204 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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      DOI: 10.1016/j.cub.2024.10.061

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    sciencedirect.com/science/article/pii/S096098222401457X
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
    1
    1. scibot 05 Oct 2024
      AB_331676

      DOI: 10.1101/2024.09.09.612106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  5. Aug 2024
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006191
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    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
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    1. scibot 19 Aug 2024
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    sciencedirect.com/science/article/pii/S1931312824002713
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    Sestrin2 drives ER-phagy in response to protein misfolding
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    1. scibot 18 Aug 2024
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    sciencedirect.com/science/article/pii/S1534580724004416
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    Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice
    1
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    mdpi.com/2073-4409/10/12/3314/htm
  10. www.embopress.org www.embopress.org
    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
    1
    1. scibot 02 Aug 2024
      anti‐S6

      DOI: 10.15252/embr.202050835

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    embopress.org/doi/full/10.15252/embr.202050835
  11. Jul 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles
    1
    1. scibot 17 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
  13. Jun 2024
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    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    sciencedirect.com/science/article/pii/S1550413124001906
  15. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
    2
    1. scibot 06 Jun 2024
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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
    1. scibot 03 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  17. May 2024
  18. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
    1
    1. scibot 25 May 2024
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      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
    1
    1. scibot 23 May 2024
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      DOI: 10.1016/j.devcel.2024.04.023

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  20. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
    2
    1. scibot 10 May 2024
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      DOI: 10.1038/nature05972

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  21. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
    1
    1. scibot 09 May 2024
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      DOI: 10.1126/sciadv.adl6082

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
    1
    1. scibot 05 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  23. Apr 2024
  24. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
    2
    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114094

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    sciencedirect.com/science/article/pii/S2211124724004224
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
    1
    1. scibot 10 Apr 2024
      RRID:AB_331676

      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  27. Mar 2024
  28. www.sciencedirect.com www.sciencedirect.com
    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
    2
    1. scibot 22 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113975

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      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  29. Feb 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1126/sciadv.abn3868

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883374/
  31. Jan 2024
  32. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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      DOI: 10.1016/j.devcel.2024.01.002

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    sciencedirect.com/science/article/pii/S1534580724000029
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    1. scibot 23 Jan 2024
      AB_331676

      DOI: 10.1126/sciadv.adk6524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  34. Dec 2023
  35. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  36. Nov 2023
  37. www.sciencedirect.com www.sciencedirect.com
    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101285

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    sciencedirect.com/science/article/pii/S2666379123004792
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.stem.2023.08.002

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    sciencedirect.com/science/article/pii/S1934590923002850
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  40. Oct 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
    1
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      DOI: 10.3390/cancers15205082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
  42. Sep 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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      DOI: 10.1016/j.tjnut.2023.02.037

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    sciencedirect.com/science/article/pii/S0022316623352799
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aggravated hepatic fibrosis induced by phenylalanine and tyrosine was ameliorated by chitooligosaccharides supplementation
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      DOI: 10.1016/j.isci.2023.107754

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    ncbi.nlm.nih.gov/pmc/articles/PMC10507131/
  45. Aug 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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      DOI: 10.1016/j.isci.2023.107368

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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  47. Jul 2023
  48. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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      DOI: 10.1158/1535-7163.MCT-22-0224

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  49. www.sciencedirect.com www.sciencedirect.com
    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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  50. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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  51. Jun 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Bursting translation on single mRNAs in live cells
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      DOI: 10.1016/j.molcel.2023.05.019

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    sciencedirect.com/science/article/pii/S1097276523003751
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    sciencedirect.com/science/article/pii/S1934590923002114
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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      DOI: 10.4103/1673-5374.367928

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  127. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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  150. Jun 2021
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  154. May 2021
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  172. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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  173. Jan 2021
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    Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma
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  175. Nov 2020
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  179. Oct 2020
  180. www.cell.com www.cell.com
    Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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  183. Sep 2020
  184. elifesciences.org elifesciences.org
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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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    The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      rabbit anti-p70 S6 kinase

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    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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      DOI: 10.1158/1541-7786.MCR-20-0024

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    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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  200. Aug 2020
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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  202. Jan 2020
  203. www.sciencedirect.com www.sciencedirect.com
    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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    A Split-Abl Kinase for Direct Activation in Cells
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