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Jul 2026
www.nature.com www.nature.com

FMR1 gene therapy restores translationally relevant phenotypes in a mouse model for fragile X syndrome

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  DOI: 10.1038/s41434-026-00630-4
  
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nature.com/articles/s41434-026-00630-4
Jun 2026
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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer

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  DOI: 10.1016/j.celrep.2026.117583
  
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Enhancing Immunotherapeutic Response in Colorectal Cancer with a Neuropilin-1-Targeting Tumor-Penetrating Peptide

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  DOI: 10.1158/2767-9764.CRC-25-0619
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13250810/
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CD157+ vascular endothelial stem cells represent a conserved subpopulation with an angiogenic gene expression profile

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  DOI: 10.1016/j.stemcr.2026.102931
  
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sciencedirect.com/science/article/pii/S2213671126001426
May 2026
www-cell-com.eproxy.lib.hku.hk www-cell-com.eproxy.lib.hku.hk

Whole-genome doubling drives immune evasion by silencing antigen presentation

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  DOI: 10.1016/j.ccell.2026.04.007
  
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www-cell-com.eproxy.lib.hku.hk/cancer-cell/fulltext/S1535-6108(26)00218-7
Apr 2026
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Hyperthermia Combined with Anti-CTLA-4 Antibody Induces Tumor Microenvironment Remodeling Involving CD4+ T Cells in Local and Distant Antitumor Effects in a Murine Triple-Negative Breast Cancer

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  DOI: 10.3390/cancers18081295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13114660/
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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  DOI: 10.1016/j.celrep.2026.117230
  
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Mar 2026
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Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier

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  DOI: 10.1016/j.celrep.2026.117050
  
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RORγt Inhibition Reduces Pro-Tumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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  DOI: 10.1158/2326-6066.CIR-24-1128
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12288671/
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A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder

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1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102641
  
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sciencedirect.com/science/article/pii/S2666379126000583
Jan 2026
link.springer.com link.springer.com

BMSC-Derived Exosomal miR-21a-5p Ameliorates Blood–Brain Barrier Injury and Hemorrhagic Transformation

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1. scibot 15 Jan 2026
  
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  DOI: 10.1007/s12035-025-05650-6
  
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link.springer.com/article/10.1007/s12035-025-05650-6
Dec 2025
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Muscle satellite cell editing by LNP-CRISPR-Cas9 to resist muscle injury

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116695
  
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sciencedirect.com/science/article/pii/S2211124725014676
54.241.53.176 54.241.53.176

1-s2.0-S2589004225026197-main-html.html

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114358
  
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54.241.53.176/ccfdaea90d00d1e2ad4294448fdfaf1320c55233/1-s2.0-S2589004225026197-main-html.html
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Restricting lipid accumulation in tumor-infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects

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  DOI: 10.1016/j.cmet.2025.11.007
  
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sciencedirect.com:5037/science/article/pii/S1550413125004917
Oct 2025
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TLR ligand sensing by lymph node FRCs directs intranodal lymphocyte accumulation to promote immune responses

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1. scibot 29 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113734
  
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Sep 2025
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Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.08.006
  
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sciencedirect.com/science/article/pii/S1074761325003693
Aug 2025
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.008
  
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Jul 2025
52.53.155.43 52.53.155.43

2025.07.10.664251v1.full-html.html

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1. scibot 22 Jul 2025
  
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  DOI: 10.1101/2025.07.10.664251
  
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52.53.155.43/1cfa6b550b40cdda3522311aa4275c22b0c379c4/2025.07.10.664251v1.full-html.html
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s Disease

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  DOI: 10.1080/17590914.2025.2506406
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12140498/
May 2025
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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  DOI: 10.1016/j.celrep.2025.115735
  
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Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain

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  DOI: 10.1016/j.cell.2025.04.038
  
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Apr 2025
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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

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  DOI: 10.1016/j.cell.2025.03.017
  
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sciencedirect.com/science/article/pii/S0092867425002909
Feb 2025
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Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.006
  
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Dec 2024
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Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.008
  
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Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia

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  DOI: 10.1016/j.celrep.2024.115056
  
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Jul 2024
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Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation

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  DOI: 10.1016/j.ijbiomac.2024.134120
  
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Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice

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1. scibot 18 Jul 2024
  
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  DOI: 10.1210/endocr/bqae069
  
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dx.doi.org/10.1210/endocr/bqae069
Jun 2024
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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti

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  DOI: 10.1016/j.cmet.2024.04.020
  
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Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity

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  DOI: 10.1016/j.celrep.2024.114300
  
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Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer

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  DOI: 10.1016/j.isci.2024.109676
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11043890/
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Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells

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  DOI: 10.1016/j.celrep.2024.114052
  
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Feb 2024
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Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.019
  
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  DOI: 10.1016/j.immuni.2024.01.019
  
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sciencedirect.com/science/article/pii/S1074761324000451
Jan 2024
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Bispecific dendritic-T cell engager potentiates anti-tumor immunity

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.cell.2023.12.011
  
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sciencedirect.com/science/article/pii/S0092867423013430
Dec 2023
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A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis

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1. scibot 02 Dec 2023
  
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  DOI: 10.1126/scitranslmed.abn7491
  
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Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing

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PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

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PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior

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MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis

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IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

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Epigenetic dosage identifies two major and functionally distinct β cell subtypes

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Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease

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PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

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Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing

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Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

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Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

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A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

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RORα is critical for mTORC1 activity in T cell-mediated colitis

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ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Distinct skeletal stem cell types orchestrate long bone skeletogenesis

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Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

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The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells

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Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

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Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung

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Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

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A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

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Untitled document

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IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties

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Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

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