125 Matching Annotations
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    ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss
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    1. scibot 17 Nov 2024
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    sciencedirect.com/science/article/pii/S1097276524008608
  3. Sep 2024
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    Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
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    sciencedirect.com/science/article/pii/S1074761324004151
  5. Aug 2024
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    On the role of p53 in the cellular response to aneuploidy
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    1. scibot 29 Aug 2024
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      DOI: 10.1016/j.celrep.2021.108892

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    sciencedirect.com/science/article/pii/S2211124721002060
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    RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4
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    sciencedirect.com/science/article/pii/S2211124724009720
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    Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
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    mdpi.com/1422-0067/22/24/13398/htm
  9. Jul 2024
  10. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3
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    Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance
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    cell.com/cell-reports/fulltext/S2211-1247(24)00738-1
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    Renal inflammation combined with renal function reserve reduction accelerate kidney aging via pentose phosphate pathway
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  14. Jun 2024
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    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    1. scibot 30 Jun 2024
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice
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    1. scibot 13 Jun 2024
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  17. May 2024
  18. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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  19. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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    1. scibot 16 May 2024
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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
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    Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
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      DOI: 10.1016/j.neuron.2024.04.006

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    sciencedirect.com/science/article/pii/S0896627324002447
  22. Apr 2024
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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    sciencedirect.com/science/article/pii/S1535610824000916
  24. Mar 2024
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    Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
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    sciencedirect.com/science/article/pii/S1534580724001424
  26. Feb 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
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    p53 promotes antiviral innate immunity by driving hexosamine metabolism
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    sciencedirect.com/science/article/pii/S2211124724000524
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    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    sciencedirect.com/science/article/pii/S1097276524000091
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  31. Jan 2024
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    Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging
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    sciencedirect.com/science/article/pii/S1074761324000268
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
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  34. Dec 2023
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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    sciencedirect.com/science/article/pii/S2589004223027360
  36. Sep 2023
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis
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      DOI: 10.7554/eLife.84710

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    ncbi.nlm.nih.gov/pmc/articles/PMC10519710/
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    C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC10470315/
  39. Jul 2023
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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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    sciencedirect.com/science/article/pii/S2211124723008446
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    Modeling epigenetic lesions that cause gliomas
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    sciencedirect.com/science/article/abs/pii/S0092867423007298
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    sciencedirect.com/science/article/pii/S2211124723008057
  43. Jun 2023
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    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    sciencedirect.com/science/article/pii/S2589004223011677
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
  47. May 2023
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    p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS
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    sciencedirect.com/science/article/pii/S2211124723004904
  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
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    sciencedirect.com/science/article/pii/S153458072300148X
  51. www.sciencedirect.com www.sciencedirect.com
    Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response
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    sciencedirect.com/science/article/pii/S2211124723004114
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    Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
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    sciencedirect.com/science/article/pii/S1534580723001326
  53. Feb 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase
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    sciencedirect.com/science/article/pii/S2589004223001840
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    Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia
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      DOI: 10.1016/j.stem.2023.01.006

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    sciencedirect.com/science/article/pii/S1934590923000061
  56. Jan 2023
  57. www.sciencedirect.com www.sciencedirect.com
    Loss of epigenetic information as a cause of mammalian aging
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      DOI: 10.1016/j.cell.2022.12.027

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    sciencedirect.com/science/article/pii/S0092867422015707
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    Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke
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  102. May 2021
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    The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells
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    Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice
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  162. academic.oup.com academic.oup.com
    Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
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      Curator: @evieth

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    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
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  164. Nov 2017
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    TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence
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    Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2
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    1. scibot 08 Nov 2017
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      Curator: @kaitlinsung

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    p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
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    1. scibot 08 Nov 2017
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      Curator: @Zeljana_Babic

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