125 Matching Annotations
  1. Nov 2024
  2. www.jneurosci.org www.jneurosci.org
    Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations
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    1. scibot 07 Nov 2024
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      DOI: 10.1523/JNEUROSCI.0095-24.2024

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    2. scibot 07 Nov 2024
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      DOI: 10.1523/JNEUROSCI.0095-24.2024

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    jneurosci.org/content/44/36/e0095242024
  3. Oct 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
    1
    1. scibot 05 Oct 2024
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      DOI: 10.1083/jcb.202401167

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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  5. aacrjournals.org aacrjournals.org
    Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/1535-7163.MCT-20-0963

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    aacrjournals.org/mct/article/20/9/1550/673361/Suppression-of-Extracellular-Vesicle-VEGF-C
  6. aacrjournals.org aacrjournals.org
    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/1541-7786.MCR-20-1022

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    aacrjournals.org/mcr/article/19/6/1063/672883/RAF-Mutant-Melanomas-Differentially-Depend-on-ERK2
  7. Sep 2024
  8. 52.53.155.43 52.53.155.43
    o-guinn-et-al-2024-fxr-deletion-attenuates-intestinal-barrier-dysfunction-in-murine-acute-intestinal-inflammation-html.html
    1
    1. scibot 06 Sep 2024
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      DOI: 10.1152/ajpgi.00063.2024

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    52.53.155.43/38c001291b888dcf9d96e78ed9f3c0ee31989d96/o-guinn-et-al-2024-fxr-deletion-attenuates-intestinal-barrier-dysfunction-in-murine-acute-intestinal-inflammation-html.html
  9. Aug 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114641

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    sciencedirect.com/science/article/pii/S2211124724009914
  11. www.sciencedirect.com www.sciencedirect.com
    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009379
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1126/science.adk0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1126/science.adk0850

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301400/
  14. www.sciencedirect.com www.sciencedirect.com
    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
    1
    1. scibot 18 Aug 2024
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    sciencedirect.com/science/article/pii/S266637912400377X
  15. academic.oup.com academic.oup.com
    Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1210/endocr/bqac140

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    academic.oup.com/endo/article-abstract/163/11/bqac140/6678177
  16. Jul 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice
    1
    1. scibot 30 Jul 2024
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      DOI: 10.1016/j.jare.2024.07.024

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    sciencedirect.com/science/article/pii/S2090123224003096
  18. www.cell.com www.cell.com
    Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
    1
    1. scibot 23 Jul 2024
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      DOI: 10.1016/j.xcrm.2024.101611

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00315-X
  19. www.science.org www.science.org
    Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1126/science.adk0850

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    science.org/doi/10.1126/science.adk0850
  20. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1126/science.adk0775

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    science.org/doi/10.1126/science.adk0775
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic expression of RAS Degrader RRSP in Pancreatic Cancer via Nanocarrier-mediated mRNA delivery
    1
    1. scibot 03 Jul 2024
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      DOI: 10.1101/2024.06.11.598439

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    ncbi.nlm.nih.gov/pmc/articles/PMC11212117/
  22. May 2024
  23. aacrjournals.org aacrjournals.org
    Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on-target resistance in NSCLC
    1
    1. scibot 23 May 2024
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      DOI: 10.1158/1078-0432.CCR-23-2951

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      RRID:AB_390780 DOI:10.1158/1078-0432.CCR-23-2951
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    aacrjournals.org/clincancerres/article/30/8/1582/742134/Discovery-of-a-Novel-Potent-EGFR-Inhibitor-Against
  24. Apr 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
    1
    1. scibot 20 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.032

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    sciencedirect.com/science/article/pii/S1534580724002004
  26. Mar 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
    1
    1. scibot 22 Mar 2024
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      DOI: 10.7554/eLife.92873

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948148/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation
    1
    1. scibot 09 Mar 2024
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      DOI: 10.1186/s13041-024-01086-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10916047/
  29. Feb 2024
  30. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  31. www.sciencedirect.com www.sciencedirect.com
    The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.001

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    sciencedirect.com/science/article/pii/S0896627324000011
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  33. Jan 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1016/j.isci.2023.108711

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    ncbi.nlm.nih.gov/pmc/articles/PMC10788224/
  35. www.science.org www.science.org
    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1126/sciadv.ade1282

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    science.org/doi/10.1126/sciadv.ade1282
  36. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/2767-9764.CRC-23-0308

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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  37. Dec 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes
    1
    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113603

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    sciencedirect.com/science/article/pii/S2211124723016157
  39. www.sciencedirect.com www.sciencedirect.com
    Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.isci.2023.108480

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    sciencedirect.com/science/article/pii/S2589004223025579
  40. Oct 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.xpro.2023.102647

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    sciencedirect.com/science/article/pii/S2666166723006147
  42. www.sciencedirect.com www.sciencedirect.com
    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113198

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    sciencedirect.com/science/article/pii/S221112472301210X
  43. Jul 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
    1
    1. scibot 29 Jul 2023
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      DOI: 10.1016/j.isci.2023.107283

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    ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
  45. www.sciencedirect.com www.sciencedirect.com
    Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development
    1
    1. scibot 28 Jul 2023
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      DOI: 10.1016/j.devcel.2023.07.004

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    sciencedirect.com/science/article/abs/pii/S1534580723003349
  46. www.sciencedirect.com www.sciencedirect.com
    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.cels.2023.06.005

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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
    1
    1. scibot 19 Jul 2023
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      DOI: 10.1158/0008-5472.CAN-21-4309

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    ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
  48. www.sciencedirect.com www.sciencedirect.com
    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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      DOI: 10.1016/j.immuni.2023.06.006

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    sciencedirect.com/science/article/pii/S1074761323002637
  49. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.008

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    sciencedirect.com/science/article/pii/S109727652300429X
  50. Jun 2023
  51. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
    2
    1. scibot 16 Jun 2023
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      DOI: 10.1126/sciadv.ade1155

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    2. scibot 12 Jun 2023
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      DOI: 10.1126/sciadv.ade1155

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    science.org/doi/10.1126/sciadv.ade1155
  52. May 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    1
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  55. Apr 2023
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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  58. Mar 2023
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    High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways
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    COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by upregulating Krox20
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  61. Feb 2023
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    Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release
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  63. Dec 2022
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    The calcium-sensing receptor (CaSR) regulates zebrafish sensorimotor decision making via a genetically defined cluster of hindbrain neurons
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  66. Oct 2022
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  69. Aug 2022
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    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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  71. Jun 2022
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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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  80. Mar 2022
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  95. Aug 2021
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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  103. Jul 2021
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    Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
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    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
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  108. Jun 2021
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  113. May 2021
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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  122. Feb 2021
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  126. Dec 2020
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  131. Sep 2020
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    Angiotensin‐(1‐7) Mitigated Angiotensin II‐induced Abdominal Aortic Aneurysms in Apolipoprotein E Knockout Mice
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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  140. Jan 2020
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    The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation
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    Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions
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  150. Nov 2018
  151. watermark.silverchair.com watermark.silverchair.com
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    Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
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    A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC5756609/
  157. link.springer.com link.springer.com
    Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
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    link.springer.com/article/10.1186/s12974-017-1050-z
  158. academic.oup.com academic.oup.com
    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
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      Curator: @evieth

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    academic.oup.com/endo/article/158/12/4270/4117214
  159. europepmc.org europepmc.org
    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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    europepmc.org/articles/PMC5655547/
  160. Nov 2017
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes
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    1. scibot 08 Nov 2017
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      Curator: @patriciaelyse_

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    ncbi.nlm.nih.gov/pmc/articles/PMC5569379/
  162. www.sciencedirect.com www.sciencedirect.com
    Endogenous, Regulatory Cysteine Sulfenylation of ERK Kinases in Response to Proliferative Signals
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0891584917307347
  163. www.sciencedirect.com www.sciencedirect.com
    Feeding State Modulates Behavioral Choice and Processing of Prey Stimuli in the Zebrafish Tectum
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      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0896627316300034