186 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    sciencedirect.com/science/article/pii/S2211124724004224
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  5. Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    1. scibot 22 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  7. Feb 2024
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    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
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    1. scibot 28 Feb 2024
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      DOI: 10.1126/sciadv.abn3868

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883374/
  9. Jan 2024
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.devcel.2024.01.002

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    sciencedirect.com/science/article/pii/S1534580724000029
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    1. scibot 23 Jan 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  12. Dec 2023
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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    sciencedirect.com/science/article/pii/S1097276523009681
  14. Nov 2023
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
    1
    1. scibot 17 Nov 2023
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    sciencedirect.com/science/article/pii/S2666379123004792
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
    1
    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.stem.2023.08.002

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    sciencedirect.com/science/article/pii/S1934590923002850
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  18. Oct 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
    1
    1. scibot 31 Oct 2023
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      DOI: 10.3390/cancers15205082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
  20. Sep 2023
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    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    1. scibot 29 Sep 2023
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      DOI: 10.1016/j.tjnut.2023.02.037

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    sciencedirect.com/science/article/pii/S0022316623352799
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation
    1
    1. scibot 22 Sep 2023
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      DOI: 10.1016/j.isci.2023.107754

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    ncbi.nlm.nih.gov/pmc/articles/PMC10507131/
  23. Aug 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
    1
    1. scibot 12 Aug 2023
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      DOI: 10.1016/j.isci.2023.107368

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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  25. Jul 2023
  26. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    1. scibot 08 Jul 2023
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      DOI: 10.1158/1535-7163.MCT-22-0224

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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
    1
    1. scibot 06 Jul 2023
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    sciencedirect.com/science/article/pii/S221112472300760X
  28. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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  29. Jun 2023
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    Bursting translation on single mRNAs in live cells
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.molcel.2023.05.019

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    sciencedirect.com/science/article/pii/S1097276523003751
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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    1. scibot 03 Jun 2023
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      DOI: 10.4103/1673-5374.367928

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    ncbi.nlm.nih.gov/pmc/articles/PMC10233788/
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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      DOI: 10.1111/jne.13187

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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  34. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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      DOI: 10.1523/JNEUROSCI.0146-23.2023

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    jneurosci.org/content/43/15/2631
  35. May 2023
  36. www.sciencedirect.com www.sciencedirect.com
    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    sciencedirect.com/science/article/pii/S2211124723004928
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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      DOI: 10.1016/j.celrep.2022.111092

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    sciencedirect.com/science/article/pii/S2211124722008944
  38. Apr 2023
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
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    sciencedirect.com/science/article/pii/S2211124723003832
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    Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression
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    sciencedirect.com/science/article/pii/S1535610823000946
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    Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
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      DOI: 10.1038/s41398-023-02411-8

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    nature.com/articles/s41398-023-02411-8
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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  45. Mar 2023
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    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
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      DOI: 10.1007/s13402-023-00793-x

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    Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus
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    sciencedirect.com/science/article/pii/S2352396423000725
  48. Feb 2023
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle
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    sciencedirect.com/science/article/pii/S0016648023000369
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Translational patterns of ionotropic glutamate and GABA receptors during brain development and behavioral stimuli revealed by polysome profiling
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      DOI: 10.1111/jnc.15771

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    onlinelibrary.wiley.com/doi/epdf/10.1111/jnc.15771
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model
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      DOI: 10.3389/fmolb.2023.1058825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9893022/
  53. Jan 2023
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    GOT1 regulates CD8+ effector and memory T cell generation
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    sciencedirect.com/science/article/pii/S2211124722018915
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    Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression
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    Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin
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  80. Jun 2022
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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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  105. Oct 2021
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    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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  128. Jun 2021
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  132. May 2021
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  157. Oct 2020
  158. www.cell.com www.cell.com
    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  161. Sep 2020
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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
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    A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation
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    The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      rabbit anti-p70 S6 kinase

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    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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  178. Aug 2020
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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  180. Jan 2020
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
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    MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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  199. Nov 2018
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    mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux
    1
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
    1
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    sciencedirect.com/science/article/pii/S155041311830514X
  202. www.sciencedirect.com www.sciencedirect.com
    Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
    1
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      RRID:AB_331676

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    sciencedirect.com/science/article/pii/S0092867418309139
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    Untitled document
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  204. academic.oup.com academic.oup.com
    Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling
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    academic.oup.com/endo/article/159/8/2966/5035244
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    ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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  209. www.jneurosci.org www.jneurosci.org
    mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation
    1
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    sciencedirect.com/science/article/pii/S1931312818302038
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
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    sciencedirect.com/science/article/pii/S1550413118301207
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    m6A Facilitates eIF4F-Independent mRNA Translation
    1
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    Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
    1
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    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
    1
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    sciencedirect.com/science/article/pii/S1550413117306290
  216. Nov 2017
  217. www.sciencedirect.com www.sciencedirect.com
    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
    1
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    sciencedirect.com/science/article/pii/S2451945617302830
  218. www.sciencedirect.com www.sciencedirect.com
    A Split-Abl Kinase for Direct Activation in Cells
    1
    1. scibot 08 Nov 2017
      Anti-p70 S6 Kinase

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  219. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    elifesciences.org/articles/29241
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    Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
    1
    1. scibot 08 Nov 2017
      Rabbit anti-p70 S6KCell Signaling9202

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    TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0092867417308309
  222. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimozide reduces toxic forms of tau in TauC3 mice via AMPK‐mediated autophagy
    1
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      AB_331676

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14109/full
  223. elifesciences.org elifesciences.org
    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
    1
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      AB_331676

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    elifesciences.org/articles/23063
  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eIF4A inactivates TORC1 in response to amino acid starvation
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      9202

      Curator: @bandrow

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    ncbi.nlm.nih.gov/pmc/articles/PMC4868951/
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    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
    3
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      RRID: AB_331676

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      AB_331676

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      AB_331676

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0092867416313137