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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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1. scibot 27 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117739
  
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sciencedirect.com/science/article/pii/S221112472600817X
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

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1. scibot 06 Jun 2026
  
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  DOI: 10.7554/eLife.108883
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13183376/
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TRIM21 induces selective autophagy of viruses and bacteria

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  DOI: 10.1016/j.molcel.2026.04.031
  
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sciencedirect.com/science/article/pii/S1097276526002856
Apr 2026
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A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway

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  DOI: 10.1016/j.chembiol.2026.03.007
  
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sciencedirect.com/science/article/pii/S2451945626000772
www.thelancet.com www.thelancet.com

Migrasome-mediated clearance of excess PLK4 defines a targetable vulnerability

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1. scibot 07 Apr 2026
  
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  DOI: 10.1016/j.ebiom.2026.106237
  
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thelancet.com/journals/ebiom/article/PIIS2352-3964(26)00119-2/fulltext
Mar 2026
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Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.002
  
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sciencedirect.com/science/article/pii/S2451945626000723
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The proteostatic landscape of healthy human oocytes

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1. scibot 21 Aug 2025
  
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  DOI: 10.1038/s44318-025-00493-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12361380/
May 2025
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SLC7A11 is an unconventional H+ transporter in lysosomes

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.004
  
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sciencedirect.com/science/article/pii/S0092867425004064
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

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1. scibot 11 Apr 2025
  
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  DOI: 10.1038/s41556-025-01653-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12081312/
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Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.devcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1534580725001558
Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.immuni.2024.09.004
  
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sciencedirect.com/science/article/pii/S1074761324004485
Jul 2024
www.biorxiv.org www.biorxiv.org

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

1
1. scibot 23 Jul 2024
  
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  DOI: 10.1101/2024.07.09.602700
  
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biorxiv.org/content/10.1101/2024.07.09.602700v1
www.cell.com www.cell.com

m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114369
  
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cell.com/cell-reports/abstract/S2211-1247(24)00697-1
Apr 2024
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Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis

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1. scibot 25 Apr 2024
  
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  DOI: 10.1111/jnc.16114
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.16114
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An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

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1. scibot 02 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114020
  
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sciencedirect.com/science/article/pii/S2211124724003486
Feb 2024
jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com

Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

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1. scibot 22 Feb 2024
  
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  DOI: 10.1186/s12974-024-03039-1
  
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2. scibot 15 Feb 2024
  
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  DOI: 10.1186/s12974-024-03039-1
  
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jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03039-1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108883
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10838789/
Dec 2023
onlinelibrary.wiley.com onlinelibrary.wiley.com

Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation

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1. scibot 29 Dec 2023
  
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  DOI: 10.1002/advs.202305620
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202305620
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Prickle2 and Igsf9b Coordinately Regulate the Cytoarchitecture of the Axon Initial Segment

1
1. scibot 20 Dec 2023
  
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  DOI: 10.1247/csf.20028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10511046/
elifesciences.org elifesciences.org

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

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1. scibot 15 Dec 2023
  
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  DOI: 10.7554/eLife.87255
  
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elifesciences.org/articles/87255
Sep 2023
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Base editing corrects the common Salla disease SLC17A5 c.115C>T variant

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.omtn.2023.08.024
  
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sciencedirect.com/science/article/pii/S2162253123002354
Jul 2023
www.embopress.org www.embopress.org

Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics

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1. scibot 05 Jul 2023
  
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  DOI: 10.15252/embr.202256538
  
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embopress.org/doi/full/10.15252/embr.202256538
Jun 2023
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Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

1
1. scibot 30 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.06.004
  
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sciencedirect.com/science/article/pii/S1097276523004264
May 2023
www.mdpi.com www.mdpi.com

Within the Ischemic Penumbra, Sub-Cellular Compartmentalization of Heat Shock Protein 70 Overlaps with Autophagy Proteins and Fails to Merge with Lysosomes

1
1. scibot 06 May 2023
  
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  a
  
  DOI: 10.3390/molecules27103122
  
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mdpi.com/1420-3049/27/10/3122/htm
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

1
1. scibot 08 Apr 2023
  
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  DOI: 10.1083/jcb.202204042
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10071310/
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

1
1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.cell.2023.01.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10062012/
elifesciences.org elifesciences.org

Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)

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1. scibot 02 Feb 2023
  
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  DOI: 10.7554/eLife.82555
  
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elifesciences.org/articles/82555
Jan 2023
link.springer.com link.springer.com

CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway

1
1. scibot 21 Jan 2023
  
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  DOI: 10.1007/s12035-023-03227-9
  
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link.springer.com/article/10.1007/s12035-023-03227-9
Dec 2022
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Ring domains are essential for GATOR2-dependent mTORC1 activation

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.molcel.2022.11.021
  
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sciencedirect.com/science/article/pii/S1097276522011340
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer

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1. scibot 31 Jul 2022
  
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  DOI: 10.3390/cancers14143543
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
May 2022
www.sciencedirect.com www.sciencedirect.com

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

1
1. scibot 13 May 2022
  
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  DOI: 10.1016/j.isci.2022.104288
  
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sciencedirect.com/science/article/pii/S2589004222005582
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment

1
1. scibot 08 Dec 2021
  
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  DOI: 10.1016/j.isci.2021.103497
  
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sciencedirect.com/science/article/pii/S2589004221014681
Sep 2021
www.sciencedirect.com www.sciencedirect.com

Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism

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1. scibot 21 Sep 2021
  
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  DOI: 10.1016/j.chom.2021.08.012
  
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sciencedirect.com/science/article/pii/S1931312821003887
Aug 2021
www.sciencedirect.com www.sciencedirect.com

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

1
1. scibot 07 Aug 2021
  
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  DOI: 10.1016/j.cmet.2018.07.019
  
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sciencedirect.com/science/article/pii/S1550413118304625
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Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

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1. scibot 04 Aug 2021
  
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  RRID:AB_470708
  
  DOI: 10.1016/j.stem.2018.10.008
  
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sciencedirect.com/science/article/pii/S1934590918304892
Jul 2021
www.cell.com www.cell.com

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

1
1. scibot 29 Jul 2021
  
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  RRID: AB_470708
  
  DOI: 10.1016/j.cell.2019.05.056
  
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cell.com/cell/fulltext/S0092-8674(19)30627-0
May 2021
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NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes

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1. scibot 22 May 2021
  
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  RRID:AB_470708
  
  DOI: 10.15252/embj.2020105990
  
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embopress.org/doi/full/10.15252/embj.2020105990
Mar 2021
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Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy

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  DOI: 10.1016/j.cell.2020.10.045
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7927154/
Feb 2021
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Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

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  DOI: 10.7554/eLife.58990
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7550188/
Sep 2020
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Synaptotagmin‐7 enhances calcium‐sensing of chromaffin cell granules and slows discharge of granule cargos

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1. scibot 26 Sep 2020
  
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  DOI: 10.1111/jnc.14986
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14986
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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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  DOI: 10.7554/eLife.37993
  
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Jan 2020
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Untitled document

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  DOI: 10.1016/j.celrep.2019.04.034
  
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sciencedirect.com/science/article/pii/S2211124719304991
Nov 2018
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Untitled document

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Untitled document

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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification

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sciencedirect.com/science/article/pii/S1931312818302142
Nov 2017
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The Chihuahua dog: A new animal model for neuronal ceroid lipofuscinosis CLN7 disease?

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  Curator note: table
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.23710/full