145 Matching Annotations
  1. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
  3. Jul 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208667/
  5. Jun 2025
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    SUV39H1-dependent methyl-degron is a critical regulator of skeletal homeostasis
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    sciencedirect.com/science/article/pii/S2211124725006813
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    RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
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    link.springer.com/article/10.1186/s12964-025-02278-w
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    Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
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    sciencedirect.com/science/article/pii/S2211124725005480
  9. May 2025
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    Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy
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    sciencedirect.com/science/article/pii/S1931312825001556
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    CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
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    sciencedirect.com/science/article/pii/S0896627325002545
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    NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis
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    sciencedirect.com/science/article/pii/S2211124725004723
  13. Apr 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
  15. Feb 2025
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    MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia
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  17. Jan 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells
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    Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis
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    nature.com/articles/s42255-024-01177-7
  20. 52.53.155.43 52.53.155.43
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  21. Dec 2024
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SIKs regulate HDAC7 stabilization and cytokine recall in late-stage T cell effector differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC10842463/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC134 controls TLR biogenesis through the ER chaperone Gp96
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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  25. Nov 2024
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury
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  27. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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  29. Sep 2024
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    CD14 is a decision-maker between Fas-mediated death and inflammation
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  31. Aug 2024
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    Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture
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  33. Jul 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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  35. Jun 2024
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    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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  37. Apr 2024
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    Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway
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    6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983109/
  44. Mar 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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    Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4/MyD88/NF-κB pathway
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  47. Feb 2024
  48. www.sciencedirect.com www.sciencedirect.com
    ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
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  50. Jan 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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  52. dx.doi.org dx.doi.org
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    dx.doi.org/10.1093/glycob/cwad087
  53. Dec 2023
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  55. Nov 2023
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10637774/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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  60. Oct 2023
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10571842/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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  63. www.cell.com www.cell.com
    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    cell.com/iscience/abstract/S2589-0042(23)02074-6
  64. www.sciencedirect.com www.sciencedirect.com
    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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  65. Aug 2023
  66. 52.53.155.43 52.53.155.43
    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2
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  69. Jul 2023
  70. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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  72. Jun 2023
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion
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    Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts
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    Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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  77. May 2023
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    YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
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    A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response
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  80. www.mdpi.com www.mdpi.com
    Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury
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    Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
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  82. Apr 2023
  83. www.cell.com www.cell.com
    Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
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    cell.com/cancer-cell/abstract/S1535-6108(23)00081-8
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    Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
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  85. Mar 2023
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    LMAN1 is a receptor for house dust mite allergens
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  87. Feb 2023
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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  89. Jan 2023
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    ERRα attenuates vascular inflammation via enhanced NFκB degradation pathway
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9804112/
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    ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
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  93. Dec 2022
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor necrosis factor is a necroptosis-associated alarmin
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    Vagus nerve stimulation is a potential treatment for ischemic stroke
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  96. Nov 2022
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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  98. Oct 2022
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
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  100. Aug 2022
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    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder
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  103. Apr 2022
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    Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB
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    Long-term and potent IOP-lowering effect of IκBα-siRNA in a nonhuman primate model of chronic ocular hypertension
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  106. Mar 2022
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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  108. Feb 2022
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
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    Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation
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    A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells
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    link.springer.com/article/10.1007/s00018-022-04154-z
  112. Jan 2022
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    Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
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  114. Dec 2021
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    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  117. Nov 2021
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    Human influenza virus challenge identifies cellular correlates of protection for oral vaccination
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  119. Aug 2021
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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  124. www.physiology.org www.physiology.org
    Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11
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