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Jul 2026
dx.doi.org dx.doi.org

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity

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  DOI: 10.1083/jcb.202509213
  
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dx.doi.org/10.1083/jcb.202509213
Jun 2026
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RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages

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  DOI: 10.1126/sciadv.adz0196
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13155314/
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Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation

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  DOI: 10.1016/j.celrep.2026.117504
  
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FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions

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  DOI: 10.1016/j.celrep.2026.117410
  
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sciencedirect.com/science/article/pii/S2211124726004882
Apr 2026
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ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging

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  DOI: 10.1016/j.cell.2026.04.010
  
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sciencedirect.com/science/article/pii/S0092867426003995
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Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade

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1. scibot 24 Apr 2026
  
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  DOI: 10.1172/JCI185220
  
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jci.org/articles/view/185220
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A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs

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  DOI: 10.1016/j.celrep.2026.117243
  
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Mar 2026
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Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells

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1. scibot 21 Mar 2026
  
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  DOI: 10.1084/jem.20240272
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11924952/
Feb 2026
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Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114954
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
Nov 2025
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HMMR has oncoprotein-like properties in neuroblastoma cells and high HMMR expression has independent prognostic potential in neuroblastomas

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1. scibot 25 Nov 2025
  
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  DOI: 10.1038/s41598-025-23141-5
  
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nature.com/articles/s41598-025-23141-5
Aug 2025
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A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations

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1. scibot 16 Aug 2025
  
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  DOI: 10.3390/ijms26157480
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12347341/
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KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1515/oncologie-2025-0171
  
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degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
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Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116096
  
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sciencedirect.com/science/article/pii/S2211124725008678
Jul 2025
www.biorxiv.org www.biorxiv.org

A naturally occurring urinary collagen type I alpha 1-derived peptide inhibits collagen type I-induced endothelial cell migration at physiological concentrations

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1. scibot 15 Jul 2025
  
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  DOI: 10.1101/2025.07.08.663687
  
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biorxiv.org/content/10.1101/2025.07.08.663687v1
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Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102218
  
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sciencedirect.com/science/article/pii/S2666379125002915
May 2025
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s44318-025-00412-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
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Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors

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1. scibot 16 May 2025
  
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  DOI: 10.1002/ijc.35471
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.35471
Apr 2025
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The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0442
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962402/
Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115340
  
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sciencedirect.com/science/article/pii/S2211124725001111
Jan 2025
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Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome

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  DOI: 10.1016/j.stem.2024.12.007
  
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sciencedirect.com/science/article/pii/S1934590924004478
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Revisiting phosphoregulation of Cdc25C during M-phase induction

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  DOI: 10.1016/j.isci.2024.111603
  
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sciencedirect.com/science/article/pii/S258900422402830X
Dec 2024
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DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways

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  DOI: 10.1016/j.celrep.2024.114984
  
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sciencedirect.com/science/article/pii/S2211124724013354
Oct 2024
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Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice

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1. scibot 04 Oct 2024
  
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  DOI: 10.1016/j.neuropharm.2024.110172
  
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sciencedirect.com/science/article/pii/S0028390824003411
Sep 2024
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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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1. scibot 26 Sep 2024
  
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  DOI: 10.1038/s44319-024-00217-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
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Key roles of C2/GAP domains in SYNGAP1-related pathophysiology

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sciencedirect.com/science/article/pii/S2211124724010842
Aug 2024
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

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  DOI: 10.1016/j.cell.2020.02.019
  
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cell.com/cell/fulltext/S0092-8674(20)30163-X
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Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

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  DOI: 10.3390/cells10123314
  
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mdpi.com/2073-4409/10/12/3314/htm
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Linking Hypothermia and Altered Metabolism with TrkB Activation

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1. scibot 02 Aug 2024
  
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  DOI: 10.1021/acschemneuro.3c00350
  
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pubs.acs.org/doi/full/10.1021/acschemneuro.3c00350
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Role of AMPA receptors in homocysteine‐NMDAR induced crosstalk between ERK and p38 MAP kinase

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1. scibot 02 Aug 2024
  
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  DOI: 10.1111/jnc.14078
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14078/full
Jul 2024
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Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord

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1. scibot 26 Jul 2024
  
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  DOI: 10.3390/ijms25137168
  
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mdpi.com/1422-0067/25/13/7168
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Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization

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  DOI: 10.1016/j.xcrm.2024.101623
  
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G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling

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1. scibot 23 Jul 2024
  
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  DOI: 10.1126/scisignal.adi0934
  
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science.org/doi/10.1126/scisignal.adi0934
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Astrocytes facilitate gabazine-evoked electrophysiological hyperactivity and distinct biochemical responses in mature neuronal cultures

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1. scibot 18 Jul 2024
  
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  DOI: 10.1111/jnc.16182
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16182
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Paradoxical activation of c-Src as a drug-resistant mechanism

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  DOI: 10.1016/j.celrep.2021.108876
  
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sciencedirect.com/science/article/pii/S221112472100190X
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.

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1. scibot 30 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.110129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11187247/
May 2024
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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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1. scibot 21 May 2024
  
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Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

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Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology

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S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis

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RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

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Identification of an H-Ras nanocluster disrupting peptide

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An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

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Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation

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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning

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Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

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Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest

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Blood flow patterns switch VEGFR2 activity through differential S-nitrosylation and S-oxidation

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Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Culture conditions of mouse ESCs impact the tumor appearance in vivo

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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

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Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C

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RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition

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Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone

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Phosphorylation barcodes direct biased chemokine signaling at CXCR3

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

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KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

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BPS Publications

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Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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mcr-21-0994-html.html

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Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

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Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice

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Tissue remodeling by an opportunistic pathogen triggers allergic inflammation

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Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

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Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway

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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

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The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

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Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen

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IL6/sIL-6Rα trans-signaling increases PGE2 production in human granulosa cells

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Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice

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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

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Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

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Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF

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Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain

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Membrane androgen receptor ZIP9 induces croaker ovarian cell apoptosis via stimulatory G protein alpha subunit and MAPkinase signaling

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Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF

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Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway

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T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

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Transmembrane adaptor protein PAG is a mediator of PD-1 inhibitory signaling in human T cells

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Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells

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Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades

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The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons

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Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence

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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Paradoxical activation of c-Src as a drug-resistant mechanism

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Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA

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Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

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Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease

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The p38 signaling pathway mediates the TGF‐β1‐induced increase in type I collagen deposition in human granulosa cells

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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

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Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

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Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF

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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System

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JNK signalling regulates antioxidant responses in neurons

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BPS Publications

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Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage

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Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

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RbFox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159

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Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

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sciencedirect.com/science/article/pii/S1534580719302771
Nov 2018
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Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons

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Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

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Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate

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onlinelibrary.wiley.com/doi/full/10.1002/pros.23702
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Propagating Wave of ERK Activation Orients Collective Cell Migration

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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

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By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis

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System identification of signaling dependent gene expression with different time-scale data

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Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex

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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

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sciencedirect.com/science/article/pii/S2213231717306687
Nov 2017
academic.oup.com academic.oup.com

TSH/IGF-1 Receptor Cross-Talk Rapidly Activates Extracellular Signal-Regulated Kinases in Multiple Cell Types

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academic.oup.com/endo/article/158/10/3676/4080141/TSH-IGF-1-Receptor-Cross-Talk-Rapidly-Activates
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High-fat diet enhances hepatic ischemia-reperfusion injury-induced apoptosis: Role of glucocorticoid receptors

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Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

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Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

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Role of AMPA receptors in homocysteine‐NMDAR induced crosstalk between ERK and p38 MAP kinase

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Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.

1
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Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors

1
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Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense

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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

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Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity

1
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bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

2
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  AB_331768
  
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2. scibot 08 Nov 2017
  
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  Curator: @gabimpine
  
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Anatomical evidence that the uninjured adjacent L4 nerve plays a significant role in the development of peripheral neuropathic pain after L5 spinal nerve ligation in rats

1
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