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Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma

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pmc.ncbi.nlm.nih.gov/articles/PMC12434397/
Aug 2025
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53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway

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sciencedirect.com/science/article/pii/S2211124725009234
Jun 2025
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Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response

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Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket

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Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
Apr 2025
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Targeting MLL1/WDR5-Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16INK4a

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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402382R
Feb 2025
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Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies

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sciencedirect.com/science/article/pii/S2666379125000370
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P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

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Dec 2024
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Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis

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  DOI: 10.1038/s41419-024-07231-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11655545/
Oct 2024
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PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer

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1. scibot 04 Oct 2024
  
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  DOI: 10.1158/1535-7163.MCT-23-0564
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
Aug 2024
www.cell.com www.cell.com

Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
Jul 2024
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HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

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1. scibot 12 Jul 2024
  
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  DOI: 10.3390/ijms25137475
  
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mdpi.com/1422-0067/25/13/7475
Apr 2024
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The role of RASA2 in predicting radioresistance in lung cancer through regulation of p53

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1. scibot 11 Apr 2024
  
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  DOI: 10.21037/tlcr-24-160
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11002505/
Feb 2024
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Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

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sciencedirect.com/science/article/pii/S2211124724000664
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ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma

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1. scibot 03 Feb 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0746
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10831340/
Nov 2023
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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113478
  
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sciencedirect.com/science/article/pii/S2211124723014900
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RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis

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1. scibot 04 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108258
  
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52.53.155.43/45fd8e5f649eeab4d04cc2e63a0e9be19b005cef/1-s2.0-S2589004223023350-main-html.html
Oct 2023
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Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.phymed.2023.155126
  
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sciencedirect.com/science/article/pii/S0944711323004865
Sep 2023
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NSD2 methylates AROS to promote SIRT1 activation and regulates fatty acid metabolism-mediated cancer radiotherapy

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113126
  
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sciencedirect.com/science/article/pii/S2211124723011385
Mar 2023
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Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma

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  DOI: 10.1016/j.celrep.2023.112212
  
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sciencedirect.com/science/article/pii/S2211124723002231
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents

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1. scibot 18 Nov 2022
  
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  DOI: 10.3389/fonc.2022.870863
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9650540/
Sep 2022
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Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10

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  DOI: 10.1530/JME-21-0100
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8489570/
Aug 2022
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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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  DOI: 10.1016/j.crmeth.2022.100271
  
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sciencedirect.com/science/article/pii/S2667237522001485
Jun 2022
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Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility

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1. scibot 03 Jun 2022
  
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  DOI: 10.1210/endocr/bqac047
  
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academic.oup.com/endo/article-abstract/163/5/bqac047/6565906
Apr 2022
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p53 directs leader cell behavior, migration, and clearance during epithelial repair

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1. scibot 29 Apr 2022
  
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  DOI: 10.1126/science.abl8876
  
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science.org/doi/full/10.1126/science.abl8876
Mar 2022
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Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma

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  DOI: 10.1016/j.ebiom.2022.103950
  
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sciencedirect.com/science/article/pii/S2352396422001347
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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

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  DOI: 10.1016/j.celrep.2022.110511
  
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sciencedirect.com/science/article/pii/S2211124722002479
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BPS Publications

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  DOI: 10.1111/bph.15804
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15804
Nov 2021
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Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

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1. scibot 05 Nov 2021
  
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  DOI: 10.1016/j.ebiom.2021.103646
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8546421/
Oct 2021
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Proteome-wide mapping of short-lived proteins in human cells

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  DOI: 10.1016/j.molcel.2021.09.015
  
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sciencedirect.com/science/article/pii/S1097276521007498
Sep 2021
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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

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1. scibot 28 Sep 2021
  
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  DOI: 10.1016/j.cell.2021.09.006
  
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sciencedirect.com/science/article/pii/S0092867421010539
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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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1. scibot 03 Sep 2021
  
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  DOI: 10.1016/j.devcel.2021.08.006
  
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sciencedirect.com/science/article/pii/S1534580721006365
Aug 2021
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Sequential oncogenic mutations influence cell competition

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  DOI: 10.1016/j.cub.2021.06.064
  
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sciencedirect.com/science/article/pii/S0960982221008939
Apr 2021
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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.10.023
  
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sciencedirect.com/science/article/pii/S0092867420313878
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2021.02.016
  
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

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  DOI: 10.1016/j.ccell.2020.10.010
  
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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

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  DOI: 10.1016/j.ccell.2020.12.014
  
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Systematic characterization of mutations altering protein degradation in human cancers

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  DOI: 10.1016/j.molcel.2021.01.020
  
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The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

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  DOI: 10.1016/j.molcel.2020.12.046
  
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Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

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Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53

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  DOI: 10.1016/j.celrep.2019.12.064
  
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The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway

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1. scibot 10 Sep 2020
  
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  DOI: 10.1111/jnc.14958
  
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Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity

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A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

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  DOI: 10.7554/eLife.47097
  
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The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression

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  AB_331476
  
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Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection

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  RRID:AB_331476
  
  DOI: 10.1111/jnc.14476
  
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Nov 2018
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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Untitled document

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Gut Epithelial Vitamin D Receptor Regulates Microbiota-Dependent Mucosal Inflammation by Suppressing Intestinal Epithelial Cell Apoptosis

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