51 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A senescence restriction point acting on chromatin integrates oncogenic signals
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    1. scibot 04 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724003723
  3. Mar 2024
  4. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    1. scibot 21 Mar 2024
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      DOI: 10.1101/2024.02.29.582877

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    biorxiv.org/content/10.1101/2024.02.29.582877v1
  5. Jan 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis
    1
    1. scibot 26 Jan 2024
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      DOI: 10.1016/j.ebiom.2023.104587

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    ncbi.nlm.nih.gov/pmc/articles/PMC10192437/
  7. Aug 2023
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
    1
    1. scibot 01 Aug 2023
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      DOI: 10.3390/ijms241411821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  9. Jul 2023
  10. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
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    1. scibot 06 Jul 2023
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    sciencedirect.com/science/article/pii/S109727652300429X
  11. Jun 2023
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    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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    1. scibot 28 Jun 2023
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      DOI: 10.1016/j.chembiol.2023.06.004

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    sciencedirect.com/science/article/pii/S2451945623001587
  13. Apr 2023
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.ccell.2023.03.021

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    sciencedirect.com/science/article/pii/S1535610823000946
  15. Feb 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
    1
    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105962

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  17. Dec 2022
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    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
    1
    1. scibot 01 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111728

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    sciencedirect.com/science/article/pii/S2211124722016060
  19. Nov 2022
  20. www.sciencedirect.com www.sciencedirect.com
    RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
    1
    1. scibot 11 Nov 2022
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      DOI: 10.1016/j.molcel.2022.10.016

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    sciencedirect.com/science/article/pii/S1097276522010164
  21. Sep 2022
  22. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
    1
    1. scibot 15 Sep 2022
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    sciencedirect.com/science/article/pii/S2211124722011287
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    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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    1. scibot 03 Sep 2022
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    sciencedirect.com/science/article/pii/S1097276522007973
  24. Apr 2022
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
    1
    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104211

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    sciencedirect.com/science/article/pii/S2589004222004813
  26. Mar 2022
  27. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
    1
    1. scibot 04 Mar 2022
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      DOI: 10.1016/j.molcel.2022.02.011

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    sciencedirect.com/science/article/pii/S1097276522001162
  28. Feb 2022
  29. www.sciencedirect.com www.sciencedirect.com
    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110351

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    2. scibot 09 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110351

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    sciencedirect.com/science/article/pii/S2211124722000675
  30. Oct 2021
  31. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109873

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    sciencedirect.com/science/article/pii/S2211124721013401
  32. Aug 2021
  33. www.sciencedirect.com www.sciencedirect.com
    An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
    1
    1. scibot 08 Aug 2021
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      DOI: 10.1016/j.stem.2018.05.003

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    sciencedirect.com/science/article/pii/S1934590918302212
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.stem.2018.05.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC5988582/
  35. Jul 2021
  36. mcr.aacrjournals.org mcr.aacrjournals.org
    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
    1
    1. scibot 30 Jul 2021
      9121

      DOI: 10.1158/1541-7786.MCR-19-0077

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    mcr.aacrjournals.org/content/17/9/1945
  37. Jun 2021
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
    1
    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.isci.2021.102643

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    ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
  39. www.sciencedirect.com www.sciencedirect.com
    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
    1
    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109233

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    sciencedirect.com/science/article/pii/S2211124721005921
  40. May 2021
  41. www.sciencedirect.com www.sciencedirect.com
    Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuropharm.2020.108302

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    sciencedirect.com/science/article/pii/S0028390820303701
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    ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
    1
    1. scibot 05 May 2021
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      DOI: 10.1016/j.devcel.2020.05.011

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    sciencedirect.com/science/article/pii/S1534580720304007
  43. Apr 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
    1
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      DOI: 10.1016/j.cell.2020.02.003

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    sciencedirect.com/science/article/pii/S0092867420301471
  45. www.nature.com www.nature.com
    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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    1. scibot 06 Apr 2021
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      DOI: 10.1038/s41556-021-00654-5

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    nature.com/articles/s41556-021-00654-5
  46. www.sciencedirect.com www.sciencedirect.com
    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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    1. scibot 01 Apr 2021
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      DOI: 10.1016/j.celrep.2021.108928

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    sciencedirect.com/science/article/pii/S2211124721002424
  47. Dec 2020
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA00844 inhibits MAPK signaling to suppress the progression of hepatocellular carcinoma by targeting AZGP1
    1
    1. scibot 12 Dec 2020
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      DOI: 10.21037/atm-20-3848

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    ncbi.nlm.nih.gov/pmc/articles/PMC7723597/
  49. Oct 2020
  50. www.sciencedirect.com www.sciencedirect.com
    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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    1. scibot 31 Oct 2020
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      DOI: 10.1016/j.cels.2020.10.002

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    sciencedirect.com/science/article/pii/S2405471220303707
  51. Sep 2020
  52. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
    1
    1. scibot 16 Sep 2020
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      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
  53. www.sciencedirect.com www.sciencedirect.com
    Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
    1
    1. scibot 08 Sep 2020
      RRID:AB_331649

      DOI: 10.1016/j.cell.2020.04.014

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    sciencedirect.com/science/article/pii/S0092867420304761
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    Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations
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      DOI: 10.1016/j.cub.2019.12.052

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    sciencedirect.com/science/article/pii/S0960982219316859
  55. Jan 2020
  56. www.sciencedirect.com www.sciencedirect.com
    EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
    1
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      DOI: 10.1016/j.celrep.2019.06.020

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    sciencedirect.com/science/article/pii/S2211124719307867
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    Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
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      DOI: 10.1016/j.molcel.2019.09.004

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    sciencedirect.com/science/article/pii/S1097276519306896
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    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
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      DOI: 10.1016/j.celrep.2019.09.009

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    sciencedirect.com/science/article/pii/S2211124719311866
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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      DOI: 10.1016/j.celrep.2019.08.090

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    sciencedirect.com/science/article/pii/S2211124719311520
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    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer
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      DOI: 10.1016/j.ebiom.2019.05.008

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    sciencedirect.com/science/article/pii/S2352396419303093
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    Untitled document
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      DOI: 10.1016/j.devcel.2019.04.007

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    sciencedirect.com/science/article/pii/S1534580719302771
  62. Nov 2018
  63. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
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    sciencedirect.com/science/article/pii/S1535610818304161
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    Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
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      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S2451945618302617
  65. www.sciencedirect.com www.sciencedirect.com
    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S1550413118303930
  66. www.sciencedirect.com www.sciencedirect.com
    Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S2451945618301557
  67. www.sciencedirect.com www.sciencedirect.com
    GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S2451945617304233
  68. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S1535610817305020
  69. www.sciencedirect.com www.sciencedirect.com
    Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S0092867417314307
  70. www.sciencedirect.com www.sciencedirect.com
    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648
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    sciencedirect.com/science/article/pii/S1535610817305159
  71. Nov 2017
  72. elifesciences.org elifesciences.org
    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @chewbeccax

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648 RRIDCUR:Validated
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    elifesciences.org/articles/21526
  73. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @gabimpine

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610817301575
  74. www.sciencedirect.com www.sciencedirect.com
    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @kaitlinsung

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276517300485
  75. elifesciences.org elifesciences.org
    Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    1
    1. scibot 08 Nov 2017
      Rabbit α ppMEK1/2

      Curator: @jcabotaj

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_331648 RRIDCUR:Missing
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    elifesciences.org/articles/11999
  76. elifesciences.org elifesciences.org
    Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    1
    1. scibot 08 Nov 2017
      Rabbit phospho MEK (pMEK) 1/2 (Ser217/221) antibody

      Curator: @jcabotaj

      Resource used:

      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_331648 RRIDCUR:Missing
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    elifesciences.org/content/5/e09976