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Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes

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1. scibot 06 Sep 2025
  
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  DOI: 10.1007/s00125-024-06313-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12276980/
Jul 2025
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.018
  
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cell.com/cell/fulltext/S0092-8674(25)00684-1
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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.006
  
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sciencedirect.com/science/article/pii/S1074761325002754
May 2025
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Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.032
  
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sciencedirect.com/science/article/pii/S0092867425005021
Apr 2025
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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.017
  
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sciencedirect.com/science/article/pii/S0092867425002909
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.004
  
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sciencedirect.com/science/article/pii/S1074761325001232
Mar 2025
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DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115364
  
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sciencedirect.com/science/article/pii/S2211124725001354
Nov 2024
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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.immuni.2024.10.013
  
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sciencedirect.com/science/article/pii/S107476132400493X
Sep 2024
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Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes

1
1. scibot 28 Sep 2024
  
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  DOI: 10.1101/2024.09.18.613649
  
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biorxiv.org/content/10.1101/2024.09.18.613649v1
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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.immuni.2024.08.015
  
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sciencedirect.com/science/article/pii/S1074761324004151
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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.029
  
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sciencedirect.com/science/article/pii/S0092867424009565
Aug 2024
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.immuni.2024.07.010
  
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sciencedirect.com/science/article/pii/S1074761324003595
Jul 2024
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Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.06.003
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00197-5
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling

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1. scibot 16 Mar 2024
  
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  DOI: 10.1084/jem.20221466
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10499045/
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Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response

2
1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113929
  
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2. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113929
  
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sciencedirect.com/science/article/pii/S2211124724002572
Feb 2024
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

2
1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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2. scibot 14 Feb 2024
  
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  RRID:AB_394763
  
  DOI: 10.1016/j.immuni.2024.01.011
  
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sciencedirect.com/science/article/pii/S1074761324000360
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling

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1. scibot 25 Jan 2024
  
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  DOI: 10.1126/sciadv.adi2012
  
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2. scibot 23 Jan 2024
  
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  DOI: 10.1126/sciadv.adi2012
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
Nov 2023
www.biorxiv.org www.biorxiv.org

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

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1. scibot 10 Nov 2023
  
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  DOI: 10.1101/2023.11.01.563607
  
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biorxiv.org/content/10.1101/2023.11.01.563607v1
Sep 2023
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Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.cmet.2023.08.010
  
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sciencedirect.com/science/article/pii/S1550413123003315
Jun 2023
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Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation

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  DOI: 10.1016/j.immuni.2023.05.004
  
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sciencedirect.com/science/article/pii/S1074761323002212
May 2023
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Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

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1. scibot 18 May 2023
  
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  DOI: 10.1016/j.isci.2023.106774
  
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sciencedirect.com/science/article/pii/S2589004223008519
Apr 2023
www.cell.com www.cell.com

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

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1. scibot 07 Apr 2023
  
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  RRID:AB_394763
  
  DOI: 10.1016/j.cell.2023.03.011
  
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cell.com/cell/fulltext/S0092-8674(23)00271-4
Mar 2023
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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.cmet.2023.02.013
  
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sciencedirect.com/science/article/pii/S1550413123000499
Feb 2023
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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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1. scibot 03 Feb 2023
  
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  DOI: 10.1016/j.ccell.2023.01.003
  
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sciencedirect.com/science/article/pii/S153561082300003X
Jan 2023
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Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury

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1. scibot 24 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112035
  
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sciencedirect.com/science/article/pii/S2211124723000463
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cbl-b Restrains Priming of Pathogenic Th17 Cells via the Inhibition of IL-6 Production by Macrophages

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1. scibot 04 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105151
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9523381/
Aug 2022
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A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

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1. scibot 02 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111142
  
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sciencedirect.com/science/article/pii/S2211124722009512
Jul 2022
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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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1. scibot 27 Jul 2022
  
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  DOI: 10.1016/j.ccell.2022.06.011
  
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sciencedirect.com/science/article/pii/S1535610822002756
Jun 2022
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Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

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1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.111011
  
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sciencedirect.com/science/article/pii/S2211124722008002
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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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1. scibot 22 Jun 2022
  
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  DOI: 10.1016/j.chembiol.2022.05.012
  
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sciencedirect.com/science/article/pii/S2451945622002045
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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.chom.2022.05.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9841318/
May 2022
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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110838
  
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sciencedirect.com/science/article/pii/S2211124722006118
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Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria

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1. scibot 18 May 2022
  
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  DOI: 10.1016/j.chom.2022.04.013
  
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sciencedirect.com/science/article/pii/S1931312822002190
Apr 2022
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Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse

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1. scibot 27 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110747
  
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Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

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Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

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Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

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Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation

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Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

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Increased demand for NAD+ relative to ATP drives aerobic glycolysis

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Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation

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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

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NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses

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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

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The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

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Untitled document

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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

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Nov 2018
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Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse

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Nov 2017
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Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

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Genome Organization Drives Chromosome Fragility

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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

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