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    PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
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    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias
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  5. May 2024
  6. 52.53.155.43 52.53.155.43
    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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  7. Apr 2024
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    Repurposing AS1411 for constructing ANM-PROTACs
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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  12. Mar 2024
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    Mecp2 knock-out astrocytes affect synaptogenesis by Interleukin 6 dependent mechanisms
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
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  17. Feb 2024
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    The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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  19. 52.53.155.43 52.53.155.43
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    A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression
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    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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    Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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  25. Jan 2024
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    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
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  32. Dec 2023
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    PIM kinases regulate early human Th17 cell differentiation
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    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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  36. Nov 2023
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    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
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    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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  42. Oct 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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  47. 52.53.155.43 52.53.155.43
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    Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice
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    Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility
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  98. www.sciencedirect.com www.sciencedirect.com
    Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
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  99. May 2022
  100. pubs.acs.org pubs.acs.org
    Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
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  102. Apr 2022
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    EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
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  105. Mar 2022
  106. www.sciencedirect.com www.sciencedirect.com
    Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
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  107. www.sciencedirect.com www.sciencedirect.com
    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    Caveolin-1 Peptide Regulates p53-microRNA-34a Feedback in Fibrotic Lung Fibroblasts
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer
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  110. www.sciencedirect.com www.sciencedirect.com
    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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  111. Feb 2022
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    Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function
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  113. www.sciencedirect.com www.sciencedirect.com
    Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A
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  114. Dec 2021
  115. www.nature.com www.nature.com
    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity
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  117. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  118. Nov 2021
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    Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
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  120. Oct 2021
  121. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  122. www.sciencedirect.com www.sciencedirect.com
    Converging purinergic and immune signaling pathways drive IL-6 secretion by Fragile X cortical astrocytes via STAT3
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  123. Sep 2021
  124. www.sciencedirect.com www.sciencedirect.com
    Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
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  125. www.sciencedirect.com www.sciencedirect.com
    Transcriptional control of brain tumor stem cells by a carbohydrate binding protein
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  126. Aug 2021
  127. www.sciencedirect.com www.sciencedirect.com
    ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
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  128. academic.oup.com academic.oup.com
    Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams
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  129. www.mdpi.com www.mdpi.com
    The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells
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  130. www.jneurosci.org www.jneurosci.org
    Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system
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      DOI: 10.1523/JNEUROSCI.2455-19.2021

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  131. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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      DOI: 10.1038/s41467-021-24687-4

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  132. Jul 2021
  133. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  134. www.sciencedirect.com www.sciencedirect.com
    Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death
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      Mouse monoclonal anti-STAT3

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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
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      Stat3 mouse mAb (124H6)

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  137. www.nature.com www.nature.com
    Treatment of type 2 diabetes with the designer cytokine IC7Fc
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      total STAT3

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  138. www.sciencedirect.com www.sciencedirect.com
    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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  139. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator–activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue
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  140. www.sciencedirect.com www.sciencedirect.com
    Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
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  141. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
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      RRID:AB_10694804

      DOI: 10.1016/j.expneurol.2018.02.012

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  142. www.sciencedirect.com www.sciencedirect.com
    Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
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      DOI: 10.1016/j.stem.2017.10.005

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    sciencedirect.com/science/article/pii/S1934590917304228
  143. www.sciencedirect.com www.sciencedirect.com
    Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway
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      AB_331757

      DOI: 10.1016/j.bbamcr.2016.08.013

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  144. Jun 2021
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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      RRID:AB_331757

      DOI: 10.7554/eLife.67315

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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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  148. May 2021
  149. www.nature.com www.nature.com
    Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure
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    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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    Binge‐Like Ethanol Drinking Activates ALK Signaling and Increases the Expression of STAT3 Target Genes in the Mouse Hippocampus and Prefrontal Cortex
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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  157. Apr 2021
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  160. Feb 2021
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    The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching
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    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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  169. Jan 2021
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    Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution
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  172. Dec 2020
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    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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    Effects of Cardiomyocyte-Specific Deletion of STAT3–A Murine Model of Heart Failure With Preserved Ejection Fraction
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  176. Sep 2020
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala
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    Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H+, K+-ATPases in Pancreatic Cancer and Stellate Cells
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    STAT3‐dependent regulation of the electrogenic Na+/HCO3− cotransporter 1 (NBCe1) functional expression in cortical astrocytes
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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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    Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer
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  187. Jan 2020
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    A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling
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    Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
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  193. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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      DOI: 10.1016/j.chom.2019.11.012

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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling
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      DOI: 10.1016/j.ebiom.2019.07.058

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  195. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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      DOI: 10.1016/j.neuron.2018.10.031

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    sciencedirect.com/science/article/pii/S0896627318309395
  196. www.sciencedirect.com www.sciencedirect.com
    Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
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      DOI: 10.1016/j.ebiom.2019.02.015

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    sciencedirect.com/science/article/pii/S2352396419300878
  197. www.sciencedirect.com www.sciencedirect.com
    Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells
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      DOI: 10.1016/j.cell.2019.03.013

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    sciencedirect.com/science/article/pii/S0092867419302752
  198. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.ccell.2019.03.002

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  199. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.chom.2019.03.012

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  200. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.03.056

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    sciencedirect.com/science/article/pii/S2211124719303869
  201. Nov 2018
  202. www.sciencedirect.com www.sciencedirect.com
    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin regulates POMC neuronal plasticity to control glucose metabolism
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    1. scibot 05 Nov 2018
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  204. www.sciencedirect.com www.sciencedirect.com
    Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice
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      9139

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  205. www.sciencedirect.com www.sciencedirect.com
    Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity
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    A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
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    sciencedirect.com/science/article/pii/S155041311830305X
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    Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
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  208. www.nature.com www.nature.com
    The cJUN NH 2 -terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution
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  209. www.sciencedirect.com www.sciencedirect.com
    Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
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  210. www.sciencedirect.com www.sciencedirect.com
    IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure
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    sciencedirect.com/science/article/pii/S0092867417313661
  211. Nov 2017
  212. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT‐1 by a Notch‐dependent mechanism
    1
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14135/full
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    sciencedirect.com/science/article/pii/S2451945617302830
  214. www.sciencedirect.com www.sciencedirect.com
    A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
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    sciencedirect.com/science/article/pii/S1550413117304345
  215. www.sciencedirect.com www.sciencedirect.com
    PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism
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      AB_331757

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1550413117301638
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response
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      AB_331757

      Curator: @gabimpine

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