36 Matching Annotations
  1. Last 7 days
  2. www.biorxiv.org www.biorxiv.org
    Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits
    1
    1. scibot 23 Jul 2024
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      DOI: 10.1101/2024.07.09.602700

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    biorxiv.org/content/10.1101/2024.07.09.602700v1
  3. www.cell.com www.cell.com
    m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication
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    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114369

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    cell.com/cell-reports/abstract/S2211-1247(24)00697-1
  4. Apr 2024
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
    1
    1. scibot 25 Apr 2024
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      DOI: 10.1111/jnc.16114

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16114
  6. www.sciencedirect.com www.sciencedirect.com
    An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
    1
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    sciencedirect.com/science/article/pii/S2211124724003486
  7. Feb 2024
  8. jneuroinflammation.biomedcentral.com jneuroinflammation.biomedcentral.com
    Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1186/s12974-024-03039-1

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      DOI: 10.1186/s12974-024-03039-1

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    jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03039-1
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1016/j.isci.2024.108883

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    ncbi.nlm.nih.gov/pmc/articles/PMC10838789/
  10. Dec 2023
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1002/advs.202305620

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prickle2 and Igsf9b Coordinately Regulate the Cytoarchitecture of the Axon Initial Segment
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1247/csf.20028

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    ncbi.nlm.nih.gov/pmc/articles/PMC10511046/
  13. elifesciences.org elifesciences.org
    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
    1
    1. scibot 15 Dec 2023
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      DOI: 10.7554/eLife.87255

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    elifesciences.org/articles/87255
  14. Sep 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
    1
    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.omtn.2023.08.024

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    sciencedirect.com/science/article/pii/S2162253123002354
  16. Jul 2023
  17. www.embopress.org www.embopress.org
    Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics
    1
    1. scibot 05 Jul 2023
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      DOI: 10.15252/embr.202256538

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    embopress.org/doi/full/10.15252/embr.202256538
  18. Jun 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.molcel.2023.06.004

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    sciencedirect.com/science/article/pii/S1097276523004264
  20. May 2023
  21. www.mdpi.com www.mdpi.com
    Within the Ischemic Penumbra, Sub-Cellular Compartmentalization of Heat Shock Protein 70 Overlaps with Autophagy Proteins and Fails to Merge with Lysosomes
    1
    1. scibot 06 May 2023
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      DOI: 10.3390/molecules27103122

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    mdpi.com/1420-3049/27/10/3122/htm
  22. Apr 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
    1
    1. scibot 08 Apr 2023
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      DOI: 10.1083/jcb.202204042

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    ncbi.nlm.nih.gov/pmc/articles/PMC10071310/
  24. Feb 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC10062012/
  26. elifesciences.org elifesciences.org
    Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)
    1
    1. scibot 02 Feb 2023
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      DOI: 10.7554/eLife.82555

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    elifesciences.org/articles/82555
  27. Jan 2023
  28. link.springer.com link.springer.com
    CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway
    1
    1. scibot 21 Jan 2023
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      DOI: 10.1007/s12035-023-03227-9

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    link.springer.com/article/10.1007/s12035-023-03227-9
  29. Dec 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Ring domains are essential for GATOR2-dependent mTORC1 activation
    1
    1. scibot 18 Dec 2022
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      DOI: 10.1016/j.molcel.2022.11.021

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    sciencedirect.com/science/article/pii/S1097276522011340
  31. Jul 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NPC1 Confers Metabolic Flexibility in Triple Negative Breast Cancer
    1
    1. scibot 31 Jul 2022
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      DOI: 10.3390/cancers14143543

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    ncbi.nlm.nih.gov/pmc/articles/PMC9319388/
  33. May 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets
    1
    1. scibot 13 May 2022
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      DOI: 10.1016/j.isci.2022.104288

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    sciencedirect.com/science/article/pii/S2589004222005582
  35. Dec 2021
  36. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
    1
    1. scibot 08 Dec 2021
      AB_470708

      DOI: 10.1016/j.isci.2021.103497

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    sciencedirect.com/science/article/pii/S2589004221014681
  37. Sep 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism
    1
    1. scibot 21 Sep 2021
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      DOI: 10.1016/j.chom.2021.08.012

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    sciencedirect.com/science/article/pii/S1931312821003887
  39. Aug 2021
  40. www.sciencedirect.com www.sciencedirect.com
    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
    1
    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.cmet.2018.07.019

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    sciencedirect.com/science/article/pii/S1550413118304625
  41. www.sciencedirect.com www.sciencedirect.com
    Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
    1
    1. scibot 04 Aug 2021
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      DOI: 10.1016/j.stem.2018.10.008

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    sciencedirect.com/science/article/pii/S1934590918304892
  42. Jul 2021
  43. www.cell.com www.cell.com
    LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
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    1. scibot 29 Jul 2021
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      DOI: 10.1016/j.cell.2019.05.056

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    cell.com/cell/fulltext/S0092-8674(19)30627-0
  44. May 2021
  45. www.embopress.org www.embopress.org
    NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes
    1
    1. scibot 22 May 2021
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      DOI: 10.15252/embj.2020105990

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    embopress.org/doi/abs/10.15252/embj.2020105990
  46. Mar 2021
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy
    1
    1. scibot 09 Mar 2021
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      DOI: 10.1016/j.cell.2020.10.045

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    ncbi.nlm.nih.gov/pmc/articles/PMC7927154/
  48. Feb 2021
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells
    1
    1. scibot 26 Feb 2021
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      DOI: 10.7554/eLife.58990

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    ncbi.nlm.nih.gov/pmc/articles/PMC7550188/
  50. Sep 2020
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptotagmin‐7 enhances calcium‐sensing of chromaffin cell granules and slows discharge of granule cargos
    1
    1. scibot 26 Sep 2020
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      DOI: 10.1111/jnc.14986

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14986
  52. elifesciences.org elifesciences.org
    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
    1
    1. scibot 05 Sep 2020
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      DOI: 10.7554/eLife.37993

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    elifesciences.org/articles/37993
  53. Jan 2020
  54. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      DOI: 10.1016/j.celrep.2019.04.034

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    sciencedirect.com/science/article/pii/S2211124719304991
  55. Nov 2018
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
  57. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S193131281830372X
  58. www.sciencedirect.com www.sciencedirect.com
    The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification
    1
    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1931312818302142
  59. Nov 2017
  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Chihuahua dog: A new animal model for neuronal ceroid lipofuscinosis CLN7 disease?
    1
    1. scibot 08 Nov 2017
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23710/full