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Oct 2026
www.sciencedirect.com www.sciencedirect.com

Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice

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sciencedirect.com/science/article/pii/S2211124726011423
Aug 2026
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Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

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sciencedirect.com/science/article/pii/S1074761326003080
Jun 2026
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Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling

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sciencedirect.com/science/article/pii/S1535610826002503
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Decoding the spatiotemporal development of human meninges

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sciencedirect.com/science/article/pii/S0092867426005076
May 2026
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Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders

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1. scibot 29 May 2026
  
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sciencedirect.com/science/article/pii/S0896627326003387
Oct 2025
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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

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1. scibot 18 Oct 2025
  
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sciencedirect.com/science/article/pii/S0896627325007457
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Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling

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1. scibot 11 Oct 2025
  
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sciencedirect.com/science/article/pii/S0896627325007111
Aug 2025
52.53.155.43 52.53.155.43

Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Axotomy

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1. scibot 21 Aug 2025
  
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52.53.155.43/224e0698b086f485b29363e9e7acf1dad378cd8e/2025.08.06.668924v2.full-html.html
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TREM2‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization

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1. scibot 30 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302306/
Oct 2024
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Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice

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sciencedirect.com/science/article/pii/S0024320524006751
Aug 2024
actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com

Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype

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1. scibot 02 Aug 2024
  
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actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01261-z
Jul 2024
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Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression

1
1. scibot 16 Jul 2024
  
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sciencedirect.com/science/article/pii/S2211124724008179
Jun 2024
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BPS Publications

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1. scibot 28 Jun 2024
  
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  DOI: 10.1111/bph.16441
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16441
May 2024
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Distinct roles of TREM2 in central nervous system cancers and peripheral cancers

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.ccell.2024.05.001
  
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sciencedirect.com/science/article/pii/S1535610824001624
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Antibody engagement with amyloid-beta does not inhibit [11C]PiB binding for PET imaging

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1. scibot 16 May 2024
  
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  DOI: 10.1111/jnc.16127
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16127
Apr 2024
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Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0299
  
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aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
Mar 2024
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Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
Feb 2024
www.embopress.org www.embopress.org

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias

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1. scibot 15 Feb 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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embopress.org/doi/10.1038/s44319-024-00077-x
Dec 2023
52.53.155.43 52.53.155.43

cd-23-0299-html.html

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52.53.155.43/2b6c279d82b7a0e0d491057f5790a1189e93077e/cd-23-0299-html.html
Oct 2023
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Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion

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1. scibot 20 Oct 2023
  
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  DOI: 10.1111/jnc.15987
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15987
52.53.155.43 52.53.155.43

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias

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1. scibot 13 Oct 2023
  
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  DOI: 10.1101/2023.06.14.544924
  
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52.53.155.43/5afe577c269e488702b5f7086020251c9f5e047d/2023.06.14.544924v1.full-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke

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1. scibot 25 Jul 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10360087/
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Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice

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sciencedirect.com/science/article/pii/S0896627323004373
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

1
1. scibot 09 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106375
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
Feb 2023
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Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome

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1. scibot 23 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112133
  
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sciencedirect.com/science/article/pii/S2211124723001444
Jan 2023
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Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.immuni.2022.11.013
  
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sciencedirect.com/science/article/pii/S1074761322006033
Dec 2022
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Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models

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  DOI: 10.1016/j.xpro.2022.101891
  
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sciencedirect.com/science/article/pii/S2666166722007717
Nov 2022
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Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111686
  
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sciencedirect.com/science/article/pii/S2211124722015601
Oct 2022
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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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1. scibot 28 Oct 2022
  
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  DOI: 10.1016/j.cell.2022.09.033
  
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sciencedirect.com/science/article/pii/S0092867422012521
Jun 2022
52.53.155.43 52.53.155.43

The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment

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1. scibot 22 Jun 2022
  
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  DOI: 10.1093/brain/awac113
  
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52.53.155.43/6c7269a8a0c4cf96641f05a6f51be2d6d8c4ab00/awac113 (1)-html.html
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awac113-html.html

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1. scibot 18 Jun 2022
  
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  DOI: 10.1093/brain/awac113
  
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52.53.155.43/30a61ebc09dbd539ad43de2662708a6ef00e0754/awac113-html.html
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Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

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  DOI: 10.1016/j.celrep.2022.110883
  
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sciencedirect.com/science/article/pii/S2211124722006581
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair

1
1. scibot 04 Sep 2021
  
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  DOI: 10.1126/sciadv.abg2712
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8373127/
Aug 2021
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

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1. scibot 27 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.08.002
  
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sciencedirect.com/science/article/pii/S0092867421009442
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BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

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1. scibot 25 Aug 2021
  
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  DOI: 10.1016/j.isci.2021.102942
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
Sep 2020
elifesciences.org elifesciences.org

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

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1. scibot 03 Sep 2020
  
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  RRID:AB_354956
  
  DOI: 10.7554/eLife.54083
  
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  Curator: @Naa003
  
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elifesciences.org/articles/54083
Jan 2020
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TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

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1. scibot 13 Jan 2020
  
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  RRID:AB_354956
  
  DOI: 10.1016/j.neuron.2019.06.010
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S0896627319305604
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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

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1. scibot 13 Jan 2020
  
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  RRID:AB_354956
  
  DOI: 10.1016/j.neuron.2019.12.007
  
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  RRID:AB_354956 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627319310499
Nov 2018
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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761318301857
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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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1. scibot 05 Nov 2018
  
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  RRID:AB_354956
  
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  (R and D Systems Cat# AF1729, RRID:AB_354956)
  
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sciencedirect.com/science/article/pii/S0896627318300564