68 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    1. scibot 14 Nov 2024
      RRID:AB_331426

      DOI: 10.1016/j.chembiol.2024.10.008

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    sciencedirect.com/science/article/pii/S2451945624004434
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    1. scibot 04 Oct 2024
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-23-0564

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  5. Sep 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 25 Sep 2024
      RRID:AB_2160592

      DOI: 10.7554/eLife.41378

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    ncbi.nlm.nih.gov/pmc/articles/PMC6298778/
  7. www.biorxiv.org www.biorxiv.org
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
    1
    1. scibot 15 Sep 2024
      RRID:AB_331426

      DOI: 10.1101/2024.09.05.611458

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    biorxiv.org/content/10.1101/2024.09.05.611458v1
  8. Jul 2024
  9. 52.53.155.43 52.53.155.43
    1-s2.0-S1535610824002319-mmc1-html.html
    1
    1. scibot 25 Jul 2024
      AB_331426

      DOI: 10.1016/j.ccell.2024.06.006

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    52.53.155.43/fa631816ea536ebd5d77bd5edcecb27537053850/1-s2.0-S1535610824002319-mmc1-html.html
  10. www.sciencedirect.com www.sciencedirect.com
    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
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    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.ccell.2024.06.006

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    sciencedirect.com/science/article/pii/S1535610824002319
  11. www.cell.com www.cell.com
    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
    1
    1. scibot 25 Jul 2024
      RRID:AB_331426

      DOI: 10.1016/j.chembiol.2024.06.012

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    cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00273-3
  12. May 2024
  13. www.biorxiv.org www.biorxiv.org
    Activation of PKR by a short-hairpin RNA
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    1. scibot 17 May 2024
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      DOI: 10.1101/2024.05.08.592371

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    biorxiv.org/content/10.1101/2024.05.08.592371v1
  14. Apr 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53
    1
    1. scibot 11 Apr 2024
      RRID:AB_331426

      DOI: 10.21037/tlcr-24-160

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    ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
    1
    1. scibot 10 Apr 2024
      RRID:AB_331426

      DOI: 10.1158/2767-9764.CRC-23-0488

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993856/
  17. Mar 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    2
    1. scibot 29 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101468

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      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
    1
    1. scibot 06 Mar 2024
      RRID:AB_331426

      DOI: 10.1158/2159-8290.CD-23-0954

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
    2
    1. scibot 06 Mar 2024
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-23-0025

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    2. scibot 06 Mar 2024
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-23-0025

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  21. Feb 2024
  22. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2159-8290.cd-23-0954

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    52.53.155.43/aaf525c30ae01b53e260240fad732783dfb4bbac/cd-23-0954-html.html
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer
    1
    1. scibot 09 Feb 2024
      RRID:AB_331426

      DOI: 10.1016/j.isci.2024.108984

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    ncbi.nlm.nih.gov/pmc/articles/PMC10847745/
  24. Jan 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
    1
    1. scibot 26 Jan 2024
      AB_331426

      DOI: 10.1186/s13148-023-01477-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10105475/
  26. www.sciencedirect.com www.sciencedirect.com
    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
    1
    1. scibot 23 Jan 2024
      RRID:AB_331426

      DOI: 10.1016/j.xcrm.2023.101388

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    sciencedirect.com/science/article/pii/S2666379123006171
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
    1
    1. scibot 05 Jan 2024
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-23-0026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  28. Dec 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
    1
    1. scibot 17 Dec 2023
      RRID:AB_331426

      DOI: 10.1016/j.xcrm.2023.101309

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    sciencedirect.com/science/article/pii/S2666379123005037
  30. Sep 2023
  31. www.sciencedirect.com www.sciencedirect.com
    Inhibition of the serine/threonine kinase BUB1 reverses taxane resistance in prostate cancer
    1
    1. scibot 01 Sep 2023
      RRID:AB_331426

      DOI: 10.1016/j.isci.2023.107681

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    sciencedirect.com/science/article/pii/S2589004223017583
  32. Aug 2023
  33. 52.53.155.43 52.53.155.43
    mct-23-0025 (1)-html.html
    1
    1. scibot 11 Aug 2023
      RRID:AB_331426

      DOI: 10.1158/1535-7163.mct-23-0025

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    52.53.155.43/1629e82c15a2ef751662f24158b1c1b52e5a2112/mct-23-0025 (1)-html.html
  34. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
    1
    1. scibot 04 Aug 2023
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-23-0110

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    aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
  35. Jun 2023
  36. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
    1
    1. scibot 03 Jun 2023
      RRID:AB_331426

      DOI: 10.1158/0008-5472.CAN-22-2045

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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  37. Mar 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
    1
    1. scibot 26 Mar 2023
      AB_331426

      DOI: 10.1371/journal.pone.0281063

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  39. Sep 2022
  40. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
    1
    1. scibot 15 Sep 2022
      RRID:AB_331426

      DOI: 10.1016/j.celrep.2022.111304

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    sciencedirect.com/science/article/pii/S2211124722011287
  41. Jul 2022
  42. www.sciencedirect.com www.sciencedirect.com
    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
    1
    1. scibot 30 Jul 2022
      RRID:AB_331426

      DOI: 10.1016/j.celrep.2022.111095

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    sciencedirect.com/science/article/pii/S221112472200897X
  43. May 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
    1
    1. scibot 05 May 2022
      RRID:AB_331426

      DOI: 10.1096/fj.202200154R

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    ncbi.nlm.nih.gov/pmc/articles/PMC9044500/
  45. Apr 2022
  46. aacrjournals.org aacrjournals.org
    DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models
    1
    1. scibot 05 Apr 2022
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      DOI: 10.1158/1535-7163.MCT-21-0554

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    aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
  47. Feb 2022
  48. www.sciencedirect.com www.sciencedirect.com
    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
    2
    1. scibot 11 Feb 2022
      RRID:AB_331426

      DOI: 10.1016/j.celrep.2022.110351

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      DOI: 10.1016/j.celrep.2022.110351

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    sciencedirect.com/science/article/pii/S2211124722000675
  49. Dec 2021
  50. mct.aacrjournals.org mct.aacrjournals.org
    Antibody-drug conjugate efficacy in neuroblastoma - role of payload, resistance mechanisms, target density, and antibody internalization
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      DOI: 10.1158/1535-7163.MCT-20-1034

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    mct.aacrjournals.org/content/20/11/2228
  51. Oct 2021
  52. www.sciencedirect.com www.sciencedirect.com
    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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      DOI: 10.1016/j.isci.2021.103168

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    sciencedirect.com/science/article/pii/S2589004221011366
  53. Aug 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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      DOI: 10.1016/j.cell.2021.07.026

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    sciencedirect.com/science/article/pii/S0092867421008850
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.molcel.2019.01.033

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    ncbi.nlm.nih.gov/pmc/articles/PMC6482433/
  56. www.mdpi.com www.mdpi.com
    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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      RRID:AB_331426

      DOI: 10.3390/ijms20102423

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    mdpi.com/1422-0067/20/10/2423
  57. www.sciencedirect.com www.sciencedirect.com
    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
    1
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      RRID:AB_331426

      DOI: 10.1016/j.celrep.2021.109455

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    sciencedirect.com/science/article/pii/S221112472100872X
  58. Jul 2021
  59. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Retinoic acid receptor‐related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia
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    1. scibot 27 Jul 2021
      AB-331426

      DOI: 10.1002/jcp.25924

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    onlinelibrary.wiley.com/doi/10.1002/jcp.25924/full
  60. www.sciencedirect.com www.sciencedirect.com
    A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope
    1
    1. scibot 22 Jul 2021
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      DOI: 10.1016/j.xcrm.2021.100344

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    sciencedirect.com/science/article/pii/S2666379121001932
  61. Jun 2021
  62. www.sciencedirect.com www.sciencedirect.com
    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
    1
    1. scibot 30 Jun 2021
      RRID:AB_331426

      DOI: 10.1016/j.chembiol.2021.06.001

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    sciencedirect.com/science/article/pii/S2451945621002683
  63. Mar 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
    1
    1. scibot 02 Mar 2021
      cleaved PARP

      DOI: 10.1016/j.jbc.2021.100475

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    sciencedirect.com/science/article/pii/S0021925821002490
  65. Oct 2020
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
    1
    1. scibot 13 Oct 2020
      RRID:AB_331426

      DOI: 10.7554/eLife.59442

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    ncbi.nlm.nih.gov/pmc/articles/PMC7541088/
  67. Sep 2020
  68. www.sciencedirect.com www.sciencedirect.com
    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
    1
    1. scibot 23 Sep 2020
      RRID:AB_331426

      DOI: 10.1016/j.ccell.2020.03.004

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    sciencedirect.com/science/article/pii/S1535610820301057
  69. www.sciencedirect.com www.sciencedirect.com
    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis
    1
    1. scibot 23 Sep 2020
      RRID:AB_331426

      DOI: 10.1016/j.immuni.2020.02.007

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    sciencedirect.com/science/article/pii/S1074761320300789
  70. academic.oup.com academic.oup.com
    BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS
    1
    1. scibot 23 Sep 2020
      RRID:AB_331426

      DOI: 10.1210/endocr/bqaa027

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    academic.oup.com/endo/article/161/4/bqaa027/5758064
  71. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
    1
    1. scibot 10 Sep 2020
      RRID:AB_331426

      DOI: 10.1158/1535-7163.MCT-19-0284

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    mct.aacrjournals.org/content/19/1/292
  72. www.mdpi.com www.mdpi.com
    Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling
    1
    1. scibot 04 Sep 2020
      PARP

      DOI: 10.3390/ijms21051773

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      Curator comments: Cleaved PARP (Asp214) Antibody (Human Specific) Cell Signaling Technology Cat# 9541

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    mdpi.com/1422-0067/21/5/1773
  73. Aug 2020
  74. www.sciencedirect.com www.sciencedirect.com
    Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia
    1
    1. scibot 16 Aug 2020
      RRID:AB_331427

      DOI: 10.1016/j.chembiol.2020.04.002

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    sciencedirect.com/science/article/pii/S2451945620301161
  75. Jan 2020
  76. www.sciencedirect.com www.sciencedirect.com
    Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.molcel.2019.10.014

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    sciencedirect.com/science/article/pii/S1097276519307920
  77. www.sciencedirect.com www.sciencedirect.com
    YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.celrep.2019.03.021

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    sciencedirect.com/science/article/pii/S2211124719303286
  78. www.sciencedirect.com www.sciencedirect.com
    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.chembiol.2017.11.007

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    sciencedirect.com/science/article/pii/S2451945617304245
  79. www.sciencedirect.com www.sciencedirect.com
    Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.ccell.2019.09.004

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    sciencedirect.com/science/article/pii/S1535610819304246
  80. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.molcel.2019.01.033

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    sciencedirect.com/science/article/pii/S109727651930053X
  81. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.molcel.2019.04.009

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    sciencedirect.com/science/article/pii/S1097276519302795
  82. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.ccell.2019.01.009

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    sciencedirect.com/science/article/pii/S1535610819300431
  83. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.celrep.2019.02.047

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    sciencedirect.com/science/article/pii/S2211124719302189
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
    1
    1. scibot 13 Jan 2020
      RRID:AB_331426

      DOI: 10.1038/s41408-018-0165-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC6333829/
  85. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 12 Jan 2020
      RRID:AB_331426

      DOI: 10.1016/j.scr.2019.101390

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    sciencedirect.com/science/article/pii/S1873506119300200
  86. Apr 2019
  87. www.sciencedirect.com www.sciencedirect.com
    An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors
    1
    1. scibot 04 Apr 2019
      AB_331427

      Identifier corrected.

      Curator: @gabimpine

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      RRID:AB_331426 RRIDCUR:SyntaxError
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    sciencedirect.com/science/article/pii/S2352396416302511
  88. Nov 2018
  89. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
    1
    1. scibot 05 Nov 2018
      RRID:AB_331426

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1535610818304161
  90. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
    1
    1. scibot 05 Nov 2018
      RRID:AB_331426

      Curator: @evieth

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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0576-6
  91. www.sciencedirect.com www.sciencedirect.com
    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
    1
    1. scibot 05 Nov 2018
      RRID:AB_331426

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    sciencedirect.com/science/article/pii/S0092867418300412
  92. www.nature.com www.nature.com
    Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death
    1
    1. scibot 05 Nov 2018
      RRID:AB_331426

      Curator: @evieth

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      RRID:AB_331426 RRIDCUR:Validated
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    nature.com/articles/s41420-018-0044-7
  93. Nov 2017
  94. www.sciencedirect.com www.sciencedirect.com
    Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma
    1
    1. scibot 08 Nov 2017
      RRID:AB_331426

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S153561081730346X
  95. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
    1
    1. scibot 08 Nov 2017
      AB_331426

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S1535610817301575
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
    2
    1. scibot 08 Nov 2017
      RRID: AB_331426

      Curator: @kaitlinsung

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      RRID:AB_331426 RRIDCUR:Missing
    2. scibot 08 Nov 2017
      AB_331426

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      (Cell Signaling Technology Cat# 9541, RRID:AB_331426)

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    ncbi.nlm.nih.gov/pmc/articles/PMC5092050/