56 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    1. scibot 05 Sep 2024
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      DOI: 10.1158/2767-9764.CRC-24-0020

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  3. Aug 2024
  4. www.mdpi.com www.mdpi.com
    Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice
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  5. Jul 2024
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    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
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    sciencedirect.com/science/article/pii/S155041312400192X
  7. Jun 2024
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    Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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    sciencedirect.com/science/article/pii/S2211124724006417
  10. Apr 2024
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    sciencedirect.com/science/article/pii/S2211124724003723
  12. Mar 2024
  13. www.biorxiv.org www.biorxiv.org
    Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
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    1. scibot 21 Mar 2024
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      DOI: 10.1101/2024.02.29.582877

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    biorxiv.org/content/10.1101/2024.02.29.582877v1
  14. Jan 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis
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  16. Aug 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
    1
    1. scibot 01 Aug 2023
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      DOI: 10.3390/ijms241411821

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    ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
  18. Jul 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
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    1. scibot 06 Jul 2023
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    sciencedirect.com/science/article/pii/S109727652300429X
  20. Jun 2023
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    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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    1. scibot 28 Jun 2023
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    sciencedirect.com/science/article/pii/S2451945623001587
  22. Apr 2023
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.ccell.2023.03.021

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    sciencedirect.com/science/article/pii/S1535610823000946
  24. Feb 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
    1
    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105962

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  26. Dec 2022
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    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
    1
    1. scibot 01 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111728

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    sciencedirect.com/science/article/pii/S2211124722016060
  28. Nov 2022
  29. www.sciencedirect.com www.sciencedirect.com
    RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation
    1
    1. scibot 11 Nov 2022
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      DOI: 10.1016/j.molcel.2022.10.016

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    sciencedirect.com/science/article/pii/S1097276522010164
  30. Sep 2022
  31. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
    1
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    sciencedirect.com/science/article/pii/S2211124722011287
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    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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    sciencedirect.com/science/article/pii/S1097276522007973
  33. Apr 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
    1
    1. scibot 26 Apr 2022
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      DOI: 10.1016/j.isci.2022.104211

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    sciencedirect.com/science/article/pii/S2589004222004813
  35. Mar 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
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    1. scibot 04 Mar 2022
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      DOI: 10.1016/j.molcel.2022.02.011

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    sciencedirect.com/science/article/pii/S1097276522001162
  37. Feb 2022
  38. www.sciencedirect.com www.sciencedirect.com
    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110351

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    2. scibot 09 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110351

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    sciencedirect.com/science/article/pii/S2211124722000675
  39. Oct 2021
  40. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
    1
    1. scibot 21 Oct 2021
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    sciencedirect.com/science/article/pii/S2211124721013401
  41. Aug 2021
  42. www.sciencedirect.com www.sciencedirect.com
    An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
    1
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      DOI: 10.1016/j.stem.2018.05.003

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    sciencedirect.com/science/article/pii/S1934590918302212
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.stem.2018.05.003

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    ncbi.nlm.nih.gov/pmc/articles/PMC5988582/
  44. Jul 2021
  45. mcr.aacrjournals.org mcr.aacrjournals.org
    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
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      9121

      DOI: 10.1158/1541-7786.MCR-19-0077

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    mcr.aacrjournals.org/content/17/9/1945
  46. Jun 2021
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
    1
    1. scibot 18 Jun 2021
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      DOI: 10.1016/j.isci.2021.102643

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    ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
  48. www.sciencedirect.com www.sciencedirect.com
    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109233

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    sciencedirect.com/science/article/pii/S2211124721005921
  49. May 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity
    1
    1. scibot 08 May 2021
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      DOI: 10.1016/j.neuropharm.2020.108302

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    sciencedirect.com/science/article/pii/S0028390820303701
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    ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
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      DOI: 10.1016/j.devcel.2020.05.011

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    sciencedirect.com/science/article/pii/S1534580720304007
  52. Apr 2021
  53. www.sciencedirect.com www.sciencedirect.com
    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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      DOI: 10.1016/j.cell.2020.02.003

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    sciencedirect.com/science/article/pii/S0092867420301471
  54. www.nature.com www.nature.com
    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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      DOI: 10.1038/s41556-021-00654-5

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    nature.com/articles/s41556-021-00654-5
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    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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      DOI: 10.1016/j.celrep.2021.108928

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    sciencedirect.com/science/article/pii/S2211124721002424
  56. Dec 2020
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA00844 inhibits MAPK signaling to suppress the progression of hepatocellular carcinoma by targeting AZGP1
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      DOI: 10.21037/atm-20-3848

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    ncbi.nlm.nih.gov/pmc/articles/PMC7723597/
  58. Oct 2020
  59. www.sciencedirect.com www.sciencedirect.com
    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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    sciencedirect.com/science/article/pii/S2405471220303707
  60. Sep 2020
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
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    Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
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      DOI: 10.1016/j.cell.2020.04.014

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    sciencedirect.com/science/article/pii/S0092867420304761
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    Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations
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      DOI: 10.1016/j.cub.2019.12.052

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    sciencedirect.com/science/article/pii/S0960982219316859
  64. Jan 2020
  65. www.sciencedirect.com www.sciencedirect.com
    EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection
    1
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      DOI: 10.1016/j.celrep.2019.06.020

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    sciencedirect.com/science/article/pii/S2211124719307867
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    Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
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      DOI: 10.1016/j.molcel.2019.09.004

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    sciencedirect.com/science/article/pii/S1097276519306896
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    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
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      RRID:AB_331648

      DOI: 10.1016/j.celrep.2019.09.009

      Resource: (Cell Signaling Technology Cat# 9121, RRID:AB_331648)

      Curator: @ethanbadger

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719311866
  68. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
    1
    1. scibot 13 Jan 2020
      RRID:AB_331648

      DOI: 10.1016/j.celrep.2019.08.090

      Resource: (Cell Signaling Technology Cat# 9121, RRID:AB_331648)

      Curator: @ethanbadger

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719311520
  69. www.sciencedirect.com www.sciencedirect.com
    Inhibition of LTA4H by bestatin in human and mouse colorectal cancer
    1
    1. scibot 12 Jan 2020
      RRID:AB_331648

      DOI: 10.1016/j.ebiom.2019.05.008

      Resource: (Cell Signaling Technology Cat# 9121, RRID:AB_331648)

      Curator: @ethanbadger

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2352396419303093
  70. www.sciencedirect.com www.sciencedirect.com
    Untitled document
    1
    1. scibot 12 Jan 2020
      RRID:AB_331648

      DOI: 10.1016/j.devcel.2019.04.007

      Resource: (Cell Signaling Technology Cat# 9121, RRID:AB_331648)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1534580719302771
  71. Nov 2018
  72. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

      Curator: @Jmenke

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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      RRID:AB_331648 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610818304161
  73. www.sciencedirect.com www.sciencedirect.com
    Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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    sciencedirect.com/science/article/pii/S2451945618302617
  74. www.sciencedirect.com www.sciencedirect.com
    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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    sciencedirect.com/science/article/pii/S1550413118303930
  75. www.sciencedirect.com www.sciencedirect.com
    Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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    sciencedirect.com/science/article/pii/S2451945618301557
  76. www.sciencedirect.com www.sciencedirect.com
    GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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    sciencedirect.com/science/article/pii/S2451945617304233
  77. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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    sciencedirect.com/science/article/pii/S1535610817305020
  78. www.sciencedirect.com www.sciencedirect.com
    Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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    sciencedirect.com/science/article/pii/S0092867417314307
  79. www.sciencedirect.com www.sciencedirect.com
    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
    1
    1. scibot 05 Nov 2018
      RRID:AB_331648

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    sciencedirect.com/science/article/pii/S1535610817305159
  80. Nov 2017
  81. elifesciences.org elifesciences.org
    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @chewbeccax

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    elifesciences.org/articles/21526
  82. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @gabimpine

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

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    sciencedirect.com/science/article/pii/S1535610817301575
  83. www.sciencedirect.com www.sciencedirect.com
    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
    1
    1. scibot 08 Nov 2017
      AB_331648

      Curator: @kaitlinsung

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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    sciencedirect.com/science/article/pii/S1097276517300485
  84. elifesciences.org elifesciences.org
    Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    1
    1. scibot 08 Nov 2017
      Rabbit α ppMEK1/2

      Curator: @jcabotaj

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648 RRIDCUR:Missing
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    elifesciences.org/articles/11999
  85. elifesciences.org elifesciences.org
    Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    1
    1. scibot 08 Nov 2017
      Rabbit phospho MEK (pMEK) 1/2 (Ser217/221) antibody

      Curator: @jcabotaj

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      (Cell Signaling Technology Cat# 9121S, RRID:AB_331648)

      SciCrunch record: RRID:AB_331648

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      RRID:AB_331648 RRIDCUR:Missing
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    elifesciences.org/content/5/e09976