91 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S096098222401457X
  3. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114663

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    sciencedirect.com/science/article/pii/S2211124724010143
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
    1
    1. scibot 01 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  6. Jul 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.devcel.2020.07.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  8. May 2024
  9. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    1. scibot 25 May 2024
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      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  10. Feb 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    1. scibot 11 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  12. Jan 2024
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
    1
    1. scibot 06 Jan 2024
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      DOI: 10.1016/j.jbc.2023.105619

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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  14. Dec 2023
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    D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.devcel.2023.11.017

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    sciencedirect.com/science/article/pii/S1534580723006159
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  17. Nov 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
    1
    1. scibot 29 Nov 2023
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      DOI: 10.1016/j.isci.2023.108278

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    sciencedirect.com/science/article/pii/S2589004223023556
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
    1
    1. scibot 03 Nov 2023
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    sciencedirect.com/science/article/pii/S1097276521001775
  20. Oct 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1523/ENEURO.0159-23.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10566546/
  22. Aug 2023
  23. www.sciencedirect.com www.sciencedirect.com
    VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis
    1
    1. scibot 25 Aug 2023
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      DOI: 10.1016/j.celrep.2023.113028

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    sciencedirect.com/science/article/pii/S2211124723010392
  24. Jul 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
    1
    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112801

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    sciencedirect.com/science/article/pii/S2211124723008124
  26. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
    1
    1. scibot 08 Jul 2023
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      DOI: 10.1158/1535-7163.MCT-22-0224

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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1158/1535-7163.MCT-22-0147

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  28. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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    1. scibot 02 Jul 2023
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      DOI: 10.1158/1535-7163.mct-22-0224

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  29. Jun 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1016/j.nbd.2023.106190

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    sciencedirect.com/science/article/pii/S096999612300205X
  31. May 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action
    1
    1. scibot 04 May 2023
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      DOI: 10.1016/j.cub.2023.04.020

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    sciencedirect.com/science/article/pii/S0960982223004682
  33. Apr 2023
  34. www.sciencedirect.com www.sciencedirect.com
    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.isci.2023.106578

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    sciencedirect.com/science/article/pii/S2589004223006557
  35. www.sciencedirect.com www.sciencedirect.com
    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1016/j.xcrm.2023.101007

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    sciencedirect.com/science/article/pii/S2666379123001179
  36. Feb 2023
  37. www.sciencedirect.com www.sciencedirect.com
    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
    1
    1. scibot 23 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112129

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    sciencedirect.com/science/article/pii/S2211124723001407
  38. Jan 2023
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
    1
    1. scibot 27 Jan 2023
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      DOI: 10.1523/JNEUROSCI.0010-22.2022

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    pmc.ncbi.nlm.nih.gov/articles/PMC9888514/
  40. Nov 2022
  41. elifesciences.org elifesciences.org
    Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
    1
    1. scibot 10 Nov 2022
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      DOI: 10.7554/eLife.82810

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    elifesciences.org/articles/82810
  42. Oct 2022
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.isci.2022.105263

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
  44. www.sciencedirect.com www.sciencedirect.com
    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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    1. scibot 13 Oct 2022
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      DOI: 10.1016/j.celrep.2022.111467

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    sciencedirect.com/science/article/pii/S2211124722013171
  45. Sep 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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    1. scibot 02 Sep 2022
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      DOI: 10.1158/2159-8290.CD-21-0551

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  47. Aug 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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      DOI: 10.1016/j.celrep.2022.111198

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    sciencedirect.com/science/article/pii/S2211124722010154
  49. Jul 2022
  50. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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      DOI: 10.1016/j.molcel.2022.06.008

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    sciencedirect.com/science/article/pii/S1097276522005445
  51. Jun 2022
  52. 52.53.155.43 52.53.155.43
    Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
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    1. scibot 28 Jun 2022
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      DOI: 10.1093/brain/awac168

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  53. May 2022
  54. www.sciencedirect.com www.sciencedirect.com
    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    sciencedirect.com/science/article/pii/S2211124722005952
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    PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
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      DOI: 10.1016/j.cell.2022.04.020

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    sciencedirect.com/science/article/pii/S0092867422004676
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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    1. scibot 05 May 2022
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      DOI: 10.1158/1541-7786.MCR-20-0753

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    ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
  57. Apr 2022
  58. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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      DOI: 10.1210/endocr/bqac035

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    academic.oup.com/endo/article/163/5/bqac035/6550639
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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      DOI: 10.7554/eLife.76963

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  60. Mar 2022
  61. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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      DOI: 10.1016/j.celrep.2022.110522

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    sciencedirect.com/science/article/pii/S2211124722002583
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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      DOI: 10.1016/j.celrep.2022.110446

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    sciencedirect.com/science/article/pii/S2211124722001735
  63. Feb 2022
  64. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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      DOI: 10.15252/embj.2021108119

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    embopress.org/doi/abs/10.15252/embj.2021108119
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  66. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  71. Oct 2021
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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  75. Sep 2021
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    Single dose of amphetamine induces delayed subregional attenuation of cholinergic interneuron activity in the striatum
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  78. Aug 2021
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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  84. Jul 2021
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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  95. Apr 2021
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    Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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  104. Oct 2020
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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    Metabolic Control over mTOR-Dependent Diapause-like State
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase
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    Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
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    1. scibot 04 Sep 2020
      RRID:AB_331682

      DOI: 10.1016/j.devcel.2020.01.025

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    sciencedirect.com/science/article/pii/S1534580720300575
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    A Metformin-Responsive Metabolic Pathway Controls Distinct Steps in Gastric Progenitor Fate Decisions and Maturation
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      DOI: 10.1016/j.stem.2020.03.006

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    sciencedirect.com/science/article/pii/S1934590920300989
  118. Jan 2020
  119. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    1. scibot 13 Jan 2020
      RRID:AB_331682

      DOI: 10.1016/j.celrep.2019.08.084

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    sciencedirect.com/science/article/pii/S2211124719311465
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.07.063

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    sciencedirect.com/science/article/pii/S2211124719309672
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.cub.2019.01.029

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    sciencedirect.com/science/article/pii/S0960982219300314
  123. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.chembiol.2019.03.012

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    sciencedirect.com/science/article/pii/S2451945619301084
  124. Nov 2018
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    m6A Facilitates eIF4F-Independent mRNA Translation
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    sciencedirect.com/science/article/pii/S1097276517307517
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    sciencedirect.com/science/article/pii/S1550413117306745
  128. Nov 2017
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    1. scibot 08 Nov 2017
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression
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    1. scibot 08 Nov 2017
      AB_331682

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1535610817301022