217 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells
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    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S2666379124005949
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    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  4. Oct 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights
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    1. scibot 09 Oct 2024
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    sciencedirect.com/science/article/pii/S155041312400370X
  6. Sep 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    1. scibot 26 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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    Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010258
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    Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1074761324004126
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    Untitled document
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.cmet.2019.02.013

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    sciencedirect.com/science/article/pii/S1550413119301020
  11. Aug 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    1. scibot 23 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006609
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009379
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S1535610824002708
  15. 52.53.155.43 52.53.155.43
    nemeth-et-al-2024-adiponectin-suppresses-stiffness-dependent-pro-fibrotic-activation-of-lung-fibroblasts-html.html
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    1. scibot 20 Aug 2024
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    52.53.155.43/b68deb9c62e0885cf46c9d0e6108ed17561f8fea/nemeth-et-al-2024-adiponectin-suppresses-stiffness-dependent-pro-fibrotic-activation-of-lung-fibroblasts-html.html
  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
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    1. scibot 02 Aug 2024
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      DOI: 10.1002/jnr.24119

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24119/full
  17. Jul 2024
  18. 52.53.155.43 52.53.155.43
    esteban-collado-et-al-2024-reactive-oxygen-species-activate-the-drosophila-tnf-receptor-wengen-for-damage-induced-html.html
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    1. scibot 23 Jul 2024
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    52.53.155.43/d7123eaccd835fd3f78bc89f6732913cb90a24e7/esteban-collado-et-al-2024-reactive-oxygen-species-activate-the-drosophila-tnf-receptor-wengen-for-damage-induced-html.html
  19. www.embopress.org www.embopress.org
    Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration
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    1. scibot 23 Jul 2024
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      DOI: 10.1038/s44318-024-00155-9

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  20. dx.doi.org dx.doi.org
    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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    1. scibot 18 Jul 2024
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      DOI: 10.1210/endocr/bqae069

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  21. 52.53.155.43 52.53.155.43
    cir-23-0666-html.html
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      DOI: 10.1158/2326-6066.cir-23-0666

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    52.53.155.43/224a4a827b6902bac940b427dd8ec5d00c9bcdbc/cir-23-0666-html.html
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
    1
    1. scibot 06 Jul 2024
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      DOI: 10.3892/or.2024.8760

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  23. Jun 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1152/ajpcell.00425.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC10228675/
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    The ribotoxic stress response drives UV-mediated cell death
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    1. scibot 06 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424005270
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    Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response
    1
    1. scibot 04 Jun 2024
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    sciencedirect.com/science/article/pii/S2211124724006156
  27. May 2024
  28. www.sciencedirect.com www.sciencedirect.com
    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
    1
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      DOI: 10.1016/j.immuni.2024.04.016

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    sciencedirect.com/science/article/pii/S1074761324002218
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
    1
    1. scibot 09 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068553/
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    sciencedirect.com/science/article/pii/S1550413124001359
  31. www.science.org www.science.org
    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
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    1. scibot 03 May 2024
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      DOI: 10.1126/science.adi2421

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  32. Apr 2024
  33. 52.53.155.43 52.53.155.43
    The activation of LBH-CRYAB signaling promotes cardiac protection against ischemia-reperfusion injury by inhibiting apoptosis and ferroptosis
    1
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  34. Mar 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Epithelial-derived interleukin-23 promotes oral mucosal immunopathology
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    1. scibot 21 Mar 2024
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    sciencedirect.com/science/article/pii/S1074761324000967
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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      DOI: 10.1186/s13041-024-01086-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
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    Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response
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      DOI: 10.1016/j.celrep.2024.113929

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    sciencedirect.com/science/article/pii/S2211124724002572
  38. Feb 2024
  39. www.mdpi.com www.mdpi.com
    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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    mdpi.com/1467-3045/45/12/620
  40. Jan 2024
  41. www.sciencedirect.com www.sciencedirect.com
    MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
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      DOI: 10.1016/j.isci.2023.108746

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    sciencedirect.com/science/article/pii/S2589004223028237
  42. www.sciencedirect.com www.sciencedirect.com
    CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise
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    sciencedirect.com/science/article/pii/S2211124723016376
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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      DOI: 10.1016/j.devcel.2023.12.002

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    sciencedirect.com/science/article/pii/S1534580723006524
  44. Dec 2023
  45. www.sciencedirect.com www.sciencedirect.com
    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    sciencedirect.com/science/article/pii/S2589004223026457
  46. Oct 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
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      DOI: 10.3390/cells12192389

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    ncbi.nlm.nih.gov/pmc/articles/PMC10571842/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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      DOI: 10.1186/s12967-023-04542-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10577912/
  49. Aug 2023
  50. www.nature.com www.nature.com
    Extracellular Pgk1 interacts neural membrane protein enolase-2 to improve the neurite outgrowth of motor neurons
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      DOI: 10.1038/s42003-023-05223-0

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    nature.com/articles/s42003-023-05223-0
  51. www.sciencedirect.com www.sciencedirect.com
    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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      DOI: 10.1016/j.molcel.2023.07.018

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    sciencedirect.com/science/article/pii/S1097276523005610
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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  103. May 2022
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    HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells
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  107. Mar 2022
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
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    Involvement of CCN1 Protein and TLR2/4 Signaling Pathways in Intestinal Epithelial Cells Response to Listeria monocytogenes
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    The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
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    Glucose-dependent insulinotropic polypeptide inhibits cardiac hypertrophy and fibrosis in diabetic mice via suppression of TGF-β2
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  121. Dec 2021
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    Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells
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  123. Nov 2021
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  126. Oct 2021
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    Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
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  130. Sep 2021
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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    Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a1
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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      Anti–phosphorylated p-38

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    Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State
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      Rabbit polyclonal anti-phospho-p38 MAPK

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    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species
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      Phospho-p38 (Thr180/Tyr182), rabbit polyclonal

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    Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
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    Exogenous C-type natriuretic peptide therapy for impaired skeletal growth in a murine model of glucocorticoid treatment
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  153. www.sciencedirect.com www.sciencedirect.com
    PEP-1-glutaredoxin-1 induces dedifferentiation of rabbit articular chondrocytes by the endoplasmic reticulum stress-dependent ERK-1/2 pathway and the endoplasmic reticulum stress-independent p38 kinase and PI-3 kinase pathways
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      RRID:AB_331640

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  154. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S0014299918303868
  155. www.sciencedirect.com www.sciencedirect.com
    Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways
    1
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      AB_331640

      DOI: 10.1016/j.biocel.2016.09.014

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  156. elifesciences.org elifesciences.org
    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration
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      DOI: 10.7554/eLife.22871

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  157. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: interactions and redundancies with TNF and IL-6
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      DOI: 10.1111/jnc.15438

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  158. Jun 2021
  159. academic.oup.com academic.oup.com
    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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      RRID:AB_331641

      DOI: 10.1210/endocr/bqab064

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  160. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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      AB_331641

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  161. www.sciencedirect.com www.sciencedirect.com
    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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      DOI: 10.1016/j.celrep.2021.109272

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  162. www.frontiersin.org www.frontiersin.org
    RAGE Differentially Altered in vitro Responses in Vascular Smooth Muscle Cells and Adventitial Fibroblasts in Diabetes-Induced Vascular Calcification
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      DOI: 10.3389/fphys.2021.676727

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  163. www.sciencedirect.com www.sciencedirect.com
    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
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      AB_331641

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  164. www.sciencedirect.com www.sciencedirect.com
    A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression
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  165. www.sciencedirect.com www.sciencedirect.com
    Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
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  166. www.sciencedirect.com www.sciencedirect.com
    Bacterial genotoxins induce T cell senescence
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      DOI: 10.1016/j.celrep.2021.109220

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    sciencedirect.com/science/article/pii/S2211124721005714
  167. May 2021
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis
    1
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      #9211

      DOI: 10.1038/s41598-021-90037-5

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  169. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
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      RRID:AB_331641

      DOI: 10.1111/jnc.15291

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15291
  170. journals.physiology.org journals.physiology.org
    Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21
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      RRID:AB_331641

      DOI: 10.1152/ajpendo.00270.2020

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    journals.physiology.org/doi/abs/10.1152/ajpendo.00270.2020
  171. www.sciencedirect.com www.sciencedirect.com
    Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.phrs.2021.105431

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    sciencedirect.com/science/article/pii/S1043661821000141
  172. www.sciencedirect.com www.sciencedirect.com
    Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
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      RRID:AB_331641

      DOI: 10.1016/j.molcel.2020.06.021

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    sciencedirect.com/science/article/pii/S1097276520304238
  173. www.sciencedirect.com www.sciencedirect.com
    mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways
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      RRID:AB_331641

      DOI: 10.1016/j.celrep.2021.109069

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    sciencedirect.com/science/article/pii/S2211124721004009
  174. Apr 2021
  175. www.sciencedirect.com www.sciencedirect.com
    Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis
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      RRID:AB_331641

      DOI: 10.1016/j.cmet.2020.10.005

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    sciencedirect.com/science/article/pii/S1550413120305386
  176. www.sciencedirect.com www.sciencedirect.com
    Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
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      RRID:AB_331641

      DOI: 10.1016/j.cell.2020.06.006

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    sciencedirect.com/science/article/pii/S0092867420306930
  177. www.sciencedirect.com www.sciencedirect.com
    Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing
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      RRID:AB_331641

      DOI: 10.1016/j.celrep.2021.108977

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    sciencedirect.com/science/article/pii/S2211124721002916
  178. Mar 2021
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence
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      RRID:AB_331

      DOI: 10.1016/j.ebiom.2021.103276

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    ncbi.nlm.nih.gov/pmc/articles/PMC7970057/
  180. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      RRID:AB_331614

      DOI: 10.1111/bph.15277

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  181. Feb 2021
  182. pubs.acs.org pubs.acs.org
    Hormetic Effects of Binaphthyl Phosphonothioates as Pro-oxidants and Antioxidants
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      DOI: 10.1021/acs.chemrestox.0c00345

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  183. elifesciences.org elifesciences.org
    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
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      RRID:AB_331641

      DOI: 10.7554/eLife.39159

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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
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      RRID:AB_331641

      DOI: 10.1172/JCI136174

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    ncbi.nlm.nih.gov/pmc/articles/PMC7410064/
  185. www.liebertpub.com www.liebertpub.com
    NF-κB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells
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      RRID:AB_331641

      DOI: 10.1089/dna.2019.5086

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  186. www.fasebj.org www.fasebj.org
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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      AB_331641

      DOI: 10.1096/fj.201900991R

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  187. Jan 2021
  188. www.sciencedirect.com www.sciencedirect.com
    Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
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      RRID:AB_331641

      DOI: 10.1016/j.ccell.2020.12.012

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  189. Dec 2020
  190. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      RRID:AB_331641

      DOI: 10.1111/bph.15060

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  191. Nov 2020
  192. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes
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      RRID:AB_331641

      DOI: 10.1111/jnc.15227

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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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      AB_331641

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  194. Sep 2020
  195. elifesciences.org elifesciences.org
    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels
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      DOI: 10.7554/eLife.57951

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  196. www.jneurosci.org www.jneurosci.org
    BRAG2a mediates mGluR-dependent AMPA receptor internalization at excitatory postsynapses through the interaction with PSD-95 and endophilin 3
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      RRID:AB_331641

      DOI: 10.1523/JNEUROSCI.1645-19.2020

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  197. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Phosphorylation‐dependent osterix degradation negatively regulates osteoblast differentiation
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      Anti‐p‐p38

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  198. www.sciencedirect.com www.sciencedirect.com
    CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b−CD103+ DCs
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      DOI: 10.1016/j.celrep.2020.02.103

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  199. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      RRID:AB_331641

      DOI: 10.1016/j.cell.2020.05.053

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  200. www.sciencedirect.com www.sciencedirect.com
    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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      RRID:AB_331641

      DOI: 10.1016/j.celrep.2020.107802

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    BMP6 down-regulates GDNF expression through SMAD1/5 and ERK1/2 signaling pathways in human granulosa-lutein cells
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    IDH2 Deficiency in Microglia Decreases the Pro-inflammatory Response <Emphasis Type="Italic">via</Emphasis> the ERK and NF-κB Pathways
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      RRID:AB_331641

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    link.springer.com/article/10.1007/s10753-018-0840-5
  243. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
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    sciencedirect.com/science/article/pii/S1550413117305703
  244. elifesciences.org elifesciences.org
    Untitled document
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      RRID:AB_331641

      Curator: @evieth

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      RRID:AB_331641 RRIDCUR:Validated
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    elifesciences.org/articles/36389