136 Matching Annotations
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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  4. Apr 2024
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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  6. Feb 2024
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    Identification of an H-Ras nanocluster disrupting peptide
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    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation
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  11. Jan 2024
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    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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  13. Dec 2023
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    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
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  15. Nov 2023
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation
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  18. Aug 2023
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    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  21. Jul 2023
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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  24. Jun 2023
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    Culture conditions of mouse ESCs impact the tumor appearance in vivo
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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  27. May 2023
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    Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C
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    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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  30. Apr 2023
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    Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone
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    Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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  33. Feb 2023
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    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  37. Jan 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
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  39. Nov 2022
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  41. Oct 2022
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    Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis
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  43. Jul 2022
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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  45. Jun 2022
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    Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR
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    Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice
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  49. Apr 2022
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    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
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    Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
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  52. Mar 2022
  53. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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      DOI: 10.7554/eLife.72849

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  54. Dec 2021
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
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      DOI: 10.7554/eLife.73430

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  58. Oct 2021
  59. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults
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  60. Aug 2021
  61. www.sciencedirect.com www.sciencedirect.com
    The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies
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    Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
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    IL6/sIL-6Rα trans-signaling increases PGE2 production in human granulosa cells
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    Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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  74. Jul 2021
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    Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
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  86. Jun 2021
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  88. May 2021
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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades
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  96. www.cell.com www.cell.com
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  97. Apr 2021
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  100. Mar 2021
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  102. Feb 2021
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA
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  104. Oct 2020
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  106. elifesciences.org elifesciences.org
    Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
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    The p38 signaling pathway mediates the TGF‐β1‐induced increase in type I collagen deposition in human granulosa cells
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      DOI: 10.1096/fj.202001377R

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  108. Sep 2020
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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      DOI: 10.1016/j.stem.2020.02.001

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  110. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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      DOI: 10.1016/j.celrep.2020.107764

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  111. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
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      DOI: 10.1016/j.chembiol.2020.06.013

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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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      DOI: 10.1002/glia.23498

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  114. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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  115. www.sciencedirect.com www.sciencedirect.com
    JNK signalling regulates antioxidant responses in neurons
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      DOI: 10.1016/j.redox.2020.101712

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  116. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15042

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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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  118. www.jneurosci.org www.jneurosci.org
    Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk
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      DOI: 10.1523/JNEUROSCI.2994-18.2019

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  119. Jan 2020
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    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
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      DOI: 10.1016/j.celrep.2019.08.087

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    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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  122. elifesciences.org elifesciences.org
    RbFox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels
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      DOI: 10.7554/eLife.49673

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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer
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      DOI: 10.1016/j.celrep.2019.03.066

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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model
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      DOI: 10.1523/ENEURO.0097-19.2019

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  125. www.sciencedirect.com www.sciencedirect.com
    Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
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      DOI: 10.1016/j.chembiol.2019.06.003

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  126. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.stem.2019.02.017

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  127. www.sciencedirect.com www.sciencedirect.com
    Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159
    1
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      DOI: 10.1016/j.chembiol.2018.10.010

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  128. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.cub.2019.02.061

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  129. www.sciencedirect.com www.sciencedirect.com
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  130. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.neuron.2019.02.011

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    sciencedirect.com/science/article/pii/S0896627319301205
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    Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility
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      DOI: 10.1016/j.cell.2019.01.039

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  132. www.sciencedirect.com www.sciencedirect.com
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  133. Nov 2018
  134. www.sciencedirect.com www.sciencedirect.com
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  135. www.sciencedirect.com www.sciencedirect.com
    Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons
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      9106

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  137. www.sciencedirect.com www.sciencedirect.com
    Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling
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  138. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate
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    Propagating Wave of ERK Activation Orients Collective Cell Migration
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    EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
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  141. www.sciencedirect.com www.sciencedirect.com
    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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  142. www.jneurosci.org www.jneurosci.org
    mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation
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  143. www.sciencedirect.com www.sciencedirect.com
    Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    System identification of signaling dependent gene expression with different time-scale data
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    ncbi.nlm.nih.gov/pmc/articles/PMC5760096/
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  146. link.springer.com link.springer.com
    Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
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    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
    1
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      Cell Signaling#9106

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  148. Nov 2017
  149. academic.oup.com academic.oup.com
    TSH/IGF-1 Receptor Cross-Talk Rapidly Activates Extracellular Signal-Regulated Kinases in Multiple Cell Types
    1
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    academic.oup.com/endo/article/158/10/3676/4080141/TSH-IGF-1-Receptor-Cross-Talk-Rapidly-Activates
  150. www.sciencedirect.com www.sciencedirect.com
    High-fat diet enhances hepatic ischemia-reperfusion injury-induced apoptosis: Role of glucocorticoid receptors
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    sciencedirect.com/science/article/pii/S0024320517305106
  151. www.sciencedirect.com www.sciencedirect.com
    Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1534580717306603
  152. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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      Curator: @kaitlinsung

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    elifesciences.org/articles/29241
  153. www.sciencedirect.com www.sciencedirect.com
    YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
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  154. www.sciencedirect.com www.sciencedirect.com
    Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization
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    sciencedirect.com/science/article/pii/S0969212617302125
  155. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Role of AMPA receptors in homocysteine‐NMDAR induced crosstalk between ERK and p38 MAP kinase
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14078/full
  156. www.jneurosci.org www.jneurosci.org
    Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.
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  157. www.sciencedirect.com www.sciencedirect.com
    Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors
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    sciencedirect.com/science/article/pii/S0898656817301109
  158. elifesciences.org elifesciences.org
    Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
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      Curator: @Zeljana_Babic

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  159. www.sciencedirect.com www.sciencedirect.com
    ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity
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  161. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z
  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Anatomical evidence that the uninjured adjacent L4 nerve plays a significant role in the development of peripheral neuropathic pain after L5 spinal nerve ligation in rats
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    onlinelibrary.wiley.com/doi/10.1002/cne.23750/full