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    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
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  3. Jun 2024
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    Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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  6. Apr 2024
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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  8. Mar 2024
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    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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  10. Jan 2024
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    Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis
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  12. Aug 2023
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    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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  14. Jul 2023
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    Oncogenic K-Ras suppresses global miRNA function
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  16. Jun 2023
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    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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  18. Apr 2023
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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  20. Feb 2023
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    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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  22. Dec 2022
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    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
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  24. Nov 2022
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    RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
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  26. Sep 2022
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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  29. Apr 2022
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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  31. Mar 2022
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    Regulation of GTPase function by autophosphorylation
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  33. Feb 2022
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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  35. Oct 2021
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    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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  37. Aug 2021
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    An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
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  40. Jul 2021
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    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
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  42. Jun 2021
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    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
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    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
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  45. May 2021
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    Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity
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    ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
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  48. Apr 2021
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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  52. Dec 2020
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    Long non-coding RNA00844 inhibits MAPK signaling to suppress the progression of hepatocellular carcinoma by targeting AZGP1
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  54. Oct 2020
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    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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  56. Sep 2020
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    sciencedirect.com/science/article/pii/S0092867420306863
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    Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
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    sciencedirect.com/science/article/pii/S0092867420304761
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    Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations
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    sciencedirect.com/science/article/pii/S0960982219316859
  60. Jan 2020
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    EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
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    Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
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    sciencedirect.com/science/article/pii/S1097276519306896
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    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer
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      DOI: 10.1016/j.ebiom.2019.05.008

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      Curator: @ethanbadger

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  66. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 12 Jan 2020
      RRID:AB_331648

      DOI: 10.1016/j.devcel.2019.04.007

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  67. Nov 2018
  68. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Curator: @Jmenke

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  69. www.sciencedirect.com www.sciencedirect.com
    Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
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  70. www.sciencedirect.com www.sciencedirect.com
    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
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  71. www.sciencedirect.com www.sciencedirect.com
    Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
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  72. www.sciencedirect.com www.sciencedirect.com
    GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death
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  73. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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  74. www.sciencedirect.com www.sciencedirect.com
    Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
    1
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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  76. Nov 2017
  77. elifesciences.org elifesciences.org
    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @chewbeccax

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    elifesciences.org/articles/21526
  78. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @gabimpine

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  79. www.sciencedirect.com www.sciencedirect.com
    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @kaitlinsung

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  80. elifesciences.org elifesciences.org
    Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    1
    1. scibot 08 Nov 2017
      Rabbit α ppMEK1/2

      Curator: @jcabotaj

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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      RRID:AB_331648 RRIDCUR:Missing
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    elifesciences.org/articles/11999
  81. elifesciences.org elifesciences.org
    Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    1
    1. scibot 08 Nov 2017
      Rabbit phospho MEK (pMEK) 1/2 (Ser217/221) antibody

      Curator: @jcabotaj

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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    elifesciences.org/content/5/e09976