115 Matching Annotations
  1. Aug 2026
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    Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes
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    sciencedirect.com/science/article/pii/S2589004226019048
  3. Jun 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13290227/
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    eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
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    PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
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    sciencedirect.com/science/article/pii/S221367112600161X
  7. May 2026
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    The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension
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    nature.com/articles/s41467-026-70601-1
  9. Apr 2026
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    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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    sciencedirect.com/science/article/pii/S2211124726003062
  11. Mar 2026
  12. 54.241.53.176 54.241.53.176
    lara-castillo-et-al-2026-exercise-beneficially-reshapes-fasted-rat-skeletal-muscle-involving-the-combined-action-of-html.html
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  13. Jan 2026
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    Valine availability controls oncogenic cell-cycle progression through translation of D-type cyclins
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    sciencedirect.com/science/article/pii/S0006295226000377
  15. Dec 2025
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    Mitochondrial VHL rewires cell metabolism in hypoxia
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    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  18. Nov 2025
  19. 54.241.53.176 54.241.53.176
    kato-et-al-2025-effects-of-repetition-duration-on-skeletal-muscle-hypertrophy-in-a-rat-model-of-resistance-exercise-html.html
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    Lactylation of mTOR enhances autophagy in skeletal muscle during exercise
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  22. Jul 2025
  23. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
  25. Jun 2025
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
  27. May 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
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    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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  30. Mar 2025
  31. www.science.org www.science.org
    Transfer RNA acetylation regulates in vivo mammalian stress signaling
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    science.org/doi/10.1126/sciadv.ads2923
  32. Feb 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
  34. Dec 2024
  35. www.cell.com www.cell.com
    TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression
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    cell.com/developmental-cell/fulltext/S1534-5807(24)00727-5
  36. Jul 2024
  37. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  38. Jun 2024
  39. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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  40. Oct 2023
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    embopress.org/doi/10.15252/embr.202356815
  43. Sep 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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  45. Aug 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10460994/
  47. Jul 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    sciencedirect.com/science/article/pii/S2589004223012087
  49. Jun 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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  51. May 2023
  52. www.embopress.org www.embopress.org
    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
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    embopress.org/doi/full/10.15252/emmm.202216951
  53. Apr 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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  55. Dec 2022
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    sciencedirect.com/science/article/pii/S2211124722017296
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    Ring domains are essential for GATOR2-dependent mTORC1 activation
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    link.springer.com/article/10.1186/s40360-022-00633-y
  59. Nov 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
  61. Oct 2022
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    An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs
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  63. Aug 2022
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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    sciencedirect.com/science/article/pii/S2667237522001485
  65. Jul 2022
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  67. Jun 2022
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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    sciencedirect.com/science/article/pii/S2211124722006593
  70. May 2022
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    sciencedirect.com/science/article/pii/S1534580722002866
  72. Apr 2022
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
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    ncbi.nlm.nih.gov/pmc/articles/PMC9013906/
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    A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration
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  75. Mar 2022
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    Neurons undergo pathogenic metabolic reprogramming in models of familial ALS
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    sciencedirect.com/science/article/pii/S2212877822000370
  77. Feb 2022
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    Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  81. Dec 2021
  82. journals.physiology.org journals.physiology.org
    Anemic Hypoxemia Reduces Myoblast Proliferation and Muscle Growth in Late Gestation Fetal Sheep
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    journals.physiology.org/doi/abs/10.1152/ajpregu.00342.2020
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    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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  84. Nov 2021
  85. 52.53.155.43 52.53.155.43
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  87. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  88. Oct 2021
  89. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    sciencedirect.com/science/article/pii/S2589004221011457
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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  91. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP281907
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    Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
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  93. Sep 2021
  94. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia
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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.15033
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    Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
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    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of human mTOR complexes by DEPTOR
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
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    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  100. Aug 2021
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
  104. Jul 2021
  105. www.sciencedirect.com www.sciencedirect.com
    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14306
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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  112. May 2021
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    Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity
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  114. Apr 2021
  115. www.cell.com www.cell.com
    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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    cell.com/current-biology/abstract/S0960-9822(21)00146-9
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  117. Mar 2021
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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    sciencedirect.com/science/article/pii/S009286742031535X
  119. Feb 2021
  120. www.cell.com www.cell.com
    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30827-3
  121. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP278933
  122. Nov 2020
  123. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S2666379120301737
  124. Sep 2020
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC6867816/
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    sciencedirect.com/science/article/pii/S1934590919305247
  127. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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