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Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

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1. scibot 24 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.117507
  
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sciencedirect.com/science/article/pii/S2589004226028865
Jul 2026
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A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia

1
1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116875
  
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sciencedirect.com/science/article/pii/S2589004226022534
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Erk inhibitors intercept Erk-mediated negative feedback while imposing cell-cycle arrest and activating p38

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1. scibot 09 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116629
  
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sciencedirect.com/science/article/pii/S2589004226020055
May 2026
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Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation

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1. scibot 20 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.012
  
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sciencedirect.com/science/article/pii/S1534580726001590
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ERK activation dynamics in maturing oocyte controls embryonic nuclear divisions in Caenorhabditis elegans

1
1. scibot 21 Nov 2025
  
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  DOI: 10.1016/j.celrep.2024.115157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874628/
54.241.53.176 54.241.53.176

2025.11.11.687669v1.full-html.html

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1. scibot 18 Nov 2025
  
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  DOI: 10.1101/2025.11.11.687669
  
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54.241.53.176/34791722a6eaf0a635c65c221f38fbecf50c3b26/2025.11.11.687669v1.full-html.html
Jul 2025
journals.biologists.com journals.biologists.com

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation

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1. scibot 02 Jul 2025
  
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  DOI: 10.1242/dev.148767
  
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journals.biologists.com/dev/article/144/14/2673/48093/COP9-signalosome-subunits-protect-Capicua-from
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Activation of GluN2D-containing NMDA receptors promotes development of axons and axon-carrying dendrites of cortical interneurons

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1093/cercor/bhaf136
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12141203/
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

1
1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.devcel.2023.08.021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7615346/
Oct 2024
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

ERK1/2 mitogen-activated protein kinase dimerization is essential for the regulation of cell motility

1
1. scibot 04 Oct 2024
  
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  DOI: 10.1002/1878-0261.13732
  
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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13732
Apr 2024
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BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice

1
1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114162
  
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sciencedirect.com/science/article/pii/S221112472400490X
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Metabolic rewiring and autophagy inhibition correct lysosomal storage disease in Mucopolysaccharidosis IIIB

1
1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108959
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10864807/
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Disruptions in cell fate decisions and transformed enteroendocrine cells drive intestinal tumorigenesis in Drosophila

1
1. scibot 28 Nov 2023
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.celrep.2023.113370
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10841758/
Oct 2023
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Peroxisomal ERK mediates Akh/glucagon action and glycemic control

1
1. scibot 14 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113200
  
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sciencedirect.com/science/article/pii/S2211124723012123
Sep 2023
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

1
1. scibot 16 Sep 2023
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.devcel.2023.08.021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7615346/
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

1
1. scibot 01 Aug 2023
  
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  DOI: 10.3390/ijms241411821
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
Jun 2023
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ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

1
1. scibot 23 Jun 2023
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.chembiol.2023.05.010
  
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sciencedirect.com/science/article/pii/S2451945623001538
Feb 2023
www.nature.com www.nature.com

Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria

4
1. scibot 18 Feb 2023
  
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  RRID:AB_477245
  
  DOI: 10.1038/s42003-023-04568-w
  
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2. scibot 18 Feb 2023
  
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  RRID:AB_477245
  
  DOI: 10.1038/s42003-023-04568-w
  
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3. scibot 18 Feb 2023
  
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  RRID:AB_477245
  
  DOI: 10.1038/s42003-023-04568-w
  
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4. scibot 18 Feb 2023
  
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  RRID:AB_477245
  
  DOI: 10.1038/s42003-023-04568-w
  
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nature.com/articles/s42003-023-04568-w
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species

1
1. scibot 17 Feb 2023
  
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  DOI: 10.1126/sciadv.add7969
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9931222/
Dec 2022
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Nodal signaling establishes a competency window for stochastic cell fate switching

1
1. scibot 06 Dec 2022
  
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  DOI: 10.1016/j.devcel.2022.11.008
  
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sciencedirect.com/science/article/pii/S1534580722008085
Oct 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants

1
1. scibot 27 Oct 2022
  
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  RRID:AB_477245
  
  DOI: 10.1242/dev.200552
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9515810/
Jul 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Manipulating bovine granulosa cell energy metabolism limits inflammation

1
1. scibot 14 Jul 2022
  
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  RRID:AB_477245
  
  DOI: 10.1530/REP-20-0554
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9272410/
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing

1
1. scibot 07 Apr 2022
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.isci.2022.104130
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8980802/
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

1
1. scibot 19 Feb 2022
  
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  RRID:AB_477245
  
  DOI: 10.26508/lsa.202101187
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
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Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation

1
1. scibot 13 Feb 2022
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.jbc.2022.101721
  
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sciencedirect.com/science/article/pii/S0021925822001612
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

1
1. scibot 12 Feb 2022
  
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  RRID:AB_477245
  
  DOI: 10.3389/fimmu.2022.815775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8825411/
Sep 2021
link.springer.com link.springer.com

Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide

1
1. scibot 04 Sep 2021
  
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  DOI: 10.1007/s00210-021-02148-5
  
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link.springer.com/article/10.1007/s00210-021-02148-5
Aug 2021
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RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

1
1. scibot 18 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109559
  
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sciencedirect.com/science/article/pii/S2211124721009931
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 03 Aug 2021
  
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  DOI: 10.1016/j.devcel.2017.11.021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5791662/
May 2021
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A systematic analysis of signaling reactivation and drug resistance

1
1. scibot 26 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109157
  
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sciencedirect.com/science/article/pii/S221112472100499X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

1
1. scibot 05 May 2021
  
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  DOI: 10.7554/eLife.59809
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8079150/
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Optogenetic investigation of BMP target gene expression diversity

1
1. scibot 16 Dec 2020
  
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  RRID:AB_477245
  
  DOI: 10.7554/eLife.58641
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7728441/
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

1
1. scibot 15 Sep 2020
  
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  DOI: 10.7554/eLife.51248
  
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  RRID:AB_477245 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6996932/
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Egfr Signaling Is a Major Regulator of Ecdysone Biosynthesis in the Drosophila Prothoracic Gland

1
1. scibot 14 Sep 2020
  
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  RRID:AB_477245
  
  DOI: 10.1016/j.cub.2020.01.092
  
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  RRID:AB_477245 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S096098222030172X
Jan 2020
elifesciences.org elifesciences.org

Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea

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1. scibot 13 Jan 2020
  
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  DOI: 10.7554/eLife.45145
  
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  Curator: @Naa003
  
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elifesciences.org/articles/45145
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ccell.2018.12.002
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1535610818305737
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Untitled document

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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.01.006
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S2211124719300063
Nov 2018
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Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2405471218302424
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A Switch-like Activation Relay of EGFR-ERK Signaling Regulates a Wave of Cellular Contractility for Epithelial Invagination

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1534580718304581
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Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish

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1. scibot 05 Nov 2018
  
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  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S2211124718309185
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Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages

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1. scibot 05 Nov 2018
  
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  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S1534580717309826
Nov 2017
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Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover

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1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1534580717307347
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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

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1. scibot 08 Nov 2017
  
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  Curator: @chewbeccax
  
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sciencedirect.com/science/article/pii/S1074761317302285
academic.oup.com academic.oup.com

Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model

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1. scibot 08 Nov 2017
  
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  Curator: @bandrow
  
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academic.oup.com/endo/article/158/3/560/2930939/Dual-Role-of-Insulin-in-Spexin-Regulation