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YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116188
  
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sciencedirect.com/science/article/pii/S2211124725009593
Aug 2025
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.jnutbio.2025.110039
  
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52.53.155.43 52.53.155.43

Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with post-menopause

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1. scibot 23 Jul 2025
  
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  DOI: 10.1152/japplphysiol.00886.2023
  
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52.53.155.43/c621f6fdd0b0ae98562b5c2c70d20e1e6e100deb/mckenna-et-al-2024-postabsorptive-and-postprandial-myofibrillar-protein-synthesis-rates-at-rest-and-after-resistance-html.html
Jun 2025
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BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

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1. scibot 28 Jun 2025
  
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  AB_331676
  
  DOI: 10.1016/j.molcel.2025.05.035
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00499-X
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PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

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1. scibot 25 Jun 2025
  
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  DOI: 10.7554/eLife.103403
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12185105/
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MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.019
  
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sciencedirect.com/science/article/pii/S0092867425005690
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.003
  
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PIM kinase control of CD8 T cell protein synthesis and cell trafficking

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.98622
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074636/
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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1. scibot 19 May 2025
  
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  AB_331676
  
  DOI: 10.1091/mbc.E24-11-0512
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11974963/
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
Apr 2025
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 11 Apr 2025
  
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  DOI: 10.1101/2025.03.18.644053
  
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biorxiv.org/content/10.1101/2025.03.18.644053v1
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Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

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1. scibot 03 Apr 2025
  
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  RRID:AB_331676
  
  DOI: 10.7554/eLife.94930
  
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elifesciences.org/articles/94930
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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.02.009
  
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sciencedirect.com/science/article/pii/S1550413125000671
Mar 2025
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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1. scibot 29 Mar 2025
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.molcel.2025.02.024
  
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sciencedirect.com/science/article/pii/S1097276525001868
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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

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1. scibot 29 Mar 2025
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.celrep.2025.115434
  
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sciencedirect.com/science/article/pii/S2211124725002050
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 24 Mar 2025
  
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  RRID: AB_AB_331676
  
  DOI: 10.1101/2025.03.18.644053
  
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biorxiv.org/content/10.1101/2025.03.18.644053v1
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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

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1. scibot 06 Mar 2025
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.xgen.2025.100782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
Feb 2025
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Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance

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1. scibot 25 Feb 2025
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.cmet.2025.01.025
  
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GDF-15 predicts epithelioid hemangioendothelioma aggressiveness and is down-regulated by sirolimus through ATF4/ATF5 suppression

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1. scibot 13 Feb 2025
  
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  RRID:AB_331676
  
  DOI: 10.1158/1078-0432.CCR-23-3991
  
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aacrjournals.org/clincancerres/article/30/22/5122/749578/GDF-15-Predicts-Epithelioid-Hemangioendothelioma
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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1. scibot 08 Feb 2025
  
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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.22.614256
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Jan 2025
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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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1. scibot 09 Jan 2025
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.celrep.2024.115191
  
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Dec 2024
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

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1. scibot 17 Dec 2024
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.immuni.2024.11.017
  
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sciencedirect.com/science/article/pii/S1074761324005326
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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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1. scibot 10 Dec 2024
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.cell.2024.11.009
  
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Nov 2024
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Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27

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1. scibot 14 Nov 2024
  
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  RRID:AB_331676
  
  DOI: 10.1016/j.cub.2024.10.061
  
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Oct 2024
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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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1. scibot 05 Oct 2024
  
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  AB_331676
  
  DOI: 10.1101/2024.09.09.612106
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
Aug 2024
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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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1. scibot 22 Aug 2024
  
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  AB_331676
  
  DOI: 10.1016/j.molcel.2024.07.021
  
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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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1. scibot 19 Aug 2024
  
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  AB_331676
  
  DOI: 10.1016/j.chom.2024.07.012
  
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sciencedirect.com/science/article/pii/S1931312824002713
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Sestrin2 drives ER-phagy in response to protein misfolding

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  RRID:AB_331676
  
  DOI: 10.1016/j.devcel.2024.07.004
  
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sciencedirect.com/science/article/pii/S1534580724004416
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Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

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1. scibot 02 Aug 2024
  
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  9202
  
  DOI: 10.3390/cells10123314
  
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mdpi.com/2073-4409/10/12/3314/htm
www.embopress.org www.embopress.org

EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

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1. scibot 02 Aug 2024
  
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  anti‐S6
  
  DOI: 10.15252/embr.202050835
  
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embopress.org/doi/full/10.15252/embr.202050835
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles

1
1. scibot 17 Jul 2024
  
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  DOI: 10.14814/phy2.16145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
Jun 2024
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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  DOI: 10.1016/j.cmet.2024.05.014
  
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52.53.155.43 52.53.155.43

Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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  DOI: 10.1101/2024.02.09.579580
  
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  DOI: 10.1101/2024.02.09.579580
  
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Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia

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SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis

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2024.02.09.579580v1.full-html.html

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling

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Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells

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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

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Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk

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PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia

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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults

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Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation

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Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

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Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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mct-22-0224 (1)-html.html

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Bursting translation on single mRNAs in live cells

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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice

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PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus

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Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling

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MTHFD2 reprograms macrophage polarization by inhibiting PTEN

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Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

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N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle

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Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling

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Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

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GOT1 regulates CD8+ effector and memory T cell generation

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Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression

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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

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Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter

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Autophagy modulates cell fate decisions during lineage commitment

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Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth

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A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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Manipulating bovine granulosa cell energy metabolism limits inflammation

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Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling

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Jun 2022
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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

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The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

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Rheb regulates nuclear mTORC1 activity independent of farnesylation

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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases

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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

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Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2

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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells

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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

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Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth

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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

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Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer

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Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis

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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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BPS Publications

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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

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Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity

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Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease

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KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

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Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

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Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties

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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

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Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity

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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity

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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system

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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

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Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

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Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade

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Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer

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β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy

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The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner

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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

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IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1

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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

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A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells

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Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice

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Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

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Untitled document

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