50 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
    1
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    sciencedirect.com/science/article/pii/S2589004224025082
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
    1
    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S1097276524008633
  4. Sep 2024
  5. www.cell.com www.cell.com
    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
    1
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    cell.com/cell/fulltext/S0092-8674(24)00911-5
  6. Jul 2024
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
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    sciencedirect.com/science/article/pii/S2211124724007939
  8. Jun 2024
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    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
    1
    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S2211124724006946
  10. Mar 2024
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
    1
    1. scibot 29 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001758
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  13. Feb 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
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    Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
    1
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    sciencedirect.com/science/article/pii/S2666379124000028
  16. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
    1
    1. scibot 29 Dec 2023
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    sciencedirect.com/science/article/pii/S2589004223027360
  18. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276523008547
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    ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress
    1
    1. scibot 17 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723014146
  21. Oct 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WIP1 is a novel specific target for growth hormone action
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.isci.2023.108117

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    ncbi.nlm.nih.gov/pmc/articles/PMC10590974/
  23. www.sciencedirect.com www.sciencedirect.com
    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113180

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    sciencedirect.com/science/article/pii/S2211124723011920
  24. Aug 2023
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    FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways
    1
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    sciencedirect.com/science/article/abs/pii/S109727652300518X
  26. Jun 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
    1
    1. scibot 17 Jun 2023
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      DOI: 10.1016/j.molcel.2022.12.004

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
  28. Apr 2023
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    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
    1
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    sciencedirect.com/science/article/pii/S2211124723004114
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
    1
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      DOI: 10.1016/j.isci.2023.106405

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
  31. Mar 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
    1
    1. scibot 30 Mar 2023
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      DOI: 10.1016/j.isci.2023.106405

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition
    1
    1. scibot 29 Mar 2023
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      DOI: 10.1158/2767-9764.CRC-22-0119

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
  34. Feb 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
    1
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      DOI: 10.1016/j.isci.2023.106107

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    sciencedirect.com/science/article/pii/S2589004223001840
  36. www.mdpi.com www.mdpi.com
    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
    1
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      DOI: 10.3390/ijms24032983

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    mdpi.com/1422-0067/24/3/2983
  37. Aug 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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      DOI: 10.1016/j.cell.2022.06.048

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    sciencedirect.com/science/article/pii/S0092867422008418
  39. Jan 2022
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    ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization
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    1. scibot 12 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110216

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    sciencedirect.com/science/article/pii/S2211124721017204
  41. Dec 2021
  42. www.sciencedirect.com www.sciencedirect.com
    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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      DOI: 10.1016/j.celrep.2021.110080

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    sciencedirect.com/science/article/pii/S2211124721015710
  43. Nov 2021
  44. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    1. scibot 30 Nov 2021
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      DOI: 10.1016/j.molcel.2021.11.002

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
  45. Jul 2021
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.cell.2019.03.001

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    ncbi.nlm.nih.gov/pmc/articles/PMC6506336/
  47. Jun 2021
  48. www.sciencedirect.com www.sciencedirect.com
    The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
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      DOI: 10.1016/j.celrep.2021.109306

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    sciencedirect.com/science/article/pii/S2211124721006823
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure
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    ncbi.nlm.nih.gov/pmc/articles/PMC8209426/
  50. May 2021
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    DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1
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      DOI: 10.1016/j.molcel.2020.07.028

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    sciencedirect.com/science/article/pii/S1097276520305190
  52. Mar 2021
  53. www.sciencedirect.com www.sciencedirect.com
    TRPS1 drives heterochromatic origin refiring and cancer genome evolution
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    sciencedirect.com/science/article/pii/S2211124721001285
  54. Jan 2021
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    A FOXO-dependent replication checkpoint restricts proliferation of damaged cells
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      DOI: 10.1016/j.celrep.2020.108675

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    sciencedirect.com/science/article/pii/S2211124720316648
  56. Sep 2020
  57. www.sciencedirect.com www.sciencedirect.com
    Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase
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    sciencedirect.com/science/article/pii/S2211124720304332
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    A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest
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      DOI: 10.1016/j.celrep.2020.107995

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    sciencedirect.com/science/article/pii/S2211124720309803
  59. Jan 2020
  60. www.sciencedirect.com www.sciencedirect.com
    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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      DOI: 10.1016/j.molcel.2019.06.043

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    sciencedirect.com/science/article/pii/S1097276519305003
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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      DOI: 10.1016/j.stem.2019.06.011

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    sciencedirect.com/science/article/pii/S1934590919302759
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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      DOI: 10.1016/j.cels.2019.11.001

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    sciencedirect.com/science/article/pii/S2405471219303874
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    sciencedirect.com/science/article/pii/S1097276519301042
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      DOI: 10.1016/j.cell.2019.03.001

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  65. Nov 2018
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
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    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
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    SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage
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    Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response
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  72. Nov 2017
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    ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks
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    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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    Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
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    Two subunits of human ORC are dispensable for DNA replication and proliferation
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