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KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer

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1. scibot 27 Sep 2025
  
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  DOI: 10.1038/s41388-025-03576-w
  
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nature.com/articles/s41388-025-03576-w
Aug 2025
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Tumor transcriptome-wide expression classifiers predict treatment sensitivity in advanced prostate cancers

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.042
  
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sciencedirect.com/science/article/pii/S0092867425008645
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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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1. scibot 14 Aug 2025
  
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  DOI: 10.1126/sciadv.abf9141
  
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The Nα-acetyl-L-lysine/Loxl2/H2O2 promotes intestinal tumor growth in Drosophila and cell proliferation in human colorectal cancer

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116126
  
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sciencedirect.com/science/article/pii/S2211124725008976
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1210/endocr/bqaf115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12280327/
Jun 2025
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Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

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  DOI: 10.1016/j.xcrm.2025.102198
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
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PTEN protein phosphatase activity regulates metastasis by targeting PKCδ

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1. scibot 12 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112741
  
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sciencedirect.com/science/article/pii/S2589004225010028
May 2025
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Mar 2025
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Safety and Efficacy of Copanlisib in Combination with Nivolumab: A Phase Ib Study in Patients with Advanced Solid Tumors

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1. scibot 20 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0407
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11907410/
Feb 2025
52.53.155.43 52.53.155.43

bqaf026-html.html

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  DOI: 10.1210/endocr/bqaf026
  
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52.53.155.43/d22fa31e4f3b177f9a2781339a7f11e7d089af3f/bqaf026-html.html
Jan 2025
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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

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1. scibot 03 Jan 2025
  
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  DOI: 10.1038/s41598-024-83912-4
  
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nature.com/articles/s41598-024-83912-4
Nov 2024
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Somatostatin interneuron fate-mapping and structure in a Pten knockout model of epilepsy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fncel.2024.1474613
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532043/
Oct 2024
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Local glycolysis supports injury-induced axonal regeneration

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1. scibot 08 Oct 2024
  
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  DOI: 10.1083/jcb.202402133
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11451009/
Sep 2024
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An ILK/STAT3 pathway controls glioblastoma stem cell plasticity

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1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.devcel.2024.09.003
  
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sciencedirect.com/science/article/pii/S1534580724005318
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Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114775
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01126-4
Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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1. scibot 28 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.08.003
  
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sciencedirect.com/science/article/pii/S1534580724004866
molecularbrain.biomedcentral.com molecularbrain.biomedcentral.com

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

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1. scibot 02 Aug 2024
  
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  anti-PTEN made in rabbit
  
  DOI: 10.1186/s13041-021-00731-8
  
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molecularbrain.biomedcentral.com/article/10.1186/s13041-021-00731-8
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Table 1 | Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells | SpringerLink

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1. scibot 02 Aug 2024
  
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  AB_823618
  
  DOI: 10.1007/s43032-019-00019-2
  
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link.springer.com/article/10.1007/s43032-019-00019-2/tables/1
Jul 2024
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DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance

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1. scibot 16 Jul 2024
  
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  DOI: 10.1038/s41416-024-02780-x
  
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nature.com/articles/s41416-024-02780-x
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Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer

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1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114487
  
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sciencedirect.com/science/article/pii/S2211124724008167
May 2024
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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

2
1. scibot 09 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114173
  
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  DOI: 10.1016/j.celrep.2024.114173
  
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52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

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1. scibot 16 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101510
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
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Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114056
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11112681/
Mar 2024
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Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina

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1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.114005
  
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sciencedirect.com/science/article/pii/S2211124724003334
Feb 2024
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Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures

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  DOI: 10.1016/j.celrep.2024.113810
  
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sciencedirect.com/science/article/pii/S2211124724001384
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A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs

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  DOI: 10.1038/s41698-024-00500-5
  
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nature.com/articles/s41698-024-00500-5
Dec 2023
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De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113518
  
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sciencedirect.com/science/article/pii/S2211124723015309
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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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  DOI: 10.1016/j.celrep.2023.113564
  
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sciencedirect.com/science/article/pii/S2211124723015760
Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.ccell.2023.09.001
  
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sciencedirect.com/science/article/pii/S1535610823003185
Aug 2023
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ccr-22-2976 (1)-html.html

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  DOI: 10.1158/1078-0432.ccr-22-2976
  
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52.53.155.43/a9d00605441caddd3b84705fb749be834fef17fa/ccr-22-2976 (1)-html.html
Jul 2023
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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  DOI: 10.1016/j.celrep.2023.112794
  
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sciencedirect.com/science/article/pii/S2211124723008057
Jun 2023
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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.ccell.2023.05.016
  
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sciencedirect.com/science/article/pii/S1535610823001836
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PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus

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1. scibot 01 Jun 2023
  
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  AB_390810
  
  DOI: 10.1111/jne.13187
  
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onlinelibrary.wiley.com/doi/10.1111/jne.13187
May 2023
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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

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1. scibot 11 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112472
  
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sciencedirect.com/science/article/pii/S2211124723004837
Apr 2023
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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression

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Neurovascular development in Pten and Tsc2 mouse mutants

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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

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Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas

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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice

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Ral GTPases are critical regulators of spinal cord myelination and homeostasis

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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role

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Stromal AR inhibits prostate tumor progression by restraining secretory luminal epithelial cells

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Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury

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The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

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Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer

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The mTOR chromatin-bound interactome in prostate cancer

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PTENα regulates endocytosis and modulates olfactory function

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In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

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Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors

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Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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PTENα regulates endocytosis and modulates olfactory function

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Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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mTOR-driven neural circuit changes initiate an epileptogenic cascade

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1

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Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation

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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

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Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells

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miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling

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Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

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  DOI: 10.7554/eLife.56651
  
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Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

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  DOI: 10.7554/eLife.51019
  
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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  DOI: 10.1016/j.celrep.2020.01.080
  
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rupress.org rupress.org

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

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  PTEN
  
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rupress.org/jem/article/217/6/e20191787/151590/Genetic-manipulation-of-LKB1-elicits-lethal
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CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation

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  DOI: 10.1016/j.neuron.2019.10.035
  
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Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?

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  DOI: 10.1016/j.expneurol.2019.113029
  
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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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  RRID:AB_390810
  
  DOI: 10.1016/j.cmet.2019.05.016
  
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Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing

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The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

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  DOI: 10.1016/j.celrep.2019.10.039
  
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Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

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  RRID:AB_390810
  
  DOI: 10.1016/j.stem.2019.09.009
  
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PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1

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  RRID:AB_390810
  
  DOI: 10.1016/j.molcel.2019.08.006
  
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Untitled document

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  DOI: 10.1016/j.cell.2019.03.005
  
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Untitled document

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  DOI: 10.1523/JNEUROSCI.0538-18.2018
  
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Untitled document

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  DOI: 10.1016/j.cell.2019.03.026
  
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sciencedirect.com/science/article/pii/S0092867419302880
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Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth

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onlinelibrary.wiley.com onlinelibrary.wiley.com

Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

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1. scibot 05 Nov 2018
  
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  RRID:AB_390810
  
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onlinelibrary.wiley.com/doi/full/10.1002/jcp.26830
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver

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1. scibot 05 Nov 2018
  
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  RRID:AB_390810
  
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Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

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Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons

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  AB_390810
  
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Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation

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1. scibot 05 Nov 2018
  
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  RRID:AB_390810
  
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sciencedirect.com/science/article/pii/S1097276517309760
Nov 2017
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Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

1
1. scibot 08 Nov 2017
  
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  9559
  
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PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network

1
1. scibot 08 Nov 2017
  
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  RRID:AB_390810
  
  Curator: @patriciaelyse_
  
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jneurosci.org/content/37/36/8595
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PTEN deletion increases hippocampal granule cell excitability in male and female mice

1
1. scibot 08 Nov 2017
  
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