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Computational design of potent and selective binders of BAK and BAX

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1. scibot 10 Sep 2025
  
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  DOI: 10.1126/sciadv.adt4170
  
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science.org/doi/10.1126/sciadv.adt4170
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Computational design of potent and selective binders of BAK and BAX

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1. scibot 09 Sep 2025
  
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  DOI: 10.1126/sciadv.adt4170
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12412652/
Oct 2024
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Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.celrep.2024.114794
  
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sciencedirect.com/science/article/pii/S2211124724011458
Sep 2024
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Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110683
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11382127/
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Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma

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1. scibot 05 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101706
  
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sciencedirect.com/science/article/pii/S2666379124004270
Apr 2024
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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

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1. scibot 10 Apr 2024
  
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  DOI: 10.1038/s41418-024-01289-3
  
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nature.com/articles/s41418-024-01289-3
Jan 2024
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A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.11.038
  
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2. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.11.038
  
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sciencedirect.com/science/article/pii/S1097276523010146
Dec 2023
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A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.038
  
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sciencedirect.com/science/article/pii/S1097276523010146
Oct 2023
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PolyQ-Expansion Causes Mitochondria Fragmentation Independent of Huntingtin and Is Distinct from Traumatic Brain Injury (TBI)/Mechanical Stress-Mediated Fragmentation Which Results from Cell Death

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1. scibot 13 Oct 2023
  
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  DOI: 10.3390/cells12192406
  
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mdpi.com/2073-4409/12/19/2406
May 2023
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Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex

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1. scibot 17 May 2023
  
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  DOI: 10.1016/j.devcel.2023.04.015
  
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sciencedirect.com/science/article/pii/S1534580723001910
Apr 2023
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Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112434
  
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sciencedirect.com/science/article/pii/S221112472300445X
Jan 2023
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DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

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1. scibot 06 Jan 2023
  
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  DOI: 10.1016/j.xcrm.2022.100880
  
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sciencedirect.com/science/article/pii/S266637912200444X
Nov 2022
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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1. scibot 03 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.10.005
  
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sciencedirect.com/science/article/pii/S1097276522009625
May 2022
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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.020
  
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sciencedirect.com/science/article/pii/S1534580722003069
Mar 2022
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Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain

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1. scibot 18 Mar 2022
  
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  DOI: 10.3389/fcell.2022.786268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8921082/
Feb 2022
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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.molcel.2022.01.008
  
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sciencedirect.com/science/article/pii/S1097276522000089
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

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1. scibot 16 Aug 2021
  
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  DOI: 10.1186/s13024-021-00470-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8353748/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Untitled document

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1. scibot 10 Aug 2021
  
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  DOI: 10.1111/jnc.14621
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14621
www.jneurosci.org www.jneurosci.org

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

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1. scibot 06 Aug 2021
  
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  DOI: 10.1523/JNEUROSCI.2462-16.2016
  
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jneurosci.org/content/37/6/1413
Jul 2021
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Untitled document

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1. scibot 31 Jul 2021
  
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  DOI: 10.1016/j.celrep.2019.03.040
  
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sciencedirect.com/science/article/pii/S2211124719303560
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BAX mitochondrial integration is regulated allosterically by its α1−α2 loop

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1. scibot 22 Jul 2021
  
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  DOI: 10.1038/s41418-021-00815-x
  
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nature.com/articles/s41418-021-00815-x
Jun 2021
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Oncogene-regulated release of extracellular vesicles

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1. scibot 12 Jun 2021
  
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  DOI: 10.1016/j.devcel.2021.05.014
  
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sciencedirect.com/science/article/pii/S1534580721004433
May 2021
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Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity

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1. scibot 26 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109180
  
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sciencedirect.com/science/article/pii/S2211124721005258
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Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

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1. scibot 19 May 2021
  
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  DOI: 10.3390/ijms22094948
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8125413/
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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109076
  
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sciencedirect.com/science/article/pii/S2211124721004071
Apr 2021
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Structure of detergent-activated BAK dimers derived from the inert monomer

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1. scibot 07 Apr 2021
  
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  DOI: 10.1016/j.molcel.2021.03.014
  
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sciencedirect.com/science/article/pii/S1097276521001829
Mar 2021
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The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

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1. scibot 17 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108869
  
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sciencedirect.com/science/article/pii/S2211124721001832
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Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

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1. scibot 11 Mar 2021
  
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  DOI: 10.1186/s13024-021-00435-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7941983/
Nov 2020
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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

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1. scibot 13 Nov 2020
  
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  DOI: 10.1016/j.neuron.2020.10.005
  
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sciencedirect.com/science/article/pii/S089662732030773X
Sep 2020
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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

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1. scibot 26 Sep 2020
  
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  DOI: 10.1038/s41419-020-2463-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7181796/
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The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation

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1. scibot 23 Sep 2020
  
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  DOI: 10.7554/eLife.55896
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7498260/
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Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107541
  
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sciencedirect.com/science/article/pii/S2211124720304411
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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

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1. scibot 13 Sep 2020
  
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  DOI: 10.1016/j.cmet.2020.06.002
  
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sciencedirect.com/science/article/pii/S155041312030303X
journals.plos.org journals.plos.org

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

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1. scibot 04 Sep 2020
  
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  cytochrome c
  
  DOI: 10.1371/journal.ppat.1008371
  
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journals.plos.org/plospathogens/article
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SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP

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1. scibot 04 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107640
  
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sciencedirect.com/science/article/pii/S2211124720305933
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Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

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1. scibot 13 Jan 2020
  
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  RRID:AB_396417
  
  DOI: 10.1016/j.molcel.2019.06.040
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_396417
  
  DOI: 10.1007/978-1-4939-8861-7_14
  
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_396417
  
  DOI: 10.1016/j.celrep.2019.03.040
  
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Untitled document

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.01.081
  
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Nov 2018
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Ensemble Properties of Bax Determine Its Function

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1. scibot 05 Nov 2018
  
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Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis

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1. scibot 05 Nov 2018
  
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  Curator: @evieth
  
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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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sciencedirect.com/science/article/pii/S1097276517308845
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Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

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sciencedirect.com/science/article/pii/S1097276517308365
Nov 2017
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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

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1. scibot 08 Nov 2017
  
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages

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1. scibot 08 Nov 2017
  
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Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

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1. scibot 08 Nov 2017
  
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  AB_396417
  
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Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

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1. scibot 08 Nov 2017
  
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  AB_396417
  
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PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise

1
1. scibot 08 Nov 2017
  
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www.jneurosci.org www.jneurosci.org

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

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1. scibot 08 Nov 2017
  
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  AB_396417
  
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jneurosci.org/content/37/6/1413
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Disordered clusters of Bak dimers rupture mitochondria during apoptosis

1
1. scibot 08 Nov 2017
  
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  AB_396417
  
  Curator: @kaitlinsung
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5302884/
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Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

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1. scibot 08 Nov 2017
  
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  AB_396417
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5016092/
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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

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1. scibot 08 Nov 2017
  
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  AB_396417
  
  Curator: @gabimpine
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5127641/