582 Matching Annotations
  1. Nov 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma
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    sciencedirect.com/science/article/pii/S2211124722014668
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    TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage
    1
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      DOI: 10.3389/fnagi.2022.967825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9637852/
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    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124722014942
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    DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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    sciencedirect.com/science/article/pii/S2352396422004947
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    Androgens improve ovarian follicle function impaired by glucocorticoids through an androgen-IGF1-FSH synergistic effect
    1
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    Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
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  10. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    sciencedirect.com/science/article/pii/S0092867422012521
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    sciencedirect.com/science/article/pii/S2451945622003567
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    Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
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    sciencedirect.com/science/article/pii/S1074761322005428
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    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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    Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy
    1
    1. scibot 08 Oct 2022
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    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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    sciencedirect.com/science/article/pii/S2211124722012840
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    Poly-L-ornithine blocks the inhibitory effects of... : Neural Regeneration Research
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  18. Sep 2022
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    Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation
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    1. scibot 24 Sep 2022
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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recombinant production of growth factors for application in cell culture
    1
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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    Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia
    1
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    Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis
    1
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    sciencedirect.com/science/article/pii/S1534580722005949
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    1. scibot 13 Sep 2022
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    sciencedirect.com/science/article/pii/S2666379122002907
  25. Aug 2022
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    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
    1
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    sciencedirect.com/science/article/pii/S2589004222011956
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    Pituitary adenomas evade apoptosis via noxa deregulation in Cushing’s disease
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    sciencedirect.com/science/article/pii/S2211124722010403
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    Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
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    Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation
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    Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing
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    Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway
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    S-nitrosylation is required for β2AR desensitization and experimental asthma
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    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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      DOI: 10.1523/JNEUROSCI.1989-21.2022

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  34. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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    JNEUROSCI.1989-21.2022.full-html.html
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    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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      DOI: 10.3390/cancers14133152

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    Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment
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      DOI: 10.1007/s00018-022-04413-z

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    A novel germline deletion of p.C630 in RET causes MTC and promotes cell proliferation and sensitivity to pralsetinib
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      DOI: 10.1210/clinem/dgac352

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac352/6605991
  44. Jun 2022
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors
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      DOI: 10.1007/s00018-022-04405-z

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    Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
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    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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    Itaconate is a lysosomal inducer that promotes antibacterial innate immunity
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    Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1/2 and inflammasome activation in PCOS
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury
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  53. May 2022
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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    Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
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  57. Apr 2022
  58. www.sciencedirect.com www.sciencedirect.com
    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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  61. Mar 2022
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    Combination of Resminostat with Ruxolitinib Exerts Antitumor Effects in the Chick Embryo Chorioallantoic Membrane Model for Cutaneous T Cell Lymphoma
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    Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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  70. Feb 2022
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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  74. Jan 2022
  75. link.springer.com link.springer.com
    miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice
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  76. academic.oup.com academic.oup.com
    Regulation of mouse primordial follicle formation by signaling through the PI3K pathway
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
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  81. Dec 2021
  82. link.springer.com link.springer.com
    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
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    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  86. Nov 2021
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    Non-canonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish
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    Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment
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    Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
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    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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    Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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    Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
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    A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer
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    Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
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    The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment
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    Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification
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    Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats
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    eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition
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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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    Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
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    TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation
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    Discovery of Covalent MKK4/7 Dual Inhibitor
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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    Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
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    Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
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    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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    Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction
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    Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
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    Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish
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