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Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids

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1. scibot 12 May 2026
  
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  DOI: 10.1111/jnc.70458
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70458
May 2026
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Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.isci.2026.115702
  
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sciencedirect.com/science/article/pii/S2589004226010771
Mar 2026
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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.02.003
  
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sciencedirect.com/science/article/pii/S0896627326000863
Feb 2026
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Multi-omic analysis of guided and unguided forebrain organoids reveals differences in cellular composition and metabolic profiles

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.crmeth.2025.101295
  
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sciencedirect.com/science/article/pii/S2667237525003315
Jan 2026
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BPS Publications

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1. scibot 15 Jan 2026
  
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  RRID:AB_477171
  
  DOI: 10.1111/bph.70285
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70285
Sep 2025
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Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.devcel.2025.08.011
  
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sciencedirect.com/science/article/pii/S1534580725005313
Aug 2025
www.nature.com www.nature.com

Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment

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1. scibot 22 Aug 2025
  
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  DOI: 10.1038/s43587-025-00940-z
  
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nature.com/articles/s43587-025-00940-z
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2025.08.04.668469v1.full-html.html

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1. scibot 13 Aug 2025
  
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  DOI: 10.1101/2025.08.04.668469
  
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52.53.155.43/70ffb5c16eb9a3da7e318e3821d53006525a9d10/2025.08.04.668469v1.full-html.html
May 2025
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Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity

1
1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115746
  
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sciencedirect.com/science/article/pii/S2211124725005170
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Novel Phosphorylated Tau Conformer Implicated in the Tauopathy Pathogenesis of Human Neurons

1
1. scibot 21 May 2025
  
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  DOI: 10.3390/biom15040585
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12025006/
Mar 2025
www.biorxiv.org www.biorxiv.org

SSAO-mediated decrease of endothelial BDNF release affects neuronal GluA1 and PSD95 expression: a peripheral mechanism inducing NVU and CNS disturbances

1
1. scibot 14 Mar 2025
  
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  RRID:AB_477171
  
  DOI: 10.1101/2025.03.04.641410
  
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biorxiv.org/content/10.1101/2025.03.04.641410v1
Jan 2025
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Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.cell.2024.12.022
  
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sciencedirect.com/science/article/pii/S0092867424014351
Dec 2024
www.researchsquare.com www.researchsquare.com

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1. scibot 20 Dec 2024
  
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  RRID:AB_477171
  
  DOI: 10.21203/rs.3.rs-1885484/v1
  
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researchsquare.com/article/rs-7216019/'https://www.researchsquare.com/article/rs-7216019/v1
Sep 2024
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Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

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1. scibot 25 Sep 2024
  
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  RRID:AB_477171
  
  DOI: 10.1016/j.stem.2019.08.013
  
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sciencedirect.com/science/article/pii/S1934590919303480
currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success

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1. scibot 13 Sep 2024
  
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  DOI: 10.1002/cpz1.948
  
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currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.948
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development

1
1. scibot 04 Sep 2024
  
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  RRID:AB_477171
  
  DOI: 10.1038/s41467-024-51996-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11366759/
Aug 2024
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ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

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1. scibot 22 Aug 2024
  
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  AB_477171
  
  DOI: 10.1016/j.celrep.2024.114626
  
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sciencedirect.com/science/article/pii/S2211124724009768
Jul 2024
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Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration

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1. scibot 17 Jul 2024
  
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  AB_477171
  
  DOI: 10.1016/j.celrep.2024.114514
  
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sciencedirect.com/science/article/pii/S221112472400843X
Jun 2024
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CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114330
  
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sciencedirect.com/science/article/pii/S2211124724006582
May 2024
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Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury

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1. scibot 21 May 2024
  
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  RRID:AB_477171
  
  DOI: 10.1016/j.celrep.2021.108889
  
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2. scibot 21 May 2024
  
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  RRID:AB_477171
  
  DOI: 10.1016/j.celrep.2021.108889
  
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sciencedirect.com/science/article/pii/S2211124721002035
Apr 2024
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BPS Publications

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1. scibot 18 Apr 2024
  
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  RRID:AB_477171
  
  DOI: 10.1111/bph.16349
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16349
52.53.155.43 52.53.155.43

Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109628
  
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52.53.155.43/32900497c457b354d1392351d9a95244fdc10aab/1-s2.0-S2589004224008502-main-html.html
www.sciencedirect.com www.sciencedirect.com

Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids

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1. scibot 02 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.007
  
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sciencedirect.com/science/article/pii/S1934590924000894
Feb 2024
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Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109051
  
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2. scibot 28 Feb 2024
  
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  RRID:AB_477171
  
  DOI: 10.1016/j.isci.2024.109051
  
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sciencedirect.com/science/article/pii/S2589004224002724
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Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.neuron.2024.01.022
  
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sciencedirect.com/science/article/pii/S0896627324000485
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3D bioprinting of human neural tissues with functional connectivity

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.stem.2023.12.009
  
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sciencedirect.com/science/article/pii/S1934590923004393
Dec 2023
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Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113576
  
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sciencedirect.com/science/article/pii/S2211124723015887
Nov 2023
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Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

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1. scibot 09 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113151
  
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sciencedirect.com/science/article/pii/S2211124723011634
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.xpro.2023.102486
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10400954/
Jul 2023
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Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.xpro.2023.102413
  
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sciencedirect.com/science/article/pii/S2666166723003805
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

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1. scibot 21 Jul 2023
  
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  DOI: 10.26508/lsa.202201691
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10355288/
May 2023
52.53.155.43 52.53.155.43

Spatially Resolved Proteomic Profiling Uncovers Structural and Functional Regulators of the Axon Initial Segment

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1. scibot 25 May 2023
  
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  DOI: 10.1101/2023.03.06.531334
  
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52.53.155.43/1b0cedf04512903e90b9ef1858ffefd94df1235f/2023.03.06.531334v1.full-html.html
www.nature.com www.nature.com

SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice

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1. scibot 05 May 2023
  
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  DOI: 10.1038/s41467-022-31566-z
  
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nature.com/articles/s41467-022-31566-z
Apr 2023
www.biorxiv.org www.biorxiv.org

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

1
1. scibot 20 Apr 2023
  
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  RRID:AB_477171
  
  DOI: 10.1101/2023.04.05.535746
  
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biorxiv.org/content/10.1101/2023.04.05.535746v1
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

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1. scibot 23 Mar 2023
  
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Generation of self-organized autonomic ganglion organoids from fibroblasts

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ncbi.nlm.nih.gov/pmc/articles/PMC10009094/
Feb 2023
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Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons

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Jan 2023
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Characterization of microglia behaviour in healthy and pathological conditions with image analysis tools

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royalsocietypublishing.org/doi/10.1098/rsob.220200
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Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains

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Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

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Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors

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ncbi.nlm.nih.gov/pmc/articles/PMC9547302/
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BPS Publications

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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15928
Jul 2022
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Hippocampal Egr1-Dependent Neuronal Ensembles Negatively Regulate Motor Learning

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Jun 2022
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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BARS Influences Neuronal Development by Regulation of Post-Golgi Trafficking

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Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins

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The metabolite p-cresol impairs dendritic development, synaptogenesis and synapse function in hippocampal neurons: Implications for autism spectrum disorder.

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onlinelibrary.wiley.com/doi/10.1111/jnc.15604
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P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold

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Intellicount: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning

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eneuro.org/content/4/6/ENEURO.0219-17.2017
Jan 2022
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Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes

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Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity

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Molecular self-avoidance in synaptic neurexin complexes

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Dec 2021
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Molecular self-avoidance in synaptic neurexin complexes

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Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity

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ncbi.nlm.nih.gov/pmc/articles/PMC8640475/
Nov 2021
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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

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ncbi.nlm.nih.gov/pmc/articles/PMC8554488/
Oct 2021
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miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation

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ncbi.nlm.nih.gov/pmc/articles/PMC8463973/
Aug 2021
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Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

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cell.com/cell-reports/fulltext/S2211-1247(21)01015-9
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Untitled document

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Protein Tyrosine Phosphatase δ mediates the Sema3A-induced cortical basal dendritic arborization through the activation of Fyn tyrosine kinase

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ncbi.nlm.nih.gov/pmc/articles/PMC6705738/
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Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth

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MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

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Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

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sciencedirect.com/science/article/pii/S1934590921001661
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Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury

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Evaluation of UBE3A antibodies in mice and human cerebral organoids

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Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment

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TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model

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ncbi.nlm.nih.gov/pmc/articles/PMC7255805/
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High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

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tandfonline.com/doi/abs/10.1080/1028415X.2020.1724453
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Distinct Effects of BDNF and NT-3 on the Dendrites and Presynaptic Boutons of Developing Olfactory Bulb GABAergic Interneurons In Vitro

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link.springer.com/article/10.1007/s10571-020-01030-x
Sep 2020
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Vitamin D Supplementation Rescues Aberrant NF-κB Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice

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Lab Resource: Multiple Stem Cell Lines CRISPR/Cas9 gene editing of a SOX9 reporter human iPSC line to produce two TRPV4 patient heterozygous missense mutant iPSC lines, MCRIi001-A-3 (TRPV4 p.F273L) and MCRIi001-A-4 (TRPV4 p.P799L)

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Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk

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Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutation iPSC line, MCRIi001-B, using CRISPR/Cas9 gene editing

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Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses

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High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

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High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

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High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

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High fructose diet-induced obesity worsens post-ischemic brain injury in the hippocampus of female rats

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A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in brain neurons

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Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons

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Altered glucose catabolism in the presynaptic and perisynaptic compartments of SOD1G93A mouse spinal cord and motor cortex indicates that mitochondria are the site of bioenergetic imbalance in ALS

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Sticker method for preparation of frozen section using adhesive film

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Generation of seven iPSC lines from peripheral blood mononuclear cells suitable to investigate Autism Spectrum Disorder

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Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons

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Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 editing

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Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

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Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity

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Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness

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Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

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Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

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Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease

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The effect of electroconvulsive seizure on survival, neuronal differentiation, and expression of the maturation marker in the adult mouse hippocampus

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Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation

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FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

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MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts

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ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease

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Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

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Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

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Pathological gamma oscillations, impaired dopamine release, synapse loss and reduced dynamic range of unitary glutamatergic synaptic transmission in the striatum of hypokinetic Q175 Huntington mice

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PRMT1 regulates astrocytic differentiation of embryonic neural stem/precursor cells

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Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties

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Matrix metalloproteinases as promising regulators of axonal regrowth in the injured adult zebrafish retinotectal system

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