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A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC

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  DOI: 10.1007/s13402-025-01152-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
Jan 2026
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C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen

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sciencedirect.com/science/article/pii/S221112472501678X
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Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102524
  
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CCL5 deficiency aggravates acute DSS-induced colitis by restricting IL-33-induced formation of Tregs in intestinal tract

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1. scibot 09 Jan 2026
  
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In vivo detection of immune responses via cytokine activity labeling

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1. scibot 08 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.011
  
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Synergistic effects of Clostridium butyricum and Akkermansia muciniphila-derived postbiotics ameliorate DSS-induced colitis and associated tumorigenesis through immunomodulation and microbiota regulation in mice

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  DOI: 10.1128/msystems.00689-25
  
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Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10

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  DOI: 10.1016/j.celrep.2025.116840
  
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sciencedirect.com/science/article/pii/S2211124725016122
Dec 2025
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Blood metabolic panels for identifying significant fibrosis and inflammation in patients with MASLD

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1. scibot 20 Dec 2025
  
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Nov 2025
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Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids

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Fluorinated prodrug-engineered nano-remodeler relieves tumor hypoxia for dual-enhanced ferroptosis-immunotherapy

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1. scibot 13 Nov 2025
  
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Oct 2025
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production

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1. scibot 01 Oct 2025
  
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Sep 2025
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Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade

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1. scibot 09 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102322
  
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Aug 2025
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High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102291
  
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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.006
  
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Jul 2025
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.018
  
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Temporally programmed STING nanoadjuvant delivery unlocks synergistic chemotherapy-induced antitumor immunity

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1. scibot 22 Jul 2025
  
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  DOI: 10.1126/sciadv.adw0797
  
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science.org/doi/10.1126/sciadv.adw0797
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Temporally programmed STING nanoadjuvant delivery unlocks synergistic chemotherapy-induced antitumor immunity

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1. scibot 22 Jul 2025
  
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  DOI: 10.1126/sciadv.adw0797
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12273768/
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

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  DOI: 10.1016/j.cell.2025.06.018
  
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cell.com/cell/fulltext/S0092-8674(25)00684-1
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Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity

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  DOI: 10.1101/2025.06.20.660762
  
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biorxiv.org/content/10.1101/2025.06.20.660762v1
Jun 2025
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Amitriptyline revitalizes ICB response via dually inhibiting Kynurenine/indole and serotonin pathways of tryptophan metabolism in ovarian cancer

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Apr 2025
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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

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Bacterial pneumonia induces senescence in resident alveolar macrophages that are outcompeted by monocytes

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Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures

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Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure

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  DOI: 10.1016/j.celrep.2025.115479
  
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Mar 2025
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A heart-brain-spleen axis controls cardiac remodeling to hypertensive stress

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Feb 2025
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The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8+ T cells in mice

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Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

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1. scibot 14 Feb 2025
  
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  DOI: 10.1371/journal.ppat.1012906
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11813105/
Jan 2025
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Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer

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Dec 2024
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Arming Oncolytic M1 Virus with Gasdermin E Enhances Antitumor Efficacy in Breast Cancer

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  DOI: 10.1016/j.isci.2024.111148
  
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Nov 2024
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Meningeal neutrophil immune signaling influences behavioral adaptation following threat

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.neuron.2024.10.018
  
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DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer

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  DOI: 10.1016/j.medj.2024.10.012
  
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Sep 2024
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CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.xgen.2024.100659
  
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Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease

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1. scibot 26 Sep 2024
  
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Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1038/s41467-024-52523-y
  
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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice

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May 2024
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Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity

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S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function

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Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

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Maternal inflammation regulates fetal emergency myelopoiesis

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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

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Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis

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A mitochondria-targeting dihydroartemisinin derivative as a reactive oxygen species -based immunogenic cell death inducer

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One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

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Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

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Commensal bacteria promote azathioprine therapy failure in inflammatory bowel disease via decreasing 6-mercaptopurine bioavailability

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SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification

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Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

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Jun 2023
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Association of growth hormone deficiency with an increased number of preadipocytes in subcutaneous fat

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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

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FAP promotes metastasis and chemoresistance via regulating YAP1 and macrophages in mucinous colorectal adenocarcinoma

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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

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Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

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Tumor propagating side population cells are a dynamic subpopulation in undifferentiated pleomorphic sarcoma

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IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

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IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

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Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens

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Macrophage CD5L is a target for cancer immunotherapy

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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

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Temporal molecular program of human hematopoietic stem and progenitor cells after birth

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STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma

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Protocol for isolation and characterization of lung tissue resident memory T cells and airway trained innate immunity after intranasal vaccination in mice

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Unravelling the sex-specific diversity and functions of adrenal gland macrophages

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Interspecies commensal interactions have nonlinear impacts on host immunity

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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production

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Isolation and analyses of lamina propria lymphocytes from mouse intestines

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Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells

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Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

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PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

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Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

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The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

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Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

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tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

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Endocardially Derived Macrophages Are Essential for Valvular Remodeling

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Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

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GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair

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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

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Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets

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Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

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During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk

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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells

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Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry

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Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses

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Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner

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Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

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Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

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Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation

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Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

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Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo

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Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

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Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

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Endocardially Derived Macrophages Are Essential for Valvular Remodeling

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Untitled document

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Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

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Dissecting FcγR Regulation through a Multivalent Binding Model

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GPR68 Senses Flow and Is Essential for Vascular Physiology

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Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

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Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

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Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity

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Expression Analysis of CB2-GFP BAC Transgenic Mice

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