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Feature-driven whole-tissue imaging with subcellular resolution

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.crmeth.2025.101148
  
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Aug 2025
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Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma

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1. scibot 21 Aug 2025
  
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  DOI: 10.1016/j.neuron.2025.07.025
  
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Targeting oncofetal fibronectin and neuropilin-1 in solid tumors with PL2 peptide

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1. scibot 14 Aug 2025
  
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  DOI: 10.1038/s41598-025-11299-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12340053/
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Sympathetic innervation maintains the murine quiescent skeletal muscle stem cell pool via perivascular-derived Angpt1

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.006
  
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sciencedirect.com/science/article/pii/S1534580725004447
Jul 2025
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AAV vectors for specific and efficient gene expression in microglia

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101116
  
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A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.045
  
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TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116001
  
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Jun 2025
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Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis | American Journal of Physiology-Cell Physiology | American Physiological Society

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1. scibot 26 Jun 2025
  
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  DOI: 10.1152/ajpcell.00022.2025
  
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journals.physiology.org/doi/full/10.1152/ajpcell.00022.2025
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Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis

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1. scibot 26 Jun 2025
  
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  DOI: 10.1152/ajpcell.00022.2025
  
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Lipocalin-2 regulates astrocyte-oligodendrocyte interaction to drive post-stroke secondary demyelination

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  DOI: 10.1016/j.celrep.2025.115899
  
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Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.stem.2025.05.014
  
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Functional ultrasound as a quantitative approach for measuring functional hyperemia in aging models

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.neuroimage.2025.121313
  
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Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115831
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00602-3
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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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1. scibot 04 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102141
  
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Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain

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1. scibot 04 Jun 2025
  
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  DOI: 10.1016/j.neuron.2025.05.004
  
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May 2025
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury

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1. scibot 24 May 2025
  
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  DOI: 10.4103/NRR.NRR-D-24-00381
  
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Specific targeting of brain endothelial cells using enhancer AAV vectors

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.neuron.2025.03.031
  
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Impact of ATF6 deletion on the embryonic brain development

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1. scibot 20 May 2025
  
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  DOI: 10.1016/j.isci.2025.112569
  
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SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.ymthe.2024.03.025
  
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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.027
  
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Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway

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1. scibot 16 May 2025
  
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  DOI: 10.1007/s12035-025-04969-4
  
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Apr 2025
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Silibinin Protects the Ischemic Brain in Mice by Exerting Anti-apoptotic Effects via the EGFR/ERK Pathway

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1-s2.0-S1525001625002941-main-html.html

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1. scibot 24 Apr 2025
  
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Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle

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1. scibot 19 Apr 2025
  
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  DOI: 10.21203/rs.3.rs-5968078/v1
  
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Mar 2025
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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

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  DOI: 10.1016/j.cell.2025.02.031
  
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Feb 2025
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Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes

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  DOI: 10.1016/j.xcrm.2025.101938
  
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Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions

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  DOI: 10.1016/j.stem.2025.01.001
  
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Differentiation of lung tissue-resident c-Kit+ cells into microvascular endothelial cells alleviates pulmonary vascular remodeling

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  DOI: 10.1016/j.devcel.2025.01.010
  
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Jan 2025
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The bacterial microbiome modulates the initiation of brain metastasis by impacting the gut-to-brain axis

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  DOI: 10.1016/j.isci.2025.111874
  
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Cyclin-dependent kinase inhibitor p18 regulates lineage transitions of excitatory neurons, astrocytes, and interneurons in the mouse cortex

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  DOI: 10.1038/s44318-024-00325-9
  
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Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing

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  DOI: 10.1016/j.neuron.2024.12.012
  
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Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome

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  DOI: 10.1016/j.isci.2024.111680
  
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Bone marrow mesenchymal stromal cells support translation in refractory acute myeloid leukemia

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  DOI: 10.1016/j.celrep.2024.115151
  
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Dec 2024
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Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.jid.2024.10.609
  
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sciencedirect.com/science/article/pii/S0022202X24029567
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Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111502
  
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Mission SpaceX CRS-19 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111382
  
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Three-dimensional characteristics of T cells and vasculature in the development of mouse esophageal cancer

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Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

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Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis

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A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response

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Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

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Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy

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Recurrent endothelin-1 mediated vascular insult leads to cognitive impairment protected by trophic factor pleiotrophin

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Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain

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Differential vascular permeability along the forebrain ventricular neurogenic niche in the adult murine brain

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The choroid plexus synergizes with immune cells during neuroinflammation

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Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

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Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis

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Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 leads to durable glioblastoma remission and immune memory in female mice

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3D Model of Mouse Embryonic Pancreas and Endocrine Compartment using Stem Cell-Derived Mesoderm and Pancreatic Progenitors

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The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair

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G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds

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Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact

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New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets

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Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation

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CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain

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FOXO1 stimulates tip cell-enriched gene expression in endothelial cells

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IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice

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Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle

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Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1

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Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety

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Histological and biochemical changes in lymphatic vessels after skeletal muscle injury induced by lengthening contraction in male mice

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Quantitative and qualitative mutational impact of ionizing radiation on normal cells

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VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells

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Therapeutic Delivery of Soluble Fractalkine Ameliorates Vascular Dysfunction in the Diabetic Retina

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Understanding the cell fate and behavior of progenitors at the origin of the mouse cardiac mitral valve

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Apoptosis recognition receptors regulate skin tissue repair in mice

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  DOI: 10.7554/eLife.86269
  
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Generation of heart and vascular system in rodents by blastocyst complementation

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Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway

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Long-term recruitment of peripheral immune cells to brain scars after a neonatal insult

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Structured wound angiogenesis instructs mesenchymal barrier compartments in the regenerating nerve

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Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon

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Transitional cell states sculpt tissue topology during lung regeneration

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Heterogeneity of perivascular astrocyte endfeet depending on vascular regions in the mouse brain

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Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation

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Protective effects of low-intensity pulsed ultrasound (LIPUS) against cerebral ischemic stroke in mice by promoting brain vascular remodeling via the inhibition of ROCK1/p-MLC2 signaling pathway

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Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

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Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study

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Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation

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Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina

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Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development

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Cooperative and competitive regulation of the astrocytic transcriptome by neurons and endothelial cells: Impact on astrocyte maturation

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Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells

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Vasculature in the mouse colon and spatial relationships with the enteric nervous system, glia, and immune cells

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MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis

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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

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Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade

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Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

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Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina

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FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress

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Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis

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A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy

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IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins

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A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors

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Characterization of the structure and control of the blood-nerve barrier identifies avenues for therapeutic delivery

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Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

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Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing

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Langerhans cells are essential components of the angiogenic niche during murine skin repair

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Brain injury triggers cell-type-specific and time-dependent endoplasmic reticulum stress responses

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Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

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Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin

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A single-cell transcriptomic inventory of murine smooth muscle cells

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Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity

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Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

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Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration

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Generation of vessel co-option lung metastases mouse models for single-cell isolation of metastases-derived cells and endothelial cells

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Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury

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Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma

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Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development

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Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

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Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow

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Rapid 3D-STORM imaging of diverse molecular targets in tissue

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Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

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Cell-specific RNA purification to study translatomes of mouse central nervous system

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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Epidermal growth factor deficiency predisposes to progressive renal disease

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Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney

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Cytokine co-stimulation effect on odontogenic differentiation of stem cells

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A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise

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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

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Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

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Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis

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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

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FOXO1 represses lymphatic valve formation and maintenance via PRDM1

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LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity

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COMMD10 is critical for Kupffer cell survival and controls Ly6Chi monocyte differentiation and inflammation in the injured liver

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Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain

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3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels

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Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

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Renal Subcapsular Delivery of PGE2 Promotes Kidney Repair by Activating Endogenous Sox9+ Stem Cells

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Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3

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Cochlear fibrocyte and osteoblast lineages expressing type 2 deiodinase identified with a Dio2 CreERt2 allele

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Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches

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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system

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Collagen XIII is required for neuromuscular synapse regeneration and functional recovery after peripheral nerve injury

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Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice

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Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF

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Tumor vessel co-option probed by single-cell analysis

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Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin

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Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells

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Pro-nociceptive roles of Schwann cell-derived galectin-3 in taxane-induced peripheral neuropathy

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Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis

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Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression

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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

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A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

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AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis

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O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

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A cellular and spatial map of the choroid plexus across brain ventricles and ages

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Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming

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Reactive astrocytes facilitate vascular repair and remodeling after stroke

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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

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Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

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Generation of Brachyury-mCherry knock-in reporter human pluripotent stem cell line (SNUe003-A-2) using CRISPR/CAS9 nuclease

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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

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CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

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TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression

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Morphology, localization, and postnatal development of dural macrophages

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Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface

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Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization

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Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury

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Activation of Neuronal Ras‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice

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Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor

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Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

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Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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Single-Cell Transcriptome Atlas of Murine Endothelial Cells

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Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

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Rapid degeneration of neurons in the penumbra region following a small, focal ischemic stroke

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Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

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Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling

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Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains

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Hippocampal neural stem cells facilitate access from circulation via apical cytoplasmic processes

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Zeb2 Is a Regulator of Astrogliosis and Functional Recovery after CNS Injury

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Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse

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Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

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Peculiar protrusions along tanycyte processes face diverse neural and non‐neural cell types in the hypothalamic parenchyma

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Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1

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Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

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