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Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD

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  DOI: 10.1016/j.isci.2025.114596
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12856326/
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A low-level Cdkn1c/p57kip2 expression in spinal progenitors drives the transition from proliferative to neurogenic modes of division

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1. scibot 31 Jan 2026
  
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  DOI: 10.1038/s44319-025-00653-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852696/
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Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression

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1. scibot 30 Jan 2026
  
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  DOI: 10.7150/ijbs.123790
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12836506/
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Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

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1. scibot 30 Jan 2026
  
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  DOI: 10.1038/s41419-025-08362-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
Jan 2026
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CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction

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1. scibot 27 Jan 2026
  
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  DOI: 10.1038/s41467-025-67865-4
  
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nature.com/articles/s41467-025-67865-4
Oct 2025
www.biorxiv.org www.biorxiv.org

CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma

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1. scibot 21 Oct 2025
  
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  DOI: 10.1101/2025.10.14.681840
  
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biorxiv.org/content/10.1101/2025.10.14.681840v1
Jul 2025
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18F-FLT PET, a Noninvasive Pharmacodynamic Biomarker of Tumor Cell Proliferation, Detected Differential Response to Various Cyclin-Dependent Kinase (CDK) Inhibitors

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0856
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214877/
May 2025
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CDK4 loss-of-function mutations cause microcephaly and short stature

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1. scibot 20 May 2025
  
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  DOI: 10.1101/gad.352311.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617628/
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 24 Mar 2025
  
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52.53.155.43/b715c1a68ef0cb7b0448e003b2c7b73d6290765e/PDF-html.html
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
52.53.155.43 52.53.155.43

Uneven mitochondrial segregation during embryonic neurogenesis

1
1. scibot 07 Feb 2025
  
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  AB_331472
  
  DOI: 10.1101/2024.11.08.622699
  
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52.53.155.43/69b7405c3f385ca181d40351a59e3a3273af371c/2024.11.08.622699.full-html.html
Dec 2024
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Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers

1
1. scibot 11 Dec 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0866
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609823/
Nov 2024
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Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

1
1. scibot 16 Nov 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0904
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
Sep 2024
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Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

1
1. scibot 25 Sep 2024
  
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  RRID:AB_2141156
  
  DOI: 10.1016/j.ccell.2020.02.002
  
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pubmed.ncbi.nlm.nih.gov/32142668/
Jul 2024
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Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114510
  
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sciencedirect.com/science/article/pii/S2211124724008398
May 2024
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Molecular subtypes of neuroendocrine carcinomas: A cross-tissue classification framework based on five transcriptional regulators

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.ccell.2024.05.002
  
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sciencedirect.com/science/article/pii/S1535610824001636
Mar 2024
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Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma

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1. scibot 06 Mar 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
Nov 2023
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Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

1
1. scibot 27 Nov 2023
  
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  RRID:AB_331472
  
  DOI: 10.1016/j.molcel.2021.03.003
  
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sciencedirect.com/science/article/pii/S1097276521001714
Sep 2023
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Palbociclib releases the latent differentiation capacity of neuroblastoma cells

1
1. scibot 30 Sep 2023
  
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  RRID:AB_331472
  
  DOI: 10.1016/j.devcel.2023.08.028
  
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sciencedirect.com/science/article/pii/S1534580723004434
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function

1
1. scibot 31 Aug 2023
  
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  RRID:AB_331472
  
  DOI: 10.21203/rs.3.rs-3182731/v1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10441460/
52.53.155.43 52.53.155.43

mct-23-0025 (1)-html.html

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1. scibot 11 Aug 2023
  
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  RRID:AB_331472
  
  DOI: 10.1158/1535-7163.mct-23-0025
  
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52.53.155.43/1629e82c15a2ef751662f24158b1c1b52e5a2112/mct-23-0025 (1)-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression

1
1. scibot 06 Jul 2023
  
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  RRID:AB_331472
  
  DOI: 10.1158/1535-7163.MCT-22-0147
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
Jun 2023
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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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1. scibot 27 Jun 2023
  
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  RRID:AB_331472
  
  DOI: 10.1016/j.isci.2023.107090
  
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sciencedirect.com/science/article/pii/S2589004223011677
Aug 2022
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The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells

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1. scibot 10 Aug 2022
  
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  RRID:AB_331472
  
  DOI: 10.1016/j.celrep.2022.111170
  
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sciencedirect.com/science/article/pii/S2211124722009834
Mar 2022
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Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma

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1. scibot 05 Mar 2022
  
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  RRID:AB_331472
  
  DOI: 10.1038/s41467-022-28515-1
  
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nature.com/articles/s41467-022-28515-1
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Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis

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  RRID:AB_331472
  
  DOI: 10.1016/j.celrep.2022.110444
  
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sciencedirect.com/science/article/pii/S2211124722001711
Oct 2021
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Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells

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1. scibot 13 Oct 2021
  
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  RRID:AB_331472
  
  DOI: 10.1016/j.celrep.2021.109808
  
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sciencedirect.com/science/article/pii/S2211124721012687
Aug 2021
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6350781/
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.006
  
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sciencedirect.com/science/article/pii/S2211124718317352
Jul 2021
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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.cell.2018.09.051
  
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sciencedirect.com/science/article/pii/S0092867418312637
May 2021
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

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  DOI: 10.1016/j.molcel.2020.04.027
  
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sciencedirect.com/science/article/pii/S1097276520302690
Apr 2021
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Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

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1. scibot 02 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.003
  
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sciencedirect.com/science/article/pii/S1097276521001714
Jan 2021
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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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1. scibot 27 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108675
  
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sciencedirect.com/science/article/pii/S2211124720316648
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway

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1. scibot 03 Oct 2020
  
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  RRID:AB_331472
  
  DOI: 10.3390/md18100494
  
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pubmed.ncbi.nlm.nih.gov/32992455/
Sep 2020
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CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.01.007
  
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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex

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  DOI: 10.1016/j.molcel.2019.12.022
  
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Untitled document

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MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance

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Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma

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Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints

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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug

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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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