97 Matching Annotations
  1. Jul 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Paradoxical activation of c-Src as a drug-resistant mechanism
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    1. scibot 10 Jul 2024
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    sciencedirect.com/science/article/pii/S221112472100190X
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p38 MAPK activation and STIM1-Orai3 association mediate TRPC6 externalization
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1152/ajpcell.00425.2022

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    ncbi.nlm.nih.gov/pmc/articles/PMC10228675/
  5. Mar 2024
  6. www.sciencedirect.com www.sciencedirect.com
    Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions
    2
    1. scibot 13 Mar 2024
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      DOI: 10.1016/j.immuni.2024.02.014

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    sciencedirect.com/science/article/pii/S1074761324000906
  7. Feb 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
    1
    1. scibot 16 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1158/2159-8290.CD-22-1401

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  10. Dec 2023
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to characterize extracellular c-Src tyrosine kinase function through substrate interaction and phosphorylation
    1
    1. scibot 10 Dec 2023
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      DOI: 10.1016/j.xpro.2023.102755

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    ncbi.nlm.nih.gov/pmc/articles/PMC10701435/
  12. Nov 2023
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    Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation
    1
    1. scibot 03 Nov 2023
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    sciencedirect.com/science/article/pii/S2211124723013736
  14. Aug 2023
  15. 52.53.155.43 52.53.155.43
    Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function
    2
    1. scibot 17 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112947

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    2. scibot 12 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112947

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  16. Jul 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
    1
    1. scibot 25 Jul 2023
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      DOI: 10.7554/eLife.82428

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    ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A back-door insight into the modulation of Src kinase activity by the polyamine spermidine
    1
    1. scibot 12 Jul 2023
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      DOI: 10.7554/eLife.85872

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    ncbi.nlm.nih.gov/pmc/articles/PMC10328509/
  19. May 2023
  20. www.sciencedirect.com www.sciencedirect.com
    PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling
    1
    1. scibot 27 May 2023
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      DOI: 10.1016/j.celrep.2023.112539

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    sciencedirect.com/science/article/pii/S2211124723005508
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    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
    1
    1. scibot 13 May 2023
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      DOI: 10.1016/j.cmet.2023.04.017

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    sciencedirect.com/science/article/pii/S1550413123001717
  22. Mar 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis
    1
    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112164

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    sciencedirect.com/science/article/pii/S2211124723001754
  24. Feb 2023
  25. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
    1
    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.003

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    sciencedirect.com/science/article/pii/S153561082300003X
  26. Dec 2022
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α5 integrin regulates hepatic tight junctions through SRC-TET1-mediated DNA hydroxymethylation
    1
    1. scibot 02 Dec 2022
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      DOI: 10.1016/j.isci.2022.105611

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    ncbi.nlm.nih.gov/pmc/articles/PMC9709229/
  28. Nov 2022
  29. www.sciencedirect.com www.sciencedirect.com
    Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation
    1
    1. scibot 24 Nov 2022
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      DOI: 10.1016/j.mcn.2022.103794

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    sciencedirect.com/science/article/pii/S1044743122001002
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
    1
    1. scibot 10 Nov 2022
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      DOI: 10.1016/j.isci.2022.105184

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    sciencedirect.com/science/article/pii/S2589004222014560
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Niraparib-induced STAT3 inhibition increases its antitumor effects
    1
    1. scibot 04 Nov 2022
      AB_331697

      DOI: 10.3389/fonc.2022.966492

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    ncbi.nlm.nih.gov/pmc/articles/PMC9618811/
  32. Oct 2022
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.isci.2022.105171

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    ncbi.nlm.nih.gov/pmc/articles/PMC9530850/
  34. Sep 2022
  35. www.sciencedirect.com www.sciencedirect.com
    Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
    1
    1. scibot 21 Sep 2022
      RRID:mAb#2101

      DOI: 10.1016/j.xcrm.2022.100659

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    sciencedirect.com/science/article/pii/S2666379122001914
  36. Aug 2022
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches
    1
    1. scibot 22 Aug 2022
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      DOI: 10.3390/cancers14153726

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    ncbi.nlm.nih.gov/pmc/articles/PMC9367554/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration
    1
    1. scibot 16 Aug 2022
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      DOI: 10.3390/cells11152343

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    ncbi.nlm.nih.gov/pmc/articles/PMC9367513/
  39. Jul 2022
  40. www.sciencedirect.com www.sciencedirect.com
    Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude
    1
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      DOI: 10.1016/j.celrep.2022.111080

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    sciencedirect.com/science/article/pii/S2211124722008786
  41. May 2022
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
    1
    1. scibot 05 May 2022
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      DOI: 10.1158/1535-7163.MCT-21-0126

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    ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
  43. Apr 2022
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HO-1 Upregulation by Kaempferol via ROS-Dependent Nrf2-ARE Cascade Attenuates Lipopolysaccharide-Mediated Intercellular Cell Adhesion Molecule-1 Expression in Human Pulmonary Alveolar Epithelial Cells
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      DOI: 10.3390/antiox11040782

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    ncbi.nlm.nih.gov/pmc/articles/PMC9028455/
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    Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells
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    1. scibot 21 Apr 2022
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      DOI: 10.1016/j.chembiol.2022.03.010

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    sciencedirect.com/science/article/pii/S2451945622001271
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis
    1
    1. scibot 09 Apr 2022
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      DOI: 10.1016/j.isci.2022.104123

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    ncbi.nlm.nih.gov/pmc/articles/PMC8987407/
  47. Mar 2022
  48. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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      DOI: 10.1002/glia.23583

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    onlinelibrary.wiley.com/doi/10.1002/glia.23583
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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      DOI: 10.1016/j.celrep.2022.110548

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    sciencedirect.com/science/article/pii/S2211124722002893
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    Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
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      DOI: 10.1016/j.ebiom.2022.103903

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    sciencedirect.com/science/article/pii/S2352396422000871
  51. Feb 2022
  52. link.springer.com link.springer.com
    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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      DOI: 10.1007/s10456-022-09831-y

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    link.springer.com/article/10.1007/s10456-022-09831-y
  53. Jan 2022
  54. www.sciencedirect.com www.sciencedirect.com
    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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      DOI: 10.1016/j.cell.2021.12.024

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    sciencedirect.com/science/article/pii/S0092867421014872
  55. Dec 2021
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR transactivates RON to drive oncogenic crosstalk
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      DOI: 10.7554/eLife.63678

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    ncbi.nlm.nih.gov/pmc/articles/PMC8654365/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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      DOI: 10.1158/1535-7163.MCT-20-0640

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    ncbi.nlm.nih.gov/pmc/articles/PMC8172524/
  58. Nov 2021
  59. www.sciencedirect.com www.sciencedirect.com
    Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling
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      DOI: 10.1016/j.celrep.2021.110036

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    sciencedirect.com/science/article/pii/S2211124721015187
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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      DOI: 10.1016/j.celrep.2021.110056

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    sciencedirect.com/science/article/pii/S2211124721015424
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    TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
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  62. Oct 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1
    1
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      DOI: 10.1016/j.isci.2021.103189

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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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  66. Sep 2021
  67. www.sciencedirect.com www.sciencedirect.com
    Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
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  68. www.sciencedirect.com www.sciencedirect.com
    Senescent immune cells release grancalcin to promote skeletal aging
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  69. Aug 2021
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    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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  71. Jul 2021
  72. www.frontiersin.org www.frontiersin.org
    Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs
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      P-Src

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  73. www.sciencedirect.com www.sciencedirect.com
    Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
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  74. May 2021
  75. www.sciencedirect.com www.sciencedirect.com
    VEGF counteracts amyloid-β-induced synaptic dysfunction
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  76. Apr 2021
  77. www.sciencedirect.com www.sciencedirect.com
    Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation
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    Parallel Chemoselective Profiling for Mapping Protein Structure
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  79. www.jneurosci.org www.jneurosci.org
    NOX1/NADPH oxidase promotes synaptic facilitation induced by repeated D2 receptor stimulation; involvement in behavioral repetition
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      rabbit anti-phospho Src family

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  80. Mar 2021
  81. www.sciencedirect.com www.sciencedirect.com
    Paradoxical activation of c-Src as a drug-resistant mechanism
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  82. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner
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      rabbit polyclonal anti‐phospho‐Src

      DOI: 10.1096/fj.202001909R

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  83. Feb 2021
  84. www.cell.com www.cell.com
    Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
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  85. link.springer.com link.springer.com
    Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
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  86. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
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      DOI: 10.1186/s12964-021-00710-5

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  87. academic.oup.com academic.oup.com
    Leptin controls glutamatergic synaptogenesis and NMDA-receptor trafficking via Fyn kinase regulation of NR2B
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  88. www.cell.com www.cell.com
    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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      DOI: 10.1016/j.celrep.2020.01.008

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  89. Dec 2020
  90. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Staphylococcus aureus Panton‐Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria
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      DOI: 10.1096/fj.201902981R

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  91. Nov 2020
  92. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth
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      anti-phospho-Src

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  93. Oct 2020
  94. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  95. Sep 2020
  96. www.sciencedirect.com www.sciencedirect.com
    Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst
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  98. www.cell.com www.cell.com
    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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  99. www.sciencedirect.com www.sciencedirect.com
    Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac
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    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
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      RRID:AB_331697

      DOI: 10.1242/dev.185405

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  102. link.springer.com link.springer.com
    mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
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      anti-Src

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  103. Jan 2020
  104. elifesciences.org elifesciences.org
    Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
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      DOI: 10.7554/eLife.46043

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    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
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      RRID:AB_331697

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  106. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Loss of tau and Fyn reduces compensatory effects of MAP2 for tau and reveals a Fyn‐independent effect of tau on calcium
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  107. www.sciencedirect.com www.sciencedirect.com
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  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection
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      DOI: 10.1111/jnc.14476

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  109. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Haem oxygenase‐1 up‐regulation by rosiglitazone via ROS‐dependent Nrf2‐antioxidant response elements axis or PPARγ attenuates LPS‐mediated lung inflammation
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      RRID:AB_331697

      DOI: 10.1111/bph.14465

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  110. www.sciencedirect.com www.sciencedirect.com
    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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      AB_331697

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  111. www.jneurosci.org www.jneurosci.org
    Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
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      DOI: 10.1523/JNEUROSCI.1873-18.2018

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  112. www.sciencedirect.com www.sciencedirect.com
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  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  114. Nov 2018
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response
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    Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth
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    Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
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    Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions
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    YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
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    Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
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    Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor
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  127. Nov 2017
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45
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    Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
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    The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
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