect.com/science/article/pii/S0028390824003411
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  20. Sep 2024
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    “β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney Disease”
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    sciencedirect.com/science/article/pii/S2589004224019989
  22. Aug 2024
  23. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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    embopress.org/doi/full/10.15252/embr.202050835
  24. pubs.acs.org pubs.acs.org
    Linking Hypothermia and Altered Metabolism with TrkB Activation
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    pubs.acs.org/doi/full/10.1021/acschemneuro.3c00350
  25. Jul 2024
  26. www.embopress.org www.embopress.org
    Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies
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    embopress.org/doi/10.1038/s44318-024-00182-6
  27. Jun 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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    sciencedirect.com/science/article/pii/S258900422401424X
  29. May 2024
  30. 52.53.155.43 52.53.155.43
    PIIS2589004224013336-html.html
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  31. 52.53.155.43 52.53.155.43
    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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    52.53.155.43/5631ba0ece03be5b6bc39fba9c8a58e52d07c519/2024.01.21.576568v1.full-html.html
  32. Feb 2024
  33. www.sciencedirect.com www.sciencedirect.com
    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    sciencedirect.com/science/article/pii/S2589004224003420
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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    link.springer.com/article/10.1007/s00213-024-06530-y
  36. Jan 2024
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  38. Aug 2023
  39. 52.53.155.43 52.53.155.43
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  40. Jul 2023
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    sciencedirect.com/science/article/pii/S1535610823002179
  42. Jun 2023
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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  44. academic.oup.com academic.oup.com
    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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    academic.oup.com/endo/article/164/5/bqad038/7069260
  45. May 2023
  46. www.sciencedirect.com www.sciencedirect.com
    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    sciencedirect.com/science/article/pii/S2211124723005478
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10185814/
  48. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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    nature.com/articles/s41467-023-38165-6
  49. Apr 2023
  50. www.nature.com www.nature.com
    Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
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    nature.com/articles/s41398-023-02411-8
  51. Mar 2023
  52. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    sciencedirect.com/science/article/pii/S2211124723001997
  53. Feb 2023
  54. www.mdpi.com www.mdpi.com
    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
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    mdpi.com/2073-4409/12/4/555
  55. Jan 2023
  56. www.nature.com www.nature.com
    Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
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    nature.com/articles/s42003-022-04387-5
  57. www.sciencedirect.com www.sciencedirect.com
    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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    sciencedirect.com/science/article/pii/S2211124722018885
  58. Dec 2022
  59. www.sciencedirect.com www.sciencedirect.com
    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    sciencedirect.com/science/article/pii/S2211124722016424
  60. Nov 2022
  61. www.researchsquare.com www.researchsquare.com
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    researchsquare.com/article/rs-7289882/'https://www.researchsquare.com/article/rs-7289882/v1
  62. Oct 2022
  63. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    sciencedirect.com/science/article/pii/S0092867422012521
  64. Sep 2022
  65. www.sciencedirect.com www.sciencedirect.com
    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    sciencedirect.com/science/article/pii/S0021925822009759
  66. Aug 2022
  67. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    sciencedirect.com/science/article/pii/S2667237522001485
  68. Jul 2022
  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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    onlinelibrary.wiley.com/doi/10.1111/ejn.15752
  70. Jun 2022
  71. academic.oup.com academic.oup.com
    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac270/6577152
  72. May 2022
  73. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    link.springer.com/article/10.1186/s13024-022-00526-y
  74. Feb 2022
  75. www.sciencedirect.com www.sciencedirect.com
    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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    sciencedirect.com/science/article/pii/S0021925822001569
  76. Oct 2021
  77. www.sciencedirect.com www.sciencedirect.com
    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    sciencedirect.com/science/article/pii/S2211124721013218
  78. Sep 2021
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8449244/
  80. Aug 2021
  81. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells
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    onlinelibrary.wiley.com/doi/10.1002/jcb.30126
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14051
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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    sciencedirect.com/science/article/pii/S2211124721009177
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pathology of nNOS expressing GABAergic neurons in mouse model of Alzheimer’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC6085873/
  85. Jul 2021
  86. www.embopress.org www.embopress.org
    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    embopress.org/doi/10.15252/embr.201948058
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    academic.oup.com/endo/article/160/2/377/5235619
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    link.springer.com/article/10.1007/s12031-018-1199-7
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8251890/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8245133/
  91. May 2021
  92. www.sciencedirect.com www.sciencedirect.com
    PSD-95 deficiency alters GABAergic inhibition in the prefrontal cortex
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    sciencedirect.com/science/article/pii/S0028390820303452
  93. www.sciencedirect.com www.sciencedirect.com
    A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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    sciencedirect.com/science/article/pii/S1097276520306122
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    sciencedirect.com/science/article/pii/S1074761320302715
  95. Mar 2021
  96. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15393
  97. Feb 2021
  98. academic.oup.com academic.oup.com
    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    academic.oup.com/endo/article/162/1/bqaa214/5992137
  99. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  100. Jan 2021
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15288
  102. Dec 2020
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15251
  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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    onlinelibrary.wiley.com/doi/10.1002/brb3.1536
  105. Sep 2020
  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14954
  107. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
  108. www.mdpi.com www.mdpi.com
    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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    mdpi.com/2073-4409/9/1/147
  109. Jan 2020
  110. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    sciencedirect.com/science/article/pii/S2451945619303964
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    SFRPs Are Biphasic Modulators of Wnt-Signaling-Elicited Cancer Stem Cell Properties beyond Extracellular Control
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    sciencedirect.com/science/article/pii/S2211124719309131
  112. academic.oup.com academic.oup.com
    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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    academic.oup.com/endo/article/160/9/2061/5518336
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    Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons
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    sciencedirect.com/science/article/pii/S221112471930573X
  115. Nov 2018
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    sciencedirect.com/science/article/pii/S0028390818302429
  117. academic.oup.com academic.oup.com
    FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2
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    academic.oup.com/endo/article/159/6/2386/4985542
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    Pathology of nNOS expressing GABAergic neurons in mouse model of Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0306452218303567
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lithium Inhibits GSK3β and Augments GluN2A Receptor Expression in the Prefrontal Cortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC5799274/
  120. www.sciencedirect.com www.sciencedirect.com
    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
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    sciencedirect.com/science/article/pii/S2213231717306687
  121. Nov 2017
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    Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
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    sciencedirect.com/science/article/pii/S0896627317307912
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  124. www.nature.com www.nature.com
    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
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    nature.com/articles/s41598-017-11654-7
  125. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′s disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14066/full
  126. www.jneurosci.org www.jneurosci.org
    TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
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    jneurosci.org/content/37/7/1772
  127. www.sciencedirect.com www.sciencedirect.com
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082