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Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.bcp.2025.117291
  
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sciencedirect.com/science/article/pii/S0006295225005568
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

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1. scibot 20 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.112708
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12272824/
Mar 2025
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Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.cmet.2025.01.021
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
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The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115365
  
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sciencedirect.com/science/article/pii/S2211124725001366
Feb 2025
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The TSH receptor antibody reactome contributes to retro-orbital inflammation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/jendso/bvae182
  
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dx.doi.org/10.1210/jendso/bvae182
Jan 2025
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ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115193
  
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sciencedirect.com/science/article/pii/S2211124724015444
Sep 2024
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Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts

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1. scibot 05 Sep 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
Aug 2024
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Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

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1. scibot 02 Aug 2024
  
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mdpi.com/2073-4409/10/12/3314/htm
Jul 2024
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

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1. scibot 24 Jul 2024
  
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sciencedirect.com/science/article/pii/S155041312400192X
Jun 2024
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Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target

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1. scibot 13 Jun 2024
  
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  DOI: 10.1038/s41467-024-49196-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11161513/
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Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform

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1. scibot 06 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114313
  
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sciencedirect.com/science/article/pii/S2211124724006417
Apr 2024
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A senescence restriction point acting on chromatin integrates oncogenic signals

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  DOI: 10.1016/j.celrep.2024.114044
  
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sciencedirect.com/science/article/pii/S2211124724003723
Mar 2024
www.biorxiv.org www.biorxiv.org

Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis

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1. scibot 21 Mar 2024
  
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  DOI: 10.1101/2024.02.29.582877
  
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biorxiv.org/content/10.1101/2024.02.29.582877v1
Jan 2024
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Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis

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1. scibot 26 Jan 2024
  
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  DOI: 10.1016/j.ebiom.2023.104587
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10192437/
Aug 2023
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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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1. scibot 01 Aug 2023
  
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  DOI: 10.3390/ijms241411821
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
Jul 2023
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Oncogenic K-Ras suppresses global miRNA function

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.008
  
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sciencedirect.com/science/article/pii/S109727652300429X
Jun 2023
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Chemical genomics reveals targetable programs of human cancers rooted in pluripotency

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1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.chembiol.2023.06.004
  
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sciencedirect.com/science/article/pii/S2451945623001587
Apr 2023
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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1. scibot 21 Apr 2023
  
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  DOI: 10.1016/j.ccell.2023.03.021
  
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sciencedirect.com/science/article/pii/S1535610823000946
Feb 2023
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Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity

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1. scibot 01 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.105962
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
Dec 2022
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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

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  DOI: 10.1016/j.celrep.2022.111728
  
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sciencedirect.com/science/article/pii/S2211124722016060
Nov 2022
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RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

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1. scibot 11 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.10.016
  
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sciencedirect.com/science/article/pii/S1097276522010164
Sep 2022
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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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  DOI: 10.1016/j.celrep.2022.111304
  
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sciencedirect.com/science/article/pii/S2211124722011287
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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

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  DOI: 10.1016/j.molcel.2022.08.012
  
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cell.com/molecular-cell/fulltext/S1097-2765(22)00797-3
Apr 2022
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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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1. scibot 26 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104211
  
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sciencedirect.com/science/article/pii/S2589004222004813
Mar 2022
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Regulation of GTPase function by autophosphorylation

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  DOI: 10.1016/j.molcel.2022.02.011
  
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sciencedirect.com/science/article/pii/S1097276522001162
Feb 2022
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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

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1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110351
  
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  DOI: 10.1016/j.celrep.2022.110351
  
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sciencedirect.com/science/article/pii/S2211124722000675
Oct 2021
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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas

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1. scibot 21 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109873
  
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sciencedirect.com/science/article/pii/S2211124721013401
Aug 2021
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An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

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1. scibot 08 Aug 2021
  
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  DOI: 10.1016/j.stem.2018.05.003
  
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sciencedirect.com/science/article/pii/S1934590918302212
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Untitled document

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  DOI: 10.1016/j.stem.2018.05.003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5988582/
Jul 2021
mcr.aacrjournals.org mcr.aacrjournals.org

KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis

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1. scibot 30 Jul 2021
  
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  DOI: 10.1158/1541-7786.MCR-19-0077
  
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mcr.aacrjournals.org/content/17/9/1945
Jun 2021
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Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

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1. scibot 18 Jun 2021
  
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  DOI: 10.1016/j.isci.2021.102643
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
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Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

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  DOI: 10.1016/j.celrep.2021.109233
  
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sciencedirect.com/science/article/pii/S2211124721005921
May 2021
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Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.neuropharm.2020.108302
  
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sciencedirect.com/science/article/pii/S0028390820303701
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ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.devcel.2020.05.011
  
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sciencedirect.com/science/article/pii/S1534580720304007
Apr 2021
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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

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1. scibot 23 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.02.003
  
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

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  DOI: 10.1038/s41556-021-00654-5
  
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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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  DOI: 10.1016/j.celrep.2021.108928
  
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Long non-coding RNA00844 inhibits MAPK signaling to suppress the progression of hepatocellular carcinoma by targeting AZGP1

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  DOI: 10.21037/atm-20-3848
  
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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

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  DOI: 10.1016/j.cels.2020.10.002
  
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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  DOI: 10.1016/j.cell.2020.05.053
  
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Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

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  RRID:AB_331649
  
  DOI: 10.1016/j.cell.2020.04.014
  
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Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations

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  RRID:AB_331648
  
  DOI: 10.1016/j.cub.2019.12.052
  
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EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection

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  RRID:AB_331648
  
  DOI: 10.1016/j.celrep.2019.06.020
  
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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

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  DOI: 10.1016/j.molcel.2019.09.004
  
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Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

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  DOI: 10.1016/j.celrep.2019.09.009
  
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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

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  RRID:AB_331648
  
  DOI: 10.1016/j.celrep.2019.08.090
  
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Inhibition of LTA4H by bestatin in human and mouse colorectal cancer

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  DOI: 10.1016/j.ebiom.2019.05.008
  
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Untitled document

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  DOI: 10.1016/j.devcel.2019.04.007
  
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Nov 2018
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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

1
1. scibot 05 Nov 2018
  
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Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site

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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

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Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation

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GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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Nov 2017
elifesciences.org elifesciences.org

Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

1
1. scibot 08 Nov 2017
  
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  AB_331648
  
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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

1
1. scibot 08 Nov 2017
  
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  AB_331648
  
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Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

1
1. scibot 08 Nov 2017
  
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Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

1
1. scibot 08 Nov 2017
  
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  Rabbit α ppMEK1/2
  
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Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

1
1. scibot 08 Nov 2017
  
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  Rabbit phospho MEK (pMEK) 1/2 (Ser217/221) antibody
  
  Curator: @jcabotaj
  
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