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Apr 2026
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NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis

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sciencedirect.com/science/article/pii/S1550413126001427
Mar 2026
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FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response

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  DOI: 10.1158/0008-5472.CAN-25-1917
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13007557/
Feb 2026
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A Genetic Interaction Between DED1 and HAT1 in Saccharomyces cerevisiae Reveals a Role for Hat1p in cytoplasmic RNA granule accumulation

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1. scibot 27 Feb 2026
  
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  DOI: 10.1093/g3journal/jkaf307
  
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academic.oup.com/g3journal/advance-article/doi/10.1093/g3journal/jkaf307/8384369
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RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer

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1. scibot 12 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.020
  
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sciencedirect.com/science/article/pii/S1097276526000626
Jan 2026
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Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination

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pmc.ncbi.nlm.nih.gov/articles/PMC12839083/
Dec 2025
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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  DOI: 10.1111/bph.70261
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70261
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NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA

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  DOI: 10.1016/j.molcel.2025.11.010
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12709618/
Nov 2025
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A sensory and motor neuropathy caused by a genetic variant of NAMPT

1
1. scibot 23 Nov 2025
  
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  DOI: 10.1126/sciadv.adx2407
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12467057/
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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116520
  
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sciencedirect.com/science/article/pii/S2211124725012914
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IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation

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  DOI: 10.1016/j.celrep.2025.116511
  
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sciencedirect.com/science/article/pii/S2211124725012823
Sep 2025
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A sensory and motor neuropathy caused by a genetic variant of NAMPT

1
1. scibot 30 Sep 2025
  
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  DOI: 10.1126/sciadv.adx2407
  
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science.org/doi/10.1126/sciadv.adx2407
Aug 2025
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Novel Coumarin Derivative SZC-6 as an Allosteric Activator of SIRT3 Alleviates Diabetic Kidney Disease via the SIRT3-Foxo3a Signaling Axis

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1. scibot 12 Aug 2025
  
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  DOI: 10.1016/j.freeradbiomed.2025.08.019
  
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sciencedirect.com/science/article/pii/S0891584925008883
Jun 2025
www.cell.com www.cell.com

HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury

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1. scibot 24 Jun 2025
  
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  DOI: 10.1016/j.stem.2025.04.010
  
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cell.com/cell-stem-cell/abstract/S1934-5909(25)00177-8
May 2025
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NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.cmet.2025.04.002
  
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sciencedirect.com/science/article/pii/S1550413125002128
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SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

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  DOI: 10.1016/j.celrep.2025.115562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074670/
Apr 2025
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BPS Publications

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1. scibot 02 Apr 2025
  
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  RRID:AB_331805
  
  DOI: 10.1111/bph.70022
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70022
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PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms

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1. scibot 02 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115484
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00255-4
Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

1
1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.cmet.2025.02.008
  
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sciencedirect.com/science/article/pii/S155041312500066X
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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.01.043
  
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cell.com/cell/abstract/S0092-8674(25)00145-X
Feb 2025
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Identification of Meibomian gland stem cell populations and mechanisms of aging

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1. scibot 20 Feb 2025
  
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  DOI: 10.1038/s41467-025-56907-6
  
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link.springer.com/article/10.1038/s41467-025-56907-6
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Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

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  DOI: 10.1016/j.celrep.2025.115269
  
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sciencedirect.com/science/article/pii/S2211124725000403
Jan 2025
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A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis

1
1. scibot 30 Jan 2025
  
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  DOI: 10.1016/j.immuni.2025.01.003
  
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sciencedirect.com/science/article/pii/S1074761325000263
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.002
  
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sciencedirect.com/science/article/pii/S2451945625000029
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Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17

1
1. scibot 15 Jan 2025
  
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  RRID:AB_331896
  
  DOI: 10.1038/s41467-025-55906-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718230/
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A conserved acetylation switch enables pharmacological control of tubby-like protein stability

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1. scibot 10 Jan 2025
  
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  rabbit antiacetylated lysine
  
  DOI: 10.1074/jbc.RA120.015839
  
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jbc.org/article/S0021-9258(20)00061-7/fulltext
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CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability

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  DOI: 10.1016/j.celrep.2024.115135
  
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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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  DOI: 10.1016/j.devcel.2024.12.024
  
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sciencedirect.com/science/article/pii/S1534580724007639
Dec 2024
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

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1. scibot 21 Dec 2024
  
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  DOI: 10.1126/sciadv.adp7423
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11567002/
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Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

1
1. scibot 20 Dec 2024
  
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  DOI: 10.1126/sciadv.adp7423
  
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science.org/doi/10.1126/sciadv.adp7423
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Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1

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1. scibot 14 Dec 2024
  
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  RRID:AB_3665836
  
  DOI: 10.1016/j.ccell.2024.11.008
  
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sciencedirect.com/science/article/pii/S1535610824004434
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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

1
1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115033
  
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sciencedirect.com/science/article/pii/S2211124724013846
Aug 2024
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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

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1. scibot 29 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114682
  
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sciencedirect.com/science/article/pii/S2211124724010337
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SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2

1
1. scibot 21 Aug 2024
  
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  AB_331805
  
  DOI: 10.1016/j.xcrm.2024.101684
  
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sciencedirect.com/science/article/pii/S2666379124004051
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Distinguishing pathophysiological features of heart failure with reduced and preserved ejection fraction: A comparative analysis of two mouse models

1
1. scibot 21 Aug 2024
  
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  RRID:AB_331
  
  DOI: 10.1113/JP286410
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP286410
52.53.155.43 52.53.155.43

Supplemental_Materials (1)-html.html

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1. scibot 02 Aug 2024
  
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  DOI: 10.2337/figshare.21183496
  
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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

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Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

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YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

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SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells

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Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration

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The acetylation of MDH1 and IDH1 is associated with energy metabolism in acute liver failure

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TSPYL2 induces renal ischemia-reperfusion injury through SREBP-2/ACMSD signaling

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Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss

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The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

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Securin acetylation prevents precocious separase activation and premature sister chromatid separation

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Acetylation-induced proteasomal degradation of the activated glucocorticoid receptor limits hormonal signaling

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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

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Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis

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Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

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Small-molecule TIP60 inhibitors enhance regulatory T cell induction through TIP60-P300 acetylation crosstalk

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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

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Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer

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Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine

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ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct

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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

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Acetylation reprograms MITF target selectivity and residence time

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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication

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British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html

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GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner

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HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway

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Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

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IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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Protocol to purify the histone deacetylase SIRT6 and assess its activity in vitro

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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

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Autophagy promotes cell survival by maintaining NAD levels

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Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation

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The redox cycling of STAT2 maintains innate immune homeostasis

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The role and mechanism of CREBH regulating SIRT3 in metabolic associated fatty liver disease

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Acetylation of p62 regulates base excision repair through interaction with APE1

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Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice

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Evidence that HDAC7 acts as an epigenetic “reader” of AR acetylation through NCoR-HDAC3 dissociation

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Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

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High-intensity interval training remodels the proteome and acetylome of human skeletal muscle

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Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

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BPS Publications

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Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization

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Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth

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Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation

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Acetylation-dependent regulation of BRAF oncogenic function

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Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules

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NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis

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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation

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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

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ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

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Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation

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Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

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Untitled document

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

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Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

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BPS Publications

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  DOI: 10.1111/bph.15490
  
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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

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Untitled document

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Untitled document

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Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

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miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

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Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish

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SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

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Mitochondrial SIRT3 confers neuroprotection in Huntington’s disease by regulation of oxidative challenges and mitochondrial dynamics

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Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

1
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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

1
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Tau seeds are subject to aberrant modifications resulting in distinct signatures

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Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

1
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Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

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  anti-acetylated-lysine
  
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nature.com/articles/s42255-020-00325-z
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Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

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Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy

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Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation

1
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PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

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cell.com/cell-metabolism/abstract/S1550-4131(18)30567-9
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Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

1
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ncbi.nlm.nih.gov/pmc/articles/PMC7262597/
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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

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Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation

1
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Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms

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Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

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Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

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BPS Publications

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  anti‐Acetyl‐Lysine
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15023
journals.physiology.org journals.physiology.org

Sugar causes obesity and metabolic syndrome in mice independently of sweet taste | American Journal of Physiology-Endocrinology and Metabolism

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  DOI: 10.1152/ajpendo.00529.2019
  
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journals.physiology.org/doi/full/10.1152/ajpendo.00529.2019
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Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1

1
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  Acetylated-Lysine
  
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CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation

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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

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Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade

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Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication

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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

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Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma

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SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism

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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

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Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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HDAC3-selective inhibition activates brown and beige fat through PRDM16

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Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

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Vitamin D Switches BAF Complexes to Protect β Cells

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A Metabolic Basis for Endothelial-to-Mesenchymal Transition

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

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NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

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Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

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Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport

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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

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