114 Matching Annotations
  1. Jun 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13290227/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
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    PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
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    sciencedirect.com/science/article/pii/S221367112600161X
  5. May 2026
  6. www.nature.com www.nature.com
    The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
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    nature.com/articles/s41467-026-70601-1
  7. Apr 2026
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    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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    sciencedirect.com/science/article/pii/S2211124726003062
  9. Mar 2026
  10. 54.241.53.176 54.241.53.176
    lara-castillo-et-al-2026-exercise-beneficially-reshapes-fasted-rat-skeletal-muscle-involving-the-combined-action-of-html.html
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    54.241.53.176/5a7e58c41b7cc918955a86b768c94be515a80eca/lara-castillo-et-al-2026-exercise-beneficially-reshapes-fasted-rat-skeletal-muscle-involving-the-combined-action-of-html.html
  11. Jan 2026
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    Valine availability controls oncogenic cell-cycle progression through translation of D-type cyclins
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    sciencedirect.com/science/article/pii/S0006295226000377
  13. Dec 2025
  14. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    sciencedirect.com:5037/science/article/pii/S1550413125005273
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    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  16. Nov 2025
  17. 54.241.53.176 54.241.53.176
    kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
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    54.241.53.176/bfd6684909749a932c0efdd415dc51455e705896/kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
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    1-s2.0-S258900422502259X-main-html.html
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    Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
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    sciencedirect.com/science/article/pii/S2451945625003447
  20. Jul 2025
  21. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
  23. Jun 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
  25. May 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
  28. Mar 2025
  29. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  30. Feb 2025
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
  32. Dec 2024
  33. www.cell.com www.cell.com
    TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00727-5
  34. Jul 2024
  35. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  36. Jun 2024
  37. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    sciencedirect.com/science/article/pii/S1550413124001918
  38. Oct 2023
  39. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  40. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    embopress.org/doi/10.15252/embr.202356815
  41. Sep 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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    sciencedirect.com/science/article/pii/S0022316623352799
  43. Aug 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
  45. Jul 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    sciencedirect.com/science/article/pii/S2589004223012087
  47. Jun 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10233788/
  49. May 2023
  50. www.embopress.org www.embopress.org
    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
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    embopress.org/doi/full/10.15252/emmm.202216951
  51. Apr 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    sciencedirect.com/science/article/pii/S0896627323002684
  53. Dec 2022
  54. www.sciencedirect.com www.sciencedirect.com
    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    sciencedirect.com/science/article/pii/S2211124722017296
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    sciencedirect.com/science/article/pii/S1097276522011340
  56. link.springer.com link.springer.com
    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    link.springer.com/article/10.1186/s40360-022-00633-y
  57. Nov 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
  59. Oct 2022
  60. www.sciencedirect.com www.sciencedirect.com
    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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    sciencedirect.com/science/article/pii/S2211124722013171
  61. Aug 2022
  62. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    sciencedirect.com/science/article/pii/S2667237522001485
  63. Jul 2022
  64. www.sciencedirect.com www.sciencedirect.com
    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    sciencedirect.com/science/article/pii/S1097276522005445
  65. Jun 2022
  66. www.sciencedirect.com www.sciencedirect.com
    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    sciencedirect.com/science/article/pii/S2211124722008087
  67. www.sciencedirect.com www.sciencedirect.com
    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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    sciencedirect.com/science/article/pii/S2211124722006593
  68. May 2022
  69. www.sciencedirect.com www.sciencedirect.com
    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    sciencedirect.com/science/article/pii/S1534580722002866
  70. Apr 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
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    ncbi.nlm.nih.gov/pmc/articles/PMC9013906/
  72. www.sciencedirect.com www.sciencedirect.com
    A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
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    sciencedirect.com/science/article/pii/S1934590922001072
  73. Mar 2022
  74. www.sciencedirect.com www.sciencedirect.com
    Neurons undergo pathogenic metabolic reprogramming in models of familial ALS
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    sciencedirect.com/science/article/pii/S2212877822000370
  75. Feb 2022
  76. www.sciencedirect.com www.sciencedirect.com
    Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation
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    sciencedirect.com/science/article/pii/S2211124722001310
  77. www.sciencedirect.com www.sciencedirect.com
    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    sciencedirect.com/science/article/pii/S2211124722000869
  78. www.sciencedirect.com www.sciencedirect.com
    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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    sciencedirect.com/science/article/pii/S1097276522000028
  79. Dec 2021
  80. journals.physiology.org journals.physiology.org
    Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep
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    journals.physiology.org/doi/abs/10.1152/ajpregu.00342.2020
  81. www.sciencedirect.com www.sciencedirect.com
    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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    sciencedirect.com/science/article/pii/S1534580721008947
  82. Nov 2021
  83. 52.53.155.43 52.53.155.43
    japplphysiol.00295.2021-html.html
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  84. 52.53.155.43 52.53.155.43
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  85. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  86. Oct 2021
  87. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    sciencedirect.com/science/article/pii/S2589004221011457
  88. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721013371
  89. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP281907
  90. www.sciencedirect.com www.sciencedirect.com
    Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
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    sciencedirect.com/science/article/pii/S221112472101295X
  91. Sep 2021
  92. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia
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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15033
  93. www.pnas.org www.pnas.org
    Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
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    pnas.org/content/118/37/e2104577118
  94. www.sciencedirect.com www.sciencedirect.com
    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    sciencedirect.com/science/article/pii/S2211124721011955
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of human mTOR complexes by DEPTOR
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
  97. www.sciencedirect.com www.sciencedirect.com
    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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    sciencedirect.com/science/article/pii/S245194562100355X
  98. Aug 2021
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6224544/
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    sciencedirect.com/science/article/pii/S1934590918305575
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  102. Jul 2021
  103. www.sciencedirect.com www.sciencedirect.com
    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5589416/
  107. www.sciencedirect.com www.sciencedirect.com
    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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    sciencedirect.com/science/article/pii/S1550413118304625
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14306
  109. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    sciencedirect.com/science/article/pii/S1550413117306745
  110. May 2021
  111. www.sciencedirect.com www.sciencedirect.com
    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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    sciencedirect.com/science/article/pii/S1534580720308005
  112. Apr 2021
  113. www.cell.com www.cell.com
    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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    cell.com/current-biology/abstract/S0960-9822(21)00146-9
  114. www.sciencedirect.com www.sciencedirect.com
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  115. Mar 2021
  116. www.sciencedirect.com www.sciencedirect.com
    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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    sciencedirect.com/science/article/pii/S009286742031535X
  117. Feb 2021
  118. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
  119. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP278933
  120. Nov 2020
  121. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S2666379120301737
  122. Sep 2020
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC6867816/
  124. www.sciencedirect.com www.sciencedirect.com
    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    sciencedirect.com/science/article/pii/S1934590919305247
  125. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902305R
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    Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
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    sciencedirect.com/science/article/pii/S2211124719317309
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