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MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

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sciencedirect.com/science/article/pii/S109727652600208X
Mar 2026
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FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response

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  DOI: 10.1158/0008-5472.CAN-25-1917
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
Jan 2026
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The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116830
  
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Dec 2025
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Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer

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  DOI: 10.1038/s41388-025-03343-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12127007/
Nov 2025
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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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  DOI: 10.1016/j.celrep.2025.116520
  
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sciencedirect.com/science/article/pii/S2211124725012914
Oct 2025
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Targeting the ERα DBD-LBD interface with mitoxantrone disrupts receptor function through proteasomal degradation

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1. scibot 08 Oct 2025
  
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  DOI: 10.1158/1535-7163.MCT-25-0405
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12496009/
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2025.09.25.678487v1.full-html.html

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1. scibot 07 Oct 2025
  
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  DOI: 10.1101/2025.09.25.678487
  
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54.241.53.176/6242d0964f3f11ac8334753a1121987506367c6b/2025.09.25.678487v1.full-html.html
Sep 2025
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TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells

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sciencedirect.com/science/article/pii/S2211124725010319
Jul 2025
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RECLASSIFICATION OF ATM MISSENSE VARIANTS OF UNCERTAIN SIGNIFICANCE BY INTEGRATING RESULTS FROM SYSTEMATIC FUNCTIONAL ASSAYS INTO AN ACMG POINTS-BASED FRAMEWORK

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1. scibot 10 Jul 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-3936
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12234152/
Jun 2025
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

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  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
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DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12014860/
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

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1. scibot 24 Mar 2025
  
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  DOI: 10.1158/1078-0432.ccr-24-3936
  
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52.53.155.43/9d2d72079ea8ca48f04203f494da6924c0f290ae/PDF-html.html
Jan 2025
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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1. scibot 18 Jan 2025
  
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  DOI: 10.1038/s41556-024-01565-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111283
  
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sciencedirect.com/science/article/pii/S2589004224025082
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Acute multi-level response to defective de novo chromatin assembly in S-phase

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.023
  
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sciencedirect.com/science/article/pii/S1097276524008633
Sep 2024
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
Jul 2024
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FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114464
  
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Jun 2024
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The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114366
  
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sciencedirect.com/science/article/pii/S2211124724006946
Mar 2024
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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sciencedirect.com/science/article/pii/S1097276524001291
Feb 2024
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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome

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  DOI: 10.1186/s13578-024-01198-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
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Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer

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  DOI: 10.1016/j.xcrm.2024.101393
  
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sciencedirect.com/science/article/pii/S2666379124000028
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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  DOI: 10.1016/j.isci.2023.108659
  
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sciencedirect.com/science/article/pii/S2589004223027360
Nov 2023
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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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  DOI: 10.1016/j.molcel.2023.10.017
  
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ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress

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  DOI: 10.1016/j.celrep.2023.113402
  
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sciencedirect.com/science/article/pii/S2211124723014146
Oct 2023
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WIP1 is a novel specific target for growth hormone action

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  DOI: 10.1016/j.isci.2023.108117
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10590974/
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Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

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  DOI: 10.1016/j.celrep.2023.113180
  
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sciencedirect.com/science/article/pii/S2211124723011920
Aug 2023
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FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

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  DOI: 10.1016/j.molcel.2023.07.004
  
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sciencedirect.com/science/article/abs/pii/S109727652300518X
Jun 2023
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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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  DOI: 10.1016/j.molcel.2022.12.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
Apr 2023
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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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  DOI: 10.1016/j.celrep.2023.112400
  
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sciencedirect.com/science/article/pii/S2211124723004114
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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

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1. scibot 04 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
Mar 2023
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TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

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1. scibot 30 Mar 2023
  
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  DOI: 10.1016/j.isci.2023.106405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
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Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition

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1. scibot 29 Mar 2023
  
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  DOI: 10.1158/2767-9764.CRC-22-0119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
Feb 2023
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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line

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Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

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ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

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An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure

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DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1

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TRPS1 drives heterochromatic origin refiring and cancer genome evolution

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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

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A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest

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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

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SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage

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Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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Two subunits of human ORC are dispensable for DNA replication and proliferation

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