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  1. Last 7 days
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    sciencedirect.com/science/article/pii/S1534580724002004
  3. Mar 2024
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    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10948148/
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    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
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  6. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
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    The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  10. Jan 2024
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    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  14. Dec 2023
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    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
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    sciencedirect.com/science/article/pii/S2211124723016157
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    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
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  17. Oct 2023
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    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
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    sciencedirect.com/science/article/pii/S2666166723006147
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  20. Jul 2023
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    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development
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    sciencedirect.com/science/article/abs/pii/S1534580723003349
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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    sciencedirect.com/science/article/pii/S1074761323002637
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    Oncogenic K-Ras suppresses global miRNA function
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  27. Jun 2023
  28. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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  29. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Multimodal characterization of murine gastruloid development
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    sciencedirect.com/science/article/pii/S1934590923001704
  32. Apr 2023
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10115456/
  35. Mar 2023
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    High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
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    sciencedirect.com/science/article/pii/S2211124723002541
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    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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  38. Feb 2023
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    Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
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    sciencedirect.com/science/article/pii/S2212877823000261
  40. Dec 2022
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    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
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    The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons
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    sciencedirect.com/science/article/pii/S2211124722016783
  43. Oct 2022
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    Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts
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    sciencedirect.com/science/article/pii/S1534580722007195
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    Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae
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    sciencedirect.com/science/article/pii/S2666166722006116
  46. Aug 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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  48. Jun 2022
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    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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  50. journals.physiology.org journals.physiology.org
    Control of coronary vascular resistance by eicosanoids via a novel GPCR
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    Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice
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    sciencedirect.com/science/article/pii/S2211124722007215
  52. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
  54. aacrjournals.org aacrjournals.org
    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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    aacrjournals.org/mct/article/21/5/810/694769/Proteolytic-pan-RAS-Cleavage-Leads-to-Tumor
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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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      DOI: 10.7554/eLife.76495

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    ncbi.nlm.nih.gov/pmc/articles/PMC9068208/
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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      DOI: 10.1186/s13024-022-00526-y

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  57. Mar 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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  59. www.sciencedirect.com www.sciencedirect.com
    RORγt phosphorylation protects against T cell-mediated inflammation
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    Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop
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  62. Feb 2022
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    Transcriptomic and Physiological Analysis of Endocrine Disrupting Chemicals Impacts on 3D Zebrafish Liver Cell Culture System
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  64. Dec 2021
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  67. elifesciences.org elifesciences.org
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  68. Oct 2021
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    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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  70. Sep 2021
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    Oncogene-dependent sloppiness in mRNA translation
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  72. Aug 2021
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
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    Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress
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    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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  80. Jul 2021
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    Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
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  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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  85. Jun 2021
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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  90. May 2021
  91. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Chronic restraint stress promotes the mobilization and recruitment of myeloid-derived suppressor cells through β-adrenergic-activated CXCL5-CXCR2-Erk signaling cascades
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  92. journals.physiology.org journals.physiology.org
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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  95. Apr 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
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      Mouse anti-p44/42 MAPK (Erk1/2) (L34F12) Monoclonal antibody

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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  99. Feb 2021
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    Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish
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    cell.com/current-biology/abstract/S0960-9822(20)31333-6
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers
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  103. Dec 2020
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA00844 inhibits MAPK signaling to suppress the progression of hepatocellular carcinoma by targeting AZGP1
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    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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  106. Oct 2020
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    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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  108. Sep 2020
  109. www.sciencedirect.com www.sciencedirect.com
    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    Angiotensin‐(1‐7) Mitigated Angiotensin II‐induced Abdominal Aortic Aneurysms in Apolipoprotein E Knockout Mice
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    Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes
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  112. elifesciences.org elifesciences.org
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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  117. Jan 2020
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    The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  127. Nov 2018
  128. watermark.silverchair.com watermark.silverchair.com
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    Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
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    A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling
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    Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
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    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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  137. Nov 2017
  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes
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    Endogenous, Regulatory Cysteine Sulfenylation of ERK Kinases in Response to Proliferative Signals
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    Feeding State Modulates Behavioral Choice and Processing of Prey Stimuli in the Zebrafish Tectum
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