128 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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    sciencedirect.com/science/article/pii/S209012322400119X
  3. Mar 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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    1. scibot 09 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
  5. Feb 2024
  6. www.mdpi.com www.mdpi.com
    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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    1. scibot 13 Feb 2024
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  7. Jan 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival
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    1. scibot 19 Jan 2024
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    sciencedirect.com/science/article/pii/S2589004224000166
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    1. scibot 18 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
  10. Dec 2023
  11. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113560

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    sciencedirect.com/science/article/pii/S2211124723015723
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    Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
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    1. scibot 02 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723014304
  13. Oct 2023
  14. www.sciencedirect.com www.sciencedirect.com
    JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1
    1
    1. scibot 28 Oct 2023
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    sciencedirect.com/science/article/pii/S221112472301135X
  15. Sep 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury
    1
    1. scibot 13 Sep 2023
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      DOI: 10.1080/15548627.2022.2119351

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    ncbi.nlm.nih.gov/pmc/articles/PMC10012955/
  17. Jun 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
    1
    1. scibot 23 Jun 2023
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    sciencedirect.com/science/article/pii/S1074761323002315
  19. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16080

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  20. May 2023
  21. 52.53.155.43 52.53.155.43
    PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis
    1
    1. scibot 19 May 2023
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      DOI: 10.1210/endocr/bqad065

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  22. www.sciencedirect.com www.sciencedirect.com
    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
    1
    1. scibot 12 May 2023
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      DOI: 10.1016/j.celrep.2023.112489

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    sciencedirect.com/science/article/pii/S2211124723005004
  23. www.mdpi.com www.mdpi.com
    Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury
    1
    1. scibot 06 May 2023
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      DOI: 10.3390/antiox10091387

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  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
    1
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      DOI: 10.1186/s13024-023-00611-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10161466/
  25. Apr 2023
  26. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
    1
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      DOI: 10.15252/emmm.202217078

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    embopress.org/doi/10.15252/emmm.202217078
  27. link.springer.com link.springer.com
    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
    1
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      DOI: 10.1186/s12935-023-02884-z

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    link.springer.com/article/10.1186/s12935-023-02884-z
  28. Mar 2023
  29. www.sciencedirect.com www.sciencedirect.com
    FSBP suppresses tumor cell migration by inhibiting the JNK pathway
    1
    1. scibot 30 Mar 2023
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      DOI: 10.1016/j.isci.2023.106440

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    sciencedirect.com/science/article/pii/S2589004223005175
  30. www.sciencedirect.com www.sciencedirect.com
    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
    1
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      DOI: 10.1016/j.cmet.2023.03.004

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    sciencedirect.com/science/article/pii/S1550413123000827
  31. elifesciences.org elifesciences.org
    Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
    1
    1. scibot 16 Mar 2023
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      DOI: 10.7554/eLife.82118

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    elifesciences.org/articles/82118
  32. Feb 2023
  33. www.sciencedirect.com www.sciencedirect.com
    CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR mutated and overexpressed oral cancer
    1
    1. scibot 25 Feb 2023
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      DOI: 10.1016/j.isci.2023.106089

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    sciencedirect.com/science/article/pii/S2589004223001669
  34. www.nature.com www.nature.com
    Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria
    4
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      DOI: 10.1038/s42003-023-04568-w

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    nature.com/articles/s42003-023-04568-w
  35. journals.lww.com journals.lww.com
    Macrophage migration inhibitory factor facilitates... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.363184

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    journals.lww.com/nrronline/Fulltext/2023/08000/Macrophage_migration_inhibitory_factor_facilitates.38.aspx
  36. Jan 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism
    1
    1. scibot 20 Jan 2023
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      DOI: 10.1016/j.isci.2022.105911

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  38. www.sciencedirect.com www.sciencedirect.com
    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    sciencedirect.com/science/article/pii/S2211124722018654
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury
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  40. 52.53.155.43 52.53.155.43
    SSRN-id4244248-html.html
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  41. Dec 2022
  42. www.mdpi.com www.mdpi.com
    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
    1
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The κ-opioid receptor-induced autophagy is implicated in stress-driven synaptic alterations
    1
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      DOI: 10.3389/fnmol.2022.1039135

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    ncbi.nlm.nih.gov/pmc/articles/PMC9709411/
  44. www.sciencedirect.com www.sciencedirect.com
    Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism
    1
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      DOI: 10.1016/j.celrep.2022.111739

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    sciencedirect.com/science/article/pii/S2211124722016175
  45. Nov 2022
  46. www.mdpi.com www.mdpi.com
    Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
    1
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      DOI: 10.3390/cells11223665

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    mdpi.com/2073-4409/11/22/3665
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combinatorial prophylactic effect of phlorotannins with photobiomodulation against tracheal stenosis
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      DOI: 10.1016/j.isci.2022.105405

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    ncbi.nlm.nih.gov/pmc/articles/PMC9664362/
  48. www.science.org www.science.org
    Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
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      DOI: 10.1126/sciadv.abn9912

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    science.org/doi/10.1126/sciadv.abn9912
  49. www.science.org www.science.org
    An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
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      DOI: 10.1126/scisignal.abi8713

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    science.org/doi/10.1126/scisignal.abi8713
  50. www.researchsquare.com www.researchsquare.com
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    1. scibot 11 Nov 2022
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      DOI: 10.21203/rs.3.rs-658360/v1

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    researchsquare.com/article/rs-1715073/v1
  51. www.cell.com www.cell.com
    Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
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      DOI: 10.1016/j.celrep.2022.111497

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    cell.com/cell-reports/abstract/S2211-1247(22)01347-X
  52. Aug 2022
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-inflammatory effects of neutral lipids, glycolipids, phospholipids from Halocynthia aurantium tunic by suppressing the activation of NF-κB and MAPKs in LPS-stimulated RAW264.7 macrophages
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      DOI: 10.1371/journal.pone.0270794

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    ncbi.nlm.nih.gov/pmc/articles/PMC9377571/
  54. www.sciencedirect.com www.sciencedirect.com
    Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity
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  55. Jul 2022
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons
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    Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons
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  60. Jun 2022
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    Undercarboxylated, but not Carboxylated, Osteocalcin suppresses TNF-α induced inflammatory signaling pathway in Myoblast
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  63. May 2022
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    Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
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  65. Apr 2022
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
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  67. Mar 2022
  68. www.sciencedirect.com www.sciencedirect.com
    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  69. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  70. Feb 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
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  73. Jan 2022
  74. ar.iiarjournals.org ar.iiarjournals.org
    The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
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    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua
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  77. Dec 2021
  78. link.springer.com link.springer.com
    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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  79. Nov 2021
  80. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  81. Oct 2021
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
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  84. www.embopress.org www.embopress.org
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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  86. Aug 2021
  87. www.nature.com www.nature.com
    Rewiring of the ubiquitinated proteome determines ageing in C. elegans
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  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo
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  93. Jul 2021
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  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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  96. www.jneurosci.org www.jneurosci.org
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  99. www.sciencedirect.com www.sciencedirect.com
    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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  100. Jun 2021
  101. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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    A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression
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    Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
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  106. May 2021
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limited inhibition of multiple nodes in a driver network blocks metastasis
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    Protein kinase B mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A
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    Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
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    Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling
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    IL-1β Upregulates StAR and Progesterone Production Through the ERK1/2- and p38-Mediated CREB Signaling Pathways in Human Granulosa-Lutein Cells
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    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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  155. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
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      RRID:AB_331659

      Curator: @patriciaelyse_

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14081/full
  156. academic.oup.com academic.oup.com
    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
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    1. scibot 08 Nov 2017
      AB_331659

      Curator: @kaitlinsung

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      RRID:AB_331659 RRIDCUR:Missing
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    academic.oup.com/endo/article/158/8/2503/3861370/Protective-Role-of-Complement-C3-Against-Cytokine
  157. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
    1
    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24119/full
  158. elifesciences.org elifesciences.org
    The c-Jun N-terminal kinase pathway of a vector insect is activated by virus capsid protein and promotes viral replication
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    1. scibot 08 Nov 2017
      AB_331659

      Curator: @chewbeccax

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    elifesciences.org/articles/26591
  159. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phosphofructokinase‐P Modulates P44/42 MAPK Levels in HeLa Cells
    1
    1. scibot 08 Nov 2017
      AB_331659

      Curator: @gabimpine

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    onlinelibrary.wiley.com/doi/10.1002/jcb.25774/full
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
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    1. scibot 08 Nov 2017
      AB_331659

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC4160779/
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders
    1
    1. scibot 08 Nov 2017
      AB_331659

      Curator: @jcabotaj

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      (Cell Signaling Technology Cat# 9251, RRID:AB_331659)

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    ncbi.nlm.nih.gov/pmc/articles/PMC4145180/