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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.012
  
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sciencedirect.com/science/article/pii/S1534580726001590
Apr 2026
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Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma

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1. scibot 16 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117176
  
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sciencedirect.com/science/article/pii/S2211124726002548
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Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.stem.2026.03.004
  
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sciencedirect.com/science/article/pii/S1934590926001141
Mar 2026
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Functional chromatin signatures premark future lineage-specific enhancers

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.xgen.2026.101189
  
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sciencedirect.com/science/article/pii/S2666979X26000510
Feb 2026
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A new form of diabetes caused by INS mutations defined by zygosity, stem cell and population data

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1. scibot 20 Feb 2026
  
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  DOI: 10.1038/s44321-025-00362-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12905373/
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Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116990
  
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sciencedirect.com/science/article/pii/S2211124726000689
Jan 2026
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High-content screening of organoids reveals the mechanisms of human pancreas acinar specification

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.stem.2025.12.023
  
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sciencedirect.com/science/article/pii/S1934590925004576
Dec 2025
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DEC1 regulates human β cell functional maturation and circadian rhythm

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116666
  
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sciencedirect.com:5037/science/article/pii/S221112472501438X
Oct 2025
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Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.devcel.2025.09.018
  
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sciencedirect.com/science/article/pii/S1534580725006033
Sep 2025
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Generation of a Flattop-T2A-H2B-Venus x C-peptide-mCherry double reporter human iPSC line to monitor WNT/Planar cell polarity pathway activity

1
1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.scr.2025.103838
  
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sciencedirect.com/science/article/pii/S1873506125001886
Aug 2025
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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo

1
1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.stem.2025.07.006
  
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sciencedirect.com/science/article/pii/S1934590925002632
Jul 2025
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Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals

1
1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116065
  
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sciencedirect.com/science/article/pii/S2211124725008368
Jun 2025
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Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

1
1. scibot 25 Jun 2025
  
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  RRID:AB_355257
  
  DOI: 10.1016/j.celrep.2021.109919
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
Mar 2025
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Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics

1
1. scibot 11 Mar 2025
  
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  AB_355257
  
  DOI: 10.1016/j.devcel.2025.02.008
  
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sciencedirect.com/science/article/pii/S1534580725001133
Feb 2025
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Expression of genes involved in thyroid hormone action in human induced pluripotent stem cells during differentiation to insulin-producing cells: Effects of iopanoic acid on differentiation

1
1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.mce.2025.112490
  
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sciencedirect.com/science/article/pii/S0303720725000413
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Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes

1
1. scibot 11 Feb 2025
  
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  RRID:AB_355257
  
  DOI: 10.1016/j.xcrm.2025.101938
  
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sciencedirect.com/science/article/pii/S2666379125000114
Dec 2024
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Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.114994
  
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sciencedirect.com/science/article/pii/S2211124724013457
Sep 2024
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Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient

1
1. scibot 27 Sep 2024
  
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  AB_355257
  
  DOI: 10.1016/j.cell.2024.09.004
  
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sciencedirect.com/science/article/pii/S0092867424010225
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Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection

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1. scibot 04 Sep 2024
  
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  AB_355257
  
  DOI: 10.1016/j.stem.2024.08.007
  
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sciencedirect.com/science/article/pii/S1934590924002935
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant

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1. scibot 23 Aug 2024
  
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  AB_355257
  
  DOI: 10.1016/j.celrep.2024.114640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11406439/
May 2024
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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.010
  
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sciencedirect.com/science/article/pii/S1934590924001371
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multiplexed in Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.cmet.2019.01.003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6436557/
Apr 2023
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Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes

2
1. scibot 12 Apr 2023
  
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  DOI: 10.1016/j.devcel.2023.03.011
  
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2. scibot 12 Apr 2023
  
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  AB_355257
  
  DOI: 10.1016/j.devcel.2023.03.011
  
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sciencedirect.com/science/article/pii/S1534580723001077
Mar 2023
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Protocol to generate human pluripotent stem cell-derived pancreatic β cells through methionine and zinc deprivation

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.xpro.2023.102183
  
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sciencedirect.com/science/article/pii/S2666166723001417
Dec 2022
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An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.stem.2022.12.001
  
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sciencedirect.com/science/article/pii/S1934590922004854
Jul 2022
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Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization

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1. scibot 27 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111120
  
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sciencedirect.com/science/article/pii/S2211124722009263
Jun 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis

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1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9212970/
Apr 2022
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The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

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1. scibot 22 Apr 2022
  
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  DOI: 10.1016/j.stem.2022.03.015
  
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sciencedirect.com/science/article/pii/S1934590922001503
Dec 2021
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Differentiation of human pluripotent stem cells into pancreatic duct-like organoids

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1. scibot 09 Dec 2021
  
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  DOI: 10.1016/j.xpro.2021.100913
  
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sciencedirect.com/science/article/pii/S2666166721006195
Nov 2021
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

1
1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109919
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8609965/
Oct 2021
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A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis

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1. scibot 22 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109875
  
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sciencedirect.com/science/article/pii/S2211124721013425
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Xeno- and feeder-free derivation of two sex-discordant sibling lines of human embryonic stem cells

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1. scibot 16 Oct 2021
  
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  DOI: 10.1016/j.scr.2021.102574
  
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sciencedirect.com/science/article/pii/S1873506121004219
Sep 2021
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Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models

1
1. scibot 04 Sep 2021
  
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  DOI: 10.1016/j.stem.2021.08.001
  
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sciencedirect.com/science/article/pii/S1934590921003386
Aug 2021
www.nature.com www.nature.com

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines

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1. scibot 16 Aug 2021
  
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  DOI: 10.1038/s41596-021-00560-y
  
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nature.com/articles/s41596-021-00560-y
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Untitled document

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1. scibot 12 Aug 2021
  
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  DOI: 10.1210/en.2018-00083
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6287593/
Apr 2021
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

1
1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.stem.2021.03.005
  
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Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells

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  DOI: 10.1016/j.chembiol.2020.08.018
  
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sciencedirect.com/science/article/pii/S2451945620303408
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Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas

1
1. scibot 22 Jan 2021
  
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  Goat PDX-1 1° antibody
  
  DOI: 10.1016/j.xpro.2020.100263
  
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Oct 2020
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Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

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1. scibot 27 Oct 2020
  
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  DOI: 10.1016/j.xcrm.2020.100125
  
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Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

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1. scibot 26 Sep 2020
  
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  RRID:AB_355257
  
  DOI: 10.1016/j.xcrm.2020.100097
  
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Generation of a homozygous ARX nuclear CFP (ARXnCFP/nCFP) reporter human iPSC line (HMGUi001-A-4)

1
1. scibot 23 Sep 2020
  
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  RRID:AB_355257
  
  DOI: 10.1016/j.scr.2020.101874
  
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Generation of an INSULIN-H2B-Cherry reporter human iPSC line

1
1. scibot 16 Sep 2020
  
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  RRID:AB_355257
  
  DOI: 10.1016/j.scr.2020.101797
  
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BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

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1. scibot 08 Sep 2020
  
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  DOI: 10.1038/s41419-020-2589-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7235254/
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SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

1
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  DOI: 10.1016/j.celrep.2020.107687
  
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Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

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1. scibot 04 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108067
  
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Sticker method for preparation of frozen section using adhesive film

1
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  DOI: 10.1016/j.jneumeth.2019.108436
  
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FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

1
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  AB_355257
  
  DOI: 10.1016/j.celrep.2019.06.034
  
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Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual

1
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  RRID:AB_355257
  
  DOI: 10.1016/j.scr.2019.101531
  
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Circadian Entrainment Triggers Maturation of Human In Vitro Islets

1
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  DOI: 10.1016/j.stem.2019.11.011
  
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Untitled document

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  DOI: 10.1016/j.cmet.2018.11.014
  
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Untitled document

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  DOI: 10.1016/j.chembiol.2018.10.019
  
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Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

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  RRID:AB_355257
  
  DOI: 10.1016/j.celrep.2019.04.083
  
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Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

1
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  RRID:AB_355257
  
  DOI: 10.7554/eLife.38519
  
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Untitled document

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  DOI: 10.1016/j.cmet.2019.01.003
  
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sciencedirect.com/science/article/pii/S1550413119300038
Nov 2018
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Untitled document

1
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academic.oup.com academic.oup.com

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academic.oup.com/endo/article/159/9/3143/4917526
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Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity

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sciencedirect.com/science/article/pii/S1534580718301564
Nov 2017
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Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development

1
1. scibot 08 Nov 2017
  
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  AB_355257
  
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