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    Leader cells promote immunosuppression to drive ovarian cancer progression in vivo
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    Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response
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    Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy
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    A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells
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    Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model
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    Local adaptive immunity in atherosclerosis with T cell activation by aortic DCs accelerates pathogenesis
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  9. Oct 2024
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    Alarmin-loaded extracellular lipid droplets induce airway neutrophil infiltration during type 2 inflammation
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    Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis
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  12. Sep 2024
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    A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
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    Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease
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    Activation of the NLRP1B inflammasome by caspase-8
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    Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    Dynamic allostery drives autocrine and paracrine TGF-β signaling
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    Endothelial metabolic control of insulin sensitivity through resident macrophages
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    Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
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  21. Aug 2024
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    Circulating platelets modulate oligodendrocyte progenitor cell differentiation during remyelination
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    Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis
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    Stepwise Ultra-pH-Sensitive Micelles Overcome a pKa Barrier for Systemic Lymph Node Delivery
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  25. Jul 2024
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    Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity
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    Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function
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    Splenic marginal zone B cells restrict Mycobacterium tuberculosis infection by shaping the cytokine pattern and cell-mediated immunity
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    JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma
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    Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
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    GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
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  32. Jun 2024
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    DOT1L maintains NK cell phenotype and function for optimal tumor control
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    Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice
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    The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation
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    Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility
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  37. May 2024
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    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus
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    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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    Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis
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    Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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    SZPMYTH_PERERA_DILHAN_2024_THESIS_J244231748-j148097451-html.html
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    Hypomethylation-enhanced CRTC2 expression drives malignant phenotypes and primary resistance to immunotherapy in hepatocellular carcinoma
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  46. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    The tautomerase activity of tumor exosomal MIF promotes pancreatic cancer progression by modulating MDSC differentiation
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    aacrjournals.org/cancerimmunolres/article/12/1/72/731979/The-Tautomerase-Activity-of-Tumor-Exosomal-MIF
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    A dopamine D1-like receptor-specific agonist improves the survival of septic mice
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  50. Mar 2024
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    Protocol for transcutaneous tumor photolabeling to track immune cells in vivo using Kaede mice
    1
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    A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation
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  53. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response
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  55. Feb 2024
  56. www.sciencedirect.com www.sciencedirect.com
    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
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  58. www.sciencedirect.com www.sciencedirect.com
    NGFR regulates stromal cell activation in germinal centers
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    Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
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  60. Jan 2024
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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  62. Dec 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch
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    VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis
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    IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis
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  66. Nov 2023
  67. www.sciencedirect.com www.sciencedirect.com
    E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC
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    Isolation of single cells from individual mouse ovaries for flow cytometry and functional analysis
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis
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  70. Oct 2023
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    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
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  72. Sep 2023
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    Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation
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    Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
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    Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease
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    BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine
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  78. Aug 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice
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    The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis
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    CYP19A1 mediates severe SARS-CoV-2 disease outcome in males
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    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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  83. 52.53.155.43 52.53.155.43
    ccr-22-2976 (1)-html.html
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia
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    NL-201 upregulates MHC-I expression and intratumoral TCR diversity, and demonstrates robust antitumor activity as monotherapy and in combination with PD-1 blockade
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      DOI: 10.1158/2326-6066.CIR-22-0304

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Voluntary exercise does not always suppress lung cancer progression
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  87. Jul 2023
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    QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
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  89. Jun 2023
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    xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
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  91. May 2023
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    Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice
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  93. www.biorxiv.org www.biorxiv.org
    CAF variants control the tumor-immune microenvironment and predict skin cancer malignancy
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  94. Apr 2023
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    Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
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  96. Mar 2023
  97. www.sciencedirect.com www.sciencedirect.com
    Immunodominant surface epitopes power immune evasion in the African trypanosome
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
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    Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
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    Smad4-mediated angiogenesis facilitates the beiging of white adipose tissue in mice
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid TLR4 Signaling Promotes Post-Injury Withdrawal Resolution of Murine Liver Fibrosis
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    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
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  103. www.sciencedirect.com www.sciencedirect.com
    A small-molecule inhibitor of Keap1–Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites
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  104. Feb 2023
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    Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
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  106. www.sciencedirect.com www.sciencedirect.com
    Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease
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  107. www.sciencedirect.com www.sciencedirect.com
    Flow cytometry and immunohistochemistry of the mouse dural meninges for immunological and virological assessments
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  108. www.sciencedirect.com www.sciencedirect.com
    XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
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  109. Jan 2023
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    Continuous germinal center invasion contributes to the diversity of the immune response
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    Flow cytometry protocol to quantify immune cells in the separated epithelium and stroma of herpes simplex virus-1-infected mouse cornea
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  112. www.sciencedirect.com www.sciencedirect.com
    Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
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  113. 52.53.155.43 52.53.155.43
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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  117. www.sciencedirect.com www.sciencedirect.com
    Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes
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  118. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
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  119. Dec 2022
  120. www.sciencedirect.com www.sciencedirect.com
    Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis
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    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness
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  123. Nov 2022
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    Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer’s disease
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  125. Oct 2022
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    Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis
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  128. 52.53.155.43 52.53.155.43
    A Microarray Patch SARS-CoV-2 Vaccine Induces Sustained Antibody Responses and Polyfunctional Cellular Immunity
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  129. Sep 2022
  130. www.sciencedirect.com www.sciencedirect.com
    Stress-triggered hematopoietic stem cell proliferation relies on PrimPol-mediated repriming
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    Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
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  132. Aug 2022
  133. www.sciencedirect.com www.sciencedirect.com
    A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice
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    Protocol for isolation and characterization of lung tissue resident memory T cells and airway trained innate immunity after intranasal vaccination in mice
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    During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
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  136. Jun 2022
  137. 52.53.155.43 52.53.155.43
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    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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    Langerhans cells are an essential cellular intermediary in chronic dermatitis
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    PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
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  141. May 2022
  142. www.sciencedirect.com www.sciencedirect.com
    Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis
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    Isolation and analyses of lamina propria lymphocytes from mouse intestines
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    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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    Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
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    A low dose adenovirus vectored vaccine expressing Schistosoma mansoni Cathepsin B protects from intestinal schistosomiasis in mice
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  147. Apr 2022
  148. www.sciencedirect.com www.sciencedirect.com
    Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
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    Aedes aegypti sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology
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    Protrudin regulates FAK activation, endothelial cell migration and angiogenesis
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  151. Mar 2022
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    Excess neuropeptides in lung signal through endothelial cells to impair gas exchange
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    AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
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    In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2
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  155. www.sciencedirect.com www.sciencedirect.com
    Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
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    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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  160. Feb 2022
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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    Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments
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  163. Jan 2022
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    Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells
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    Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation
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  167. Dec 2021
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    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective viral genome strategy elicits broad protective immunity against respiratory viruses
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
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  172. Nov 2021
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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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  176. Oct 2021
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines
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    The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo
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  179. Sep 2021
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    tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche
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  181. Aug 2021
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  183. www.biorxiv.org www.biorxiv.org
    Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung
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    NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
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    Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
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    Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
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  190. Jul 2021
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  192. www.sciencedirect.com www.sciencedirect.com
    Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity
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    Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma
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    Macrophage and neutrophil death programs differentially confer resistance to tuberculosis
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  195. Jun 2021
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    Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
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    Type I interferon decreases macrophage energy metabolism during mycobacterial infection
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  198. May 2021
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    Sensitive intranuclear flow cytometric quantification of IRF4 protein in multiple myeloma and normal human hematopoietic cells
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    RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes
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    A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma
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    Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation
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    An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells
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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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  205. Apr 2021
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    The dystonia gene THAP1 controls DNA double-strand break repair choice
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    Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype
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  210. Mar 2021
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    Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells
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  212. Feb 2021
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury
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  217. Jan 2021
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    QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis
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  219. Dec 2020
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    Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates
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    Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice
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    Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3+ Treg Cells by Multiparameter Flow Cytometry
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  223. Nov 2020
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    Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain
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    An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis
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  226. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation
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  227. Oct 2020
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    Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing
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  229. Sep 2020
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    Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity
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    Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling
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    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis
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    Soluble Aβ Oligomers and Protofibrils Induce NLRP3 Inflammasome Activation in Microglia
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    Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter
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    Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung
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    A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity
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    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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    Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids
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    Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
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    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation
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    CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection
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    Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity
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