103 Matching Annotations
  1. Aug 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11949624/
  3. onlinelibrary.wiley.com onlinelibrary.wiley.com
    5-HT6 Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5-HT6 Receptor Constitutive Activity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70179
  4. Jul 2025
  5. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
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    Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs
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    sciencedirect.com/science/article/pii/S1534580725004332
  7. Jun 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-driven refractory vascular malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162881/
  9. May 2025
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    De novo serine biosynthesis is protective in mitochondrial disease
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    sciencedirect.com/science/article/pii/S2211124725004814
  11. Mar 2025
  12. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  13. Feb 2025
  14. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225002901-main-html.html
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    52.53.155.43/ad050befce46ee469606c03d2c9e736a6b526b04/1-s2.0-S2589004225002901-main-html.html
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    Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations
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    biorxiv.org/lookup/doi/10.1101/2024.10.16.618777
  16. Jan 2025
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742900/
  18. Dec 2024
  19. www.sciencedirect.com www.sciencedirect.com
    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    sciencedirect.com/science/article/pii/S2211124724014529
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  21. Nov 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27
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    sciencedirect.com/science/article/pii/S096098222401457X
  23. Aug 2024
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    sciencedirect.com/science/article/pii/S2211124724010143
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  26. Jul 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  28. May 2024
  29. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  30. Feb 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  32. Jan 2024
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  34. Dec 2023
  35. www.sciencedirect.com www.sciencedirect.com
    D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
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    sciencedirect.com/science/article/pii/S1534580723006159
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    sciencedirect.com/science/article/pii/S0092867423010814
  37. Nov 2023
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    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
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    sciencedirect.com/science/article/pii/S2589004223023556
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  40. Oct 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10566546/
  42. Aug 2023
  43. www.sciencedirect.com www.sciencedirect.com
    VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis
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    sciencedirect.com/science/article/pii/S2211124723010392
  44. Jul 2023
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    sciencedirect.com/science/article/pii/S2211124723008124
  46. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
  48. 52.53.155.43 52.53.155.43
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  49. Jun 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months
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    sciencedirect.com/science/article/pii/S096999612300205X
  51. May 2023
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    Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action
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    sciencedirect.com/science/article/pii/S0960982223004682
  53. Apr 2023
  54. www.sciencedirect.com www.sciencedirect.com
    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    sciencedirect.com/science/article/pii/S2589004223006557
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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    sciencedirect.com/science/article/pii/S2666379123001179
  56. Feb 2023
  57. www.sciencedirect.com www.sciencedirect.com
    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    sciencedirect.com/science/article/pii/S2211124723001407
  58. Jan 2023
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC9888514/
  60. Nov 2022
  61. elifesciences.org elifesciences.org
    Contrasting effects of Ksr2, an obesity gene, on trabecular bone volume and bone marrow adiposity
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    elifesciences.org/articles/82810
  62. Oct 2022
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
  64. www.sciencedirect.com www.sciencedirect.com
    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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    sciencedirect.com/science/article/pii/S2211124722013171
  65. Sep 2022
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC8904296/
  67. Aug 2022
  68. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids
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    sciencedirect.com/science/article/pii/S2211124722010154
  69. Jul 2022
  70. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    sciencedirect.com/science/article/pii/S1097276522005445
  71. Jun 2022
  72. 52.53.155.43 52.53.155.43
    Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
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    52.53.155.43/00d780a79ebc92b585e494955dbf20fdd81b79ed/awac168-html.html
  73. May 2022
  74. www.sciencedirect.com www.sciencedirect.com
    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    sciencedirect.com/science/article/pii/S2211124722005952
  75. www.sciencedirect.com www.sciencedirect.com
    PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0092867422004676
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8568653/
  77. Apr 2022
  78. academic.oup.com academic.oup.com
    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    academic.oup.com/endo/article/163/5/bqac035/6550639
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  80. Mar 2022
  81. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    sciencedirect.com/science/article/pii/S2211124722002583
  82. www.sciencedirect.com www.sciencedirect.com
    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    sciencedirect.com/science/article/pii/S2211124722001735
  83. Feb 2022
  84. www.embopress.org www.embopress.org
    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    embopress.org/doi/abs/10.15252/embj.2021108119
  85. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    sciencedirect.com/science/article/pii/S1097276522000028
  86. Nov 2021
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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    ncbi.nlm.nih.gov/pmc/articles/PMC8598234/
  88. elifesciences.org elifesciences.org
    mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion
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    elifesciences.org/articles/69015
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC1A5 provides glutamine and asparagine necessary for bone development in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8553342/
  90. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  91. Oct 2021
  92. www.sciencedirect.com www.sciencedirect.com
    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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    sciencedirect.com/science/article/pii/S0021925821010966
  93. www.sciencedirect.com www.sciencedirect.com
    Functional heterogeneity of POMC neurons relies on mTORC1 signaling
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    sciencedirect.com/science/article/pii/S2211124721012602
  94. www.sciencedirect.com www.sciencedirect.com
    Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
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    sciencedirect.com/science/article/pii/S1534580721007310
  95. Sep 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single dose of amphetamine induces delayed subregional attenuation of cholinergic interneuron activity in the striatum
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    ncbi.nlm.nih.gov/pmc/articles/PMC8454923/
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    Oncogene-dependent sloppiness in mRNA translation
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  98. Aug 2021
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8362135/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC5479329/
  101. www.sciencedirect.com www.sciencedirect.com
    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    sciencedirect.com/science/article/pii/S0092867418313230
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14311
  103. www.sciencedirect.com www.sciencedirect.com
    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    sciencedirect.com/science/article/pii/S1535610818305269
  104. Jul 2021
  105. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14874
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  107. Jun 2021
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    Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity
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    sciencedirect.com/science/article/pii/S1535610821002841
  109. May 2021
  110. www.sciencedirect.com www.sciencedirect.com
    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    sciencedirect.com/science/article/pii/S107476132100176X
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    sciencedirect.com/science/article/pii/S1097276520306870
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  114. www.sciencedirect.com www.sciencedirect.com
    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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    sciencedirect.com/science/article/pii/S1934590921000588
  115. Apr 2021
  116. www.sciencedirect.com www.sciencedirect.com
    Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
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    sciencedirect.com/science/article/pii/S1550413120306719
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    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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  118. www.sciencedirect.com www.sciencedirect.com
    SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis
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    sciencedirect.com/science/article/pii/S221112472100351X
  119. www.sciencedirect.com www.sciencedirect.com
    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    sciencedirect.com/science/article/pii/S1550413121001662
  120. www.sciencedirect.com www.sciencedirect.com
    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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    sciencedirect.com/science/article/pii/S153561082030369X
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  122. Jan 2021
  123. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
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    onlinelibrary.wiley.com/doi/full/10.1111/acel.13302
  124. Oct 2020
  125. www.sciencedirect.com www.sciencedirect.com
    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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    sciencedirect.com/science/article/pii/S2211124720312195
  126. Sep 2020
  127. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    sciencedirect.com/science/article/pii/S2211124720307440
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    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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