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Fungus Rhizopus arrhizus promotes MASLD-associated hepatocellular carcinoma through generating kynurenic acid

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  DOI: 10.1016/j.cmet.2026.09.005
  
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sciencedirect.com/science/article/pii/S1550413126003803
Sep 2026
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Bacteroides acidifaciens enriched by KRAS mutation promotes colorectal tumorigenesis

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  DOI: 10.1016/j.chom.2026.08.010
  
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sciencedirect.com/science/article/pii/S1931312826003525
Aug 2026
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Cinnamaldehyde protects against aluminum oxide nanoparticle–induced cognitive dysfunction in male Swiss mice by attenuating hippocampal ERK/p38 hyperphosphorylation and enhancing

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  DOI: 10.1016/j.neuro.2026.103556
  
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An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression

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1. scibot 19 Aug 2026
  
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  DOI: 10.64898/2026.07.14.738492
  
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biorxiv.org/content/10.64898/2026.07.14.738492v1
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BPS Publications

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1. scibot 08 Aug 2026
  
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  DOI: 10.1111/bph.15472
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15472
Jul 2026
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M1C IS NECESSARY FOR DARAXONRASIB RESISTANCE OF NSCLC KRAS(G12C) MUTANT CELLS

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1. scibot 12 Jul 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13334778/
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Erk inhibitors intercept Erk-mediated negative feedback while imposing cell-cycle arrest and activating p38

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1. scibot 09 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116629
  
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BPS Publications

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  DOI: 10.1111/bph.70528
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70528
May 2026
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Genome-Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

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1. scibot 28 May 2026
  
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  DOI: 10.1002/advs.202515158
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202515158
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Dengue protease-mediated activation and polarization of macrophages

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  DOI: 10.1016/j.ijbiomac.2026.152322
  
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sciencedirect.com/science/article/pii/S014181302602249X
Apr 2026
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Tuning the sensitivity of mechanosensory receptors through histidine scanning

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.cell.2025.12.050
  
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cell.com/cell/fulltext/S0092-8674(25)01499-0
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Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs

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1. scibot 09 Apr 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-1123
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.004
  
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sciencedirect.com/science/article/pii/S1097276526001607
Mar 2026
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1-s2.0-S2589004226008801-main-html.html

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115505
  
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Identification and characterization of BRAF⇔TP53 interactions in melanoma

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117078
  
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sciencedirect.com/science/article/pii/S2211124726001567
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BPS Publications

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1. scibot 19 Mar 2026
  
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  DOI: 10.1111/bph.70379
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70379
Jan 2026
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Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.007
  
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sciencedirect.com/science/article/pii/S0092867425014205
Dec 2025
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Targeting KRAS Inhibitor–Resistant Pancreatic Cancer with an MUC1-C Antibody–Drug Conjugate

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1. scibot 19 Dec 2025
  
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  DOI: 10.1158/1078-0432.CCR-25-2333
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12703357/
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M1C is a druggable target for NSCLC KRAS G12C mutant tumors resistant to KRAS inhibitors

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1. scibot 16 Dec 2025
  
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  DOI: 10.64898/2025.12.02.691049
  
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biorxiv.org/content/10.64898/2025.12.02.691049v1
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Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy

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1. scibot 10 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.015
  
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sciencedirect.com:5037/science/article/pii/S009286742501311X
Oct 2025
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An enteric-DRG pathway for interoception and visceral pain in mice

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  DOI: 10.1016/j.neuron.2025.09.035
  
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Tuning insulin receptor signaling using de novo-designed agonists

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  DOI: 10.1016/j.molcel.2025.09.020
  
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Sep 2025
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Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice

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1. scibot 20 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12422933/
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Phenotypic pleiotropy of missense variants in human B cell confinement receptor P2RY8

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.xgen.2025.100981
  
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sciencedirect.com/science/article/pii/S2666979X2500237X
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Cooperativity between Ras pathway mutations in colonic tumorigenesis

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1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.09.05.673994
  
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biorxiv.org/content/10.1101/2025.09.05.673994v1
Aug 2025
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PKD and scaffold NHERF1 mediate hypoxia-induced gene expression in 3T3-L1 adipocytes

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1. scibot 29 Aug 2025
  
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  DOI: 10.1530/JME-25-0011
  
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sciencedirect.com/org/science/article/pii/S1479681325000226
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jme-JME-25-0011-html.html

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Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

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  DOI: 10.3389/fragi.2025.1628835
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12339548/
Jun 2025
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Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway

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  DOI: 10.1016/j.cels.2025.101321
  
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sciencedirect.com/science/article/pii/S2405471225001541
Feb 2025
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Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

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  DOI: 10.1523/JNEUROSCI.0438-24.2024
  
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jneurosci.org/content/44/50/e0438242024
Jan 2025
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Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells

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  DOI: 10.1111/jnc.16300
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16300
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Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

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  DOI: 10.1016/j.ccell.2024.12.004
  
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Dec 2024
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1-s2.0-S2589004224028980-main-html.html

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1. scibot 24 Dec 2024
  
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Nov 2024
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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114917
  
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sciencedirect.com/science/article/pii/S2211124724012683
Aug 2024
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Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.76940
  
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A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery

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BPS Publications

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Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response

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An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

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Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

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Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress

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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis

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Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer

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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

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TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins

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Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling

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Oncogenic K-Ras suppresses global miRNA function

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

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Acetate controls endothelial-to-mesenchymal transition

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How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

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Prominin-1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice

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Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21

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VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection

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Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury

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A new paradigm for epidermal growth factor receptor expression exists in PTC and NIFTP regulated by microRNAs

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Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer

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Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma

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Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex

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Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines

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Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin

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Opioids Cause Sex-Specific Vascular Changes via Cofilin-Extracellular Signal-Regulated Kinase Signaling: Female Mice Present Higher Risk of Developing Morphine-Induced Vascular Dysfunction than Male Mice

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Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding

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Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell

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A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

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Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts

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Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

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Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons

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Regulation of GTPase function by autophosphorylation

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

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c-FOS drives reversible basal to squamous cell carcinoma transition

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Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

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Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis

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Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

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Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

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Differential Effects of Toll-Like Receptor Activation and Differential Mediation by MAP Kinases of Immune Responses in Microglial Cells

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1

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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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Discovery of Covalent MKK4/7 Dual Inhibitor

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LncRNA RP6‐65G23.1 accelerates proliferation and inhibits apoptosis via p‐ERK1/2/p‐AKT signaling pathway on keratinocytes

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BPS Publications

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Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms

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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

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Injectable Hydrogel Containing Tauroursodeoxycholic Acid for Anti-neuroinflammatory Therapy After Spinal Cord Injury in Rats

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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Protocol for Barcoding T Cells Combined with Timed Stimulations

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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

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Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

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Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

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Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

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CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity

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Regulation of T‐type Ca2+ channel expression by interleukin‐6 in sensory‐like ND7/23 cells post‐herpes simplex virus (HSV‐1) infection

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Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells

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Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

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Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

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RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

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Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)

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The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor

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Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity

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Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival

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academic.oup.com/endo/article/158/10/3647/4080743/Gonadotropin-Dependent-Neuregulin-1-Signaling
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Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT1A and 5-HT7 receptors

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  RRID:AB_331775
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S104474311730180X
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
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  RRID:AB_331775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
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A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

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1. scibot 08 Nov 2017
  
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  AB_331775
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1097276517304586
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Modulation of Autophagy by BDNF Underlies Synaptic Plasticity

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1. scibot 08 Nov 2017
  
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  AB_331775
  
  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1550413117303479
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 08 Nov 2017
  
  in Public
  
  AB_331775
  
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  (Cell Signaling Technology Cat# 4377, RRID:AB_331775)
  
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sciencedirect.com/science/article/pii/S2405471216304082
www.jneurosci.org www.jneurosci.org

Soluble cpg15 from Astrocytes Ameliorates Neurite Outgrowth Recovery of Hippocampal Neurons after Mouse Cerebral Ischemia

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1. scibot 08 Nov 2017
  
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  AB_331775
  
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jneurosci.org/content/37/6/1628.long
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Genetic disruption of the core circadian clock impairs hippocampus-dependent memory

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1. scibot 08 Nov 2017
  
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  AB_331775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4105720/

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