23 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology
    1
    1. scibot 26 Sep 2024
      AB_397973

      DOI: 10.1016/j.isci.2024.110937

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    sciencedirect.com/science/article/pii/S258900422402162X
  3. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Combined treatment with the histone deacetylase inhibitor LBH589 and a splice‐switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells
    1
    1. scibot 25 Sep 2024
      RRID:AB_397973

      DOI: 10.1111/jnc.14935

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      Curator comments: Mouse Anti-SMN Monoclonal Antibody, Unconjugated, Clone 8 BD Biosciences Cat# 610646

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14935
  4. Jul 2024
  5. www.cell.com www.cell.com
    Arginine methylation-enabled FUS phase separation with SMN contributes to neuronal granule formation
    1
    1. scibot 30 Jul 2024
      RRID:AB_397973

      DOI: 10.1016/j.celrep.2024.114537

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    cell.com/cell-reports/abstract/S2211-1247(24)00866-0
  6. Mar 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy
    1
    1. scibot 23 Mar 2024
      RRID:AB_397973

      DOI: 10.7554/eLife.92731

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945524/
  8. Aug 2023
  9. www.science.org www.science.org
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
    1
    1. scibot 12 Aug 2023
      RRID:AB_397973

      DOI: 10.1126/sciadv.adf6895

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    science.org/doi/10.1126/sciadv.adf6895
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
    1
    1. scibot 10 Aug 2023
      RRID:AB_397973

      DOI: 10.1126/sciadv.adf6895

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    ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
  11. Mar 2023
  12. www.sciencedirect.com www.sciencedirect.com
    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
    1
    1. scibot 02 Mar 2023
      RRID:AB_397973

      DOI: 10.1016/j.neuron.2023.02.004

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    sciencedirect.com/science/article/pii/S089662732300082X
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects
    1
    1. scibot 02 Mar 2023
      RRID:AB_397973

      DOI: 10.3390/ijms24044198

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    ncbi.nlm.nih.gov/pmc/articles/PMC9961752/
  14. Jan 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
    1
    1. scibot 15 Jan 2023
      RRID:AB_397973

      DOI: 10.26508/lsa.202201457

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    ncbi.nlm.nih.gov/pmc/articles/PMC9834662/
  16. Sep 2022
  17. www.sciencedirect.com www.sciencedirect.com
    SMN controls neuromuscular junction integrity through U7 snRNP
    1
    1. scibot 21 Sep 2022
      RRID:AB_397973

      DOI: 10.1016/j.celrep.2022.111393

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    sciencedirect.com/science/article/pii/S221112472201230X
  18. Jun 2022
  19. www.sciencedirect.com www.sciencedirect.com
    Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks
    1
    1. scibot 22 Jun 2022
      RRID:AB_397973

      DOI: 10.1016/j.nbd.2022.105795

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    sciencedirect.com/science/article/pii/S0969996122001875
  20. www.sciencedirect.com www.sciencedirect.com
    Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy
    1
    1. scibot 10 Jun 2022
      RRID:AB_397973

      DOI: 10.1016/j.cell.2022.04.031

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    sciencedirect.com/science/article/pii/S0092867422005293
  21. May 2022
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NOVA1 promotes SMN2 exon 7 splicing by binding the UCAC motif and increases SMN protein expression
    1
    1. scibot 24 May 2022
      RRID:AB_397973

      DOI: 10.4103/1673-5374.339005

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    ncbi.nlm.nih.gov/pmc/articles/PMC9120702/
  23. Dec 2021
  24. academic.oup.com academic.oup.com
    A novel CARM1-HuR axis involved in muscle differentiation and plasticity misregulated in spinal muscular atrophy
    1
    1. scibot 21 Dec 2021
      RRID:AB_397973

      DOI: 10.1093/hmg/ddab333

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab333/6428333
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models
    1
    1. scibot 02 Dec 2021
      RRID:AB_397973

      DOI: 10.1016/j.isci.2021.103376

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    ncbi.nlm.nih.gov/pmc/articles/PMC8605199/
  26. Nov 2021
  27. www.sciencedirect.com www.sciencedirect.com
    RNA promotes the formation of spatial compartments in the nucleus
    1
    1. scibot 05 Nov 2021
      RRID:AB_397973

      DOI: 10.1016/j.cell.2021.10.014

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    sciencedirect.com/science/article/pii/S0092867421012307
  28. May 2021
  29. www.sciencedirect.com www.sciencedirect.com
    A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein
    1
    1. scibot 12 May 2021
      RRID:AB_397973

      DOI: 10.1016/j.celrep.2021.109125

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    sciencedirect.com/science/article/pii/S2211124721004642
  30. Sep 2020
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases
    2
    1. scibot 10 Sep 2020
      RRID:AB_397973

      DOI: 10.3389/fmolb.2020.00055

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      Curator: @evieth

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    2. scibot 03 Sep 2020
      RRID:AB_397973

      DOI: 10.3389/fmolb.2020.00055

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      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC7181958/
  32. Jan 2020
  33. link.springer.com link.springer.com
    Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
    1
    1. scibot 13 Jan 2020
      AB_397973

      DOI: 10.1007/s12640-019-00121-y

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      Curator: @Naa003

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      RRID:AB_397973 RRIDCUR:Validated
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    link.springer.com/article/10.1007/s12640-019-00121-y
  34. www.sciencedirect.com www.sciencedirect.com
    Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
    1
    1. scibot 13 Jan 2020
      RRID:AB_397973

      DOI: 10.1016/j.celrep.2019.11.058

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      Curator: @ethanbadger

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      RRID:AB_397973 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719315499
  35. www.sciencedirect.com www.sciencedirect.com
    The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA
    1
    1. scibot 13 Jan 2020
      RRID:AB_397973

      DOI: 10.1016/j.celrep.2019.11.013

      Resource: (BD Biosciences Cat# 610647, RRID:AB_397973)

      Curator: @ethanbadger

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      RRID:AB_397973 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719314846
  36. Nov 2017
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA)
    1
    1. scibot 08 Nov 2017
      AB_397973

      Curator: @gabimpine

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      RRID:AB_397973 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC4581247/