89 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833220/
  3. Jan 2026
  4. www.nature.com www.nature.com
    Calcium overload induced mitochondrial and lysosomal dysfunction is regulated by Tousled-like kinase in a-synucleinopathy
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    nature.com/articles/s41419-025-08213-8
  5. Nov 2025
  6. link.springer.com link.springer.com
    Attenuating α-synuclein pathology in mice with in situ engineered astrocytes
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    link.springer.com/article/10.1186/s40035-025-00518-0
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12617525/
  8. www.science.org www.science.org
    CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology
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    science.org/doi/10.1126/sciadv.adu0726
  9. Sep 2025
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12407564/
  11. Jul 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  13. www.eneuro.org www.eneuro.org
    SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures
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    eneuro.org/content/8/4/ENEURO.0166-21.2021
  14. May 2025
  15. www.sciencedirect.com www.sciencedirect.com
    Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0889159125001977
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chronic Vanadium Exposure Promotes Aggregation of Alpha‐Synuclein, Tau and Amyloid Beta in Mouse Brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12082766/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046008/
  18. link.springer.com link.springer.com
    Microglia-driven inflammation induces progressive tauopathies and synucleinopathies
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    link.springer.com/article/10.1038/s12276-025-01450-z
  19. Apr 2025
  20. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/d714363667c36879138a1281f0e5ba96fe4c1e37/PDF-html.html
  21. Mar 2025
  22. link.springer.com link.springer.com
    Proximity proteomics reveals unique and shared pathological features between multiple system atrophy and Parkinson’s disease
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    link.springer.com/article/10.1186/s40478-025-01958-5
  23. www.sciencedirect.com www.sciencedirect.com
    Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2666379125000722
  24. Feb 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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    pmc.ncbi.nlm.nih.gov/articles/PMC11846974/
  26. 52.53.155.43 52.53.155.43
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    52.53.155.43/01dd9728947fbe4affbd9309aaacf50825c24057/2024.10.14.618089.full-html.html
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    1-s2.0-S2589004225001956-main-html.html
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  28. Jan 2025
  29. www.sciencedirect.com www.sciencedirect.com
    14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity
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    sciencedirect.com/science/article/pii/S0969996125000178
  30. www.sciencedirect.com www.sciencedirect.com
    G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
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    sciencedirect.com/science/article/pii/S2211124724015298
  31. Dec 2024
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
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    pmc.ncbi.nlm.nih.gov/articles/PMC11634889/
  33. Nov 2024
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson’s model
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    pmc.ncbi.nlm.nih.gov/articles/PMC11576395/
  35. Sep 2024
  36. www.biorxiv.org www.biorxiv.org
    Comparing alpha-synuclein-interactomes between multiple systems atrophy and Parkinson’s disease reveals unique and shared pathological features
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    biorxiv.org/content/10.1101/2024.09.20.613717v1
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384018/
  38. Jul 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
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    ncbi.nlm.nih.gov/pmc/articles/PMC11377155/
  40. Jun 2024
  41. www.sciencedirect.com www.sciencedirect.com
    Sex-specific biphasic alpha-synuclein response and alterations of interneurons in a COVID-19 hamster model
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    sciencedirect.com/science/article/pii/S2352396424002263
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  44. May 2024
  45. www.biorxiv.org www.biorxiv.org
    Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
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    biorxiv.org/content/10.1101/2024.05.24.595642v1
  46. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 infection exacerbates the cellular pathology of Parkinson’s disease in human dopaminergic neurons and a mouse model
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    sciencedirect.com/science/article/pii/S2666379124002623
  47. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  48. Apr 2024
  49. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16114
  50. www.nature.com www.nature.com
    Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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    nature.com/articles/s41419-024-06534-8
  51. Dec 2023
  52. www.sciencedirect.com www.sciencedirect.com
    Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
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    sciencedirect.com/science/article/pii/S0896627323008942
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    ncbi.nlm.nih.gov/pmc/articles/PMC10730909/
  54. Jul 2023
  55. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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    52.53.155.43/5185b06857919afc7fae38712332798a8a903a3a/2023.06.05.543428v1.full-html.html
  56. Jun 2023
  57. onlinelibrary.wiley.com onlinelibrary.wiley.com
    METTL14 is decreased and regulates m6A modification of α-synuclein in Parkinson's disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15882
  58. May 2023
  59. link.springer.com link.springer.com
    CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue
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    link.springer.com/article/10.1186/s12915-023-01582-6
  60. Oct 2022
  61. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression
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    sciencedirect.com/science/article/pii/S1873506122003014
  62. Sep 2022
  63. link.springer.com link.springer.com
    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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    link.springer.com/article/10.1007/s00401-022-02491-8
  64. Jul 2022
  65. elifesciences.org elifesciences.org
    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
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    elifesciences.org/articles/78055
  66. Jun 2022
  67. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
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    sciencedirect.com/science/article/pii/S009286742200592X
  68. May 2022
  69. link.springer.com link.springer.com
    Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
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    link.springer.com/article/10.1007/s11064-022-03612-1
  70. Apr 2022
  71. www.sciencedirect.com www.sciencedirect.com
    Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
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    sciencedirect.com/science/article/pii/S2211124722004272
  72. Mar 2022
  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14656
  74. Oct 2021
  75. www.sciencedirect.com www.sciencedirect.com
    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0896627321007042
  76. Sep 2021
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24952
  78. Aug 2021
  79. www.nature.com www.nature.com
    Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation
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    nature.com/articles/s41419-021-04046-3
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8350547/
  81. www.sciencedirect.com www.sciencedirect.com
    Methamphetamine persistently increases alpha-synuclein and suppresses gene promoter methylation within striatal neurons
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    sciencedirect.com/science/article/pii/S0006899319302902
  82. www.jneurosci.org www.jneurosci.org
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    jneurosci.org/content/34/43/14304
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    sciencedirect.com/science/article/pii/S2211124718317315
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  85. Jul 2021
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  87. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Brain region‐dependent differential expression of alpha‐synuclein
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    onlinelibrary.wiley.com/doi/10.1002/cne.23901/full
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC5409983/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology
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    ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
  90. link.springer.com link.springer.com
    Synuclein expression in the lizard Anolis carolinensis
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    link.springer.com/article/10.1007/s00359-016-1108-x
  91. May 2021
  92. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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    sciencedirect.com/science/article/pii/S2211124721004332
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In situ architecture of neuronal α-Synuclein inclusions
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    ncbi.nlm.nih.gov/pmc/articles/PMC8046968/
  94. Apr 2021
  95. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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    sciencedirect.com/science/article/pii/S0092867421003792
  96. Mar 2021
  97. www.sciencedirect.com www.sciencedirect.com
    The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
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    sciencedirect.com/science/article/pii/S2211124721001571
  98. Feb 2021
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
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    ncbi.nlm.nih.gov/pmc/articles/PMC7406352/
  100. Oct 2020
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a‐synuclein in mouse brain
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15199
  102. Sep 2020
  103. www.jbc.org www.jbc.org
    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
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    jbc.org/content/295/23/8005/T1.expansion.html
  104. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Changes in the cellular fatty acid profile drive the proteasomal degradation of α‐synuclein and enhance neuronal survival
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001344R
  105. www.sciencedirect.com www.sciencedirect.com
    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
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    sciencedirect.com/science/article/pii/S2451945620301070
  106. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein
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    pubmed.ncbi.nlm.nih.gov/32900375/
  107. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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    jneurosci.org/content/40/2/459
  108. Jan 2020
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC6920361/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC6706297/
  111. link.springer.com link.springer.com
    Motor Neurons Pathology After Chronic Exposure to MPTP in Mice
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    link.springer.com/article/10.1007/s12640-019-00121-y
  112. www.sciencedirect.com www.sciencedirect.com
    Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies
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    sciencedirect.com/science/article/pii/S2211124719307673
  113. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14312
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14656
  115. Nov 2017
  116. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0403-7
  117. www.sciencedirect.com www.sciencedirect.com
    Proteasome Activation by Small Molecules
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    sciencedirect.com/science/article/pii/S2451945617301526
  118. www.sciencedirect.com www.sciencedirect.com
    Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
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    sciencedirect.com/science/article/pii/S0092867416315902
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC4205554/
  121. www.jneurosci.org www.jneurosci.org
    Exogenous α-Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release
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    jneurosci.org/content/34/32/10603.long